BG105836A - Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands - Google Patents

Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands

Info

Publication number: BG105836A
Authority: BG; Bulgaria
Prior art keywords: group; covalent bond; acetylcholine receptor; receptor ligands; nicotinic acetylcholine
Prior art date: 1999-01-29

Application number

BG105836A

Other languages

Bulgarian (bg)

English (en)

Inventor

William BUNNELLE

Daniela CRISTINA

Jerome Daanen

Michael DART

Michael Meyer

Keith Ryther

Michael Schrimpf

Kevin Sippy

Richard Toupence

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2001-08-22

Publication date

2002-03-29

2001-08-22 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2002-03-29 Publication of BG105836A publication Critical patent/BG105836A/xx

Links

102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title 1
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title 1
239000003446 ligand Substances 0.000 title 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000005062 synaptic transmission Effects 0.000 abstract 1
125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG105836A 1999-01-29 2001-08-22 Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands BG105836A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US23983899A	1999-01-29	1999-01-29
PCT/US2000/001620 WO2000044755A1 (fr)	1999-01-29	2000-01-25	Derives diazabicycliques utiles en tant que ligands du recepteur nicotinique de l'acetylcholine

Publications (1)

Publication Number	Publication Date
BG105836A true BG105836A (en)	2002-03-29

Family

ID=22903947

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105836A BG105836A (en)	1999-01-29	2001-08-22	Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands

Country Status (26)

Country	Link
EP (2)	EP1147112B1 (fr)
JP (1)	JP4676062B2 (fr)
KR (1)	KR20010101725A (fr)
CN (2)	CN1345320A (fr)
AR (1)	AR034538A1 (fr)
AT (2)	ATE394401T1 (fr)
AU (1)	AU773795B2 (fr)
BG (1)	BG105836A (fr)
BR (1)	BR0007664A (fr)
CA (1)	CA2361525C (fr)
CO (1)	CO5150231A1 (fr)
CZ (1)	CZ20012716A3 (fr)
DE (2)	DE60006213T2 (fr)
DK (1)	DK1147112T3 (fr)
ES (2)	ES2305373T3 (fr)
HK (1)	HK1043116B (fr)
HU (1)	HUP0200332A3 (fr)
IL (1)	IL144340A0 (fr)
NO (1)	NO20013731L (fr)
NZ (1)	NZ512884A (fr)
PT (1)	PT1147112E (fr)
SK (1)	SK10692001A3 (fr)
TR (1)	TR200102162T2 (fr)
TW (1)	TW200300021A (fr)
WO (1)	WO2000044755A1 (fr)
ZA (1)	ZA200105835B (fr)

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2000
- 2000-01-25 ES ES03017562T patent/ES2305373T3/es not_active Expired - Lifetime
- 2000-01-25 WO PCT/US2000/001620 patent/WO2000044755A1/fr not_active Ceased
- 2000-01-25 CA CA002361525A patent/CA2361525C/fr not_active Expired - Fee Related
- 2000-01-25 BR BR0007664-3A patent/BR0007664A/pt not_active IP Right Cessation
- 2000-01-25 NZ NZ512884A patent/NZ512884A/xx unknown
- 2000-01-25 DE DE60006213T patent/DE60006213T2/de not_active Expired - Lifetime
- 2000-01-25 TR TR2001/02162T patent/TR200102162T2/xx unknown
- 2000-01-25 SK SK1069-2001A patent/SK10692001A3/sk unknown
- 2000-01-25 HK HK02102948.7A patent/HK1043116B/en not_active IP Right Cessation
- 2000-01-25 CN CN00805544A patent/CN1345320A/zh active Pending
- 2000-01-25 AU AU28569/00A patent/AU773795B2/en not_active Ceased
- 2000-01-25 CZ CZ20012716A patent/CZ20012716A3/cs unknown
- 2000-01-25 AT AT03017562T patent/ATE394401T1/de not_active IP Right Cessation
- 2000-01-25 EP EP00906998A patent/EP1147112B1/fr not_active Expired - Lifetime
- 2000-01-25 JP JP2000596011A patent/JP4676062B2/ja not_active Expired - Fee Related
- 2000-01-25 AT AT00906998T patent/ATE253067T1/de active
- 2000-01-25 EP EP03017562A patent/EP1359152B1/fr not_active Expired - Lifetime
- 2000-01-25 DK DK00906998T patent/DK1147112T3/da active
- 2000-01-25 IL IL14434000A patent/IL144340A0/xx unknown
- 2000-01-25 DE DE60038823T patent/DE60038823D1/de not_active Expired - Lifetime
- 2000-01-25 CN CNA2004100974823A patent/CN1636996A/zh active Pending
- 2000-01-25 KR KR1020017009420A patent/KR20010101725A/ko not_active Ceased
- 2000-01-25 HU HU0200332A patent/HUP0200332A3/hu unknown
- 2000-01-25 PT PT00906998T patent/PT1147112E/pt unknown
- 2000-01-25 ES ES00906998T patent/ES2209825T3/es not_active Expired - Lifetime
- 2000-01-26 CO CO00004294A patent/CO5150231A1/es unknown
- 2000-01-28 AR ARP000100393A patent/AR034538A1/es not_active Application Discontinuation
- 2000-03-01 TW TW091133012A patent/TW200300021A/zh unknown
2001
- 2001-07-16 ZA ZA200105835A patent/ZA200105835B/en unknown
- 2001-07-30 NO NO20013731A patent/NO20013731L/no not_active Application Discontinuation
- 2001-08-22 BG BG105836A patent/BG105836A/xx unknown

Also Published As

Publication number	Publication date
CA2361525A1 (fr)	2000-08-03
CZ20012716A3 (cs)	2001-11-14
CN1636996A (zh)	2005-07-13
HK1043116A1 (en)	2002-09-06
SK10692001A3 (sk)	2002-01-07
DE60006213T2 (de)	2004-07-29
WO2000044755A1 (fr)	2000-08-03
KR20010101725A (ko)	2001-11-14
ZA200105835B (en)	2002-10-16
DE60006213D1 (de)	2003-12-04
DK1147112T3 (da)	2004-02-23
AU773795B2 (en)	2004-06-03
NZ512884A (en)	2004-03-26
BR0007664A (pt)	2002-05-07
CO5150231A1 (es)	2002-04-29
DE60038823D1 (de)	2008-06-19
AU2856900A (en)	2000-08-18
JP4676062B2 (ja)	2011-04-27
HUP0200332A2 (en)	2002-06-29
AR034538A1 (es)	2004-03-03
CN1345320A (zh)	2002-04-17
IL144340A0 (en)	2002-05-23
HUP0200332A3 (en)	2002-09-30
TW200300021A (en)	2003-05-01
EP1359152A2 (fr)	2003-11-05
JP2002535409A (ja)	2002-10-22
EP1359152B1 (fr)	2008-05-07
EP1359152A3 (fr)	2003-12-17
EP1147112B1 (fr)	2003-10-29
PT1147112E (pt)	2004-03-31
ES2209825T3 (es)	2004-07-01
HK1043116B (en)	2004-10-15
ES2305373T3 (es)	2008-11-01
NO20013731D0 (no)	2001-07-30
ATE253067T1 (de)	2003-11-15
ATE394401T1 (de)	2008-05-15
EP1147112A1 (fr)	2001-10-24
TR200102162T2 (tr)	2001-12-21
CA2361525C (fr)	2009-12-08
NO20013731L (no)	2001-09-18

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