BG106115A - Синергичните ефекти на амлодипин и аторвастатин метаболит като база за комбинирана терапия - Google Patents

Синергичните ефекти на амлодипин и аторвастатин метаболит като база за комбинирана терапия Download PDF

Info

Publication number: BG106115A
Authority: BG; Bulgaria
Prior art keywords: pharmaceutical composition; amlodipine; organs; blood pressure; lipid
Prior art date: 1999-04-23

Application number

BG106115A

Other languages

Bulgarian (bg)

English (en)

Inventor

Preston Mason

Original Assignee

Preston Mason

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-23

Filing date

2001-11-16

Publication date

2002-11-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG106115(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-11-16 Application filed by Preston Mason filed Critical Preston Mason

2002-11-29 Publication of BG106115A publication Critical patent/BG106115A/bg

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XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical class C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims abstract description 82
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)

BG106115A 1999-04-23 2001-11-16 Синергичните ефекти на амлодипин и аторвастатин метаболит като база за комбинирана терапия BG106115A (bg)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US13066599P	1999-04-23	1999-04-23
US14530599P	1999-07-23	1999-07-23
US15112199P	1999-08-27	1999-08-27
US16659299P	1999-11-19	1999-11-19
PCT/US2000/010465 WO2000064443A1 (en)	1999-04-23	2000-04-18	Synergistic effects of amlodipine and atorvastatin

Publications (1)

Publication Number	Publication Date
BG106115A true BG106115A (bg)	2002-11-29

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ID=27494873

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106115A BG106115A (bg)	1999-04-23	2001-11-16	Синергичните ефекти на амлодипин и аторвастатин метаболит като база за комбинирана терапия

Country Status (30)

Country	Link
EP (1)	EP1173172B1 (pt)
JP (1)	JP2002542289A (pt)
KR (1)	KR20020024581A (pt)
CN (1)	CN1351492A (pt)
AP (1)	AP2001002324A0 (pt)
AT (1)	ATE314846T1 (pt)
AU (1)	AU4647000A (pt)
BG (1)	BG106115A (pt)
BR (1)	BR0010689A (pt)
CA (1)	CA2370639A1 (pt)
CZ (1)	CZ20013793A3 (pt)
DE (1)	DE60025344T2 (pt)
DK (1)	DK1173172T3 (pt)
EA (1)	EA004435B1 (pt)
EE (1)	EE200100555A (pt)
ES (1)	ES2256005T3 (pt)
HK (1)	HK1043741A1 (pt)
HU (1)	HUP0201016A3 (pt)
IL (1)	IL146085A0 (pt)
IS (1)	IS6118A (pt)
NO (1)	NO20015128L (pt)
OA (1)	OA11870A (pt)
PE (1)	PE20010055A1 (pt)
PL (1)	PL351408A1 (pt)
PT (1)	PT1173172E (pt)
SK (1)	SK15382001A3 (pt)
SV (1)	SV2002000058A (pt)
TN (1)	TNSN00085A1 (pt)
UY (1)	UY26118A1 (pt)
WO (1)	WO2000064443A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030114497A1 (en) *	2001-07-31	2003-06-19	Laman Alani	Pharmaceutical compositions of amlodipine and atorvastatin
CN100430057C (zh) *	2005-04-08	2008-11-05	石药集团中奇制药技术（石家庄）有限公司	左旋氨氯地平和阿托伐他汀的药物组合物
KR101467110B1 (ko) *	2013-08-01	2014-11-28	한국방송공사	코로나링을 구비한 지선애자

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5385929A (en) *	1994-05-04	1995-01-31	Warner-Lambert Company	[(Hydroxyphenylamino) carbonyl] pyrroles
GT199800127A (es) *	1997-08-29	2000-02-01		Combinaciones terapeuticas.

2000
- 2000-04-18 DE DE60025344T patent/DE60025344T2/de not_active Expired - Fee Related
- 2000-04-18 AU AU46470/00A patent/AU4647000A/en not_active Abandoned
- 2000-04-18 WO PCT/US2000/010465 patent/WO2000064443A1/en not_active Ceased
- 2000-04-18 ES ES00928200T patent/ES2256005T3/es not_active Expired - Lifetime
- 2000-04-18 PL PL00351408A patent/PL351408A1/xx unknown
- 2000-04-18 HU HU0201016A patent/HUP0201016A3/hu unknown
- 2000-04-18 KR KR1020017013547A patent/KR20020024581A/ko not_active Withdrawn
- 2000-04-18 JP JP2000613434A patent/JP2002542289A/ja not_active Withdrawn
- 2000-04-18 CA CA002370639A patent/CA2370639A1/en not_active Abandoned
- 2000-04-18 EP EP00928200A patent/EP1173172B1/en not_active Expired - Lifetime
- 2000-04-18 HK HK02105343.1A patent/HK1043741A1/zh unknown
- 2000-04-18 EA EA200101112A patent/EA004435B1/ru not_active IP Right Cessation
- 2000-04-18 CZ CZ20013793A patent/CZ20013793A3/cs unknown
- 2000-04-18 IL IL14608500A patent/IL146085A0/xx unknown
- 2000-04-18 CN CN00807935A patent/CN1351492A/zh active Pending
- 2000-04-18 EE EEP200100555A patent/EE200100555A/xx unknown
- 2000-04-18 OA OA1200100272A patent/OA11870A/en unknown
- 2000-04-18 AP APAP/P/2001/002324A patent/AP2001002324A0/en unknown
- 2000-04-18 DK DK00928200T patent/DK1173172T3/da active
- 2000-04-18 SK SK1538-2001A patent/SK15382001A3/sk unknown
- 2000-04-18 AT AT00928200T patent/ATE314846T1/de not_active IP Right Cessation
- 2000-04-18 BR BR0010689-5A patent/BR0010689A/pt not_active IP Right Cessation
- 2000-04-18 PT PT00928200T patent/PT1173172E/pt unknown
- 2000-04-19 PE PE2000000374A patent/PE20010055A1/es not_active Application Discontinuation
- 2000-04-21 TN TNTNSN00085A patent/TNSN00085A1/fr unknown
- 2000-04-24 UY UY26118A patent/UY26118A1/es unknown
- 2000-04-25 SV SV2000000058A patent/SV2002000058A/es unknown
2001
- 2001-10-19 NO NO20015128A patent/NO20015128L/no not_active Application Discontinuation
- 2001-10-19 IS IS6118A patent/IS6118A/is unknown
- 2001-11-16 BG BG106115A patent/BG106115A/bg unknown

Also Published As

Publication number	Publication date
HUP0201016A3 (en)	2003-03-28
EP1173172A4 (en)	2002-08-07
EA004435B1 (ru)	2004-04-29
NO20015128D0 (no)	2001-10-19
WO2000064443A1 (en)	2000-11-02
JP2002542289A (ja)	2002-12-10
AU4647000A (en)	2000-11-10
HUP0201016A2 (hu)	2002-07-29
SK15382001A3 (sk)	2002-05-09
PE20010055A1 (es)	2001-01-30
ES2256005T3 (es)	2006-07-16
EP1173172A1 (en)	2002-01-23
DE60025344T2 (de)	2006-09-28
UY26118A1 (es)	2001-03-16
CZ20013793A3 (cs)	2002-05-15
TNSN00085A1 (fr)	2005-11-10
AP2001002324A0 (en)	2001-12-31
EE200100555A (et)	2002-12-16
NO20015128L (no)	2001-12-20
IL146085A0 (en)	2002-07-25
SV2002000058A (es)	2002-02-05
EP1173172B1 (en)	2006-01-04
HK1043741A1 (zh)	2002-09-27
KR20020024581A (ko)	2002-03-30
OA11870A (en)	2006-03-27
DE60025344D1 (de)	2006-03-30
BR0010689A (pt)	2002-02-19
DK1173172T3 (da)	2006-05-15
CN1351492A (zh)	2002-05-29
ATE314846T1 (de)	2006-02-15
EA200101112A1 (ru)	2002-06-27
CA2370639A1 (en)	2000-11-02
WO2000064443A9 (en)	2002-08-29
IS6118A (is)	2001-10-19
PT1173172E (pt)	2006-05-31
PL351408A1 (en)	2003-04-22

Publication	Publication Date	Title
US7129265B2 (en)	2006-10-31	Synergistic effects of amlodipine and atorvastatin metabolite as a basis for combination therapy
KR100586754B1 (ko)	2006-06-08	지단백질 산화의 억제
Hussein et al.	1997	Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL
Stein et al.	2016	Efficacy and safety of gemcabene as add-on to stable statin therapy in hypercholesterolemic patients
AU2002211452B2 (en)	2005-10-27	Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases
US20230381166A1 (en)	2023-11-30	Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
Jorge et al.	1997	Rapid reversal of endothelial dysfunction in hypercholesterolaemic rabbits treated with simvastatin and pravastatin
Sherratt et al.	2019	Rosmarinic acid and its esters inhibit membrane cholesterol domain formation through an antioxidant mechanism based, in nonlinear fashion, on alkyl chain length
EP1173172B1 (en)	2006-01-04	Synergistic effects of amlodipine and the hydroxylated metabolite of atorvastatin
Illingworth	1989	New horizons in combination drug therapy for hypercholesterolemia
Lapenna et al.	2001	Antioxidant activity of amiodarone on human lipoprotein oxidation
JP2002542289A5 (pt)	2007-06-07
MXPA01010694A (en)	2002-06-05	Synergistic effects of amlodipine and atorvastatin
Grieve et al.	2000	Chylomicron remnants potentiate phenylephrine-induced contractions of rat aorta by an endothelium-dependent mechanism
MXPA00003200A (en)	2001-05-17	Inhibtion of lipoprotein oxidation
Weir et al.	1996	Experimental Myocardial Ischemia/Myocardial Infarction/Pulmonary Artery Constriction: Anorexic Agents Aminorex, Fenfluramine, and Dexfenfluramine Inhibit Potassium Current in Rat Pulmonary Vascular Smooth Muscle and Cause Pulmonary Vasoconstriction