BG106985A - Съединения, притежаващи антитуморна активност, метод за получаване и фармацевтични състави, които ги съдържат - Google Patents

Съединения, притежаващи антитуморна активност, метод за получаване и фармацевтични състави, които ги съдържат

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Publication number
BG106985A
BG106985A BG106985A BG10698502A BG106985A BG 106985 A BG106985 A BG 106985A BG 106985 A BG106985 A BG 106985A BG 10698502 A BG10698502 A BG 10698502A BG 106985 A BG106985 A BG 106985A
Authority
BG
Bulgaria
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
tumor activity
Prior art date
Application number
BG106985A
Other languages
English (en)
Inventor
Srinivas Nanduri
Sriram Rajagopal
Sairam Pothukuchi
Sunilkumar PILLAI
Ranjan Chakrabarti
Original Assignee
Dr. Reddy's Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Limited filed Critical Dr. Reddy's Laboratories Limited
Publication of BG106985A publication Critical patent/BG106985A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до нови производни на андрографолид, до техни стереоизомери, до полиморфни форми, до техни фармацевтично приемливи соли и солвати. Новите производни на андрографолид имат общаформула. Те са ефикасни при лечение на рак, вирус на херпес симплекс (HSV), вирус на човешка имунна недостатъчност (HIV), псориазис, рестеноза, атеросклероза и други сърдечно-съдови нарушения като антивирусни, антималарични, антибактериални, хепатозащитни и имунорегулиращи средства, както и при лечение на метаболитни нарушения.
BG106985A 2000-02-03 2002-08-07 Съединения, притежаващи антитуморна активност, метод за получаване и фармацевтични състави, които ги съдържат BG106985A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN89MA2000 2000-02-03
PCT/IB2001/000127 WO2001057026A1 (en) 2000-02-03 2001-02-02 Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BG106985A true BG106985A (bg) 2003-04-30

Family

ID=11097156

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106985A BG106985A (bg) 2000-02-03 2002-08-07 Съединения, притежаващи антитуморна активност, метод за получаване и фармацевтични състави, които ги съдържат

Country Status (18)

Country Link
US (1) US6410590B1 (bg)
EP (1) EP1261604A1 (bg)
JP (1) JP2003522166A (bg)
KR (1) KR20030004342A (bg)
CN (1) CN1416428A (bg)
AU (1) AU3043101A (bg)
BG (1) BG106985A (bg)
BR (1) BR0108064A (bg)
CA (1) CA2398996A1 (bg)
CZ (1) CZ20022655A3 (bg)
HU (1) HUP0204347A3 (bg)
IL (1) IL150905A0 (bg)
MX (1) MXPA02007513A (bg)
NO (1) NO20023643L (bg)
NZ (1) NZ520521A (bg)
RU (1) RU2002123576A (bg)
WO (1) WO2001057026A1 (bg)
ZA (1) ZA200206112B (bg)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576662B2 (en) * 2000-05-05 2003-06-10 Dr. Reddy's Laboratories Limited Compounds having anticancer activity : process for their preparation and pharmaceutical compositions containing them
CN100430054C (zh) * 2002-12-31 2008-11-05 北京大学第一医院 穿心莲二萜内酯在制备抑制血管生成药物中的应用
CN100408571C (zh) * 2003-02-25 2008-08-06 北京医工生物技术研究所 穿心莲内酯三马来酸半酯及其盐和它们的药物组合物
AU2004315105A1 (en) * 2004-02-03 2005-08-18 Universidad Austral De Chile Composition of labdane diterpenes extracted from Andrographis paniculata, useful for the treatment of autoimmune diseases, and Alzheimer disease by activation of PPR-gamma receptors
US8445533B2 (en) 2004-11-08 2013-05-21 Cornell Research Foundation, Inc. Andrographolide derivatives to treat viral infections
CN101129354B (zh) * 2005-06-06 2011-02-02 河南大学 含有三乙酰穿心莲内酯的药物组合物及其医药用途
JP2007176934A (ja) * 2005-11-30 2007-07-12 Kose Corp 血小板活性化因子アセチルヒドロラーゼ機能調整剤
CN101481375B (zh) * 2005-12-07 2011-06-01 郑州大学 穿心莲内酯c15位取代系列衍生物及其制备方法
CN100999520B (zh) * 2007-01-05 2010-12-01 郑州大学 异穿心莲内酯类似物及其制备方法
AU2008258958B2 (en) * 2007-05-31 2013-05-16 Suntory Holdings Limited Anti-fatigue Agents and Oral Compositions Containing Andrographolide as Active Ingredient
CN100584841C (zh) * 2007-08-08 2010-01-27 暨南大学 穿心莲内酯衍生物及其在制药中的应用
US20090117209A1 (en) * 2007-11-02 2009-05-07 Hutchison Medipharma Enterprises Limited Andrographis paniculata extract
AU2012359081B2 (en) 2011-12-21 2015-09-17 Innobioscience, Llc Combination therapy with interferon and andrographolides for multiple sclerosis
CN102526026B (zh) * 2012-02-10 2013-07-03 郑州大学 15-苄亚基-14-脱氧-11,12-脱氢穿心莲内酯衍生物在制备保肝药物中的用途
US20170354639A1 (en) * 2014-10-24 2017-12-14 Biogen Ma Inc. Diterpenoid derivatives and methods of use thereof
CN106606506A (zh) * 2015-10-21 2017-05-03 复旦大学 对映半日花烷型二萜在制备抗补体药物中的用途
CN105954457A (zh) * 2016-06-24 2016-09-21 广西灵峰药业有限公司 一种金香胶囊的生产质量控制方法
CN109942520B (zh) * 2019-04-10 2023-08-01 大理金明动物药业有限公司 穿心莲内酯磺化物及其制备方法与应用
CN116898841A (zh) * 2023-09-11 2023-10-20 中国中医科学院广安门医院 一种穿心莲内酯改构化合物l8或其衍生物的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6388124A (ja) 1986-09-30 1988-04-19 Toyo Jozo Co Ltd 抗腫瘍剤
GB8917295D0 (en) 1989-07-28 1989-09-13 Ruffles Graham K Anti-viral compositions
AU4376396A (en) 1994-12-06 1996-06-26 Paracelsian, Inc. Use of andrographolide compounds to treat or prevent pathogenicity of diseases

Also Published As

Publication number Publication date
KR20030004342A (ko) 2003-01-14
NO20023643L (no) 2002-09-30
HUP0204347A2 (en) 2003-05-28
ZA200206112B (en) 2003-10-31
BR0108064A (pt) 2002-10-29
EP1261604A1 (en) 2002-12-04
US6410590B1 (en) 2002-06-25
CN1416428A (zh) 2003-05-07
IL150905A0 (en) 2003-02-12
JP2003522166A (ja) 2003-07-22
HUP0204347A3 (en) 2005-04-28
NZ520521A (en) 2004-05-28
NO20023643D0 (no) 2002-07-31
CA2398996A1 (en) 2001-08-09
CZ20022655A3 (cs) 2003-04-16
US20020032229A1 (en) 2002-03-14
WO2001057026A1 (en) 2001-08-09
AU3043101A (en) 2001-08-14
RU2002123576A (ru) 2004-01-10
MXPA02007513A (es) 2004-08-23

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