BG107023A - 3-aminoquinazolin-2,4-dione antibacterial agents - Google Patents

3-aminoquinazolin-2,4-dione antibacterial agents

Info

Publication number: BG107023A
Authority: BG; Bulgaria
Prior art keywords: aminoquinazolin; alkyl; antibacterial agents; aryl; heterocyclic
Prior art date: 2000-01-24

Application number

BG107023A

Other languages

Bulgarian (bg)

English (en)

Inventor

Paul Bird

Edmund Ellsworth

Dai Nguyen

Joseph SANCHEZ

Howard Showalter

Rajeshwar Singh

Michael STIER

Tuan Tran

Brian Watson

Judy Yip

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-24

Filing date

2002-08-22

Publication date

2003-04-30

2002-08-22 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2003-04-30 Publication of BG107023A publication Critical patent/BG107023A/xx

Links

NMGODFWGUBLTTA-UHFFFAOYSA-N 3-amino-1h-quinazoline-2,4-dione Chemical compound C1=CC=C2C(=O)N(N)C(=O)NC2=C1 NMGODFWGUBLTTA-UHFFFAOYSA-N 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Paper (AREA)

BG107023A 2000-01-24 2002-08-22 3-aminoquinazolin-2,4-dione antibacterial agents BG107023A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17825200P	2000-01-24	2000-01-24
US24126700P	2000-10-18	2000-10-18
PCT/US2000/033656 WO2001053273A1 (fr)	2000-01-24	2000-12-12	Agents antibacteriens contenant 3-aminoquinazolin-2,4-dione

Publications (1)

Publication Number	Publication Date
BG107023A true BG107023A (en)	2003-04-30

Family

ID=26874138

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107023A BG107023A (en)	2000-01-24	2002-08-22	3-aminoquinazolin-2,4-dione antibacterial agents

Country Status (38)

Country	Link
US (2)	US7094780B1 (fr)
EP (1)	EP1255739B1 (fr)
JP (1)	JP4811978B2 (fr)
KR (1)	KR20020067701A (fr)
CN (1)	CN1425008A (fr)
AP (1)	AP2002002603A0 (fr)
AR (1)	AR030186A1 (fr)
AT (1)	ATE398110T1 (fr)
AU (1)	AU783078B2 (fr)
BG (1)	BG107023A (fr)
BR (1)	BR0017010A (fr)
CA (1)	CA2393802C (fr)
CO (1)	CO5320600A1 (fr)
CR (1)	CR6709A (fr)
DE (1)	DE60039194D1 (fr)
EA (1)	EA005585B1 (fr)
EE (1)	EE200200412A (fr)
ES (1)	ES2304992T3 (fr)
GE (1)	GEP20053429B (fr)
HK (1)	HK1054237A1 (fr)
HN (1)	HN2001000009A (fr)
HR (1)	HRP20020696A2 (fr)
HU (1)	HUP0204101A3 (fr)
IL (1)	IL150393A0 (fr)
IS (1)	IS6448A (fr)
MA (1)	MA26866A1 (fr)
MX (1)	MXPA02005989A (fr)
NO (1)	NO20023516L (fr)
OA (1)	OA12316A (fr)
PA (1)	PA8510101A1 (fr)
PE (1)	PE20011060A1 (fr)
PL (1)	PL356837A1 (fr)
SK (1)	SK10572002A3 (fr)
SV (1)	SV2001000288A (fr)
TN (1)	TNSN01011A1 (fr)
UY (1)	UY26551A1 (fr)
WO (1)	WO2001053273A1 (fr)
YU (1)	YU55902A (fr)

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DE69840599D1 (de)	1997-09-15	2009-04-09	Procter & Gamble	Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
ATE315038T1 (de)	2001-05-30	2006-02-15	Warner Lambert Co	Antibakterielle mittel
WO2002102793A2 (fr) *	2001-06-19	2002-12-27	Warner-Lambert Company Llc	Agents antibacteriens
US6900224B2 (en) *	2002-07-31	2005-05-31	The Procter & Gamble Company	Antimicrobial quinolones, their compositions and uses
EP1667994A1 (fr) *	2003-09-12	2006-06-14	Warner-Lambert Company LLC	Agents antibacteriens a base de quinolone
WO2005026153A1 (fr) *	2003-09-12	2005-03-24	Warner-Lambert Company Llc	Quinazoline-2,4-diones a titre d'agents antibacteriens
EP1687296A1 (fr) *	2003-11-18	2006-08-09	Warner-Lambert Company LLC	Derives antibacteriens d'aminoquinazolidinedione
WO2006019965A2 (fr) *	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Inhibiteurs de la dipeptidyl peptidase
GB0416730D0 (en)	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
BRPI0607241A2 (pt) *	2005-01-26	2009-08-25	Hoffmann La Roche	derivados de fenil metanona e o uso dos mesmos como inibidores do transportador de glicina 1
GB0507298D0 (en) *	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
US7977346B2 (en)	2006-01-17	2011-07-12	Guoqing Paul Chen	Spiro compounds and methods of use
SMP200800058B (it)	2006-03-28	2009-09-07	Procter & Gamble	Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico
US7456279B2 (en)	2006-03-28	2008-11-25	The Procter & Gamble Company	Coupling process for preparing quinolone intermediates
US20080139574A1 (en)	2006-11-30	2008-06-12	Cadila Healthcare Limited	Novel quinoline derivatives
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WO2011031745A1 (fr)	2009-09-09	2011-03-17	Achaogen, Inc.	Analogues de fluoroquinolone antibactériens
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US9732083B2 (en)	2011-03-15	2017-08-15	Merck Sharp & Dohme Corp.	Tricyclic gyrase inhibitors
KR102032934B1 (ko) *	2011-12-21	2019-10-16	지앙수 헨그루이 메디슨 컴퍼니 리미티드	피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도
ES2704744T3 (es)	2012-06-13	2019-03-19	Incyte Holdings Corp	Compuestos tricíclicos sustituidos como inhibidores de FGFR
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
JP6460991B2 (ja)	2012-09-12	2019-01-30	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	抗菌剤として使用するための三環式ジャイレース阻害剤
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
EA035095B1 (ru)	2013-04-19	2020-04-27	Инсайт Холдингс Корпорейшн	Бициклические гетероциклы в качестве ингибиторов fgfr
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (fr)	2015-02-20	2016-08-25	Incyte Corporation	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MX373169B (es)	2015-02-20	2020-04-24	Incyte Holdings Corp	Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr).
CN108530448A (zh) *	2017-03-02	2018-09-14	浙江司太立制药股份有限公司	含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CR20200590A (es)	2018-05-04	2021-04-26	Incyte Corp	Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
MA52493A (fr)	2018-05-04	2021-03-10	Incyte Corp	Sels d'un inhibiteur de fgfr
CN111620866A (zh) *	2019-02-27	2020-09-04	南京药石科技股份有限公司	一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
WO2020185532A1 (fr)	2019-03-08	2020-09-17	Incyte Corporation	Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
WO2021007269A1 (fr)	2019-07-09	2021-01-14	Incyte Corporation	Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
WO2021067374A1 (fr)	2019-10-01	2021-04-08	Incyte Corporation	Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
TWI891666B (zh)	2019-10-14	2025-08-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之雙環雜環
WO2021076728A1 (fr)	2019-10-16	2021-04-22	Incyte Corporation	Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
BR112022010664A2 (pt)	2019-12-04	2022-08-16	Incyte Corp	Derivados de um inibidor de fgfr
EP4069696A1 (fr)	2019-12-04	2022-10-12	Incyte Corporation	Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
WO2021146424A1 (fr)	2020-01-15	2021-07-22	Incyte Corporation	Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
CN111499513B (zh) *	2020-04-24	2023-03-14	上海毕得医药科技股份有限公司	一种2,3,4,5-四溴苯甲酸酯的合成方法
TW202304459A (zh)	2021-04-12	2023-02-01	美商英塞特公司	包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
WO2022261159A1 (fr)	2021-06-09	2022-12-15	Incyte Corporation	Hétérocycles tricycliques utiles en tant qu'inhibiteurs de fgfr
EP4352059A1 (fr)	2021-06-09	2024-04-17	Incyte Corporation	Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr

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DE1068263B (fr) *		1959-11-05
FR1203542A (fr) *	1958-02-25	1960-01-19	Rhone Poulenc Sa	Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation
ATE8626T1 (de) *	1980-03-10	1984-08-15	Berri-Balzac Societe Dite:	3-amino-(1h,3h)-2,4-chinazolindionderivate.
GB2097784A (en) *	1981-04-28	1982-11-10	Davidson Dr John Stirton	Dihydrobenzotriazepine diones; aminoquinazoline diones
WO1994014809A1 (fr)	1992-12-23	1994-07-07	Byk Gulden Lomberg Chemische Fabrik Gmbh	Derives anneles d'uracile
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AU763839B2 (en)	1998-05-26	2003-07-31	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
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2000
- 2000-12-12 CN CN00818578A patent/CN1425008A/zh active Pending
- 2000-12-12 WO PCT/US2000/033656 patent/WO2001053273A1/fr not_active Ceased
- 2000-12-12 YU YU55902A patent/YU55902A/sh unknown
- 2000-12-12 EA EA200200661A patent/EA005585B1/ru not_active IP Right Cessation
- 2000-12-12 AT AT00984246T patent/ATE398110T1/de not_active IP Right Cessation
- 2000-12-12 KR KR1020027009515A patent/KR20020067701A/ko not_active Withdrawn
- 2000-12-12 AP APAP/P/2002/002603A patent/AP2002002603A0/en unknown
- 2000-12-12 ES ES00984246T patent/ES2304992T3/es not_active Expired - Lifetime
- 2000-12-12 US US10/182,221 patent/US7094780B1/en not_active Expired - Fee Related
- 2000-12-12 PL PL00356837A patent/PL356837A1/xx not_active Application Discontinuation
- 2000-12-12 HU HU0204101A patent/HUP0204101A3/hu unknown
- 2000-12-12 GE GE4912A patent/GEP20053429B/en unknown
- 2000-12-12 OA OA1200200210A patent/OA12316A/en unknown
- 2000-12-12 IL IL15039300A patent/IL150393A0/xx unknown
- 2000-12-12 EP EP00984246A patent/EP1255739B1/fr not_active Expired - Lifetime
- 2000-12-12 CA CA2393802A patent/CA2393802C/fr not_active Expired - Fee Related
- 2000-12-12 HK HK03106519.6A patent/HK1054237A1/zh unknown
- 2000-12-12 BR BR0017010-0A patent/BR0017010A/pt not_active Application Discontinuation
- 2000-12-12 MX MXPA02005989A patent/MXPA02005989A/es active IP Right Grant
- 2000-12-12 SK SK1057-2002A patent/SK10572002A3/sk unknown
- 2000-12-12 DE DE60039194T patent/DE60039194D1/de not_active Expired - Lifetime
- 2000-12-12 AU AU20899/01A patent/AU783078B2/en not_active Ceased
- 2000-12-12 HR HR20020696A patent/HRP20020696A2/hr not_active Application Discontinuation
- 2000-12-12 EE EEP200200412A patent/EE200200412A/xx unknown
- 2000-12-12 JP JP2001553275A patent/JP4811978B2/ja not_active Expired - Fee Related
2001
- 2001-01-19 PA PA20018510101A patent/PA8510101A1/es unknown
- 2001-01-22 CO CO01004183A patent/CO5320600A1/es not_active Application Discontinuation
- 2001-01-22 SV SV2001000288A patent/SV2001000288A/es not_active Application Discontinuation
- 2001-01-22 TN TNTNSN01011A patent/TNSN01011A1/fr unknown
- 2001-01-22 UY UY26551A patent/UY26551A1/es not_active Application Discontinuation
- 2001-01-22 HN HN2001000009A patent/HN2001000009A/es unknown
- 2001-01-22 PE PE2001000066A patent/PE20011060A1/es not_active Application Discontinuation
- 2001-01-23 AR ARP010100278A patent/AR030186A1/es unknown
2002
- 2002-06-27 IS IS6448A patent/IS6448A/is unknown
- 2002-07-19 CR CR6709A patent/CR6709A/es not_active Application Discontinuation
- 2002-07-22 MA MA26734A patent/MA26866A1/fr unknown
- 2002-07-23 NO NO20023516A patent/NO20023516L/no not_active Application Discontinuation
- 2002-08-22 BG BG107023A patent/BG107023A/xx unknown
2006
- 2006-06-13 US US11/452,121 patent/US7582627B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060287308A1 (en)	2006-12-21
US20060183762A1 (en)	2006-08-17
CA2393802A1 (fr)	2001-07-26
IL150393A0 (en)	2002-12-01
UY26551A1 (es)	2001-04-30
MA26866A1 (fr)	2004-12-20
HRP20020696A2 (en)	2003-12-31
ATE398110T1 (de)	2008-07-15
AU2089901A (en)	2001-07-31
KR20020067701A (ko)	2002-08-23
PA8510101A1 (es)	2003-06-30
US7582627B2 (en)	2009-09-01
HUP0204101A2 (hu)	2003-04-28
YU55902A (sh)	2006-01-16
EE200200412A (et)	2003-10-15
IS6448A (is)	2002-06-27
CA2393802C (fr)	2011-04-19
EA200200661A1 (ru)	2003-02-27
EP1255739A1 (fr)	2002-11-13
SK10572002A3 (sk)	2003-10-07
JP4811978B2 (ja)	2011-11-09
HK1054237A1 (zh)	2003-11-21
CO5320600A1 (es)	2003-09-30
NO20023516D0 (no)	2002-07-23
CR6709A (es)	2003-11-25
US7094780B1 (en)	2006-08-22
NO20023516L (no)	2002-07-23
PE20011060A1 (es)	2001-10-12
BR0017010A (pt)	2002-11-05
EP1255739B1 (fr)	2008-06-11
CN1425008A (zh)	2003-06-18
ES2304992T3 (es)	2008-11-01
AR030186A1 (es)	2003-08-13
HUP0204101A3 (en)	2004-05-28
WO2001053273A1 (fr)	2001-07-26
AP2002002603A0 (en)	2002-09-30
DE60039194D1 (de)	2008-07-24
GEP20053429B (en)	2005-01-25
MXPA02005989A (es)	2002-10-23
JP2003520277A (ja)	2003-07-02
AU783078B2 (en)	2005-09-22
PL356837A1 (en)	2004-07-12
SV2001000288A (es)	2001-11-30
HN2001000009A (es)	2001-06-13
EA005585B1 (ru)	2005-04-28
OA12316A (en)	2006-05-15
TNSN01011A1 (fr)	2005-11-10

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ATE271868T1 (de)	2004-08-15	Neue cathechole als antimikrobielle mittel
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MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
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