BG107793A - Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' - Google Patents
Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' Download PDFInfo
- Publication number
- BG107793A BG107793A BG107793A BG10779303A BG107793A BG 107793 A BG107793 A BG 107793A BG 107793 A BG107793 A BG 107793A BG 10779303 A BG10779303 A BG 10779303A BG 107793 A BG107793 A BG 107793A
- Authority
- BG
- Bulgaria
- Prior art keywords
- propyl
- piperidine
- methoxyquinolin
- carboxylic acid
- hydroxy
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 25
- -1 heterocyclylalkyl piperidine derivatives Chemical class 0.000 claims abstract 22
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 15
- 150000003254 radicals Chemical class 0.000 claims abstract 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 8
- 125000005170 cycloalkyloxycarbonyl group Chemical group 0.000 claims abstract 7
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 4
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000003884 phenylalkyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims 2
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- KXLQEEVGEUPIQR-UHFFFAOYSA-N 1-(2-cyclopentylsulfanylethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(F)=C1CCCC(CC1)(C(O)=O)CCN1CCSC1CCCC1 KXLQEEVGEUPIQR-UHFFFAOYSA-N 0.000 claims 1
- RAWWZDRAVRVSQD-UHFFFAOYSA-N 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiophen-2-ylsulfanylethyl)piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(Cl)=C1CCCC(CC1)(C(O)=O)CCN1CCSC1=CC=CS1 RAWWZDRAVRVSQD-UHFFFAOYSA-N 0.000 claims 1
- AFUHYRRQNQUTQH-UHFFFAOYSA-N 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(Cl)=C1CCCC(CC1)(C(O)=O)CCN1CCOC1=CC(F)=CC(F)=C1 AFUHYRRQNQUTQH-UHFFFAOYSA-N 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910003827 NRaRb Inorganic materials 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 1
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 claims 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical group [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 claims 1
- 125000004660 phenylalkylthio group Chemical group 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- WRTSXKKAXLYBSH-UHFFFAOYSA-N trifluoromethyl benzoate Chemical compound FC(F)(F)OC(=O)C1=CC=CC=C1 WRTSXKKAXLYBSH-UHFFFAOYSA-N 0.000 claims 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- LTVOKYUPTHZZQH-UHFFFAOYSA-N difluoromethane Chemical group F[C]F LTVOKYUPTHZZQH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0014738A FR2816618B1 (fr) | 2000-11-15 | 2000-11-15 | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| PCT/FR2001/003559 WO2002040474A2 (fr) | 2000-11-15 | 2001-11-14 | Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG107793A true BG107793A (bg) | 2004-08-31 |
Family
ID=8856503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG107793A BG107793A (bg) | 2000-11-15 | 2003-05-09 | Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' |
Country Status (28)
| Country | Link |
|---|---|
| EP (2) | EP1695964A1 (cs) |
| JP (1) | JP2004514661A (cs) |
| KR (1) | KR100849608B1 (cs) |
| CN (1) | CN1483031A (cs) |
| AR (1) | AR034006A1 (cs) |
| AT (1) | ATE337311T1 (cs) |
| AU (2) | AU2002218365B2 (cs) |
| BG (1) | BG107793A (cs) |
| BR (1) | BR0115312A (cs) |
| CA (1) | CA2429311A1 (cs) |
| CZ (1) | CZ20031316A3 (cs) |
| DE (1) | DE60122567T2 (cs) |
| DK (1) | DK1337529T3 (cs) |
| EA (1) | EA200300568A1 (cs) |
| EE (1) | EE200300207A (cs) |
| ES (1) | ES2271119T3 (cs) |
| FR (1) | FR2816618B1 (cs) |
| HR (1) | HRP20030379A2 (cs) |
| HU (1) | HUP0303758A3 (cs) |
| IL (1) | IL155841A0 (cs) |
| NO (2) | NO20032187L (cs) |
| PL (1) | PL363004A1 (cs) |
| PT (1) | PT1337529E (cs) |
| SK (1) | SK5822003A3 (cs) |
| TN (1) | TNSN01160A1 (cs) |
| WO (1) | WO2002040474A2 (cs) |
| YU (1) | YU46803A (cs) |
| ZA (1) | ZA200303794B (cs) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452619A (zh) | 2000-07-26 | 2003-10-29 | 史密斯克莱·比奇曼公司 | 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物 |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| US7109213B2 (en) | 2002-01-29 | 2006-09-19 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| JP4445753B2 (ja) | 2002-01-29 | 2010-04-07 | グラクソ グループ リミテッド | アミノピペリジン誘導体 |
| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| FR2842807A1 (fr) * | 2002-07-23 | 2004-01-30 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant |
| GB0217294D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| DE10256405A1 (de) * | 2002-12-02 | 2004-06-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Topoisomerase IV inhibieren |
| AU2003303956A1 (en) | 2002-11-05 | 2004-11-23 | Smithkline Beecham Corporation | Antibacterial agents |
| ES2350977T3 (es) | 2002-11-05 | 2011-01-28 | Glaxo Group Limited | Agentes antibacterianos. |
| DE60324179D1 (de) | 2002-12-04 | 2008-11-27 | Glaxo Group Ltd | Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel |
| US7232833B2 (en) | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2862301B1 (fr) * | 2003-11-17 | 2007-12-21 | Aventis Pharma Sa | Nouveau procede de preparation de quinoleines 3-fluorees |
| FR2867472B1 (fr) * | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2006081182A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| JP2008528598A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| JP2008528586A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| EP1845995A4 (en) | 2005-01-25 | 2010-03-03 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| RU2007131400A (ru) | 2005-03-01 | 2009-04-10 | Вайет (Us) | Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| JP2009524643A (ja) | 2006-01-26 | 2009-07-02 | アクテリオン ファーマシューティカルズ リミテッド | テトラヒドロピラン抗生物質 |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| CA2689102C (en) | 2007-06-15 | 2016-07-26 | Actelion Pharmaceuticals Ltd | 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| JP2012505866A (ja) | 2008-10-17 | 2012-03-08 | グラクソ グループ リミテッド | 抗菌剤として使用される三環式窒素化合物 |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| JP6389174B2 (ja) * | 2012-08-15 | 2018-09-12 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 化学的方法 |
| AR101674A1 (es) | 2014-08-22 | 2017-01-04 | Glaxosmithkline Ip Dev Ltd | Uso de un compuesto tricíclico que contiene nitrógeno |
| WO2016138988A1 (en) * | 2015-03-02 | 2016-09-09 | University Of Copenhagen | Piperazine inhibitors of bacterial gyrase and topoisomerase iv |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908031A (nl) | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| JPH0239546A (ja) | 1988-07-29 | 1990-02-08 | Origin Electric Co Ltd | 混成集積回路の製造方法 |
| NZ232091A (en) | 1989-01-16 | 1990-12-21 | Bellon Labor Sa Roger | 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof |
| AU2717899A (en) * | 1998-01-26 | 1999-08-09 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| JP2002535323A (ja) * | 1999-01-20 | 2002-10-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | プロテインキナーゼ阻害剤としてのピペリジニルキノリン |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-11-15 FR FR0014738A patent/FR2816618B1/fr not_active Expired - Fee Related
-
2001
- 2001-11-13 AR ARP010105289A patent/AR034006A1/es unknown
- 2001-11-14 DK DK01996538T patent/DK1337529T3/da active
- 2001-11-14 DE DE60122567T patent/DE60122567T2/de not_active Expired - Fee Related
- 2001-11-14 HR HR20030379A patent/HRP20030379A2/hr not_active Application Discontinuation
- 2001-11-14 ES ES01996538T patent/ES2271119T3/es not_active Expired - Lifetime
- 2001-11-14 EP EP06010725A patent/EP1695964A1/fr not_active Withdrawn
- 2001-11-14 EA EA200300568A patent/EA200300568A1/ru unknown
- 2001-11-14 AU AU2002218365A patent/AU2002218365B2/en not_active Ceased
- 2001-11-14 PT PT01996538T patent/PT1337529E/pt unknown
- 2001-11-14 PL PL01363004A patent/PL363004A1/xx not_active Application Discontinuation
- 2001-11-14 TN TNTNSN01160A patent/TNSN01160A1/fr unknown
- 2001-11-14 AU AU1836502A patent/AU1836502A/xx active Pending
- 2001-11-14 WO PCT/FR2001/003559 patent/WO2002040474A2/fr not_active Ceased
- 2001-11-14 AT AT01996538T patent/ATE337311T1/de not_active IP Right Cessation
- 2001-11-14 EP EP01996538A patent/EP1337529B1/fr not_active Expired - Lifetime
- 2001-11-14 YU YU46803A patent/YU46803A/sh unknown
- 2001-11-14 HU HU0303758A patent/HUP0303758A3/hu unknown
- 2001-11-14 CN CNA018210996A patent/CN1483031A/zh active Pending
- 2001-11-14 JP JP2002543484A patent/JP2004514661A/ja active Pending
- 2001-11-14 EE EEP200300207A patent/EE200300207A/xx unknown
- 2001-11-14 SK SK582-2003A patent/SK5822003A3/sk unknown
- 2001-11-14 CZ CZ20031316A patent/CZ20031316A3/cs unknown
- 2001-11-14 BR BR0115312-9A patent/BR0115312A/pt not_active Application Discontinuation
- 2001-11-14 CA CA002429311A patent/CA2429311A1/en not_active Abandoned
- 2001-11-14 IL IL15584101A patent/IL155841A0/xx unknown
- 2001-11-14 KR KR1020037006600A patent/KR100849608B1/ko not_active Expired - Fee Related
-
2003
- 2003-05-09 BG BG107793A patent/BG107793A/bg unknown
- 2003-05-14 NO NO20032187A patent/NO20032187L/no unknown
- 2003-05-15 ZA ZA200303794A patent/ZA200303794B/xx unknown
-
2007
- 2007-04-25 NO NO20072142A patent/NO20072142L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100849608B1 (ko) | 헤테로사이클릴알킬 피페리딘 유도체, 이의 제조방법 및당해 유도체를 함유하는 조성물 | |
| US6603005B2 (en) | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | |
| US6602884B2 (en) | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them | |
| JP4262481B2 (ja) | キノリルプロピルピペリジン誘導体、その製造およびそれを含む組成物 | |
| US6403610B1 (en) | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them | |
| CN100415736C (zh) | 喹啉基丙基哌啶衍生物以及其作为抗微生物剂的应用 | |
| US7232834B2 (en) | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor | |
| CZ2002940A3 (cs) | Chinolylpropylpiperidinové deriváty, jejich příprava a jejich pouľití | |
| KR20120011093A (ko) | 치환된 헤테로사이클릭 유도체 및 조성물 및 항균제로서의 이의 약학적 용도 | |
| CA2520764A1 (en) | 4-substituted quinolein derivatives with antimicrobial activity | |
| US20040224946A1 (en) | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them | |
| TWI444380B (zh) | ７-胺基亞烷基-雜環喹諾酮及啶酮 | |
| CZ20004587A3 (en) | Tetrahydroquinoline derivatives | |
| US6806277B2 (en) | Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them | |
| JPH05345777A (ja) | ７−（４，４−ジアルキル−３−アミノ置換ピロリジニル）キノロン−３−カルボン酸誘導体 |