BG107793A - Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' - Google Patents

Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' Download PDF

Info

Publication number: BG107793A
Authority: BG; Bulgaria
Prior art keywords: propyl; piperidine; methoxyquinolin; carboxylic acid; hydroxy
Prior art date: 2000-11-15

Application number

BG107793A

Other languages

Bulgarian (bg)

English (en)

Inventor

Eric Bacque

Jean-Christophe Carry

Youssef El-Ahmad

Michel Evers

Philippe Hubert

Jean-Luc Malleron

Serge Mignani

Guy Pantel

Michel Tabart

Fabrice Viviani

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-15

Filing date

2003-05-09

Publication date

2004-08-31

2003-05-09 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2004-08-31 Publication of BG107793A publication Critical patent/BG107793A/bg

Links

239000000203 mixture Substances 0.000 title claims abstract 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 25
-1 heterocyclylalkyl piperidine derivatives Chemical class 0.000 claims abstract 22
125000000623 heterocyclic group Chemical group 0.000 claims abstract 15
150000003254 radicals Chemical class 0.000 claims abstract 15
125000000753 cycloalkyl group Chemical group 0.000 claims abstract 12
125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 10
150000003839 salts Chemical class 0.000 claims abstract 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 8
125000005170 cycloalkyloxycarbonyl group Chemical group 0.000 claims abstract 7
125000000217 alkyl group Chemical group 0.000 claims 11
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 11
229910052739 hydrogen Inorganic materials 0.000 claims 10
239000001257 hydrogen Substances 0.000 claims 10
125000003118 aryl group Chemical group 0.000 claims 9
229910052757 nitrogen Inorganic materials 0.000 claims 9
125000003545 alkoxy group Chemical group 0.000 claims 7
125000004432 carbon atom Chemical group C* 0.000 claims 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
125000005843 halogen group Chemical group 0.000 claims 6
125000004468 heterocyclylthio group Chemical group 0.000 claims 5
125000004433 nitrogen atom Chemical group N* 0.000 claims 5
229910052717 sulfur Inorganic materials 0.000 claims 5
125000002252 acyl group Chemical group 0.000 claims 4
125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
238000006243 chemical reaction Methods 0.000 claims 4
125000005366 cycloalkylthio group Chemical group 0.000 claims 4
125000005844 heterocyclyloxy group Chemical group 0.000 claims 4
238000000034 method Methods 0.000 claims 4
125000004414 alkyl thio group Chemical group 0.000 claims 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
125000002619 bicyclic group Chemical group 0.000 claims 3
125000000000 cycloalkoxy group Chemical group 0.000 claims 3
125000001153 fluoro group Chemical group F* 0.000 claims 3
229910052736 halogen Inorganic materials 0.000 claims 3
150000002367 halogens Chemical class 0.000 claims 3
125000004415 heterocyclylalkyl group Chemical group 0.000 claims 3
229910052760 oxygen Inorganic materials 0.000 claims 3
125000003884 phenylalkyl group Chemical group 0.000 claims 3
125000001424 substituent group Chemical group 0.000 claims 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
239000002253 acid Substances 0.000 claims 2
125000004103 aminoalkyl group Chemical group 0.000 claims 2
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
238000009833 condensation Methods 0.000 claims 2
230000005494 condensation Effects 0.000 claims 2
125000004093 cyano group Chemical group *C#N 0.000 claims 2
125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
125000005842 heteroatom Chemical group 0.000 claims 2
125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
125000005359 phenoxyalkyl group Chemical group 0.000 claims 2
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 2
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
125000004434 sulfur atom Chemical group 0.000 claims 2
KXLQEEVGEUPIQR-UHFFFAOYSA-N 1-(2-cyclopentylsulfanylethyl)-4-[3-(3-fluoro-6-methoxyquinolin-4-yl)propyl]piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(F)=C1CCCC(CC1)(C(O)=O)CCN1CCSC1CCCC1 KXLQEEVGEUPIQR-UHFFFAOYSA-N 0.000 claims 1
RAWWZDRAVRVSQD-UHFFFAOYSA-N 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-(2-thiophen-2-ylsulfanylethyl)piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(Cl)=C1CCCC(CC1)(C(O)=O)CCN1CCSC1=CC=CS1 RAWWZDRAVRVSQD-UHFFFAOYSA-N 0.000 claims 1
AFUHYRRQNQUTQH-UHFFFAOYSA-N 4-[3-(3-chloro-6-methoxyquinolin-4-yl)propyl]-1-[2-(3,5-difluorophenoxy)ethyl]piperidine-4-carboxylic acid Chemical compound C12=CC(OC)=CC=C2N=CC(Cl)=C1CCCC(CC1)(C(O)=O)CCN1CCOC1=CC(F)=CC(F)=C1 AFUHYRRQNQUTQH-UHFFFAOYSA-N 0.000 claims 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
229910003827 NRaRb Inorganic materials 0.000 claims 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims 1
239000000654 additive Substances 0.000 claims 1
239000003513 alkali Substances 0.000 claims 1
125000003282 alkyl amino group Chemical group 0.000 claims 1
125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
125000006242 amine protecting group Chemical group 0.000 claims 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims 1
125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 1
125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
125000001188 haloalkyl group Chemical group 0.000 claims 1
125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 claims 1
HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical group [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
125000002950 monocyclic group Chemical group 0.000 claims 1
ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 claims 1
239000001301 oxygen Substances 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 claims 1
125000004660 phenylalkylthio group Chemical group 0.000 claims 1
238000002360 preparation method Methods 0.000 claims 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
238000000926 separation method Methods 0.000 claims 1
239000011593 sulfur Substances 0.000 claims 1
125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
WRTSXKKAXLYBSH-UHFFFAOYSA-N trifluoromethyl benzoate Chemical compound FC(F)(F)OC(=O)C1=CC=CC=C1 WRTSXKKAXLYBSH-UHFFFAOYSA-N 0.000 claims 1
125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
LTVOKYUPTHZZQH-UHFFFAOYSA-N difluoromethane Chemical group F[C]F LTVOKYUPTHZZQH-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

BG107793A 2000-11-15 2003-05-09 Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа' BG107793A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0014738A FR2816618B1 (fr)	2000-11-15	2000-11-15	Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
PCT/FR2001/003559 WO2002040474A2 (fr)	2000-11-15	2001-11-14	Derives heterocyclylalcoyl piperidine et leur application comme antimicrobiens

Publications (1)

Publication Number	Publication Date
BG107793A true BG107793A (bg)	2004-08-31

Family

ID=8856503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107793A BG107793A (bg)	2000-11-15	2003-05-09	Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа'

Country Status (28)

Country	Link
EP (2)	EP1695964A1 (cs)
JP (1)	JP2004514661A (cs)
KR (1)	KR100849608B1 (cs)
CN (1)	CN1483031A (cs)
AR (1)	AR034006A1 (cs)
AT (1)	ATE337311T1 (cs)
AU (2)	AU2002218365B2 (cs)
BG (1)	BG107793A (cs)
BR (1)	BR0115312A (cs)
CA (1)	CA2429311A1 (cs)
CZ (1)	CZ20031316A3 (cs)
DE (1)	DE60122567T2 (cs)
DK (1)	DK1337529T3 (cs)
EA (1)	EA200300568A1 (cs)
EE (1)	EE200300207A (cs)
ES (1)	ES2271119T3 (cs)
FR (1)	FR2816618B1 (cs)
HR (1)	HRP20030379A2 (cs)
HU (1)	HUP0303758A3 (cs)
IL (1)	IL155841A0 (cs)
NO (2)	NO20032187L (cs)
PL (1)	PL363004A1 (cs)
PT (1)	PT1337529E (cs)
SK (1)	SK5822003A3 (cs)
TN (1)	TNSN01160A1 (cs)
WO (1)	WO2002040474A2 (cs)
YU (1)	YU46803A (cs)
ZA (1)	ZA200303794B (cs)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1305308B1 (en)	2000-07-26	2006-12-20	Smithkline Beecham Plc	Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
GB0101577D0 (en)	2001-01-22	2001-03-07	Smithkline Beecham Plc	Compounds
GB0112834D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
GB0112836D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
GB0118238D0 (en) *	2001-07-26	2001-09-19	Smithkline Beecham Plc	Medicaments
US7312212B2 (en)	2002-01-29	2007-12-25	Glaxo Group Limited	Aminopiperidine derivatives
EP1470131A2 (en)	2002-01-29	2004-10-27	Glaxo Group Limited	Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them
TW200406413A (en)	2002-06-26	2004-05-01	Glaxo Group Ltd	Compounds
AR040336A1 (es)	2002-06-26	2005-03-30	Glaxo Group Ltd	Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
FR2842807A1 (fr) *	2002-07-23	2004-01-30	Aventis Pharma Sa	Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
GB0217294D0 (en) *	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicaments
FR2844268B1 (fr) *	2002-09-11	2004-10-22	Aventis Pharma Sa	Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) *	2002-09-11	2006-05-19	Aventis Pharma Sa	Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
DE10256405A1 (de) *	2002-12-02	2004-06-17	Morphochem Aktiengesellschaft für kombinatorische Chemie	Neue Verbindungen, die Topoisomerase IV inhibieren
US7232832B2 (en)	2002-11-05	2007-06-19	Smithkline Beecham Corporation	Antibacterial agents
EP1560488B1 (en)	2002-11-05	2010-09-01	Glaxo Group Limited	Antibacterial agents
WO2004050036A2 (en)	2002-12-04	2004-06-17	Glaxo Group Limited	Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
US7232833B2 (en)	2003-03-28	2007-06-19	Novexel	4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
FR2852954B1 (fr) *	2003-03-28	2006-07-14	Aventis Pharma Sa	Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
FR2862301B1 (fr) *	2003-11-17	2007-12-21	Aventis Pharma Sa	Nouveau procede de preparation de quinoleines 3-fluorees
FR2867472B1 (fr) *	2004-03-12	2008-07-18	Aventis Pharma Sa	Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
WO2006081182A2 (en)	2005-01-25	2006-08-03	Glaxo Group Limited	Antibacterial agents
JP2008528598A (ja)	2005-01-25	2008-07-31	グラクソグループリミテッド	抗菌剤
EP1845995A4 (en)	2005-01-25	2010-03-03	Glaxo Group Ltd	ANTIBACTERIAL AGENTS
JP2008528586A (ja)	2005-01-25	2008-07-31	グラクソグループリミテッド	抗菌剤
RU2007131400A (ru)	2005-03-01	2009-04-10	Вайет (Us)	Соединения циннолина и их применение в качестве модуляторов х-рецепторов печени
MY150958A (en) *	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
ATE536351T1 (de)	2006-01-26	2011-12-15	Actelion Pharmaceuticals Ltd	Tetrahydropyran-antibiotika
EP2001887B1 (en)	2006-04-06	2010-09-15	Glaxo Group Limited	Pyrrolo-quinoxalinone derivatives as antibacterials
EP1992628A1 (en)	2007-05-18	2008-11-19	Glaxo Group Limited	Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
ATE520687T1 (de)	2007-06-15	2011-09-15	Actelion Pharmaceuticals Ltd	3-amino-6-(1-amino-ethyl)-tetrahydropyranderiva e
EP2080761A1 (en)	2008-01-18	2009-07-22	Glaxo Group Limited	Compounds
EP2352734A1 (en)	2008-10-17	2011-08-10	Glaxo Group Limited	Tricyclic nitrogen compounds used as antibacterials
US8318940B2 (en)	2009-01-15	2012-11-27	Glaxo Group Limited	Naphthyridin-2 (1 H)-one compounds useful as antibacterials
BR112015003101B1 (pt) *	2012-08-15	2022-06-14	Glaxo Group Limited	Processo para a preparação de um composto
US10702521B2 (en)	2014-08-22	2020-07-07	Glaxosmithkline Intellectual Property Development Limited	Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
WO2016138988A1 (en) *	2015-03-02	2016-09-09	University Of Copenhagen	Piperazine inhibitors of bacterial gyrase and topoisomerase iv
TW201722965A (zh)	2015-08-16	2017-07-01	葛蘭素史密斯克藍智慧財產發展有限公司	用於抗菌應用之化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7908031A (nl)	1979-11-01	1981-06-01	Acf Chemiefarma Nv	Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.
JPH0239546A (ja)	1988-07-29	1990-02-08	Origin Electric Co Ltd	混成集積回路の製造方法
AU623474B2 (en)	1989-01-16	1992-05-14	Laboratoire Roger Bellon	New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them
CA2318842A1 (en) *	1998-01-26	1999-07-29	Julie Dorothy Warrack	Quinoline derivatives as antibacterials
JP2002535323A (ja) *	1999-01-20	2002-10-22	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	プロテインキナーゼ阻害剤としてのピペリジニルキノリン
FR2852954B1 (fr) *	2003-03-28	2006-07-14	Aventis Pharma Sa	Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent

2000
- 2000-11-15 FR FR0014738A patent/FR2816618B1/fr not_active Expired - Fee Related
2001
- 2001-11-13 AR ARP010105289A patent/AR034006A1/es unknown
- 2001-11-14 AU AU2002218365A patent/AU2002218365B2/en not_active Ceased
- 2001-11-14 AU AU1836502A patent/AU1836502A/xx active Pending
- 2001-11-14 EA EA200300568A patent/EA200300568A1/ru unknown
- 2001-11-14 CZ CZ20031316A patent/CZ20031316A3/cs unknown
- 2001-11-14 CN CNA018210996A patent/CN1483031A/zh active Pending
- 2001-11-14 EE EEP200300207A patent/EE200300207A/xx unknown
- 2001-11-14 YU YU46803A patent/YU46803A/sh unknown
- 2001-11-14 IL IL15584101A patent/IL155841A0/xx unknown
- 2001-11-14 SK SK582-2003A patent/SK5822003A3/sk unknown
- 2001-11-14 DK DK01996538T patent/DK1337529T3/da active
- 2001-11-14 JP JP2002543484A patent/JP2004514661A/ja active Pending
- 2001-11-14 WO PCT/FR2001/003559 patent/WO2002040474A2/fr not_active Ceased
- 2001-11-14 BR BR0115312-9A patent/BR0115312A/pt not_active Application Discontinuation
- 2001-11-14 PL PL01363004A patent/PL363004A1/xx not_active Application Discontinuation
- 2001-11-14 ES ES01996538T patent/ES2271119T3/es not_active Expired - Lifetime
- 2001-11-14 AT AT01996538T patent/ATE337311T1/de not_active IP Right Cessation
- 2001-11-14 HU HU0303758A patent/HUP0303758A3/hu unknown
- 2001-11-14 EP EP06010725A patent/EP1695964A1/fr not_active Withdrawn
- 2001-11-14 TN TNTNSN01160A patent/TNSN01160A1/fr unknown
- 2001-11-14 EP EP01996538A patent/EP1337529B1/fr not_active Expired - Lifetime
- 2001-11-14 HR HR20030379A patent/HRP20030379A2/hr not_active Application Discontinuation
- 2001-11-14 KR KR1020037006600A patent/KR100849608B1/ko not_active Expired - Fee Related
- 2001-11-14 CA CA002429311A patent/CA2429311A1/en not_active Abandoned
- 2001-11-14 PT PT01996538T patent/PT1337529E/pt unknown
- 2001-11-14 DE DE60122567T patent/DE60122567T2/de not_active Expired - Fee Related
2003
- 2003-05-09 BG BG107793A patent/BG107793A/bg unknown
- 2003-05-14 NO NO20032187A patent/NO20032187L/no unknown
- 2003-05-15 ZA ZA200303794A patent/ZA200303794B/xx unknown
2007
- 2007-04-25 NO NO20072142A patent/NO20072142L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU1836502A (en)	2002-05-27
NO20032187D0 (no)	2003-05-14
CZ20031316A3 (cs)	2003-10-15
AR034006A1 (es)	2004-01-21
AU2002218365B2 (en)	2007-07-05
CN1483031A (zh)	2004-03-17
EP1695964A1 (fr)	2006-08-30
IL155841A0 (en)	2003-12-23
ZA200303794B (en)	2004-06-29
HUP0303758A3 (en)	2009-08-28
DK1337529T3 (da)	2006-12-18
SK5822003A3 (en)	2004-06-08
FR2816618B1 (fr)	2002-12-27
DE60122567T2 (de)	2007-08-23
FR2816618A1 (fr)	2002-05-17
KR100849608B1 (ko)	2008-07-31
EA200300568A1 (ru)	2003-12-25
BR0115312A (pt)	2003-09-23
PT1337529E (pt)	2006-12-29
NO20072142L (no)	2007-04-25
YU46803A (sh)	2006-05-25
HUP0303758A2 (hu)	2004-03-01
KR20030060934A (ko)	2003-07-16
EP1337529A2 (fr)	2003-08-27
EE200300207A (et)	2003-08-15
JP2004514661A (ja)	2004-05-20
DE60122567D1 (de)	2006-10-05
WO2002040474A3 (fr)	2002-10-31
WO2002040474A2 (fr)	2002-05-23
TNSN01160A1 (fr)	2005-11-10
ES2271119T3 (es)	2007-04-16
HRP20030379A2 (en)	2005-04-30
EP1337529B1 (fr)	2006-08-23
NO20032187L (no)	2003-06-26
PL363004A1 (en)	2004-11-15
ATE337311T1 (de)	2006-09-15
CA2429311A1 (en)	2002-05-23

Publication	Publication Date	Title
BG107793A (bg)	2004-08-31	Х...'...ро-иклилалкилпип...ридинови производни, 'яхно'о пол"-аван... и 'ъ''ави, кои'о ги 'ъдържа'
US6603005B2 (en)	2003-08-05	Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
US6602884B2 (en)	2003-08-05	Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
JP4262481B2 (ja)	2009-05-13	キノリルプロピルピペリジン誘導体、その製造およびそれを含む組成物
US6403610B1 (en)	2002-06-11	Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
CN100415736C (zh)	2008-09-03	喹啉基丙基哌啶衍生物以及其作为抗微生物剂的应用
US7232834B2 (en)	2007-06-19	Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor
CZ2002940A3 (cs)	2002-07-17	Chinolylpropylpiperidinové deriváty, jejich příprava a jejich pouľití
KR20120011093A (ko)	2012-02-06	치환된 헤테로사이클릭 유도체 및 조성물 및 항균제로서의 이의 약학적 용도
AU658905B2 (en)	1995-05-04	Methanoanthracenes having antidopaminergic activity
CA2520764A1 (en)	2004-10-14	4-substituted quinolein derivatives with antimicrobial activity
US20040224946A1 (en)	2004-11-11	4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
TWI444380B (zh)	2014-07-11	７-胺基亞烷基-雜環喹諾酮及啶酮
CZ20004587A3 (en)	2001-05-16	Tetrahydroquinoline derivatives
US6806277B2 (en)	2004-10-19	Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them