BG108038A - Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes - Google Patents

Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes

Info

Publication number: BG108038A
Authority: BG; Bulgaria
Prior art keywords: alkyl; inhibitors; nicotinamide; derivatives useful; biaryl derivatives
Prior art date: 2001-01-31

Application number

BG108038A

Other languages

Bulgarian (bg)

English (en)

Inventor

Robert J. Chambers

Thomas V. Magee

Anthony Marfat

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-31

Filing date

2003-07-28

Publication date

2004-07-30

2003-07-28 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2004-07-30 Publication of BG108038A publication Critical patent/BG108038A/xx

Links

239000003112 inhibitor Substances 0.000 title abstract 2
101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
108010044467 Isoenzymes Proteins 0.000 title 1
229960003966 nicotinamide Drugs 0.000 title 1
235000005152 nicotinamide Nutrition 0.000 title 1
239000011570 nicotinamide Substances 0.000 title 1
DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
206010006458 Bronchitis chronic Diseases 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
206010006451 bronchitis Diseases 0.000 abstract 1
208000007451 chronic bronchitis Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
210000003979 eosinophil Anatomy 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
125000003003 spiro group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)

BG108038A 2001-01-31 2003-07-28 Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes BG108038A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26549201P	2001-01-31	2001-01-31
PCT/IB2001/002341 WO2002060875A1 (en)	2001-01-31	2001-12-06	Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes

Publications (1)

Publication Number	Publication Date
BG108038A true BG108038A (en)	2004-07-30

Family

ID=23010671

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108038A BG108038A (en)	2001-01-31	2003-07-28	Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes

Country Status (25)

Country	Link
US (2)	US6649633B2 (cs)
EP (1)	EP1355884A1 (cs)
JP (1)	JP2004520386A (cs)
KR (1)	KR20030074761A (cs)
CN (1)	CN1518542A (cs)
BG (1)	BG108038A (cs)
BR (1)	BR0116852A (cs)
CA (1)	CA2436535A1 (cs)
CR (1)	CR7025A (cs)
CZ (1)	CZ20031895A3 (cs)
EA (1)	EA200300621A1 (cs)
EC (2)	ECSP034710A (cs)
EE (1)	EE200300360A (cs)
HU (1)	HUP0400637A2 (cs)
IL (1)	IL156413A0 (cs)
IS (1)	IS6846A (cs)
MA (1)	MA26983A1 (cs)
MX (1)	MXPA03006887A (cs)
NO (1)	NO20033397L (cs)
NZ (1)	NZ526453A (cs)
OA (1)	OA12540A (cs)
PL (1)	PL364135A1 (cs)
SK (1)	SK8792003A3 (cs)
WO (1)	WO2002060875A1 (cs)
ZA (1)	ZA200304894B (cs)

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WO2002094321A1 (en) *	2001-05-23	2002-11-28	Tanabe Seiyaku Co., Ltd.	Compositions for promoting healing of bone fracture
US6951869B2 (en) *	2002-02-26	2005-10-04	Schlesinger Stephen L	Use of leukotriene receptor antagonist for treatment of scarring
EP1424101A3 (en) *	2002-11-29	2004-08-18	NOZAKI, Masako	Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
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JP2006522151A (ja) *	2003-04-01	2006-09-28	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	不妊症におけるホスホジエステラーゼ阻害剤
GB0309781D0 (en) *	2003-04-29	2003-06-04	Glaxo Group Ltd	Compounds
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GB0317498D0 (en) *	2003-07-25	2003-08-27	Pfizer Ltd	Compounds
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2001
- 2001-12-06 WO PCT/IB2001/002341 patent/WO2002060875A1/en not_active Ceased
- 2001-12-06 CA CA002436535A patent/CA2436535A1/en not_active Abandoned
- 2001-12-06 SK SK879-2003A patent/SK8792003A3/sk not_active Application Discontinuation
- 2001-12-06 OA OA1200300175A patent/OA12540A/en unknown
- 2001-12-06 KR KR10-2003-7010074A patent/KR20030074761A/ko not_active Ceased
- 2001-12-06 NZ NZ526453A patent/NZ526453A/en unknown
- 2001-12-06 PL PL01364135A patent/PL364135A1/xx not_active Application Discontinuation
- 2001-12-06 CN CNA018230717A patent/CN1518542A/zh active Pending
- 2001-12-06 HU HU0400637A patent/HUP0400637A2/hu unknown
- 2001-12-06 EA EA200300621A patent/EA200300621A1/ru unknown
- 2001-12-06 JP JP2002561026A patent/JP2004520386A/ja active Pending
- 2001-12-06 IL IL15641301A patent/IL156413A0/xx unknown
- 2001-12-06 EP EP01273556A patent/EP1355884A1/en not_active Withdrawn
- 2001-12-06 EE EEP200300360A patent/EE200300360A/xx unknown
- 2001-12-06 BR BR0116852-5A patent/BR0116852A/pt not_active IP Right Cessation
- 2001-12-06 MX MXPA03006887A patent/MXPA03006887A/es not_active Application Discontinuation
- 2001-12-06 CZ CZ20031895A patent/CZ20031895A3/cs unknown
2002
- 2002-01-31 US US10/062,813 patent/US6649633B2/en not_active Expired - Fee Related
2003
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- 2003-06-24 ZA ZA200304894A patent/ZA200304894B/en unknown
- 2003-07-02 US US10/613,988 patent/US6953810B2/en not_active Expired - Fee Related
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- 2003-07-21 MA MA27241A patent/MA26983A1/fr unknown
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- 2003-07-30 NO NO20033397A patent/NO20033397L/no not_active Application Discontinuation
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Also Published As

Publication number	Publication date
KR20030074761A (ko)	2003-09-19
IS6846A (is)	2003-06-16
ZA200304894B (en)	2004-06-24
EA200300621A1 (ru)	2003-12-25
HUP0400637A2 (hu)	2004-06-28
CR7025A (es)	2003-11-25
PL364135A1 (en)	2004-12-13
US6649633B2 (en)	2003-11-18
WO2002060875A8 (en)	2003-07-31
OA12540A (en)	2006-06-05
EE200300360A (et)	2003-12-15
IL156413A0 (en)	2004-01-04
ECSP034710A (es)	2003-09-24
CA2436535A1 (en)	2002-08-08
MA26983A1 (fr)	2004-12-20
MXPA03006887A (es)	2003-11-13
BR0116852A (pt)	2004-02-25
CN1518542A (zh)	2004-08-04
US20020193612A1 (en)	2002-12-19
NO20033397D0 (no)	2003-07-30
US6953810B2 (en)	2005-10-11
JP2004520386A (ja)	2004-07-08
SK8792003A3 (en)	2004-09-08
NZ526453A (en)	2005-01-28
US20040048903A1 (en)	2004-03-11
ECSP034709A (es)	2003-09-24
CZ20031895A3 (cs)	2004-08-18
NO20033397L (no)	2003-09-19
WO2002060875A1 (en)	2002-08-08
EP1355884A1 (en)	2003-10-29

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