BG108220A - Заместени в 6-та позиция индолинони и тяхното използване като инхибитори на киназа - Google Patents
Заместени в 6-та позиция индолинони и тяхното използване като инхибитори на киназа Download PDFInfo
- Publication number
- BG108220A BG108220A BG108220A BG10822003A BG108220A BG 108220 A BG108220 A BG 108220A BG 108220 A BG108220 A BG 108220A BG 10822003 A BG10822003 A BG 10822003A BG 108220 A BG108220 A BG 108220A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- group
- amino
- phenyl
- carbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10117204A DE10117204A1 (de) | 2001-04-06 | 2001-04-06 | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2002/003583 WO2002081445A1 (de) | 2001-04-06 | 2002-03-30 | In 6-stellung substituierte indoline und ihre verwendung als kinase-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG108220A true BG108220A (bg) | 2004-09-30 |
Family
ID=7680648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG108220A BG108220A (bg) | 2001-04-06 | 2003-10-01 | Заместени в 6-та позиция индолинони и тяхното използване като инхибитори на киназа |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6858641B2 (pl) |
| EP (1) | EP1379501A1 (pl) |
| JP (1) | JP2004525173A (pl) |
| KR (1) | KR20030090712A (pl) |
| CN (1) | CN1509270A (pl) |
| AR (1) | AR035813A1 (pl) |
| BG (1) | BG108220A (pl) |
| BR (1) | BR0208900A (pl) |
| CA (1) | CA2442695A1 (pl) |
| CZ (1) | CZ20032975A3 (pl) |
| DE (1) | DE10117204A1 (pl) |
| EA (1) | EA200301005A1 (pl) |
| EC (1) | ECSP034776A (pl) |
| EE (1) | EE200300491A (pl) |
| HU (1) | HUP0303737A3 (pl) |
| IL (1) | IL158254A0 (pl) |
| MX (1) | MXPA03008896A (pl) |
| NO (1) | NO20034434L (pl) |
| PE (1) | PE20021058A1 (pl) |
| PL (1) | PL366458A1 (pl) |
| SK (1) | SK12412003A3 (pl) |
| WO (1) | WO2002081445A1 (pl) |
| ZA (1) | ZA200307306B (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| AU2008309517B2 (en) | 2007-10-12 | 2013-03-14 | Astrazeneca Ab | Inhibitors of protein kinases |
| PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| EP2303841A1 (en) * | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| AU2009275964A1 (en) | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | New compounds |
| EA201201274A1 (ru) | 2010-03-10 | 2013-04-30 | Инджениум Фармасьютиклз Гмбх | Ингибиторы протеинкиназ |
| CN102267934B (zh) * | 2010-06-02 | 2013-04-17 | 金凯美(大连)医药科技有限公司 | 一种6-甲氧羰基吲哚酮的制备方法 |
| ES2956820T3 (es) | 2015-12-24 | 2023-12-28 | Respivert Ltd | Compuestos de indolinonas y su uso en el tratamiento de enfermedades fibróticas |
| JP7039480B2 (ja) * | 2016-03-08 | 2022-03-22 | レスピバート・リミテツド | プロテインキナーゼ阻害剤としてのインドール誘導体およびそれらの使用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0929520B1 (en) * | 1996-08-23 | 2005-11-02 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6043254A (en) * | 1998-04-03 | 2000-03-28 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase-inhibiting activity |
| DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6169106B1 (en) * | 1998-04-15 | 2001-01-02 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase inhibitory activity |
| DE19824922A1 (de) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6319918B1 (en) * | 1998-06-04 | 2001-11-20 | Boehringer Ingelheim Pharma Kg | Substituted indolinones with kinase inhibitory activity |
| DE19924401A1 (de) | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19940829A1 (de) | 1999-08-27 | 2001-03-01 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| WO2001016130A1 (de) | 1999-08-27 | 2001-03-08 | Boehringer Ingelheim Pharma Kg | Substituierte indolinone als tyrosinkinase inhibitoren |
| DE10042696A1 (de) | 2000-08-31 | 2002-03-14 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
-
2001
- 2001-04-06 DE DE10117204A patent/DE10117204A1/de not_active Withdrawn
-
2002
- 2002-03-30 CA CA002442695A patent/CA2442695A1/en not_active Abandoned
- 2002-03-30 EE EEP200300491A patent/EE200300491A/xx unknown
- 2002-03-30 JP JP2002579433A patent/JP2004525173A/ja not_active Ceased
- 2002-03-30 KR KR10-2003-7013027A patent/KR20030090712A/ko not_active Withdrawn
- 2002-03-30 EA EA200301005A patent/EA200301005A1/ru unknown
- 2002-03-30 HU HU0303737A patent/HUP0303737A3/hu unknown
- 2002-03-30 BR BR0208900-9A patent/BR0208900A/pt not_active Application Discontinuation
- 2002-03-30 EP EP02735201A patent/EP1379501A1/de not_active Withdrawn
- 2002-03-30 CN CNA028099184A patent/CN1509270A/zh active Pending
- 2002-03-30 CZ CZ20032975A patent/CZ20032975A3/cs unknown
- 2002-03-30 MX MXPA03008896A patent/MXPA03008896A/es unknown
- 2002-03-30 IL IL15825402A patent/IL158254A0/xx unknown
- 2002-03-30 WO PCT/EP2002/003583 patent/WO2002081445A1/de not_active Ceased
- 2002-03-30 PL PL02366458A patent/PL366458A1/pl not_active Application Discontinuation
- 2002-03-30 SK SK1241-2003A patent/SK12412003A3/sk unknown
- 2002-04-04 US US10/116,365 patent/US6858641B2/en not_active Expired - Lifetime
- 2002-04-05 AR ARP020101257A patent/AR035813A1/es not_active Application Discontinuation
- 2002-04-05 PE PE2002000279A patent/PE20021058A1/es not_active Application Discontinuation
-
2003
- 2003-09-18 ZA ZA200307306A patent/ZA200307306B/xx unknown
- 2003-09-24 EC EC2003004776A patent/ECSP034776A/es unknown
- 2003-10-01 BG BG108220A patent/BG108220A/bg unknown
- 2003-10-03 NO NO20034434A patent/NO20034434L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL366458A1 (pl) | 2005-02-07 |
| HUP0303737A2 (hu) | 2004-03-01 |
| WO2002081445A1 (de) | 2002-10-17 |
| KR20030090712A (ko) | 2003-11-28 |
| CZ20032975A3 (cs) | 2004-02-18 |
| ECSP034776A (es) | 2003-12-01 |
| US6858641B2 (en) | 2005-02-22 |
| SK12412003A3 (sk) | 2004-04-06 |
| MXPA03008896A (es) | 2003-12-08 |
| EA200301005A1 (ru) | 2004-04-29 |
| NO20034434D0 (no) | 2003-10-03 |
| HUP0303737A3 (en) | 2004-09-28 |
| JP2004525173A (ja) | 2004-08-19 |
| AR035813A1 (es) | 2004-07-14 |
| US20030092756A1 (en) | 2003-05-15 |
| CN1509270A (zh) | 2004-06-30 |
| ZA200307306B (en) | 2004-08-31 |
| NO20034434L (no) | 2003-10-03 |
| EE200300491A (et) | 2004-02-16 |
| DE10117204A1 (de) | 2002-10-10 |
| IL158254A0 (en) | 2004-05-12 |
| BR0208900A (pt) | 2004-04-20 |
| CA2442695A1 (en) | 2002-10-17 |
| EP1379501A1 (de) | 2004-01-14 |
| PE20021058A1 (es) | 2003-01-20 |
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