BG108435A - Novel crystalline forms of 4-[4-[4-(hydroxydiphenyl methyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride - Google Patents

Novel crystalline forms of 4-[4-[4-(hydroxydiphenyl methyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride

Info

Publication number: BG108435A
Authority: BG; Bulgaria
Prior art keywords: alpha; hydrochloride; hydroxybutyl; piperidinyl; acetic acid
Prior art date: 2001-06-18

Application number

BG108435A

Other languages

Bulgarian (bg)

English (en)

Inventor

Reddy SATYANARAYANA

Rajan Thirumalai

Rao Bhaskara

Original Assignee

Dr. Reddy's Laboratories Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-18

Filing date

2003-12-11

Publication date

2004-12-30

2003-12-11 Application filed by Dr. Reddy's Laboratories Ltd. filed Critical Dr. Reddy's Laboratories Ltd.

2004-12-30 Publication of BG108435A publication Critical patent/BG108435A/xx

Links

RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 title abstract 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
229960003592 fexofenadine Drugs 0.000 abstract 2
RRJFVPUCXDGFJB-UHFFFAOYSA-N Fexofenadine hydrochloride Chemical compound Cl.C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RRJFVPUCXDGFJB-UHFFFAOYSA-N 0.000 abstract 1
229960000354 fexofenadine hydrochloride Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG108435A 2001-06-18 2003-12-11 Novel crystalline forms of 4-[4-[4-(hydroxydiphenyl methyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride BG108435A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN484MA2001		2001-06-18

Publications (1)

Publication Number	Publication Date
BG108435A true BG108435A (en)	2004-12-30

Family

ID=34566868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108435A BG108435A (en)	2001-06-18	2003-12-11	Novel crystalline forms of 4-[4-[4-(hydroxydiphenyl methyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride

Country Status (20)

Country	Link
EP (2)	EP2261209A1 (fr)
JP (2)	JP2005507374A (fr)
KR (1)	KR20040015734A (fr)
CN (1)	CN100390145C (fr)
AU (1)	AU2001278094B2 (fr)
BG (1)	BG108435A (fr)
BR (1)	BR0117054A (fr)
CA (2)	CA2450858C (fr)
CO (1)	CO5540340A2 (fr)
CZ (1)	CZ20033358A3 (fr)
EE (1)	EE200400010A (fr)
HU (1)	HUP0401546A2 (fr)
IL (2)	IL159266A0 (fr)
MX (1)	MXPA03011728A (fr)
NZ (1)	NZ530118A (fr)
PL (1)	PL367632A1 (fr)
RU (1)	RU2269516C2 (fr)
SK (1)	SK15372003A3 (fr)
WO (1)	WO2002102777A2 (fr)
ZA (1)	ZA200309557B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL158334A0 (en) *	2001-04-09	2004-05-12	Teva Pharma	Polymorphs of fexofenadine hydrochloride
US20040044038A1 (en)	2002-06-10	2004-03-04	Barnaba Krochmal	Polymorphic form XVI of fexofenadine hydrochloride
GB0319935D0 (en)	2003-08-26	2003-09-24	Cipla Ltd	Polymorphs
JP2007532687A (ja) *	2004-04-26	2007-11-15	テバファーマシューティカルインダストリーズリミティド	フェキソフェナジン塩酸塩の結晶形およびその製造方法
ITMI20041143A1 (it) *	2004-06-08	2004-09-08	Dipharma Spa	Polimorfi di fexofenadina e procedimento per la loro preparazione
ITMI20041568A1 (it) *	2004-07-30	2004-10-30	Dipharma Spa	"polimorfi di fexofenadina base"
JP2008514641A (ja) *	2004-09-28	2008-05-08	テバファーマシューティカルインダストリーズリミティド	結晶形フェキソフェナジン、およびその調製方法
WO2007007347A1 (fr) *	2005-07-07	2007-01-18	Wockhardt Limited	Procédé industriel de préparation du chlorhydrate de fexofénadine avec un minimum de produits secondaires
RU2283649C1 (ru) *	2005-10-27	2006-09-20	Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН")	Фармацевтическая композиция для лечения аллергических заболеваний
US20090306135A1 (en)	2008-03-24	2009-12-10	Mukesh Kumar Sharma	Stable amorphous fexofenadine hydrochloride
CN104072402B (zh) *	2014-07-16	2016-08-17	昆山龙灯瑞迪制药有限公司	一种新结晶形式的盐酸非索非那定化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4254129A (en) *	1979-04-10	1981-03-03	Richardson-Merrell Inc.	Piperidine derivatives
EP1688142A1 (fr) *	1992-08-03	2006-08-09	Sepracor Inc.	Le carboxylate de la terfénadine et le traitement de l'irritation de la peau
EP1178041A1 (fr) *	1994-05-18	2002-02-06	Aventis Pharmaceuticals Inc.	Procédés de préparation de formes anhydres et hydratées de derivés de piperidine antihistaminiques
US6153754A (en) *	1995-12-21	2000-11-28	Albany Molecular Research, Inc.	Process for production of piperidine derivatives
IN191492B (fr)	1999-05-25	2003-12-06	Ranbaxy Lab Ltd
GB0018691D0 (en) *	2000-07-28	2000-09-20	Rolabo Sl	Process

2001
- 2001-07-31 IL IL15926601A patent/IL159266A0/xx unknown
- 2001-07-31 JP JP2003505320A patent/JP2005507374A/ja active Pending
- 2001-07-31 AU AU2001278094A patent/AU2001278094B2/en not_active Ceased
- 2001-07-31 RU RU2004101045/04A patent/RU2269516C2/ru not_active IP Right Cessation
- 2001-07-31 NZ NZ530118A patent/NZ530118A/en unknown
- 2001-07-31 EE EEP200400010A patent/EE200400010A/xx unknown
- 2001-07-31 CA CA002450858A patent/CA2450858C/fr not_active Expired - Fee Related
- 2001-07-31 PL PL01367632A patent/PL367632A1/xx not_active Application Discontinuation
- 2001-07-31 BR BR0117054-6A patent/BR0117054A/pt not_active Application Discontinuation
- 2001-07-31 WO PCT/US2001/023994 patent/WO2002102777A2/fr not_active Ceased
- 2001-07-31 SK SK1537-2003A patent/SK15372003A3/sk unknown
- 2001-07-31 CA CA002646802A patent/CA2646802A1/fr not_active Abandoned
- 2001-07-31 MX MXPA03011728A patent/MXPA03011728A/es active IP Right Grant
- 2001-07-31 KR KR10-2003-7016163A patent/KR20040015734A/ko not_active Ceased
- 2001-07-31 CZ CZ20033358A patent/CZ20033358A3/cs unknown
- 2001-07-31 EP EP10010066A patent/EP2261209A1/fr not_active Withdrawn
- 2001-07-31 CN CNB018233791A patent/CN100390145C/zh not_active Expired - Fee Related
- 2001-07-31 EP EP01956057A patent/EP1399422A2/fr not_active Withdrawn
- 2001-07-31 HU HU0401546A patent/HUP0401546A2/hu unknown
2003
- 2003-12-09 ZA ZA200309557A patent/ZA200309557B/xx unknown
- 2003-12-09 IL IL159266A patent/IL159266A/en not_active IP Right Cessation
- 2003-12-11 BG BG108435A patent/BG108435A/xx unknown
- 2003-12-18 CO CO03110519A patent/CO5540340A2/es not_active Application Discontinuation
2007
- 2007-11-06 JP JP2007289084A patent/JP2008094848A/ja active Pending

Also Published As

Publication number	Publication date
HUP0401546A2 (hu)	2004-12-28
NZ530118A (en)	2007-05-31
CA2646802A1 (fr)	2002-12-27
WO2002102777A2 (fr)	2002-12-27
SK15372003A3 (sk)	2004-08-03
MXPA03011728A (es)	2004-07-08
CN1518540A (zh)	2004-08-04
PL367632A1 (en)	2005-03-07
WO2002102777A3 (fr)	2003-02-27
CA2450858C (fr)	2009-04-07
RU2269516C2 (ru)	2006-02-10
RU2004101045A (ru)	2005-06-27
IL159266A (en)	2010-11-30
EE200400010A (et)	2004-02-16
EP1399422A2 (fr)	2004-03-24
JP2008094848A (ja)	2008-04-24
IL159266A0 (en)	2004-06-01
WO2002102777A8 (fr)	2003-10-30
BR0117054A (pt)	2004-07-27
CA2450858A1 (fr)	2002-12-27
KR20040015734A (ko)	2004-02-19
CN100390145C (zh)	2008-05-28
CZ20033358A3 (en)	2004-04-14
CO5540340A2 (es)	2005-07-29
EP2261209A1 (fr)	2010-12-15
AU2001278094B2 (en)	2006-01-12
ZA200309557B (en)	2004-09-14
JP2005507374A (ja)	2005-03-17

Publication	Publication Date	Title
FI80447B (fi)	1990-02-28	Foerfarande foer framstaellning av farmaceutiskt vaerdefulla fenylaettiksyraderivat.
BG108435A (en)	2004-12-30	Novel crystalline forms of 4-[4-[4-(hydroxydiphenyl methyl)-1-piperidinyl]-1-hydroxybutyl]-alpha, alpha-dimethylbenzene acetic acid and its hydrochloride
DK153709B (da)	1988-08-22	Analogifremgangsmaade til fremstilling af 4-substituerede piperidinoalkanolderivater
JP2009533369A5 (fr)	2011-02-17
KR20000064507A (ko)	2000-11-06	피페리딘유도체의제조방법
US5166148A (en)	1992-11-24	2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
JP2010536713A5 (fr)	2012-08-09
AU2005272389A1 (en)	2006-02-16	Novel cyclic aminobenzoic acid derivative
WO2007072087A3 (fr)	2007-09-07	Nouveau procédé pour la production de chlorhydrate de donépézil polymorphe (i) extrêmement pur
JP5673729B2 (ja)	2015-02-18	４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
NO20082474L (no)	2008-06-02	Fremgangsmate for fremstilling av en leukotrienantagonist og intermediater derav
CA2376540A1 (fr)	2001-01-11	Procede de preparation de benzenesulphonate d'amlodipine
NZ555095A (en)	2010-07-30	Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
IL150982A (en)	2007-02-11	Process for making Donafzil
WO2007144391A1 (fr)	2007-12-21	Procédé de préparation de rémifentanil, intermédiaires de celui-ci, utilisation desdits intermédiaires et procédés pour leur préparation
JP5585822B2 (ja)	2014-09-10	光学活性ニペコチン酸誘導体の製造方法
SI1260505T1 (en)	2005-06-30	A process for the preparation of 4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-butyl)-alpha, alpha-dimethylbenzeneacetic acid
AU2008288430A1 (en)	2009-02-19	Novel preparation process
WO2009047797A3 (fr)	2011-05-26	Procédé de préparation d'un dérivé du perhydroisoindole
JP2004091486A5 (fr)	2006-09-21
TW200637856A (en)	2006-11-01	Process for producing thiazolidinedion compound and intermediate thereof
KR100914691B1 (ko)	2009-08-28	도네페질 또는 그의 제조용 중간체의 제조방법
EA200801505A1 (ru)	2008-10-30	Способ получения фармацевтического промежуточного соединения
TW200612912A (en)	2006-05-01	Benzyloxy derivatives as maob inhibitors
JP2012232980A (ja)	2012-11-29	新規製造方法