BG48932A3 - Метод за получаване на амидни съединения - Google Patents

Метод за получаване на амидни съединения

Info

Publication number
BG48932A3
BG48932A3 BG085365A BG8536588A BG48932A3 BG 48932 A3 BG48932 A3 BG 48932A3 BG 085365 A BG085365 A BG 085365A BG 8536588 A BG8536588 A BG 8536588A BG 48932 A3 BG48932 A3 BG 48932A3
Authority
BG
Bulgaria
Prior art keywords
lower alkyl
substituted
halogen
amino
hydrogen
Prior art date
Application number
BG085365A
Other languages
English (en)
Inventor
Yasuo Itoh
Hideo Kato
Eiichi Koshinaka
Nobuo Ogawa
Hiroyuki Nishino
Jun Sakaguchi
Original Assignee
Hokuriku Pharmaceutical Co.Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62221211A external-priority patent/JPS6466153A/ja
Priority claimed from JP62236250A external-priority patent/JPS6479144A/ja
Priority claimed from JP62242765A external-priority patent/JPS6485960A/ja
Priority claimed from JP62249749A external-priority patent/JPH0193568A/ja
Application filed by Hokuriku Pharmaceutical Co.Ltd. filed Critical Hokuriku Pharmaceutical Co.Ltd.
Publication of BG48932A3 publication Critical patent/BG48932A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Hybrid Electric Vehicles (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Съединенията, получени по метода, намират приложение в медицината. Те са ефективни при активирането на стомашно двигателната функция. Съединенията имат формула: в която r1означава водород, нисш алкокси, хидрокси, нисш алкил, халоген, амино, който може да се замести с нисш алкил, нитро, циано, сулфамоил, който може да се замести с нисш алкил; r2 е водород, нисш алкокси, хидрокси, нисш алкил, халоген, амино, нитро, или r1 и r2 могат заедно да образуват метилендиоксиостатък; r3 означава водород, нисш алкил, халоген, или амино; r4 и r5 могат да са еднакви или различни и всяко означава нисш алкил или r4 и r5 могат заедно с азота да образуват 1-пиролидинил или пиперидинов остатък и техните фармакологичноприемливи, киселинноадиционни соли. Методът за получаването на амидите с формула i се състои в това, че съответно заместено реактивоспособно производно на бензоената киселина взаимодейства със заместен аминоетоксибензиламин в органичен разтворител. 1 претенция
BG085365A 1987-09-05 1988-09-02 Метод за получаване на амидни съединения BG48932A3 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP62221211A JPS6466153A (en) 1987-09-05 1987-09-05 Amide compound and digestive tract motion-activator containing said compound as active ingredient
JP62236250A JPS6479144A (en) 1987-09-22 1987-09-22 Amide compound and agent for promoting motion of digestive tract containing said compound
JP62242765A JPS6485960A (en) 1987-09-29 1987-09-29 Amide compound and reactivator for motion of digestive tube comprising said compound as active ingredient
JP62249749A JPH0193568A (ja) 1987-10-05 1987-10-05 アミド化合物、及びそれを有効成分とする消化管運動賦活剤

Publications (1)

Publication Number Publication Date
BG48932A3 true BG48932A3 (bg) 1991-06-14

Family

ID=27476995

Family Applications (1)

Application Number Title Priority Date Filing Date
BG085365A BG48932A3 (bg) 1987-09-05 1988-09-02 Метод за получаване на амидни съединения

Country Status (15)

Country Link
US (1) US4983633A (bg)
EP (1) EP0306827B1 (bg)
KR (1) KR940000058B1 (bg)
AT (1) ATE66913T1 (bg)
AU (1) AU606988B2 (bg)
BG (1) BG48932A3 (bg)
CA (1) CA1335101C (bg)
DE (1) DE3864636D1 (bg)
DK (1) DK169816B1 (bg)
ES (1) ES2037779T3 (bg)
FI (1) FI87644C (bg)
HU (1) HU198447B (bg)
SU (1) SU1627082A3 (bg)
UA (1) UA6330A1 (bg)
YU (1) YU46706B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
EP0774460A1 (en) * 1994-03-30 1997-05-21 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compound and use thereof as medicine
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
AU1180400A (en) * 1998-11-16 2000-06-05 Hokuriku Seiyaku Co. Ltd Remedies for digestive tract functional disorder
EP1206446B1 (de) 1999-08-07 2004-05-26 Boehringer Ingelheim Pharma GmbH & Co.KG Carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE10235312A1 (de) 2002-08-01 2004-02-12 Basf Ag Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte
CN1305837C (zh) * 2004-06-11 2007-03-21 吉林修正药业新药研发中心 一种改进的伊托必利原料药的制备方法
KR100595117B1 (ko) * 2004-07-28 2006-06-30 일양약품주식회사 이토프라이드·염산염 중간체인4-[2-(디메틸아미노)에톡시]벤질아민의 새로운 제조방법
ITMI20042168A1 (it) * 2004-11-12 2005-02-12 Erregierre Spa Processo di preparazione di itopride cloridrato
KR100663167B1 (ko) * 2005-10-27 2007-01-02 동우신테크 주식회사 염산 이토프리드의 제조방법
WO2007074386A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar A novel process for synthesis of itopride and it’s novel intermediate-n-(4-hydroxybenzyl)-3,4-dimethoxybenzamide
KR100836528B1 (ko) * 2007-07-25 2008-06-10 주식회사 휴온스 이토프리드 염산염의 제조방법
CN101967103A (zh) * 2010-09-28 2011-02-09 浙江金伯士药业有限公司 一种伊托必利中间体的制备新方法
CN103073446B (zh) * 2011-10-26 2014-12-24 珠海保税区丽珠合成制药有限公司 盐酸伊托必利的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1069640B (de) * 1959-11-26 F. Hoffmann-La Roche S. Co. Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von anfemetisch wirksamen Benzylaminderivaten
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
NL130752C (bg) * 1964-05-07

Also Published As

Publication number Publication date
FI884077A0 (fi) 1988-09-05
YU46706B (sh) 1994-04-05
KR940000058B1 (ko) 1994-01-05
SU1627082A3 (ru) 1991-02-07
FI87644C (fi) 1993-02-10
ES2037779T3 (es) 1993-07-01
DE3864636D1 (de) 1991-10-10
US4983633A (en) 1991-01-08
UA6330A1 (uk) 1994-12-29
DK492288A (da) 1989-03-06
HU198447B (en) 1989-10-30
ATE66913T1 (de) 1991-09-15
DK492288D0 (da) 1988-09-05
AU606988B2 (en) 1991-02-21
EP0306827A1 (en) 1989-03-15
HUT47531A (en) 1989-03-28
AU2186288A (en) 1989-03-09
FI87644B (fi) 1992-10-30
YU160088A (en) 1990-06-30
CA1335101C (en) 1995-04-04
DK169816B1 (da) 1995-03-06
KR890005036A (ko) 1989-05-11
FI884077A7 (fi) 1989-03-06
EP0306827B1 (en) 1991-09-04

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