BG63388B1 - Нови заместени с хетероцикъл бензамиди и тяхното използване за лечение на болести - Google Patents
Нови заместени с хетероцикъл бензамиди и тяхното използване за лечение на болести Download PDFInfo
- Publication number
- BG63388B1 BG63388B1 BG103399A BG10339999A BG63388B1 BG 63388 B1 BG63388 B1 BG 63388B1 BG 103399 A BG103399 A BG 103399A BG 10339999 A BG10339999 A BG 10339999A BG 63388 B1 BG63388 B1 BG 63388B1
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- Bulgaria
- Prior art keywords
- alkyl
- formula
- heterocycle
- phenyl
- treatment
- Prior art date
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- ZMCBYSBVJIMENC-UHFFFAOYSA-N tricaine Chemical compound CCOC(=O)C1=CC=CC(N)=C1 ZMCBYSBVJIMENC-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19650975A DE19650975A1 (de) | 1996-12-09 | 1996-12-09 | Neue heterocyclisch substituierte Benzamide und deren Anwendung |
| PCT/EP1997/006653 WO1998025899A1 (fr) | 1996-12-09 | 1997-11-28 | Nouveaux benzamides substitues de maniere heterocyclique et leur utilisation pour lutter contre des maladies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG103399A BG103399A (en) | 2000-01-31 |
| BG63388B1 true BG63388B1 (bg) | 2001-12-29 |
Family
ID=7814035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103399A BG63388B1 (bg) | 1996-12-09 | 1999-05-12 | Нови заместени с хетероцикъл бензамиди и тяхното използване за лечение на болести |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6172072B1 (fr) |
| EP (1) | EP0946509A1 (fr) |
| JP (1) | JP2001505889A (fr) |
| KR (1) | KR20000057445A (fr) |
| CN (1) | CN1239949A (fr) |
| AR (1) | AR010339A1 (fr) |
| AU (1) | AU742732B2 (fr) |
| BG (1) | BG63388B1 (fr) |
| BR (1) | BR9713884A (fr) |
| CA (1) | CA2273988A1 (fr) |
| CO (1) | CO4910161A1 (fr) |
| CZ (1) | CZ292391B6 (fr) |
| DE (1) | DE19650975A1 (fr) |
| HR (1) | HRP970671A2 (fr) |
| HU (1) | HUP0000496A3 (fr) |
| ID (1) | ID22490A (fr) |
| IL (1) | IL129358A0 (fr) |
| NO (1) | NO992770L (fr) |
| NZ (1) | NZ335066A (fr) |
| SK (1) | SK56699A3 (fr) |
| TR (1) | TR199901282T2 (fr) |
| TW (1) | TW420666B (fr) |
| WO (1) | WO1998025899A1 (fr) |
| ZA (1) | ZA9710979B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010042839A (ko) * | 1998-04-20 | 2001-05-25 | 스타르크, 카르크 | 시스테인 프로테아제를 억제하는 효과를 나타내고헤테로시클릭 치환체가 있는 신규 아미드 |
| RU2260009C2 (ru) * | 1999-11-05 | 2005-09-10 | Сосьете Де Консей Де Решерш Э Д'Аппликасьон Сьентифик (С.К.Р.А.С.) | Новые гетероциклические соединения и их применение в качестве лекарственных средств |
| FR2800737B1 (fr) * | 1999-11-05 | 2006-06-30 | Sod Conseils Rech Applic | Nouveaux composes heterocycliques et leur application a titre de medicaments |
| GB0031302D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Napthalene derivatives |
| KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
| EP1562897B1 (fr) | 2002-11-12 | 2009-09-16 | Merck & Co., Inc. | Inhibiteurs de beta-secretase phenylcarboxamide utilises dans le traitement de la maladie d'alzheimer |
| WO2005019188A1 (fr) * | 2003-08-22 | 2005-03-03 | Takeda Pharmaceutical Company Limited | Derive de pyrimidine fusionne et utilisation associee |
| US7320992B2 (en) * | 2003-08-25 | 2008-01-22 | Amgen Inc. | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| FR2863268B1 (fr) * | 2003-12-09 | 2006-02-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments |
| EP1700850B1 (fr) * | 2003-12-22 | 2015-07-15 | Ajinomoto Co., Inc. | Derivé phenylalanine |
| GB0416730D0 (en) | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| US20070010537A1 (en) * | 2004-08-20 | 2007-01-11 | Kazumasa Hamamura | Fused pyramidine derivative and use thereof |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| US7834023B2 (en) * | 2006-09-20 | 2010-11-16 | Portola Pharmaceuticals, Inc. | Substituted dihydroquinazolines as platelet ADP receptor inhibitors |
| PT2439205E (pt) | 2006-12-29 | 2015-07-16 | Abbvie Deutschland | Compostos de carboxamida e seus usos como inibidores de calpaína |
| CN101686680B (zh) | 2007-03-09 | 2015-12-09 | 伊沃泰克美国股份有限公司 | 作为p2x7调节剂的双环杂芳基化合物及其用途 |
| TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| CN102939126B (zh) | 2010-04-30 | 2015-09-16 | 雅培心脏血管系统股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
| US9062027B2 (en) | 2010-12-09 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| SG11201406345XA (en) | 2012-04-03 | 2014-11-27 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors v |
| EP3426674A4 (fr) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | Composés céto-amides cycliques utilisés en tant que modulateurs de la calpaïne, et leurs procédés de production et d'utilisation |
| EP3481835A4 (fr) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | Modulateurs de calpain et leurs utilisations thérapeutiques |
| SG10201912574WA (en) | 2016-09-28 | 2020-02-27 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
| EP3886854A4 (fr) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Composés pyrrole et pyrazole et leurs procédés d'utilisation |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8524663D0 (en) * | 1985-10-07 | 1985-11-13 | Fujisawa Pharmaceutical Co | Quinazoline derivatives |
| DE3717828A1 (de) * | 1987-05-27 | 1988-12-15 | Hoechst Ag | Siliziumhaltige benzoesaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung im pflanzenschutz |
| DE4000204A1 (de) | 1990-01-05 | 1991-07-11 | Steag Ag | Vorrichtung zum dosierten austragen von schuettfaehigem feststoff |
| EP0473551A1 (fr) * | 1990-08-31 | 1992-03-04 | Ciba-Geigy Ag | Dérivés de 3-arylaracile, procédé pour leur préparation et herbicides les contenant |
| EP0564650B1 (fr) | 1990-12-28 | 1995-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Derive de quinoline |
| WO1992011850A2 (fr) | 1990-12-28 | 1992-07-23 | Cortex Pharmaceuticals, Inc. | Utilisation d'inhibiteurs de la calpaine dans l'inhibition et le traitement de la neurodegenerescence |
| CA2071621C (fr) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Derives d'aldehyde |
| EP0650368A1 (fr) | 1992-06-24 | 1995-05-03 | Cortex Pharmaceuticals, Inc. | Emploi d'inhibiteurs de calpaine dans l'inhibition et le traitement d'etats medicaux associes a une activite de calpaine accrue |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
-
1996
- 1996-12-09 DE DE19650975A patent/DE19650975A1/de not_active Withdrawn
-
1997
- 1997-11-28 EP EP97952007A patent/EP0946509A1/fr not_active Withdrawn
- 1997-11-28 CN CN97180437A patent/CN1239949A/zh active Pending
- 1997-11-28 CA CA002273988A patent/CA2273988A1/fr not_active Abandoned
- 1997-11-28 KR KR1019990705071A patent/KR20000057445A/ko not_active Withdrawn
- 1997-11-28 IL IL12935897A patent/IL129358A0/xx unknown
- 1997-11-28 CZ CZ19991743A patent/CZ292391B6/cs not_active IP Right Cessation
- 1997-11-28 BR BR9713884-3A patent/BR9713884A/pt not_active IP Right Cessation
- 1997-11-28 US US09/308,350 patent/US6172072B1/en not_active Expired - Fee Related
- 1997-11-28 WO PCT/EP1997/006653 patent/WO1998025899A1/fr not_active Ceased
- 1997-11-28 AU AU55580/98A patent/AU742732B2/en not_active Ceased
- 1997-11-28 HU HU0000496A patent/HUP0000496A3/hu unknown
- 1997-11-28 JP JP52615598A patent/JP2001505889A/ja active Pending
- 1997-11-28 SK SK566-99A patent/SK56699A3/sk unknown
- 1997-11-28 TR TR1999/01282T patent/TR199901282T2/xx unknown
- 1997-11-28 NZ NZ335066A patent/NZ335066A/xx unknown
- 1997-11-28 ID IDW990486D patent/ID22490A/id unknown
- 1997-12-08 ZA ZA9710979A patent/ZA9710979B/xx unknown
- 1997-12-08 TW TW086118462A patent/TW420666B/zh active
- 1997-12-08 HR HR19650975.0A patent/HRP970671A2/hr not_active Application Discontinuation
- 1997-12-09 AR ARP970105766A patent/AR010339A1/es not_active Application Discontinuation
- 1997-12-09 CO CO97071820A patent/CO4910161A1/es unknown
-
1999
- 1999-05-12 BG BG103399A patent/BG63388B1/bg unknown
- 1999-06-08 NO NO992770A patent/NO992770L/no unknown
-
2000
- 2000-09-21 US US09/666,304 patent/US6436949B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SK56699A3 (en) | 1999-10-08 |
| TR199901282T2 (xx) | 1999-10-21 |
| CA2273988A1 (fr) | 1998-06-18 |
| CN1239949A (zh) | 1999-12-29 |
| ZA9710979B (en) | 1999-06-18 |
| NO992770D0 (no) | 1999-06-08 |
| CZ174399A3 (cs) | 1999-08-11 |
| HRP970671A2 (en) | 1998-10-31 |
| AU742732B2 (en) | 2002-01-10 |
| CO4910161A1 (es) | 2000-04-24 |
| IL129358A0 (en) | 2000-02-17 |
| EP0946509A1 (fr) | 1999-10-06 |
| KR20000057445A (ko) | 2000-09-15 |
| TW420666B (en) | 2001-02-01 |
| AR010339A1 (es) | 2000-06-07 |
| NZ335066A (en) | 2000-03-27 |
| AU5558098A (en) | 1998-07-03 |
| DE19650975A1 (de) | 1998-06-10 |
| US6172072B1 (en) | 2001-01-09 |
| BR9713884A (pt) | 2000-02-29 |
| WO1998025899A1 (fr) | 1998-06-18 |
| CZ292391B6 (cs) | 2003-09-17 |
| NO992770L (no) | 1999-06-08 |
| HUP0000496A3 (en) | 2002-11-28 |
| HUP0000496A2 (hu) | 2000-09-28 |
| JP2001505889A (ja) | 2001-05-08 |
| BG103399A (en) | 2000-01-31 |
| ID22490A (id) | 1999-10-21 |
| US6436949B1 (en) | 2002-08-20 |
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