BG63484B1 - Орален фармацевтичен състав с модифицирано освобождаване съдържащ 5-аминосалицилова киселина и метод за лечение на чревни заболявания - Google Patents

Орален фармацевтичен състав с модифицирано освобождаване съдържащ 5-аминосалицилова киселина и метод за лечение на чревни заболявания Download PDF

Info

Publication number: BG63484B1
Authority: BG; Bulgaria
Prior art keywords: aminosalicylic acid; granules; composition; minutes; released
Prior art date: 1995-12-21

Application number

BG102556A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102556A (en

Inventor

Svenn JEPSEN

Soren Halskov

Original Assignee

Farmaceutisk Laboratorium Ferring A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-21

Filing date

1998-06-18

Publication date

2002-03-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24302375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63484(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-06-18 Application filed by Farmaceutisk Laboratorium Ferring A/S filed Critical Farmaceutisk Laboratorium Ferring A/S

1999-02-26 Publication of BG102556A publication Critical patent/BG102556A/xx

2002-03-29 Publication of BG63484B1 publication Critical patent/BG63484B1/bg

Links

238000011282 treatment Methods 0.000 title claims abstract description 13
KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 title claims description 61
229960004963 mesalazine Drugs 0.000 title claims description 58
238000000034 method Methods 0.000 title abstract description 13
208000028774 intestinal disease Diseases 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 69
206010009900 Colitis ulcerative Diseases 0.000 claims abstract description 7
201000006704 Ulcerative Colitis Diseases 0.000 claims abstract description 7
208000011231 Crohn disease Diseases 0.000 claims abstract description 6
210000002429 large intestine Anatomy 0.000 claims abstract description 6
230000002757 inflammatory effect Effects 0.000 claims abstract 3
239000008187 granular material Substances 0.000 claims description 101
210000002784 stomach Anatomy 0.000 claims description 17
239000002552 dosage form Substances 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 13
150000002148 esters Chemical class 0.000 claims description 12
239000001856 Ethyl cellulose Substances 0.000 claims description 10
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 10
235000019325 ethyl cellulose Nutrition 0.000 claims description 10
229920001249 ethyl cellulose Polymers 0.000 claims description 10
239000000463 material Substances 0.000 claims description 10
239000008188 pellet Substances 0.000 claims description 10
239000000546 pharmaceutical excipient Substances 0.000 claims description 10
210000000813 small intestine Anatomy 0.000 claims description 10
238000001727 in vivo Methods 0.000 claims description 9
208000022559 Inflammatory bowel disease Diseases 0.000 claims description 7
230000004888 barrier function Effects 0.000 claims description 7
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
239000007931 coated granule Substances 0.000 claims description 6
201000010099 disease Diseases 0.000 claims description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
239000008108 microcrystalline cellulose Substances 0.000 claims description 6
229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
229920002678 cellulose Polymers 0.000 claims description 5
239000001913 cellulose Substances 0.000 claims description 5
235000010980 cellulose Nutrition 0.000 claims description 5
230000001747 exhibiting effect Effects 0.000 claims description 4
238000000338 in vitro Methods 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
230000002496 gastric effect Effects 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 2
208000018556 stomach disease Diseases 0.000 claims 4
238000004519 manufacturing process Methods 0.000 claims 1
229940126601 medicinal product Drugs 0.000 claims 1
239000002253 acid Substances 0.000 abstract description 2
239000003826 tablet Substances 0.000 description 14
238000004090 dissolution Methods 0.000 description 13
230000000052 comparative effect Effects 0.000 description 7
238000009472 formulation Methods 0.000 description 6
210000001072 colon Anatomy 0.000 description 5
210000001035 gastrointestinal tract Anatomy 0.000 description 5
230000000968 intestinal effect Effects 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
239000002775 capsule Substances 0.000 description 4
239000012530 fluid Substances 0.000 description 4
238000010191 image analysis Methods 0.000 description 4
238000002156 mixing Methods 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
238000003756 stirring Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
241000252983 Caecum Species 0.000 description 3
241000275031 Nica Species 0.000 description 3
210000004534 cecum Anatomy 0.000 description 3
239000011248 coating agent Substances 0.000 description 3
238000000576 coating method Methods 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
238000001035 drying Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
239000000543 intermediate Substances 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
210000000664 rectum Anatomy 0.000 description 3
239000011734 sodium Substances 0.000 description 3
238000010998 test method Methods 0.000 description 3
238000012360 testing method Methods 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
239000002131 composite material Substances 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
239000000470 constituent Substances 0.000 description 2
-1 cycrohexyl Chemical group 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000005259 measurement Methods 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
229940072223 pentasa Drugs 0.000 description 2
230000036470 plasma concentration Effects 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
241000894007 species Species 0.000 description 2
238000005563 spheronization Methods 0.000 description 2
230000004936 stimulating effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
238000013268 sustained release Methods 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
229920000856 Amylose Polymers 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
241001103145 Pentas Species 0.000 description 1
241000906446 Theraps Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
125000003342 alkenyl group Chemical group 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
150000007860 aryl ester derivatives Chemical class 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
125000002843 carboxylic acid group Chemical group 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
239000008199 coating composition Substances 0.000 description 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000003413 degradative effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000001066 destructive effect Effects 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000001198 duodenum Anatomy 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
230000030136 gastric emptying Effects 0.000 description 1
239000008202 granule composition Substances 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
229910017053 inorganic salt Inorganic materials 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008141 laxative Substances 0.000 description 1
230000002475 laxative effect Effects 0.000 description 1
125000005644 linolenyl group Chemical group 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
238000011418 maintenance treatment Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
230000003534 oscillatory effect Effects 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
238000010880 proctocolectomy Methods 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008213 purified water Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000012216 screening Methods 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000007939 sustained release tablet Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
125000005065 undecenyl group Chemical group C(=CCCCCCCCCC)* 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BG102556A 1995-12-21 1998-06-18 Орален фармацевтичен състав с модифицирано освобождаване съдържащ 5-аминосалицилова киселина и метод за лечение на чревни заболявания BG63484B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57595495A	1995-12-21	1995-12-21
PCT/DK1996/000551 WO1997023199A1 (fr)	1995-12-21	1996-12-23	Composition pharmaceutique orale a liberation modifiee contenant 5-asa et procede de traitement de maladies intestinales

Publications (2)

Publication Number	Publication Date
BG102556A BG102556A (en)	1999-02-26
BG63484B1 true BG63484B1 (bg)	2002-03-29

Family

ID=24302375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102556A BG63484B1 (bg)	1995-12-21	1998-06-18	Орален фармацевтичен състав с модифицирано освобождаване съдържащ 5-аминосалицилова киселина и метод за лечение на чревни заболявания

Country Status (27)

Country	Link
EP (1)	EP0871434B2 (fr)
JP (1)	JP4714836B2 (fr)
KR (2)	KR100542544B1 (fr)
CN (1)	CN1155369C (fr)
AT (1)	ATE205704T1 (fr)
AU (1)	AU702934B2 (fr)
BG (1)	BG63484B1 (fr)
BR (1)	BR9612213A (fr)
CA (1)	CA2240281C (fr)
CZ (1)	CZ289290B6 (fr)
DE (2)	DE69615400T3 (fr)
DK (1)	DK0871434T4 (fr)
EE (1)	EE03740B1 (fr)
ES (1)	ES2149733T5 (fr)
HU (1)	HU228856B1 (fr)
IL (1)	IL124858A (fr)
IS (1)	IS1834B (fr)
NO (1)	NO320498B1 (fr)
NZ (1)	NZ325201A (fr)
PL (1)	PL186790B1 (fr)
PT (1)	PT871434E (fr)
RU (1)	RU2181043C2 (fr)
SI (1)	SI0871434T2 (fr)
SK (1)	SK282669B6 (fr)
TR (1)	TR199801158T2 (fr)
UA (1)	UA67721C2 (fr)
WO (1)	WO1997023199A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2463055C2 (ru) *	2011-01-12	2012-10-10	Петр Леонидович Щербаков	Способ лечения воспалительных заболеваний кишечника

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19732903A1 (de)	1997-07-30	1999-02-04	Falk Pharma Gmbh	Pellet-Formulierung zur Behandlung des Intestinaltraktes
AU764469B2 (en)	1999-01-29	2003-08-21	Disphar International B.V.	Pharmaceutical compositions
RU2191782C2 (ru) *	2000-09-21	2002-10-27	Институт нефтехимии и катализа АН РБ и УНЦ РАН	Способ получения модифицированной гиалуроновой кислоты
CA2359812C (fr)	2000-11-20	2004-02-10	The Procter & Gamble Company	Formes posologiques pharmaceutiques a couches multiples permettant de reduire l'impact des revetement fractures
US8282955B2 (en) *	2001-10-15	2012-10-09	Ferring B.V.	Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of ulcerative colitis and Crohn's disease
PT1441700E (pt) *	2001-10-15	2007-10-29	Ferring Bv	Método para a preparação de uma composição compreendendo ácido 5-aminosalicílico para uso em tratamento de colites ulcerosas ou da doença de crohn
RU2286156C2 (ru) *	2001-10-15	2006-10-27	Ферринг Бв	Способ приготовления фармацевтической композиции, включающей в себя 5-аминосалициловую кислоту, для применения в лечении неспецифического язвенного колита и болезни крона
JP2007523664A (ja) *	2003-04-23	2007-08-23	フェリングベスローテンフェンノートシャップ	医薬組成物用サシェ
EP1547601A1 (fr) *	2003-12-23	2005-06-29	Ferring B.V.	Procédé de revêtement
RU2297835C1 (ru)	2005-09-26	2007-04-27	Закрытое акционерное общество "Партнер"	Препарат для лечения неинфекционных воспалительных болезней кишечника
ES2690205T3 (es) *	2006-04-13	2018-11-19	Neurotech Pharmaceuticals Co., Ltd.	Composición farmacéutica para tratar o prevenir enfermedades inflamatorias
EP2328549B1 (fr) *	2008-08-22	2017-11-15	Reckitt Benckiser Healthcare (UK) Limited	Compositions contre le mal de gorge
WO2010040113A1 (fr)	2008-10-03	2010-04-08	Salix Pharmaceuticals, Ltd.	Compositions et procédés permettant de traiter les maladies intestinales à l’aide de mésalamine granulée
EP2340812A1 (fr)	2009-12-18	2011-07-06	Ferring International Center S.A.	Granules pour préparations pharmaceutiques, procédés et appareil pour leur production
CN102319218B (zh) *	2011-09-22	2014-10-01	贝沃特医药技术(上海)有限公司	一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法
WO2013144176A1 (fr)	2012-03-30	2013-10-03	Laboratorios Del Dr. Esteve, S.A.	Formulation à libération contrôlée comprenant de la mésalamine
RU2752082C1 (ru) *	2020-09-29	2021-07-22	федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации	Средство с гранулами, содержащими 5-аминосалициловую кислоту и фолиевую кислоту, с контролируемым высвобождением

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1981002671A1 (fr) *	1980-03-20	1981-10-01	Ferring Farma Lab	Composition pharmaceutique et methode de traitement de la colite ulcereuse et la maladie de crohn par voie orale
US4960765A (en) *	1980-03-20	1990-10-02	Farmaceutisk Laboratorium Ferring A/S	Pharmaceutical composition and method for the treatment of colitis ulcerosa and Crohn's disease by oral administration
SE457505B (sv) *	1984-01-10	1989-01-09	Lejus Medical Ab	Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning
FR2649611A1 (fr) *	1989-07-13	1991-01-18	Philippe Perovitch	Procede de preparation galenique d'une composition therapeutique notamment a base d'aspirine
GB8926639D0 (en) *	1989-11-24	1990-01-17	Agricultural & Food Res	Delayed release formulations
IT1246382B (it) *	1990-04-17	1994-11-18	Eurand Int	Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon

1996
- 1996-12-23 KR KR1019980704656A patent/KR100542544B1/ko not_active Expired - Lifetime
- 1996-12-23 RU RU98111765/14A patent/RU2181043C2/ru active
- 1996-12-23 SI SI9630388T patent/SI0871434T2/sl unknown
- 1996-12-23 IL IL12485896A patent/IL124858A/xx not_active IP Right Cessation
- 1996-12-23 WO PCT/DK1996/000551 patent/WO1997023199A1/fr not_active Ceased
- 1996-12-23 PL PL96327323A patent/PL186790B1/pl unknown
- 1996-12-23 JP JP52323797A patent/JP4714836B2/ja not_active Expired - Lifetime
- 1996-12-23 DE DE69615400T patent/DE69615400T3/de not_active Expired - Lifetime
- 1996-12-23 ES ES96943884T patent/ES2149733T5/es not_active Expired - Lifetime
- 1996-12-23 HU HU0001084A patent/HU228856B1/hu unknown
- 1996-12-23 DK DK96943884T patent/DK0871434T4/da active
- 1996-12-23 AU AU13661/97A patent/AU702934B2/en not_active Expired
- 1996-12-23 AT AT96943884T patent/ATE205704T1/de active
- 1996-12-23 NZ NZ325201A patent/NZ325201A/en not_active IP Right Cessation
- 1996-12-23 EE EE9800191A patent/EE03740B1/xx unknown
- 1996-12-23 CN CNB96199679XA patent/CN1155369C/zh not_active Expired - Lifetime
- 1996-12-23 DE DE0871434T patent/DE871434T1/de active Pending
- 1996-12-23 CZ CZ19981946A patent/CZ289290B6/cs not_active IP Right Cessation
- 1996-12-23 TR TR1998/01158T patent/TR199801158T2/xx unknown
- 1996-12-23 SK SK834-98A patent/SK282669B6/sk not_active IP Right Cessation
- 1996-12-23 EP EP96943884A patent/EP0871434B2/fr not_active Expired - Lifetime
- 1996-12-23 PT PT96943884T patent/PT871434E/pt unknown
- 1996-12-23 BR BR9612213-7A patent/BR9612213A/pt not_active IP Right Cessation
- 1996-12-23 UA UA98063228A patent/UA67721C2/uk unknown
- 1996-12-23 CA CA002240281A patent/CA2240281C/fr not_active Expired - Lifetime
- 1996-12-23 KR KR1020057014255A patent/KR100598714B1/ko not_active Expired - Lifetime
1998
- 1998-06-15 IS IS4772A patent/IS1834B/is unknown
- 1998-06-18 BG BG102556A patent/BG63484B1/bg unknown
- 1998-06-22 NO NO19982904A patent/NO320498B1/no not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2463055C2 (ru) *	2011-01-12	2012-10-10	Петр Леонидович Щербаков	Способ лечения воспалительных заболеваний кишечника

Also Published As

Publication number	Publication date
PL186790B1 (pl)	2004-02-27
HU228856B1 (en)	2013-06-28
DK0871434T4 (da)	2008-04-07
ES2149733T5 (es)	2008-05-01
NO982904D0 (no)	1998-06-22
KR100542544B1 (ko)	2006-05-10
DK0871434T3 (da)	2002-01-07
SI0871434T2 (sl)	2008-04-30
CN1207672A (zh)	1999-02-10
WO1997023199A1 (fr)	1997-07-03
KR19990076584A (ko)	1999-10-15
EP0871434B1 (fr)	2001-09-19
HK1017615A1 (en)	1999-11-26
EE03740B1 (et)	2002-06-17
IS1834B (is)	2002-11-15
JPH11510191A (ja)	1999-09-07
EP0871434A1 (fr)	1998-10-21
SK282669B6 (sk)	2002-11-06
ES2149733T1 (es)	2000-11-16
AU702934B2 (en)	1999-03-11
UA67721C2 (en)	2004-07-15
NO982904L (no)	1998-06-22
BG102556A (en)	1999-02-26
KR20050087886A (ko)	2005-08-31
PL327323A1 (en)	1998-12-07
HUP0001084A2 (hu)	2000-11-28
IS4772A (is)	1998-06-15
DE69615400T2 (de)	2002-05-23
JP4714836B2 (ja)	2011-06-29
KR100598714B1 (ko)	2006-07-10
CA2240281A1 (fr)	1997-07-03
HUP0001084A3 (en)	2000-12-28
IL124858A0 (en)	1999-01-26
IL124858A (en)	2003-03-12
ATE205704T1 (de)	2001-10-15
EE9800191A (et)	1998-12-15
DE871434T1 (de)	2001-04-05
BR9612213A (pt)	1999-12-28
ES2149733T3 (es)	2002-04-01
DE69615400D1 (de)	2001-10-25
EP0871434B2 (fr)	2007-12-12
CN1155369C (zh)	2004-06-30
TR199801158T2 (xx)	1998-09-21
NO320498B1 (no)	2005-12-12
SI0871434T1 (en)	2002-04-30
RU2181043C2 (ru)	2002-04-10
CZ289290B6 (cs)	2001-12-12
SK83498A3 (en)	1999-01-11
CZ194698A3 (cs)	1998-10-14
NZ325201A (en)	1998-11-25
CA2240281C (fr)	2007-02-27
DE69615400T3 (de)	2008-08-07
AU1366197A (en)	1997-07-17
PT871434E (pt)	2002-02-28

Publication	Publication Date	Title
EP0871434B1 (fr)	2001-09-19	Composition pharmaceutique orale a liberation modifiee contenant 5-asa et procede de traitement de maladies intestinales
JP4789806B2 (ja)	2011-10-12	パントプラゾール多粒子処方
US6004581A (en)	1999-12-21	Modified release oral pharmaceutical composition and method for the treatment of bowel diseases
US20090118256A1 (en)	2009-05-07	Chronotherapeutic diltiazem formulations and the administration thereof
EP1235562B1 (fr)	2009-05-06	Formulations a base de diltiazem chronotherapeutiques et leur administration
CA2684586A1 (fr)	2008-10-30	Composition a dose elevee d'acide ursodesoxycholique
US20030083360A1 (en)	2003-05-01	Compaction process for manufacture of sodium phenytoin dosage form
RU98111765A (ru)	2000-05-20	Фармацевтическая композиция для орального введения с модифицированным высвобождением, содержащая 5-аск, и способ лечения кишечных заболеваний
EP1128826B1 (fr)	2004-01-21	Formulation entero-soluble de chromones
JP4438268B2 (ja)	2010-03-24	薬物顆粒の製造方法、および薬物顆粒、ならびにそれを用いた医薬製剤
JP2012511039A (ja)	2012-05-17	固定用量組合せのためのタムスロシンペレット剤
WO2022058989A1 (fr)	2022-03-24	Composition pharmaceutique multiparticulaire de quétiapine
UA81121C2 (en)	2007-12-10	Microcapsules for the delayed, controlled release of perindopril, use thereof for the preparation of pharmaceutical composition and pharmaceutical composition containing microcapsules
CA2307547C (fr)	2007-08-14	Formulations chronotherapeutiques du diltiazem et administration de celles-ci
CA2292247A1 (fr)	2001-06-10	Formulations chronotherapeutiques du diltiazem et administration de celles-ci
US20060153914A1 (en)	2006-07-13	Chronotherapeutic diltiazem formulations and the administration thereof

BG63484B1 - Орален фармацевтичен състав с модифицирано освобождаване съдържащ 5-аминосалицилова киселина и метод за лечение на чревни заболявания - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (2)

Family

ID=24302375

Family Applications (1)

Country Status (27)

Cited By (1)

Families Citing this family (17)

Family Cites Families (6)

Cited By (1)

Also Published As

Similar Documents