BG64314B1 - 2,4,4-тризаместени 1,3-диоксолани с противогъбично действие - Google Patents

2,4,4-тризаместени 1,3-диоксолани с противогъбично действие Download PDF

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Publication number
BG64314B1
BG64314B1 BG103982A BG10398299A BG64314B1 BG 64314 B1 BG64314 B1 BG 64314B1 BG 103982 A BG103982 A BG 103982A BG 10398299 A BG10398299 A BG 10398299A BG 64314 B1 BG64314 B1 BG 64314B1
Authority
BG
Bulgaria
Prior art keywords
formula
compound
alkyl
compounds
aryl
Prior art date
Application number
BG103982A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103982A (en
Inventor
Lieven Meerpoel
Jan Heeres
Frank C. Odds
Hugo Florent A. Vanden Bossche
Louis Jozef E. Van Der Veken
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG103982A publication Critical patent/BG103982A/xx
Publication of BG64314B1 publication Critical patent/BG64314B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG103982A 1997-07-11 1999-12-10 2,4,4-тризаместени 1,3-диоксолани с противогъбично действие BG64314B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202181 1997-07-11
PCT/EP1998/004194 WO1999002523A1 (en) 1997-07-11 1998-07-07 2,4,4-trisubstituted-1,3-dioxolane antifungals

Publications (2)

Publication Number Publication Date
BG103982A BG103982A (en) 2000-08-31
BG64314B1 true BG64314B1 (bg) 2004-09-30

Family

ID=8228553

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103982A BG64314B1 (bg) 1997-07-11 1999-12-10 2,4,4-тризаместени 1,3-диоксолани с противогъбично действие

Country Status (33)

Country Link
US (1) US6387906B1 (pl)
EP (1) EP1068200B1 (pl)
KR (1) KR100540460B1 (pl)
AP (1) AP1379A (pl)
AR (1) AR015130A1 (pl)
AT (1) ATE289303T1 (pl)
AU (1) AU749760B2 (pl)
BG (1) BG64314B1 (pl)
BR (1) BRPI9811679B8 (pl)
CA (1) CA2295090C (pl)
CZ (1) CZ297453B6 (pl)
DE (1) DE69829082T2 (pl)
DK (1) DK1068200T3 (pl)
EA (1) EA002828B1 (pl)
EE (1) EE04155B1 (pl)
ES (1) ES2238765T3 (pl)
GE (1) GEP20033054B (pl)
HR (1) HRP20000007B1 (pl)
HU (1) HU225159B1 (pl)
ID (1) ID23783A (pl)
IL (1) IL133919A (pl)
MY (1) MY118844A (pl)
NO (1) NO318328B1 (pl)
NZ (1) NZ501982A (pl)
PL (1) PL193703B1 (pl)
PT (1) PT1068200E (pl)
SI (1) SI1068200T1 (pl)
SK (1) SK285321B6 (pl)
TR (1) TR200000154T2 (pl)
TW (1) TW593312B (pl)
UA (1) UA71543C2 (pl)
WO (1) WO1999002523A1 (pl)
ZA (1) ZA986160B (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
EP2255009A4 (en) * 2008-03-03 2011-08-10 Stiefel Laboratories PROCESSES FOR THE PREPARATION OF ENANTIOMERICALLY PURE DIOL AND DIOXOLANE COMPOUNDS
US8431699B2 (en) * 2009-02-27 2013-04-30 Vertichem Corporation Method for manufacture of 2-oxoimidazolidines
CN105777486B (zh) * 2016-03-30 2018-09-11 浙江大学宁波理工学院 一种2-[2-(2,4-二氟苯基)-2-丙烯-1-基]-1,3-丙二醇的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
NZ233502A (en) 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
IL103558A0 (en) 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
NZ278882A (en) 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds

Also Published As

Publication number Publication date
ID23783A (id) 2000-05-11
ES2238765T3 (es) 2005-09-01
IL133919A (en) 2002-02-10
CZ297453B6 (cs) 2006-12-13
BR9811679A (pt) 2000-09-19
TW593312B (en) 2004-06-21
DE69829082D1 (de) 2005-03-24
CZ463799A3 (cs) 2000-04-12
EA002828B1 (ru) 2002-10-31
NZ501982A (en) 2000-10-27
PL338009A1 (en) 2000-09-25
DE69829082T2 (de) 2005-12-29
DK1068200T3 (da) 2005-06-20
HRP20000007B1 (en) 2008-12-31
CA2295090C (en) 2009-09-08
ZA986160B (en) 2000-01-10
PL193703B1 (pl) 2007-03-30
AP2000001730A0 (en) 2000-03-31
AU8857698A (en) 1999-02-08
MY118844A (en) 2005-01-31
BRPI9811679B1 (pt) 2016-10-18
BG103982A (en) 2000-08-31
UA71543C2 (uk) 2004-12-15
NO20000114L (no) 2000-03-13
EE04155B1 (et) 2003-10-15
KR20010020576A (ko) 2001-03-15
NO318328B1 (no) 2005-03-07
AP1379A (en) 2005-03-29
US6387906B1 (en) 2002-05-14
EA200000116A1 (ru) 2000-08-28
NO20000114D0 (no) 2000-01-10
EP1068200B1 (en) 2005-02-16
EE200000020A (et) 2000-10-16
AU749760B2 (en) 2002-07-04
ATE289303T1 (de) 2005-03-15
IL133919A0 (en) 2001-04-30
SK285321B6 (sk) 2006-11-03
SI1068200T1 (pl) 2005-08-31
HRP20000007A2 (en) 2000-12-31
TR200000154T2 (tr) 2000-06-21
HU225159B1 (en) 2006-07-28
HUP0004459A3 (en) 2002-11-28
WO1999002523A1 (en) 1999-01-21
GEP20033054B (en) 2003-08-25
CA2295090A1 (en) 1999-01-21
EP1068200A1 (en) 2001-01-17
HK1032404A1 (en) 2001-07-20
PT1068200E (pt) 2005-07-29
KR100540460B1 (ko) 2006-01-12
AR015130A1 (es) 2001-04-18
BRPI9811679B8 (pt) 2021-05-25
SK184199A3 (en) 2000-07-11
HUP0004459A2 (hu) 2002-04-29

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