BG99594A - Метод за получаване на енантиомерно чист 6-/(4-хлорофенил)- (1н-1,2,4-триазол-1-ил)метил/-1-метил-1н-бензотриазол, междинни продукти и методи за получаването им - Google Patents

Метод за получаване на енантиомерно чист 6-/(4-хлорофенил)- (1н-1,2,4-триазол-1-ил)метил/-1-метил-1н-бензотриазол, междинни продукти и методи за получаването им Download PDF

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Publication number
BG99594A
BG99594A BG99594A BG9959495A BG99594A BG 99594 A BG99594 A BG 99594A BG 99594 A BG99594 A BG 99594A BG 9959495 A BG9959495 A BG 9959495A BG 99594 A BG99594 A BG 99594A
Authority
BG
Bulgaria
Prior art keywords
formula
acid
reaction
product
salt
Prior art date
Application number
BG99594A
Other languages
Bulgarian (bg)
English (en)
Inventor
Albert Willemsens
Walter Verstappen
Alex Copmans
Anna Vandendriessche
Knaep Alfons De
Marc Venet
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG99594A publication Critical patent/BG99594A/bg

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18Benzotriazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG99594A 1992-11-10 1995-04-20 Метод за получаване на енантиомерно чист 6-/(4-хлорофенил)- (1н-1,2,4-триазол-1-ил)метил/-1-метил-1н-бензотриазол, междинни продукти и методи за получаването им BG99594A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92203443 1992-11-10
PCT/EP1993/003066 WO1994011364A1 (en) 1992-11-10 1993-11-02 Process for preparing enantiomerically pure 6-[(4-chlorophenyl)(1h^_-triazol-1,2,4-triazol-1-yl)methyl]-1-methyl-1h^_-benzotriazole

Publications (1)

Publication Number Publication Date
BG99594A true BG99594A (bg) 1996-01-31

Family

ID=8211029

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99594A BG99594A (bg) 1992-11-10 1995-04-20 Метод за получаване на енантиомерно чист 6-/(4-хлорофенил)- (1н-1,2,4-триазол-1-ил)метил/-1-метил-1н-бензотриазол, междинни продукти и методи за получаването им

Country Status (18)

Country Link
US (2) US5663354A (pl)
EP (1) EP0668861A1 (pl)
JP (1) JPH08502990A (pl)
AU (1) AU679704B2 (pl)
BG (1) BG99594A (pl)
BR (1) BR9307409A (pl)
CA (1) CA2148489A1 (pl)
CZ (1) CZ115195A3 (pl)
FI (1) FI952251A0 (pl)
HU (1) HUT72073A (pl)
NO (1) NO951808D0 (pl)
NZ (1) NZ257551A (pl)
PL (1) PL176059B1 (pl)
RO (1) RO114327B1 (pl)
RU (1) RU95112576A (pl)
SG (1) SG50476A1 (pl)
SK (1) SK59995A3 (pl)
WO (1) WO1994011364A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL176059B1 (pl) * 1992-11-10 1999-03-31 Janssen Pharmaceutica Nv Sposób wytwarzania enancjomerycznie czystego 6-[(4-chlorofenylo) (1H-1,2,4-triazol-1-ilo)-metylo]-1-metylo-1H-benzotriazolu
US8795629B2 (en) * 2009-02-13 2014-08-05 Brookhaven Science Associates, Llc Radio-methyl vorozole and methods for making and using the same
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
CA3087557C (en) 2018-01-03 2025-06-17 Ecolab Usa Inc. Benzotriazole derivatives as corrosion inhibitors
CN115650962B (zh) * 2022-10-31 2024-07-30 吉林大学 一种用于钯催化偶联反应的荧光配体化合物及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943574A (en) * 1987-06-01 1990-07-24 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them
NZ224714A (en) * 1987-06-01 1990-03-27 Janssen Pharmaceutica Nv Substituted benzotriazole derivatives and pharmaceutical compositions
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
PL176059B1 (pl) * 1992-11-10 1999-03-31 Janssen Pharmaceutica Nv Sposób wytwarzania enancjomerycznie czystego 6-[(4-chlorofenylo) (1H-1,2,4-triazol-1-ilo)-metylo]-1-metylo-1H-benzotriazolu

Also Published As

Publication number Publication date
PL308905A1 (en) 1995-09-04
RO114327B1 (ro) 1999-03-30
CZ115195A3 (en) 1995-11-15
AU679704B2 (en) 1997-07-10
US5663354A (en) 1997-09-02
AU5420394A (en) 1994-06-08
WO1994011364A1 (en) 1994-05-26
CA2148489A1 (en) 1994-05-26
PL176059B1 (pl) 1999-03-31
SK59995A3 (en) 1995-10-11
SG50476A1 (en) 1998-07-20
HUT72073A (en) 1996-03-28
FI952251A7 (fi) 1995-05-09
JPH08502990A (ja) 1996-04-02
FI952251L (fi) 1995-05-09
NZ257551A (en) 1995-10-26
RU95112576A (ru) 1997-03-20
NO951808L (no) 1995-05-09
BR9307409A (pt) 1999-08-24
US5746840A (en) 1998-05-05
NO951808D0 (no) 1995-05-09
FI952251A0 (fi) 1995-05-09
EP0668861A1 (en) 1995-08-30

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