BR0008631A - Glicina betaìna para uso antitrombótico - Google Patents
Glicina betaìna para uso antitrombóticoInfo
- Publication number
- BR0008631A BR0008631A BR0008631-2A BR0008631A BR0008631A BR 0008631 A BR0008631 A BR 0008631A BR 0008631 A BR0008631 A BR 0008631A BR 0008631 A BR0008631 A BR 0008631A
- Authority
- BR
- Brazil
- Prior art keywords
- betaine
- glycine
- relates
- glycine betaine
- thrombi
- Prior art date
Links
- UNBPSYYIFVLVID-UHFFFAOYSA-N 2-aminoacetic acid;2-(trimethylazaniumyl)acetate Chemical compound NCC(O)=O.C[N+](C)(C)CC([O-])=O UNBPSYYIFVLVID-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 230000002785 anti-thrombosis Effects 0.000 title 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 6
- 229960003237 betaine Drugs 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 208000024659 Hemostatic disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000001435 Thromboembolism Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000034158 bleeding Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 230000001991 pathophysiological effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Patente de Invenção: "GLICINA BETAìNA PARA USO ANTITROMBóTICO". Esta invenção refere-se ao uso de glicina betaína para eliminar ataques vasculares fisiopatológicos. A invenção refere-se à atividade curativa e preventiva de glicina betaína na patogênese de doenças tromboembólicas e hemostáticas de origem arterial ou venosa. Glicina betaína apresenta uma atividade de prevenção ao inibir a formação de trombos e uma atividade curativa que inibe a proliferação de trombos ao eliminá-los. A invenção caracteriza-se pelo fato de que glicina betaína não apresenta qualquer risco de hemorragia ou alergia contrariamente a moléculas e tratamentos presentemente utilizados. A invenção também refere-se ao uso de glicina betaína como anticoagulante para conservação de sangue.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9900144A BE1012495A3 (fr) | 1999-03-02 | 1999-03-02 | La glycine-betaine pour son usage antithrombotique. |
| PCT/BE2000/000021 WO2000051596A1 (fr) | 1999-03-02 | 2000-03-01 | La glycine betaïne pour son usage antithrombotique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0008631A true BR0008631A (pt) | 2002-02-13 |
Family
ID=3891794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0008631-2A BR0008631A (pt) | 1999-03-02 | 2000-03-01 | Glicina betaìna para uso antitrombótico |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6855734B2 (pt) |
| EP (1) | EP1156796B1 (pt) |
| JP (1) | JP2002538113A (pt) |
| KR (1) | KR100767270B1 (pt) |
| CN (1) | CN1194681C (pt) |
| AT (1) | ATE311226T1 (pt) |
| AU (1) | AU2897900A (pt) |
| BE (1) | BE1012495A3 (pt) |
| BR (1) | BR0008631A (pt) |
| CA (1) | CA2362558C (pt) |
| DE (1) | DE60024415T2 (pt) |
| EA (1) | EA004047B1 (pt) |
| ES (1) | ES2254144T3 (pt) |
| HK (1) | HK1044276B (pt) |
| HU (1) | HUP0105397A3 (pt) |
| IL (1) | IL145068A0 (pt) |
| MX (1) | MXPA01008426A (pt) |
| NZ (1) | NZ513905A (pt) |
| PL (1) | PL204560B1 (pt) |
| WO (1) | WO2000051596A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900213A1 (hu) * | 1999-02-01 | 2000-12-28 | Gábor Bogye | Gyógykompozíció(k) gesztagén tipusú hormon tartalmú gyógyszerek thromb-embóliás mellékhatásainak mérséklésére |
| US7608640B2 (en) | 1999-03-02 | 2009-10-27 | Jallal Messadek | Glycine betaine and its use |
| CA2441948A1 (en) * | 2001-02-05 | 2002-08-15 | Jallal Messadek | Glycine betaine and its use as anti-hemorrhagic agent |
| BE1015608A6 (fr) | 2003-07-15 | 2005-06-07 | Messadek Jallal | Traitement des arterites. |
| US20060160896A1 (en) * | 2002-02-04 | 2006-07-20 | Jallal Messadek | Therapeutic treatment |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| CA2477245A1 (en) * | 2002-02-25 | 2003-09-04 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| EP1569692B1 (en) * | 2002-11-25 | 2010-11-10 | Jallal Messadek | Betaine and salicylic acid compositions |
| US8697679B2 (en) | 2003-03-07 | 2014-04-15 | N.V. Nutricia | Method and composition for treating or preventing catabolism or stimulating anabolism in a mammal undergoing metabolic stress |
| ES2278314T3 (es) * | 2003-04-17 | 2007-08-01 | Jallal Messadek | Formulaciones orales para la liberacion controlada de la betaina. |
| CA2575760A1 (en) * | 2003-08-04 | 2005-02-10 | Jallal Messadek | Selected betaines and their uses |
| BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
| WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
| WO2006086856A1 (en) | 2005-02-15 | 2006-08-24 | Messadek, Jallal | Combination therapeutic compositions and method of use |
| EP2540696B1 (en) | 2005-02-24 | 2020-01-01 | Diffusion Pharmaceuticals LLC | Trans carotenoids, formulation and uses |
| ATE540690T1 (de) | 2005-04-27 | 2012-01-15 | Jallal Messadek | Insulinkombinationen |
| US9597311B2 (en) * | 2005-09-27 | 2017-03-21 | Robert Benson Aylor | Suppression and prevention of tumors |
| US8557863B2 (en) * | 2005-09-27 | 2013-10-15 | Robert Benson Aylor | Suppression and prevention of tumors |
| CN101687757A (zh) | 2007-04-13 | 2010-03-31 | 扩散药品有限公司 | 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用 |
| KR20100083820A (ko) * | 2007-10-31 | 2010-07-22 | 디퓨젼 파마슈티컬즈 엘엘씨 | 저분자 확산을 촉진시키는 신규한 치료요법 |
| WO2009065193A1 (en) * | 2007-11-21 | 2009-05-28 | Jallal Messadek | Treatment of aspirin resistance with betaine and/or betaine enriched molasses |
| EP2445339B1 (en) | 2009-06-22 | 2019-08-07 | Diffusion Pharmaceuticals LLC | Diffusion enhancing compound and its use with a thrombolytic |
| AU2011262361A1 (en) | 2010-06-02 | 2013-01-10 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
| CA3018550A1 (en) | 2016-03-24 | 2017-09-28 | Diffusion Pharmaceuticals Llc | Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer |
| CN109342606B (zh) * | 2018-12-05 | 2021-11-02 | 宁波市产品食品质量检验研究院(宁波市纤维检验所) | 一种水产品中甘氨酸甜菜碱的检测方法 |
| US11285349B1 (en) * | 2019-10-07 | 2022-03-29 | TFS Holdings, LLC | Sprinkler system antifreeze compositions and methods |
| CN111505131B (zh) * | 2020-01-02 | 2023-03-31 | 东莞东华医院有限公司 | 基于血清代谢组学改变建立的预测冠心病斑块不稳定性临床模型 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980277A (en) * | 1987-10-16 | 1990-12-25 | Cultor Ltd. | Cryoprotectant solution and method |
| HU210122B (en) | 1988-03-23 | 1995-02-28 | Biorex Kutato Fejlesztoe Kft | Process for production of composition against thromboembolytic conditions of circulating system and heart |
| EP0347864A3 (en) * | 1988-06-24 | 1992-04-01 | Andries Johannes Cornelus Strydom | Anti-atherogenic agents |
| WO1995015750A1 (en) * | 1993-12-10 | 1995-06-15 | Hashim Sami A | Reducing likelihood of vascular disorders in susceptible patients |
| JP3119430B2 (ja) * | 1995-07-25 | 2000-12-18 | 大鵬薬品工業株式会社 | 水酸基ラジカル消去剤 |
| LV11727B (en) * | 1995-08-21 | 1997-08-20 | Kalvins Ivars | Pharmaceutical composition |
| US5880098A (en) * | 1996-04-12 | 1999-03-09 | Pharmacia & Upjohn Aktiebolag | Therapeutic treatment |
| SE9601396D0 (sv) * | 1996-04-12 | 1996-04-12 | Dieter Haeussinger | New therapeutic treatment 2 |
| US6008221A (en) * | 1996-11-06 | 1999-12-28 | Bristol-Myers Squibb Company | Method for treating Alzheimer's disease with folic acid |
| US6162852A (en) | 1996-12-13 | 2000-12-19 | Isolyser Company, Inc. | Degradable polymers |
-
1999
- 1999-03-02 BE BE9900144A patent/BE1012495A3/fr not_active IP Right Cessation
-
2000
- 2000-03-01 EA EA200100925A patent/EA004047B1/ru not_active IP Right Cessation
- 2000-03-01 ES ES00907365T patent/ES2254144T3/es not_active Expired - Lifetime
- 2000-03-01 CN CNB008045054A patent/CN1194681C/zh not_active Expired - Fee Related
- 2000-03-01 HU HU0105397A patent/HUP0105397A3/hu unknown
- 2000-03-01 EP EP00907365A patent/EP1156796B1/fr not_active Expired - Lifetime
- 2000-03-01 DE DE60024415T patent/DE60024415T2/de not_active Expired - Lifetime
- 2000-03-01 AT AT00907365T patent/ATE311226T1/de not_active IP Right Cessation
- 2000-03-01 BR BR0008631-2A patent/BR0008631A/pt not_active Application Discontinuation
- 2000-03-01 WO PCT/BE2000/000021 patent/WO2000051596A1/fr not_active Ceased
- 2000-03-01 AU AU28979/00A patent/AU2897900A/en not_active Abandoned
- 2000-03-01 PL PL350408A patent/PL204560B1/pl not_active IP Right Cessation
- 2000-03-01 KR KR1020017011119A patent/KR100767270B1/ko not_active Expired - Fee Related
- 2000-03-01 JP JP2000602064A patent/JP2002538113A/ja active Pending
- 2000-03-01 MX MXPA01008426A patent/MXPA01008426A/es active IP Right Grant
- 2000-03-01 IL IL14506800A patent/IL145068A0/xx unknown
- 2000-03-01 HK HK02103986.8A patent/HK1044276B/zh not_active IP Right Cessation
- 2000-03-01 CA CA002362558A patent/CA2362558C/fr not_active Expired - Fee Related
- 2000-03-01 NZ NZ513905A patent/NZ513905A/en unknown
-
2001
- 2001-08-31 US US09/945,391 patent/US6855734B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60024415D1 (de) | 2006-01-05 |
| CN1194681C (zh) | 2005-03-30 |
| CA2362558C (fr) | 2009-06-02 |
| HK1044276A1 (en) | 2002-10-18 |
| EP1156796A1 (fr) | 2001-11-28 |
| ATE311226T1 (de) | 2005-12-15 |
| IL145068A0 (en) | 2002-06-30 |
| ES2254144T3 (es) | 2006-06-16 |
| HK1044276B (zh) | 2006-12-22 |
| NZ513905A (en) | 2001-09-28 |
| WO2000051596A9 (fr) | 2001-10-11 |
| PL350408A1 (en) | 2002-12-02 |
| HUP0105397A2 (hu) | 2002-05-29 |
| BE1012495A3 (fr) | 2000-11-07 |
| CN1342071A (zh) | 2002-03-27 |
| AU2897900A (en) | 2000-09-21 |
| CA2362558A1 (fr) | 2000-09-08 |
| KR100767270B1 (ko) | 2007-10-17 |
| DE60024415T2 (de) | 2006-09-21 |
| HUP0105397A3 (en) | 2003-03-28 |
| WO2000051596A1 (fr) | 2000-09-08 |
| PL204560B1 (pl) | 2010-01-29 |
| JP2002538113A (ja) | 2002-11-12 |
| EA200100925A1 (ru) | 2002-04-25 |
| KR20020021369A (ko) | 2002-03-20 |
| MXPA01008426A (es) | 2003-06-06 |
| US6855734B2 (en) | 2005-02-15 |
| EP1156796B1 (fr) | 2005-11-30 |
| US20020065320A1 (en) | 2002-05-30 |
| EA004047B1 (ru) | 2003-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: A61K 31/205 Ipc: A61K 31/205 (2009.01), A61P 7/04 (2009.01), A61P 7 |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |