BR0010080A - Inibidores de renina - Google Patents

Inibidores de renina

Info

Publication number
BR0010080A
BR0010080A BR0010080-3A BR0010080A BR0010080A BR 0010080 A BR0010080 A BR 0010080A BR 0010080 A BR0010080 A BR 0010080A BR 0010080 A BR0010080 A BR 0010080A
Authority
BR
Brazil
Prior art keywords
renin inhibitors
glaucoma
restenosis
diseases
compounds
Prior art date
Application number
BR0010080-3A
Other languages
English (en)
Other versions
BR0010080B1 (pt
Inventor
Volker Breu
Hans-Peter Maerki
Eric Vieira
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0010080A publication Critical patent/BR0010080A/pt
Publication of BR0010080B1 publication Critical patent/BR0010080B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: "INIBIDORES DE RENINA". A presente invenção refere-se a um composto da fórmula (I) em que R^ 1^, R^ 2^ e R^ 3~ são como definidos na descrição e reivindicações e seus sais farmaceuticamente aceitáveis. Os compostos são úteis para o tratamento de doenças que estão associadas com restenose, glaucoma, infarto cardíaco, alta pressão sang³ínea e perda de órgão terminal, por exemplo, insuficiência cardíaca e insuficiência dos rins.
BRPI0010080-3A 1999-04-27 2000-04-19 inibidores de renina BR0010080B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99108199 1999-04-27
PCT/EP2000/003555 WO2000064873A1 (en) 1999-04-27 2000-04-19 Renin inhibitors

Publications (2)

Publication Number Publication Date
BR0010080A true BR0010080A (pt) 2002-01-15
BR0010080B1 BR0010080B1 (pt) 2012-03-20

Family

ID=8238050

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0010080-3A BR0010080B1 (pt) 1999-04-27 2000-04-19 inibidores de renina

Country Status (35)

Country Link
US (2) US6376672B1 (pt)
EP (1) EP1175400B1 (pt)
JP (1) JP3808706B2 (pt)
KR (1) KR100443684B1 (pt)
CN (1) CN1147471C (pt)
AR (2) AR018719A1 (pt)
AT (1) ATE512949T1 (pt)
AU (1) AU763718B2 (pt)
BR (1) BR0010080B1 (pt)
CA (1) CA2370888C (pt)
CO (1) CO5170513A1 (pt)
CZ (1) CZ302012B6 (pt)
DK (1) DK1175400T3 (pt)
EG (1) EG23979A (pt)
ES (1) ES2366668T3 (pt)
GC (1) GC0000251A (pt)
HK (1) HK1045999B (pt)
HR (1) HRP20010762A2 (pt)
HU (1) HU227764B1 (pt)
IL (2) IL146002A0 (pt)
JO (1) JO2256B1 (pt)
MA (1) MA26787A1 (pt)
MX (1) MXPA01010934A (pt)
MY (1) MY127894A (pt)
NO (1) NO320803B1 (pt)
NZ (1) NZ514981A (pt)
PE (1) PE20010069A1 (pt)
PL (1) PL199895B1 (pt)
PT (1) PT1175400E (pt)
RS (1) RS51156B (pt)
RU (1) RU2213731C2 (pt)
TR (1) TR200103095T2 (pt)
TW (1) TWI224593B (pt)
WO (1) WO2000064873A1 (pt)
ZA (1) ZA200108735B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US6835686B2 (en) * 2001-07-05 2004-12-28 Millennium Specialty Chemicals Catalyst system and process for rearrangement of epoxides to allylic alcohols
US20060009497A1 (en) * 2002-06-27 2006-01-12 Actelion Pharmaceuticals, Ltd. Novel tetrahydropyridine derivatives as renin inhibitors
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
CN1972912A (zh) * 2003-04-29 2007-05-30 埃科特莱茵药品有限公司 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物
TW200513461A (en) * 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
US20050209141A1 (en) * 2003-10-17 2005-09-22 Silver Randi B Mast cell-derived renin
BRPI0416976A (pt) 2003-11-26 2007-02-21 Novartis Ag derivados de 4-fenilpiperidina como inibidores de renina
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
EP2248520A3 (en) 2004-10-08 2010-11-17 Novartis AG Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
AR055756A1 (es) * 2005-03-31 2007-09-05 Speedel Experimenta Ag Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos
TW200722424A (en) * 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
EP1897879A3 (en) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
CN101151262B (zh) * 2005-03-31 2011-07-06 斯皮德尔实验股份公司 取代的哌啶
JP2008535825A (ja) * 2005-03-31 2008-09-04 シュペーデル・エクスペリメンタ・アーゲー レニン阻害剤としての３，４，５−置換ピペリジン
US7799805B2 (en) 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
RU2008119687A (ru) * 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
CN101356156B (zh) * 2005-11-14 2012-12-05 生命医药公司 天冬氨酸蛋白酶抑制剂
NZ569135A (en) * 2005-12-30 2011-08-26 Novartis Ag 3,5-Substituted piperidine compounds as renin inhibitors
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
WO2008021552A2 (en) * 2006-08-18 2008-02-21 Duke University Biased ligands and methods of identifying same
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds
WO2009000811A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
AU2008320806A1 (en) * 2007-11-02 2009-05-07 Novartis Ag 4,4-disubstituted piperidines as renin inhibitors
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
US8728984B2 (en) 2009-10-14 2014-05-20 Rainer Oberbauer Acute kidney injury risk testing
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2810644A1 (en) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
DK231088D0 (da) 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
DE3640475A1 (de) 1986-11-27 1988-06-09 Hoechst Sa Lab Arzneimittel auf basis von derivaten des 3,4-diphenylpiperidins, die verwendung der derivate als arzneimittel sowie neue 3,4-diphenylpiperidinderivate und verfahren zu ihrer herstellung
EP0594618B1 (en) 1991-06-24 1996-04-24 B.V. Optische Industrie "De Oude Delft" Device for measuring the respiration of a person
AU6735396A (en) 1995-07-24 1997-02-18 Railfix N.V. Electrical permanent-magnet system for manoeuvring a magnetic, particularly a ferromagnetic, load
PL193686B1 (pl) * 1995-09-07 2007-03-30 Hoffmann La Roche Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych
WO1999012532A2 (en) * 1997-09-08 1999-03-18 F.Hoffmann-La Roche Ag Piperidine derivatives against malaria
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors

Also Published As

Publication number Publication date
HU227764B1 (en) 2012-02-28
PL353442A1 (en) 2003-11-17
HRP20010762A2 (en) 2005-02-28
EG23979A (en) 2008-02-27
RU2213731C2 (ru) 2003-10-10
CA2370888C (en) 2005-08-23
PL199895B1 (pl) 2008-11-28
HK1045999A1 (en) 2002-12-20
PE20010069A1 (es) 2001-03-03
ES2366668T3 (es) 2011-10-24
DK1175400T3 (da) 2011-07-18
US6376672B1 (en) 2002-04-23
AU763718B2 (en) 2003-07-31
MY127894A (en) 2006-12-29
JP2002543063A (ja) 2002-12-17
TR200103095T2 (tr) 2002-04-22
AR018719A1 (es) 2001-11-28
NZ514981A (en) 2004-02-27
NO20015206L (no) 2001-10-25
AU4296800A (en) 2000-11-10
NO20015206D0 (no) 2001-10-25
EP1175400B1 (en) 2011-06-15
AR070473A2 (es) 2010-04-07
MXPA01010934A (es) 2002-05-06
GC0000251A (en) 2006-11-01
KR20010109529A (ko) 2001-12-10
PT1175400E (pt) 2011-08-11
IL146002A0 (en) 2002-07-25
CA2370888A1 (en) 2000-11-02
JO2256B1 (en) 2004-10-07
IL146002A (en) 2007-03-08
EP1175400A1 (en) 2002-01-30
CN1147471C (zh) 2004-04-28
YU77101A (sh) 2004-09-03
KR100443684B1 (ko) 2004-08-09
CN1349503A (zh) 2002-05-15
US6673931B2 (en) 2004-01-06
CZ20013854A3 (cs) 2002-04-17
US20020087002A1 (en) 2002-07-04
WO2000064873A1 (en) 2000-11-02
CO5170513A1 (es) 2002-06-27
CZ302012B6 (cs) 2010-09-08
HK1045999B (zh) 2004-10-21
JP3808706B2 (ja) 2006-08-16
ZA200108735B (en) 2003-01-23
RS51156B (sr) 2010-10-31
TWI224593B (en) 2004-12-01
NO320803B1 (no) 2006-01-30
MA26787A1 (fr) 2004-12-20
HUP0203669A2 (hu) 2003-02-28
HUP0203669A3 (en) 2003-12-29
ATE512949T1 (de) 2011-07-15
BR0010080B1 (pt) 2012-03-20

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 24 E 25 DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/03/2012, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 14A E 15A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.