BR0010366A - Composto, composição farmacêutica, método de preparar um composto, e, composto para uso em terapia - Google Patents

Composto, composição farmacêutica, método de preparar um composto, e, composto para uso em terapia

Info

Publication number
BR0010366A
BR0010366A BR0010366-7A BR0010366A BR0010366A BR 0010366 A BR0010366 A BR 0010366A BR 0010366 A BR0010366 A BR 0010366A BR 0010366 A BR0010366 A BR 0010366A
Authority
BR
Brazil
Prior art keywords
compound
carbon atoms
optionally
pyrimidinyl
pyridinyl
Prior art date
Application number
BR0010366-7A
Other languages
English (en)
Inventor
Keith Hopkinson Gibson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0010366A publication Critical patent/BR0010366A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO DE PREPARAR UM COMPOSTO, E, COMPOSTO PARA USO EM TERAPIA". Um composto de fórmula (I) ou um seu sal farmaceuticamente aceitável, para uso na manufatura de um medicamento para inibição de MEK em um mamífero com uma doença mediada por MEK, em que: n é 0-1; Y é selecionado de -NH-, -O-, -S- ou -NR^ 7^, em que R^ 7^ é alquila de 1-6 átomos de carbono, R^ 6^ é cicloalquila de 3 a 7 átomos de carbono, que pode ser opcionalmente substituída por um ou mais grupos alquila de 1 a 6 átomos de carbono; ou é um anel piridinila, pirimidinila ou fenila; em que o anel piridinila, pirimidinila ou fenila podem ser substituídos por um, dois ou três substituintes especificados; ou R^ 6^ é um grupo -R^ 8^-X-R^ 9^, em que R^ 8^ é uma cicloalquila divalente de 3 a 7 átomos de carbono, que pode ser opcionalmente substituída ainda por um ou mais grupos alquila de 1 a 6 átomos de carbono; ou é opcionalmente um anel piridinila, pirimidinila ou fenila; em que o anel piridinila, pirimidinila ou fenila pode ser opcionalmente substituído ainda por um ou mais substituintes especificados, X é selecionado de CH~ 2~, -NH-, -O-, -S- ou -NR^ 5^, em que R^ 5^ é alquila de 1-6 átomos de carbono e R^ 9^ é um grupo (CH~ 2~)~ m~R^ 10^ em que m é 0, ou um número inteiro de 1-3 e R^ 10^ é um anel arila opcionalmente substituída ou cicloalquila opcionalmente substituída de até 10 átomos de carbono, ou R^ 10^ é um anel heterocíclico contendo 1 ou 2 átomos de oxigênio e, opcionalmente, um ou mais substituintes; e R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são, cada um independentemente, selecionados de hidrogênio ou vários grupos orgânicos especificados. Os novos compostos são também descritos e reivindicados.
BR0010366-7A 1999-05-08 2000-05-03 Composto, composição farmacêutica, método de preparar um composto, e, composto para uso em terapia BR0010366A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9910580.1A GB9910580D0 (en) 1999-05-08 1999-05-08 Chemical compounds
PCT/GB2000/001698 WO2000068199A1 (en) 1999-05-08 2000-05-03 Quinoline derivatives as inhibitors of mek enzymes

Publications (1)

Publication Number Publication Date
BR0010366A true BR0010366A (pt) 2002-02-13

Family

ID=10852989

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010366-7A BR0010366A (pt) 1999-05-08 2000-05-03 Composto, composição farmacêutica, método de preparar um composto, e, composto para uso em terapia

Country Status (16)

Country Link
US (1) US6638945B1 (pt)
EP (1) EP1178965B1 (pt)
JP (1) JP2002544194A (pt)
KR (1) KR20020000803A (pt)
CN (1) CN1350524A (pt)
AT (1) ATE250582T1 (pt)
AU (1) AU4589200A (pt)
BR (1) BR0010366A (pt)
CA (1) CA2371469A1 (pt)
DE (1) DE60005504T2 (pt)
GB (1) GB9910580D0 (pt)
IL (1) IL146319A0 (pt)
NO (1) NO20015447L (pt)
TR (1) TR200103185T2 (pt)
WO (1) WO2000068199A1 (pt)
ZA (1) ZA200108969B (pt)

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JP6604942B2 (ja) 2013-06-13 2019-11-13 バイオマトリカ，インク． 細胞安定化
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
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US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
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Also Published As

Publication number Publication date
ZA200108969B (en) 2003-01-30
CA2371469A1 (en) 2000-11-16
EP1178965A1 (en) 2002-02-13
ATE250582T1 (de) 2003-10-15
GB9910580D0 (en) 1999-07-07
AU4589200A (en) 2000-11-21
US6638945B1 (en) 2003-10-28
EP1178965B1 (en) 2003-09-24
NO20015447D0 (no) 2001-11-07
NO20015447L (no) 2001-12-12
IL146319A0 (en) 2002-07-25
CN1350524A (zh) 2002-05-22
JP2002544194A (ja) 2002-12-24
TR200103185T2 (tr) 2002-05-21
DE60005504D1 (de) 2003-10-30
WO2000068199A1 (en) 2000-11-16
DE60005504T2 (de) 2004-06-24
KR20020000803A (ko) 2002-01-05

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007.