BR0011529A - Compostos de heterociclos fundidos tricìclicos, processo para preparar os mesmos e uso destes - Google Patents

Compostos de heterociclos fundidos tricìclicos, processo para preparar os mesmos e uso destes

Info

Publication number
BR0011529A
BR0011529A BR0011529-0A BR0011529A BR0011529A BR 0011529 A BR0011529 A BR 0011529A BR 0011529 A BR0011529 A BR 0011529A BR 0011529 A BR0011529 A BR 0011529A
Authority
BR
Brazil
Prior art keywords
compounds
same
tricyclic fused
inhibition
fused heterocycles
Prior art date
Application number
BR0011529-0A
Other languages
English (en)
Inventor
Shuji Jinno
Takaaki Okita
Naomi Ohtsuka
Shinya Yamashita
Junichiro Hata
Jiro Takeo
Original Assignee
Nippon Suisan Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Suisan Kaisha Ltd filed Critical Nippon Suisan Kaisha Ltd
Publication of BR0011529A publication Critical patent/BR0011529A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A61K31/31—Mercury compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"COMPOSTOS DE HETEROCICLOS FUNDIDOS TRICìCLICOS, PROCESSO PARA PREPARAR OS MESMOS E USO DESTES". Compostos representados pela fórmula (1), em que X é, por exemplo, CH, CH~ 2~, CHR (em que R é um grupo alquila inferior ou um grupo alquila inferior substituído) ou CRR' (em que R e R' são os mesmos como o R acima definido); Y é, por exemplo, CH, CH~ 2~ ou C=O; Z é, por exemplo, O, S, S=O ou SO~ 2~; U é C ou N; R~ 1~, a R~ 4~ são cada um independentemente, por exemplo, um átomo de hidrogênio, OR, SR, (em que R é o mesmo como acima definido), ou um anel aromático, um anel aromático substituído ou um heterociclo; pelo menos um de R~ 5~ e R~ 8~ é, por exemplo, OH e o restante de R~ 5~ e R~ 8~ são cada um independentemente, por exemplo, um átomo de hidrogênio ou OH, isómeros ópticos destes, conjugados destes ou sais farmaceuticamente aceitáveis destes são fornecidos. Estes compostos são caracterizados em ter uma faixa ampla de ações farmacológicas tais como uma excelente ação de relaxação dos músculos lisos da traquéia, uma inibição de hipersenbilidade das vias aéreas e uma inibição de infiltração de células inflamatórias nas vias aéreas e, além disso, alta segurança.
BR0011529-0A 1999-06-03 2000-06-02 Compostos de heterociclos fundidos tricìclicos, processo para preparar os mesmos e uso destes BR0011529A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15718199 1999-06-03
PCT/JP2000/003592 WO2000075127A1 (en) 1999-06-03 2000-06-02 Tricyclic fused heterocycle compounds, process for preparing the same and use thereof

Publications (1)

Publication Number Publication Date
BR0011529A true BR0011529A (pt) 2002-12-17

Family

ID=15643970

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011529-0A BR0011529A (pt) 1999-06-03 2000-06-02 Compostos de heterociclos fundidos tricìclicos, processo para preparar os mesmos e uso destes

Country Status (22)

Country Link
US (3) US6602898B1 (pt)
EP (1) EP1182200B1 (pt)
JP (1) JP3471778B2 (pt)
KR (1) KR20020016812A (pt)
CN (1) CN1192027C (pt)
AT (1) ATE303376T1 (pt)
AU (1) AU777414B2 (pt)
BG (1) BG106169A (pt)
BR (1) BR0011529A (pt)
CA (1) CA2370013A1 (pt)
CZ (1) CZ20014261A3 (pt)
DE (1) DE60022341T2 (pt)
DK (1) DK1182200T3 (pt)
ES (1) ES2248080T3 (pt)
HU (1) HUP0201203A3 (pt)
IL (1) IL146732A0 (pt)
NO (1) NO20015832L (pt)
NZ (1) NZ515666A (pt)
PL (1) PL352840A1 (pt)
RU (1) RU2211837C2 (pt)
WO (1) WO2000075127A1 (pt)
ZA (1) ZA200109565B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
PL1710241T3 (pl) * 2005-04-07 2010-04-30 Msd Oss Bv Związki pośrednie do wytwarzania trans-5-chloro-2-metylo-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oksepino[4,5-c]pirolu
JP5773585B2 (ja) * 2009-06-29 2015-09-02 日東電工株式会社 発光性トリアリール
TWI698430B (zh) * 2015-02-13 2020-07-11 南北兄弟藥業投資有限公司 三環化合物及其在藥物中的應用
TW201808283A (zh) * 2016-08-05 2018-03-16 廣東東陽光藥業有限公司 含氮三環化合物及其在藥物中的應用
US10654797B2 (en) 2016-11-03 2020-05-19 North & South Brother Pharmacy Investment Company Limited Solid forms of an adamantyl compound, compositions and uses thereof
CN110128432B (zh) 2018-02-02 2021-03-02 广东东阳光药业有限公司 含氮三环化合物及其在药物中的应用
CN118271327A (zh) * 2022-12-30 2024-07-02 广东东阳光药业股份有限公司 三环化合物的晶型及其用途

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
DE1302590B (pt) 1966-08-03 1970-11-12
US4104280A (en) 1977-02-04 1978-08-01 Syntex (U.S.A.) Inc. Dibenzo [b.f]thiepin and dibenzo[b.f]oxepin derivatives
PT68303A (en) 1977-07-26 1978-08-01 Merck & Co Inc Process for the preparation of dibenzo/b,f/thiepin
JPS54122284A (en) 1978-02-17 1979-09-21 Dainippon Pharmaceut Co Ltd Dibenzb,foxepin derivative
JPS54115388A (en) 1978-03-01 1979-09-07 Nippon Chemiphar Co Ltd Acetic acid derivative and its preparation
US4237160A (en) 1979-11-27 1980-12-02 Merck Sharp & Dohme (I.A.) Corp. 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
DE3203065A1 (de) 1982-01-30 1983-08-04 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von dibenzoxepinonen
FR2693655B1 (fr) 1992-07-20 1994-10-14 Virbac Vaccin antirabique avirulent.
PT805155E (pt) 1994-09-28 2002-09-30 Nippon Suisan Kaisha Ltd Novo composto heterociclico condensado, anti-oxidante triciclico
PT726265E (pt) * 1995-02-08 2001-12-28 Novartis Ag 10-amino-alifatil-dibenzo¬b,f| oxepinas com accao antineurodegenerativa
WO1996025927A1 (en) 1995-02-22 1996-08-29 Nippon Suisan Kaisha, Ltd. Glutamic acid receptor blocker and cerebral function ameliorant
CN1184967C (zh) 1996-01-19 2005-01-19 日本水产株式会社 气管平滑肌松弛剂
AR008371A1 (es) * 1996-05-30 2000-01-19 Novartis Ag Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativ
JPH10204079A (ja) * 1997-01-20 1998-08-04 Nippon Suisan Kaisha Ltd ジベンゾオキセピンおよびジベンゾチエピン誘導体の製造方法
ES2273413T3 (es) * 1997-04-15 2007-05-01 Kyowa Hakko Kogyo Co., Ltd. Compuestos triciclicos.

Also Published As

Publication number Publication date
EP1182200B1 (en) 2005-08-31
DE60022341T2 (de) 2006-06-29
BG106169A (bg) 2002-05-31
WO2000075127A8 (en) 2001-03-15
NZ515666A (en) 2003-10-31
PL352840A1 (en) 2003-09-08
CA2370013A1 (en) 2000-12-14
US6602898B1 (en) 2003-08-05
ATE303376T1 (de) 2005-09-15
ZA200109565B (en) 2003-04-11
JP3471778B2 (ja) 2003-12-02
IL146732A0 (en) 2002-07-25
WO2000075127A1 (en) 2000-12-14
US20040127713A1 (en) 2004-07-01
CN1353703A (zh) 2002-06-12
CZ20014261A3 (cs) 2002-06-12
ES2248080T3 (es) 2006-03-16
NO20015832D0 (no) 2001-11-29
KR20020016812A (ko) 2002-03-06
HUP0201203A2 (en) 2002-08-28
NO20015832L (no) 2002-02-01
EP1182200A9 (en) 2002-05-22
US6700013B2 (en) 2004-03-02
DE60022341D1 (de) 2005-10-06
HUP0201203A3 (en) 2004-12-28
EP1182200A1 (en) 2002-02-27
DK1182200T3 (da) 2005-12-27
CN1192027C (zh) 2005-03-09
AU777414B2 (en) 2004-10-14
US20030220360A1 (en) 2003-11-27
US7410997B2 (en) 2008-08-12
RU2211837C2 (ru) 2003-09-10
AU5104400A (en) 2000-12-28

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.