BR0012457A - Alcalóides de indolcarbazol de um actinomiceto marinho - Google Patents

Alcalóides de indolcarbazol de um actinomiceto marinho

Info

Publication number
BR0012457A
BR0012457A BR0012457-5A BR0012457A BR0012457A BR 0012457 A BR0012457 A BR 0012457A BR 0012457 A BR0012457 A BR 0012457A BR 0012457 A BR0012457 A BR 0012457A
Authority
BR
Brazil
Prior art keywords
carbon atoms
alkaloids
indolcarbazole
hydrogen atom
alkyl group
Prior art date
Application number
BR0012457-5A
Other languages
English (en)
Inventor
Dolores Garcia Gravalos
Julia Perez
Maria Canedo Librada
Francisco Romero
Fernando Romero
Fernando Espliego
Original Assignee
Inst Biomar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Biomar Sa filed Critical Inst Biomar Sa
Publication of BR0012457A publication Critical patent/BR0012457A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Patente de Invenção: "ALCALóIDES DE INDOLCARBAZOL DE UM ACTINOMICETO MARINHO". A invenção fornece composto de fórmula (1) em que R^ 1^ é um átomo de hidrogênio, um grupo de alquila tendo de 1 a 6 átomos de carbono ou um grupo de alcóxi tendo de 1 a 6 átomos de carbono; e R^ 2^ é um átomo de hidrogênio, um grupo de alquila tendo de 1 a 6 átomos de carbono ou um grupo de alcóxi tendo de 1 a 6 átomos de carbono; e sais farmaceuticamente aceitáveis destes. A invenção da mesma forma relata a um processo para obter os compostos, composições contendo-os e seu uso terapêutico. Os compostos exibem excelente atividade contra cepas de células de câncer de mamífero.
BR0012457-5A 1999-06-28 2000-06-28 Alcalóides de indolcarbazol de um actinomiceto marinho BR0012457A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9915069.0A GB9915069D0 (en) 1999-06-28 1999-06-28 New indolocarbazole alkaloids from a marine actinomycete
PCT/GB2000/002473 WO2001000627A1 (en) 1999-06-28 2000-06-28 New indolocarbazole alkaloids from a marine actinomycete

Publications (1)

Publication Number Publication Date
BR0012457A true BR0012457A (pt) 2002-04-02

Family

ID=10856186

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012457-5A BR0012457A (pt) 1999-06-28 2000-06-28 Alcalóides de indolcarbazol de um actinomiceto marinho

Country Status (17)

Country Link
US (1) US6852715B1 (pt)
EP (1) EP1189908B1 (pt)
JP (1) JP2003503412A (pt)
KR (1) KR20020037730A (pt)
CN (1) CN1152881C (pt)
AT (1) ATE247662T1 (pt)
AU (1) AU775414B2 (pt)
BR (1) BR0012457A (pt)
CA (1) CA2377147C (pt)
DE (1) DE60004669T2 (pt)
DK (1) DK1189908T3 (pt)
ES (1) ES2202142T3 (pt)
GB (1) GB9915069D0 (pt)
IL (1) IL147307A0 (pt)
MX (1) MXPA02000173A (pt)
PT (1) PT1189908E (pt)
WO (1) WO2001000627A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7222176B1 (en) 2000-08-28 2007-05-22 Datacore Software Corporation Apparatus and method for using storage domains for controlling data in storage area networks
CN103980266B (zh) * 2014-04-02 2016-01-20 浙江大学 一种具有抗菌活性的化合物及其制备方法
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
CN107417743B (zh) * 2017-06-15 2020-07-21 杭州科兴生物化工有限公司 星孢菌素醛基取代衍生物及其制备方法和应用
CN107674105B (zh) * 2017-09-27 2020-05-22 杭州科兴生物化工有限公司 吲哚咔唑类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
JPH05247055A (ja) 1992-03-03 1993-09-24 Meiji Seika Kaisha Ltd スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤
KR950702994A (ko) * 1992-08-12 1995-08-23 로렌스 티. 웰츠 탁솔과 복합된, 단백질 키나제 억제제 및 관련 화합물(protein kinase inhibitors and related compounds combined with taxol)

Also Published As

Publication number Publication date
AU5554400A (en) 2001-01-31
MXPA02000173A (es) 2002-07-30
EP1189908B1 (en) 2003-08-20
US6852715B1 (en) 2005-02-08
PT1189908E (pt) 2003-11-28
DK1189908T3 (da) 2003-10-06
DE60004669T2 (de) 2004-07-08
ATE247662T1 (de) 2003-09-15
KR20020037730A (ko) 2002-05-22
DE60004669D1 (de) 2003-09-25
CA2377147C (en) 2009-04-07
CN1152881C (zh) 2004-06-09
AU775414B2 (en) 2004-07-29
EP1189908A1 (en) 2002-03-27
CN1371379A (zh) 2002-09-25
ES2202142T3 (es) 2004-04-01
IL147307A0 (en) 2002-08-14
GB9915069D0 (en) 1999-08-25
JP2003503412A (ja) 2003-01-28
CA2377147A1 (en) 2001-01-04
WO2001000627A1 (en) 2001-01-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1927 DE 11/12/2007.