BR0013551A - Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas - Google Patents

Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas

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Publication number
BR0013551A
BR0013551A BR0013551-8A BR0013551A BR0013551A BR 0013551 A BR0013551 A BR 0013551A BR 0013551 A BR0013551 A BR 0013551A BR 0013551 A BR0013551 A BR 0013551A
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BR
Brazil
Prior art keywords
inhibitors
jnk
kinases
cjun
terminal
Prior art date
Application number
BR0013551-8A
Other languages
English (en)
Inventor
Jeremy Green
Guy Bemis
Anne-Laure Grillot
Mark Lederboer
Francisco Salituro
Edmundo Harrington
Huai Gao
Christopher Baker
Jingrong Cao
Michael Hale
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR0013551A publication Critical patent/BR0013551A/pt

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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Abstract

"INIBIDORES DE CINASES DE N-TERMINAL c-JUN (JNK) E OUTRAS CINASES DE PROTEìNA". A presente invenção refere-se aos compostos da fórmula (I) onde R^ 1^ é H CONH~ 2~, T~ (n)~-R ou T~ (n)~-Ar^ 2^, n pode ser zero ou um, e G, XYZ, e Q são como descritos abaixo. Estes compostos são inibidores da cinase de proteína, particularmente inibidores de JNK, uma cinase de proteína de mamífero envolveu proliferação de célula, morte de célula e resposta aos estímulos extracelulares. A invenção da mesma forma relata aos métodos para produção destes inibidores. A invenção da mesma forma fornece composições farmacêuticas compreendendo os inibidores da invenção e métodos de utilização daquelas composições no tratamento e prevenção de vários distúrbios.
BR0013551-8A 1999-08-13 2000-08-11 Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas BR0013551A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14879599P 1999-08-13 1999-08-13
US16692299P 1999-11-22 1999-11-22
US21151700P 2000-06-14 2000-06-14
PCT/US2000/022445 WO2001012621A1 (en) 1999-08-13 2000-08-11 INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES

Publications (1)

Publication Number Publication Date
BR0013551A true BR0013551A (pt) 2003-06-17

Family

ID=27386739

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013551-8A BR0013551A (pt) 1999-08-13 2000-08-11 Inibidores de cinases n-terminal cjun (jnk) e outras cinases de proteìnas

Country Status (22)

Country Link
US (2) US6693108B2 (pt)
EP (1) EP1218369B1 (pt)
JP (1) JP2003531103A (pt)
KR (1) KR20020030791A (pt)
CN (1) CN1222520C (pt)
AR (1) AR032130A1 (pt)
AT (1) ATE402163T1 (pt)
AU (1) AU6909600A (pt)
BR (1) BR0013551A (pt)
CA (1) CA2381882C (pt)
CO (1) CO5200770A1 (pt)
CZ (1) CZ2002534A3 (pt)
DE (1) DE60039616D1 (pt)
HK (1) HK1045507A1 (pt)
HU (1) HUP0300340A3 (pt)
MX (1) MXPA02001565A (pt)
MY (1) MY133159A (pt)
NO (1) NO20020713L (pt)
NZ (1) NZ517694A (pt)
PL (1) PL366110A1 (pt)
SK (1) SK3572002A3 (pt)
WO (1) WO2001012621A1 (pt)

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US20040072888A1 (en) 1999-08-19 2004-04-15 Bennett Brydon L. Methods for treating inflammatory conditions or inhibiting JNK
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WO2002083668A1 (en) * 2001-04-10 2002-10-24 Vertex Pharmaceuticals Incorporated Isoxaxole derivatives as inhibitors of src and other protein kinases
AU2002338642A1 (en) * 2001-04-13 2002-10-28 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
CN1300116C (zh) 2001-04-16 2007-02-14 卫材株式会社 1h－吲唑化合物
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US6790846B2 (en) * 2001-05-24 2004-09-14 The Procter & Gamble Company Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
CA2450769A1 (en) * 2001-06-15 2002-12-27 Vertex Pharmaceuticals Incorporated 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors
US6589997B2 (en) * 2001-06-29 2003-07-08 North Shore-Long Island Jewish Health System Small-molecule modulators of hepatocyte growth factor/scatter factor activities
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