BR0014019A - Processo para a detecção de formas oxidadas da guanilatociclase e processo para a separação por ativadores da guanilatociclase solúvel com ferro de inibição oxidado - Google Patents

Processo para a detecção de formas oxidadas da guanilatociclase e processo para a separação por ativadores da guanilatociclase solúvel com ferro de inibição oxidado

Info

Publication number
BR0014019A
BR0014019A BR0014019-8A BR0014019A BR0014019A BR 0014019 A BR0014019 A BR 0014019A BR 0014019 A BR0014019 A BR 0014019A BR 0014019 A BR0014019 A BR 0014019A
Authority
BR
Brazil
Prior art keywords
guanylatocyclase
oxidized
guanylate cyclase
soluble
soluble guanylate
Prior art date
Application number
BR0014019-8A
Other languages
English (en)
Other versions
BR0014019B1 (pt
Inventor
Ursula Schindler
Hartmut Strobel
Peter Schindler
Alexander Muelsch
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0014019A publication Critical patent/BR0014019A/pt
Publication of BR0014019B1 publication Critical patent/BR0014019B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Patente de Invenção: "PROCESSO PARA A DETECçãO DE FORMAS OXIDADAS DA GUANILATOCICLASE E PROCESSO PARA A SEPARAçãO POR ATIVADORES DA GUANILATOCICLASE SOLúVEL COM FERRO DE INIBIçãO OXIDADO". A invenção refere-se a um processo para a detecção de uma guanilatociciase solúvel, seus ferros de inibição no estágio de oxidação trivalente, bem como um processo para encontrar substâncias químicas, as quais estimulam a atividade de uma guanilatociclase solúvel, quando o ferro de inibição de pelo menos uma parte desta guanilatociclase solúvel é oxidado trivalente e, além disso, um diagnóstico para detectar uma guanilatocicla-se solúvel com ferro de inibição trivalente.
BRPI0014019-8A 1999-09-15 2000-08-19 Processo para a detecção de uma guanilatociclase solúvel BR0014019B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19944226A DE19944226A1 (de) 1999-09-15 1999-09-15 Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen
DE19944226.6 1999-09-15
PCT/EP2000/008102 WO2001020023A2 (de) 1999-09-15 2000-08-19 Verfahren zum nachweis von oxidierten formen der löslichen guanylatzyklase

Publications (2)

Publication Number Publication Date
BR0014019A true BR0014019A (pt) 2002-05-21
BR0014019B1 BR0014019B1 (pt) 2014-02-11

Family

ID=7922127

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014019-8A BR0014019B1 (pt) 1999-09-15 2000-08-19 Processo para a detecção de uma guanilatociclase solúvel

Country Status (17)

Country Link
US (3) US6500631B1 (pt)
EP (1) EP1218535B1 (pt)
JP (1) JP4814466B2 (pt)
KR (1) KR100818537B1 (pt)
AT (1) ATE311473T1 (pt)
AU (1) AU783268B2 (pt)
BR (1) BR0014019B1 (pt)
CA (1) CA2382488C (pt)
DE (2) DE19944226A1 (pt)
DK (1) DK1218535T3 (pt)
ES (1) ES2252046T3 (pt)
IL (3) IL148600A0 (pt)
MX (1) MXPA02001835A (pt)
NO (1) NO332145B1 (pt)
NZ (1) NZ517783A (pt)
WO (1) WO2001020023A2 (pt)
ZA (1) ZA200202025B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19944226A1 (de) * 1999-09-15 2001-03-29 Aventis Pharma Gmbh Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen
DE102006054562A1 (de) * 2006-11-20 2008-05-21 Bayer Healthcare Ag Verfahren zum Nachweis von Pyrophosphat mit Biolumineszenz Detektion
JP5350607B2 (ja) * 2007-06-14 2013-11-27 キッコーマン株式会社 グアニル酸シクラーゼ活性測定法
JP5570731B2 (ja) * 2008-02-28 2014-08-13 旭化成ファーマ株式会社 ピロリン酸の測定方法
US8293101B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
EP3444615B1 (en) * 2017-08-15 2021-09-08 Freiberg Instruments GmbH Methods and compositions for diagnostic evaluation and therapeutic correction of the no-haem signalling pathway(s) in animals and humans
EP4011873A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU876715A1 (ru) * 1980-02-08 1981-10-30 Научно-исследовательский институт морфологии человека АМН СССР Способ вы влени распределени гуанилатциклазы в ткан х
US5618665A (en) * 1993-01-22 1997-04-08 Regents Of The University Of Minnesota Enzymatic fluorometric assay for adenylate cyclase
US6002817A (en) * 1997-09-29 1999-12-14 The Regents Of The University Of Michigan Optical sensors for the detection of nitric oxide
DE19744026A1 (de) * 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE19830430A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1332943C (zh) * 1998-07-08 2007-08-22 萨诺费－阿文蒂斯德国有限公司 硫取代的磺酰基氨基羧酸n－芳基酰胺,其制备方法、用途以及含有该化合物的药物制剂
DE19837015C2 (de) * 1998-08-14 2003-03-20 Vasopharm Biotech Gmbh Isolierte und gereinigte humane lösliche Guanylylcyclase alpha1/beta1 (hsGCalpha1/beta1)
DE19944226A1 (de) * 1999-09-15 2001-03-29 Aventis Pharma Gmbh Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen
DE10140421A1 (de) * 2001-08-17 2003-03-06 Bayer Ag Neue Kombination
GB2395431A (en) * 2002-11-20 2004-05-26 Northwick Park Inst For Medica Combination of a metal carbonyl compound and a guanylate cyclase stimulant or stabilizer for the therapeutic delivery of carbon monoxide

Also Published As

Publication number Publication date
CA2382488A1 (en) 2001-03-22
US6500631B1 (en) 2002-12-31
NO20021196D0 (no) 2002-03-11
EP1218535A2 (de) 2002-07-03
BR0014019B1 (pt) 2014-02-11
IL196874A (en) 2011-03-31
CA2382488C (en) 2012-02-07
IL148600A (en) 2009-09-01
NZ517783A (en) 2004-06-25
KR20020047164A (ko) 2002-06-21
WO2001020023A3 (de) 2001-11-15
WO2001020023A2 (de) 2001-03-22
US6913898B2 (en) 2005-07-05
JP2003509061A (ja) 2003-03-11
ATE311473T1 (de) 2005-12-15
NO20021196L (no) 2002-03-11
ES2252046T3 (es) 2006-05-16
KR100818537B1 (ko) 2008-04-01
EP1218535B1 (de) 2005-11-30
JP4814466B2 (ja) 2011-11-16
US20050227308A1 (en) 2005-10-13
IL148600A0 (en) 2002-09-12
DK1218535T3 (da) 2006-03-27
DE50011765D1 (de) 2006-01-05
NO332145B1 (no) 2012-07-02
US7309579B2 (en) 2007-12-18
AU6839600A (en) 2001-04-17
US20030054433A1 (en) 2003-03-20
AU783268B2 (en) 2005-10-06
ZA200202025B (en) 2004-04-28
DE19944226A1 (de) 2001-03-29
MXPA02001835A (es) 2002-08-12

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/02/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2319 DE 16-06-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.