BR0014252A - Nanopartìculas magnéticas tendo atividade bioquìmica, método para sua produção e seus usos - Google Patents

Nanopartìculas magnéticas tendo atividade bioquìmica, método para sua produção e seus usos

Info

Publication number
BR0014252A
BR0014252A BR0014252-2A BR0014252A BR0014252A BR 0014252 A BR0014252 A BR 0014252A BR 0014252 A BR0014252 A BR 0014252A BR 0014252 A BR0014252 A BR 0014252A
Authority
BR
Brazil
Prior art keywords
biochemical activity
intracellular
magnetic nanoparticles
production
magnetic
Prior art date
Application number
BR0014252-2A
Other languages
English (en)
Inventor
Bahr K Michael
Dimitri Berkov
Norbert Buske
Joachim Clement
Peter Gornert
Kay-Oliver Kliche
Thomas Kober
Matthias Schnabelrauch
Sebastian Vogt
Kerstin Wagner
Christian Gansau
Klaus Hoffken
Original Assignee
Biomedical Apherese Systeme Gm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomedical Apherese Systeme Gm filed Critical Biomedical Apherese Systeme Gm
Publication of BR0014252A publication Critical patent/BR0014252A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"NANOPARTìCULAS MAGNéTICAS TENDO ATIVIDADE BIOQUìMICA, MéTODO PARA SUA PRODUçãO E SEUS USOS". Que tem por objetivo prover nanopartículas capazes de especificamente formar ligações com biomacromoléculas intracelulares mesmo na região intracelular das células, de forma que a separação é possível através de exposição a um campo magnético exterior. Isto é realizado por meio de nanopartículas magnéticas que tem atividade bioquímica, consistidas de uma partícula de núcleo magnético e uma camada envoltória fixada a partícula nucleada, e incluindo um composto de fórmula geral M-S-L-Z (I), os locais de acoplamento entre S e L e L e Z tendo grupos funcionais covalentemente ligados, onde: M representa a dita partícula de núcleo magnético; S representa um substrato biocompatível fixado a M; L representa um grupo de ligação; e Z representa um grupo composto de ácidos nucléicos, peptídeos ou proteínas ou derivados daí provenientes, cujo grupo tem pelo menos uma estrutura capaz de se ligar especificamente a um domínio de ligação de uma biomacromolécula intracelular.
BR0014252-2A 1999-09-14 2000-09-14 Nanopartìculas magnéticas tendo atividade bioquìmica, método para sua produção e seus usos BR0014252A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19944971 1999-09-14
PCT/EP2000/009004 WO2001019405A2 (de) 1999-09-14 2000-09-14 Magnetische nanoteilchen mit biochemischer wirksamkeit und verfahren zu ihrer herstellung sowie ihre verwendung

Publications (1)

Publication Number Publication Date
BR0014252A true BR0014252A (pt) 2002-11-19

Family

ID=7922617

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014252-2A BR0014252A (pt) 1999-09-14 2000-09-14 Nanopartìculas magnéticas tendo atividade bioquìmica, método para sua produção e seus usos

Country Status (9)

Country Link
US (1) US6767635B1 (pt)
EP (1) EP1216060A2 (pt)
JP (1) JP2003509034A (pt)
CN (1) CN1379687A (pt)
AU (1) AU1694301A (pt)
BR (1) BR0014252A (pt)
CA (1) CA2384429A1 (pt)
DE (1) DE10046508A1 (pt)
WO (1) WO2001019405A2 (pt)

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JP2022553357A (ja) * 2019-10-22 2022-12-22 オトマグネティクス，インコーポレイテッド 中耳炎のための脂質コーティングされた酸化鉄ナノ粒子
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CN114858543A (zh) * 2021-02-03 2022-08-05 杭州欣捷生物技术有限公司 用于全血快速分离的组合物和方法
US20220354973A1 (en) * 2021-04-20 2022-11-10 Regents Of The University Of Minnesota Iron nitride nanoparticle suspension
CN115739042B (zh) * 2022-11-07 2024-06-04 浙江大学 一种表面修饰磁性纳米颗粒及分离水中多价噬菌体的方法

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