BR0014378A - Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas - Google Patents

Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas

Info

Publication number
BR0014378A
BR0014378A BR0014378-2A BR0014378A BR0014378A BR 0014378 A BR0014378 A BR 0014378A BR 0014378 A BR0014378 A BR 0014378A BR 0014378 A BR0014378 A BR 0014378A
Authority
BR
Brazil
Prior art keywords
indolyl
acid derivatives
therapeutically valuable
valuable properties
glyoxylic acid
Prior art date
Application number
BR0014378-2A
Other languages
English (en)
Inventor
Bernd Nickel
Thomas Klenner
Gerald Bacher
Thomas Beckers
Peter Emig
Juergen Engel
Erik Bruyneel
Guenter Kamp
Kirsten Peters
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of BR0014378A publication Critical patent/BR0014378A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DERIVADOS DE áCIDO INDOLIL-3-GLIOXìLICO TENDO PROPRIEDADES TERAPEUTICAMENTE VALIOSAS". A invenção refere-se ao uso de indol-3-glioxilamidas N-substituídas [sic] da fórmula geral 1 para o tratamento de tumor, em particular no caso de resistência farmacêutica e metástase de carcinoma e como inibidores de angiogênese, com efeitos colaterais acentuadamente menor, em particular neurotoxicidade acentuadamente menor e produtos farmacêuticos compreendendo as mesmas.
BR0014378-2A 1999-09-28 2000-09-26 Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas BR0014378A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (1)

Publication Number Publication Date
BR0014378A true BR0014378A (pt) 2003-07-29

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014378-2A BR0014378A (pt) 1999-09-28 2000-09-26 Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas

Country Status (32)

Country Link
EP (1) EP1218006B1 (pt)
JP (1) JP2003510274A (pt)
KR (1) KR100759242B1 (pt)
CN (1) CN1301712C (pt)
AR (1) AR025885A1 (pt)
AT (1) ATE459356T1 (pt)
AU (1) AU783436B2 (pt)
BG (1) BG106639A (pt)
BR (1) BR0014378A (pt)
CA (1) CA2386069C (pt)
CZ (1) CZ303246B6 (pt)
DE (1) DE50015879D1 (pt)
DZ (1) DZ3196A1 (pt)
EE (1) EE200200169A (pt)
ES (1) ES2342042T3 (pt)
GE (1) GEP20043250B (pt)
HK (1) HK1048941B (pt)
HR (1) HRP20020369A2 (pt)
HU (1) HUP0202788A3 (pt)
IL (2) IL148670A0 (pt)
IS (1) IS6319A (pt)
MX (1) MXPA02002824A (pt)
NO (1) NO322614B1 (pt)
NZ (1) NZ517988A (pt)
PL (1) PL199576B1 (pt)
RS (1) RS51302B (pt)
RU (1) RU2282444C2 (pt)
SK (1) SK287533B6 (pt)
TW (1) TWI269654B (pt)
UA (1) UA75872C2 (pt)
WO (1) WO2001022954A2 (pt)
ZA (1) ZA200202556B (pt)

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DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
DE10037310A1 (de) 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
JP4878285B2 (ja) * 2003-06-05 2012-02-15 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング アポトーシス誘発作用を有するインドール誘導体
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
NZ552298A (en) * 2004-05-23 2011-04-29 Gerard M Housey Method for identifying inhibitors or activators of a theramutein by comparing the phenoresponse of cells exposed to a test compound
CA2587276A1 (en) * 2004-11-08 2006-05-18 Baxter International Inc. Nanoparticulate compositions of tubulin inhibitor compounds
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
MX2007007919A (es) 2004-12-31 2008-01-22 Reddy Us Therapeutics Inc Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp).
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CA2670778A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
IN2014CN02290A (pt) 2011-09-27 2015-06-19 Reddys Lab Ltd Dr
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
WO2014144715A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (en) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
RU2047603C1 (ru) * 1991-12-09 1995-11-10 Матвей Абрамович Рехтер 1-алкил-2-ацилиндолы и способы их получения
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
WO1994008581A1 (fr) * 1992-10-20 1994-04-28 Toray Industries, Inc. Inhibiteur d'infiltration d'eosinophiles
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
CA2286038A1 (en) 1997-04-08 1998-10-15 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
GEP20032920B (en) * 1998-02-25 2003-03-25 Genetics Inst Inhibitors of Phospholipase Enzymes
JP2004500308A (ja) * 1998-03-12 2004-01-08 ノボ　ノルディスク　アクティーゼルスカブ プロテインチロシンホスアターゼのモジュレーター
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DK1076657T3 (da) * 1998-04-28 2004-11-08 Elbion Ag Hidtil ukendte hydroxyindoler, deres anvendelse som inhibitorer for phosphodiesterase 4 og fremgangsmåde til deres fremstilling
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
WO2000067802A1 (en) * 1999-05-10 2000-11-16 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
CA2386069C (en) 2012-08-14
PL199576B1 (pl) 2008-10-31
IL148670A (en) 2009-09-01
EP1218006A2 (de) 2002-07-03
GEP20043250B (en) 2004-06-25
MXPA02002824A (es) 2003-07-21
AR025885A1 (es) 2002-12-18
NO20021367L (no) 2002-05-22
HUP0202788A2 (hu) 2003-01-28
IS6319A (is) 2002-03-21
CZ20021005A3 (cs) 2004-01-14
UA75872C2 (en) 2006-06-15
YU22702A (sh) 2004-12-31
SK287533B6 (sk) 2011-01-04
NO20021367D0 (no) 2002-03-19
IL148670A0 (en) 2002-09-12
NO322614B1 (no) 2006-11-06
CN1376064A (zh) 2002-10-23
ATE459356T1 (de) 2010-03-15
KR20030019295A (ko) 2003-03-06
AU783436B2 (en) 2005-10-27
HK1048941B (zh) 2007-09-21
SK4072002A3 (en) 2003-11-04
HUP0202788A3 (en) 2003-02-28
ES2342042T3 (es) 2010-07-01
EE200200169A (et) 2003-04-15
PL364811A1 (en) 2004-12-13
JP2003510274A (ja) 2003-03-18
RS51302B (sr) 2010-12-31
NZ517988A (en) 2004-10-29
CA2386069A1 (en) 2001-04-05
DZ3196A1 (fr) 2001-04-05
RU2282444C2 (ru) 2006-08-27
EP1218006B1 (de) 2010-03-03
WO2001022954A3 (de) 2002-03-28
HK1048941A1 (en) 2003-04-25
DE50015879D1 (de) 2010-04-15
WO2001022954A2 (de) 2001-04-05
TWI269654B (en) 2007-01-01
AU7782900A (en) 2001-04-30
ZA200202556B (en) 2003-08-27
CN1301712C (zh) 2007-02-28
BG106639A (bg) 2002-12-29
KR100759242B1 (ko) 2007-09-18
HRP20020369A2 (en) 2004-12-31
CZ303246B6 (cs) 2012-06-20

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ZIOPHARM ONCOLOGY, INC. (US)

Free format text: TRANSFERIDO DE: BAXTER HEALTHCARE S.A.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 31/00

Ipc: A61K 31/4439 (2009.01), A61K 31/404 (2009.01), A61

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8,11,10(VIII),24 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.