BR0014563A - Uso de fator de crescimento de transformação beta e fatores de crescimento anabólico, produto, e, composição farmacêutica - Google Patents
Uso de fator de crescimento de transformação beta e fatores de crescimento anabólico, produto, e, composição farmacêuticaInfo
- Publication number
- BR0014563A BR0014563A BR0014563-7A BR0014563A BR0014563A BR 0014563 A BR0014563 A BR 0014563A BR 0014563 A BR0014563 A BR 0014563A BR 0014563 A BR0014563 A BR 0014563A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- product
- growth factor
- anabolic
- growth factors
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 230000001195 anabolic effect Effects 0.000 title abstract 3
- 230000009466 transformation Effects 0.000 title abstract 2
- 239000000047 product Substances 0.000 title 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 2
- 210000004347 intestinal mucosa Anatomy 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 102000009618 Transforming Growth Factors Human genes 0.000 abstract 1
- 108010009583 Transforming Growth Factors Proteins 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 235000013365 dairy product Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
"USO DE FATOR DE CRESCIMENTO DE TRANSFORMAçãO BETA E FATORES DE CRESCIMENTO ANABóLICO, PRODUTO, E, COMPOSIçãO FARMACêUTICA". A presente invenção refere-se ao uso de fator de crescimento de transformação <225> (TGF-<225>) e fatores de crescimento anabólico (AGF) no tratamento e/ou prevenção de mau funcionamento ou doença da mucosa intestinal. Mais particularmente, a invenção refere-se ao tratamento e/ou prevenção de dano da mucosa intestinal como resultado de quimioterapia ou radioterapia ou de doenças inflamatórias do intestino com um produto compreendendo: a) uma primeira composição farmacêutica compreendendo TGF-<225> obtido por extração de um produto lácteo de mamífero na ausência substancial de fator de crescimento semelhante a insulina 1 (IGF-1), b) uma segunda composição farmacêutica compreendendo AGF na ausência substancial de TGF-<225>; em que a primeira e segunda composição são administradas seq³encialmente.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL1999/000620 WO2001024812A1 (en) | 1999-10-06 | 1999-10-06 | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
| PCT/NL2000/000719 WO2001024813A1 (en) | 1999-10-06 | 2000-10-06 | Use of tgf beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0014563A true BR0014563A (pt) | 2002-06-11 |
Family
ID=19866617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0014563-7A BR0014563A (pt) | 1999-10-06 | 2000-10-06 | Uso de fator de crescimento de transformação beta e fatores de crescimento anabólico, produto, e, composição farmacêutica |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1221965A1 (pt) |
| JP (1) | JP2003510367A (pt) |
| CN (2) | CN1378458A (pt) |
| AU (2) | AU6232899A (pt) |
| BR (1) | BR0014563A (pt) |
| WO (2) | WO2001024812A1 (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3928186A1 (de) * | 1989-08-25 | 1991-03-14 | Niehoff Kg Maschf | Greifvorrichtung fuer drahtspulen und dergleichen |
| FR2827290B1 (fr) | 2001-07-13 | 2004-07-09 | Pierre Jouan Biotechnologies Sa | Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques |
| GB0229658D0 (en) * | 2002-12-20 | 2003-01-22 | Cleeve Richard J | Bird feed |
| TWI356681B (en) * | 2003-11-12 | 2012-01-21 | J Oil Mills Inc | Body taste improver comprising long-chain highly u |
| EP1740615B1 (en) | 2004-03-31 | 2014-11-05 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
| US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
| US8075934B2 (en) | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
| US7744895B2 (en) * | 2005-08-31 | 2010-06-29 | Yamanashi University | Methods of treating allergies using TGF-β1 and allergens |
| CN101505781A (zh) * | 2006-06-22 | 2009-08-12 | 阿根尼克斯有限公司 | 作为辐射防护物质的乳铁蛋白 |
| US8350006B2 (en) | 2008-10-24 | 2013-01-08 | Mead Johnson Nutrition Company | Methods for determining the bioactivity of TGF-β in a composition |
| US8986769B2 (en) | 2008-10-24 | 2015-03-24 | Mead Johnson Nutrition Company | Methods for preserving endogenous TGF-β |
| US8367354B2 (en) | 2008-10-24 | 2013-02-05 | Mead Johnson Nutrition Company | Methods for determining the levels of TGF-β in a composition |
| SG10201704531XA (en) * | 2008-12-08 | 2017-07-28 | Soligenix Inc | Topically active steroids for use in radiation and chemotherapeutics injury |
| JP5552386B2 (ja) * | 2010-07-09 | 2014-07-16 | 株式会社ファンケル | L−アスコルビン酸−2−リン酸−6−脂肪酸凍結乾燥製剤及び化粧料 |
| US20120171328A1 (en) | 2011-01-05 | 2012-07-05 | Dattatreya Banavara | Composition comprising heat labile milk proteins and process for preparing same |
| CN103732623B (zh) | 2011-06-03 | 2017-09-29 | 佐马技术有限公司 | 对TGF‑β具有特异性的抗体 |
| WO2014122143A1 (en) | 2013-02-05 | 2014-08-14 | Engmab Ag | Method for the selection of antibodies against bcma |
| EP2762496A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Method for the selection of antibodies against BCMA |
| EP2762497A1 (en) | 2013-02-05 | 2014-08-06 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3023437A1 (en) | 2014-11-20 | 2016-05-25 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| EP3029068A1 (en) | 2014-12-03 | 2016-06-08 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| WO2016115345A1 (en) | 2015-01-14 | 2016-07-21 | The Brigham And Women's Hospital, | Treatment of cancer with anti-lap monoclonal antibodies |
| EP3770171A1 (en) | 2015-04-03 | 2021-01-27 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
| SI3331910T1 (sl) | 2015-08-03 | 2020-07-31 | Engmab Sarl | Monoklonska protitelesa proti humani antigen dozorevanja limfocitov B (BCMA) |
| MX2018002043A (es) | 2015-08-17 | 2018-07-06 | Janssen Pharmaceutica Nv | ANTICUERPOS ANTI-BCMA, MOLíCULAS DE UNIíN A ANTíGENOS BIESPECíFICAS QUE SE UNEN A BCMA Y CD3, Y USOS DE ESTOS. |
| PE20241349A1 (es) | 2016-09-14 | 2024-07-03 | Teneobio Inc | Anticuerpos de union a cd3 |
| JP7267914B2 (ja) | 2016-11-02 | 2023-05-02 | エンクマフ エスアーエールエル | Bcma及びcd3に対する二重特異性抗体、及び多発性骨髄腫を治療するために併用して使用される免疫療法薬 |
| IL317134A (en) | 2016-12-21 | 2025-01-01 | Teneobio Inc | An antibody containing only heavy chains that binds a human B-cell maturation antigen, a pharmaceutical composition containing the same, its use in the treatment of B-cell disorders and a method for its preparation |
| KR20250007003A (ko) | 2017-06-20 | 2025-01-13 | 테네오바이오, 인코포레이티드 | 항-bcma 중쇄-단독 항체 |
| CN110945026B (zh) | 2017-06-20 | 2024-03-19 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| PL423673A1 (pl) * | 2017-12-01 | 2019-06-03 | Lewandowska Agata | Kompozycja do podawania doustnego, zastosowanie kompozycji w zapobieganiu i leczeniu mucositis oraz sposób leczenia mucositis |
| UA130542C2 (uk) | 2018-05-16 | 2026-03-18 | Янссен Байотек, Інк. | Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта |
| BR112020024074A2 (pt) | 2018-07-20 | 2021-02-17 | Teneobio, Inc. | anticorpos de cadeia pesada com ligação a cd19 |
| CN110051698A (zh) * | 2019-03-18 | 2019-07-26 | 天津大学 | 基于微囊化处理的肠道原生菌基因改造的方法 |
| WO2020206330A1 (en) | 2019-04-05 | 2020-10-08 | Teneobio, Inc. | Heavy chain antibodies binding to psma |
| CR20210622A (es) | 2019-06-14 | 2022-06-27 | Teneobio Inc | Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3 |
| MX2022001065A (es) | 2019-07-30 | 2022-02-14 | Shanghai Hansoh Biomedical Co Ltd | Anticuerpo anti-bcma, fragmento de union al antigeno y uso medico del mismo. |
| BR112022011902A2 (pt) | 2019-12-20 | 2022-09-06 | Novartis Ag | Terapias de combinação |
| TW202330622A (zh) | 2020-04-29 | 2023-08-01 | 美商泰尼歐生物公司 | 具有經修飾重鏈恆定區之多特異性重鏈抗體 |
| IL297601A (en) | 2020-04-29 | 2022-12-01 | Teneobio Inc | Multispecific heavy chain antibodies with modified heavy chain constant regions |
| JP2023524875A (ja) | 2020-05-11 | 2023-06-13 | ヤンセン バイオテツク,インコーポレーテツド | 多発性骨髄腫を治療するための方法 |
| CN116472049A (zh) | 2020-06-30 | 2023-07-21 | 特尼奥生物股份有限公司 | 与bcma结合的多特异性抗体 |
| JP2024507180A (ja) | 2021-02-16 | 2024-02-16 | ヤンセン ファーマシューティカ エヌ.ベー. | Bcma、gprc5d、及びcd3を標的とする三重特異的抗体 |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| TW202309522A (zh) | 2021-05-11 | 2023-03-01 | 美商健生生物科技公司 | 用於監測復發性及/或難治性多發性骨髓瘤之治療的方法及組成物 |
| MX2024005392A (es) | 2021-11-03 | 2024-08-06 | Janssen Biotech Inc | Métodos para tratar cánceres y potenciar la eficacia de anticuerpos biespecíficos para bcmaxcd3. |
| WO2025134049A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of al amyloidosis |
| WO2025134050A1 (en) | 2023-12-21 | 2025-06-26 | Janssen Biotech, Inc | Trispecific antibody targeting bcma, gprc5d and cd3 for the treatment of multiple myeloma |
| US20250262300A1 (en) | 2024-02-16 | 2025-08-21 | Kite Pharma, Inc. | Systems, methods, and kits for generating and administering engineered t cells and cd38 targeting compounds as a combination therapy |
| CN118020946A (zh) * | 2024-03-06 | 2024-05-14 | 美赞臣婴幼儿营养品技术(广州)有限公司 | 保护肠道屏障和/或预防中枢神经系统疾病的营养组合物及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3206784C2 (de) * | 1982-02-25 | 1985-05-09 | Pfrimmer & Co Pharmazeutische Werke Erlangen Gmbh, 8520 Erlangen | Glutaminhaltige Zubereitungen für orale oder intravenöse Applikation |
| EP0269408A3 (en) * | 1986-11-26 | 1989-08-30 | Genentech, Inc. | Tgf-beta in the treatment of inflammatory disorders |
| US5147854A (en) * | 1990-05-22 | 1992-09-15 | Hoffmann-La Roche Inc. | Tgf-b compositions and method |
| US5824297A (en) * | 1990-06-25 | 1998-10-20 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
| AUPN271295A0 (en) * | 1995-05-02 | 1995-05-25 | Gropep Pty Ltd | Method of treatment |
| SE9002732D0 (sv) * | 1990-08-24 | 1990-08-24 | Kabivitrum Ab | Product containing growth factor |
| US5817625A (en) * | 1992-09-21 | 1998-10-06 | Oncogene Science, Inc. | Methods of prevention of oral mucositis with transforming growth factor beta |
| US5451411A (en) * | 1993-10-15 | 1995-09-19 | University Of Washington | Methods and compositions for the oral delivery of therapeutic agents |
| DE69506095T2 (de) * | 1995-08-04 | 1999-06-24 | Naamloze Vennootschap Nutricia, Zoetermeer | Diätfasern enthaltende Nahrungszusammensetzung |
| EP0852913A1 (en) * | 1997-01-14 | 1998-07-15 | Societe Des Produits Nestle S.A. | Composition and method for treatment of inflammatory conditions of the gastro-intestinal tract |
| NL1005677C2 (nl) * | 1997-03-27 | 1998-09-29 | Campina Melkunie Bv | Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. |
| DE19757414A1 (de) * | 1997-12-23 | 1999-07-01 | Nutricia Nv | Fettmischung |
-
1999
- 1999-10-06 WO PCT/NL1999/000620 patent/WO2001024812A1/en not_active Ceased
- 1999-10-06 AU AU62328/99A patent/AU6232899A/en not_active Withdrawn
-
2000
- 2000-10-06 JP JP2001527812A patent/JP2003510367A/ja active Pending
- 2000-10-06 CN CN00814004A patent/CN1378458A/zh active Pending
- 2000-10-06 EP EP00971890A patent/EP1221965A1/en not_active Ceased
- 2000-10-06 BR BR0014563-7A patent/BR0014563A/pt not_active IP Right Cessation
- 2000-10-06 EP EP07100978A patent/EP1779863A1/en not_active Withdrawn
- 2000-10-06 WO PCT/NL2000/000719 patent/WO2001024813A1/en not_active Ceased
- 2000-10-06 CN CNB2004100749613A patent/CN1299766C/zh not_active Expired - Fee Related
- 2000-10-06 AU AU10632/01A patent/AU1063201A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001024813A1 (en) | 2001-04-12 |
| AU1063201A (en) | 2001-05-10 |
| JP2003510367A (ja) | 2003-03-18 |
| CN1626239A (zh) | 2005-06-15 |
| CN1378458A (zh) | 2002-11-06 |
| EP1221965A1 (en) | 2002-07-17 |
| WO2001024812A1 (en) | 2001-04-12 |
| CN1299766C (zh) | 2007-02-14 |
| EP1779863A1 (en) | 2007-05-02 |
| AU6232899A (en) | 2001-05-10 |
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Legal Events
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| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
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| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 38/18 (2006.01), A61K 36/899 (2006.01), A61K |