BR0014565A - Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce - Google Patents

Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce

Info

Publication number
BR0014565A
BR0014565A BR0014565-3A BR0014565A BR0014565A BR 0014565 A BR0014565 A BR 0014565A BR 0014565 A BR0014565 A BR 0014565A BR 0014565 A BR0014565 A BR 0014565A
Authority
BR
Brazil
Prior art keywords
hydroxy
methoxyphenyl
producing
methyl ester
methylbutyl
Prior art date
Application number
BR0014565-3A
Other languages
English (en)
Inventor
Shigeru Kawahara
Kazutaka Nagashima
Kenichi Mori
Tadashi Takemoto
Eriko Ono
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR0014565A publication Critical patent/BR0014565A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)

Abstract

"PROCESSOS PARA PRODUZIR DERIVADO DE ASPARTIL DIPEPTìDEO éSTER, PARA PRODUZIR 3-(3-HIDRóXI-4METOXIFENIL)-3-METILBUTILALDEìDO E PARA PRODUZIR N-[N[3-(3-HIDRóXI-4-METOXIFENIL)3-METILBUTIL]-L-ALFA-ASP ARTIL] -L-FENILALANINA 1-METIL éSTER, DERIVADO DE BENZENO, CRISTAL DE N-[N-[3-(3-HIDRóXI-4-METóXIFENIL)-3-METILBUTIL]-L-ALFA-AS PARTIL]-L-FENILALANINA 1-METIL éSTER, ADOçANTE OU UM ALIMENTO E BEBIDA OU OUTRO PRODUTO COM UM SABOR DOCE CONFERIDO, E, PROCESSO PARA CONFERIR UM SABOR DOCE" 3-(3-hidróxi-4-metoxifenil)-3-metilbutilaldeído é produzido por uma reação, pela qual o grupo carboxila no ácido 3-(3-hidróxi-4-metoxifenil)-3-metilbutírico, que pode ser obtido pela reação de um 2-halogenoanisol com o ácido 3-metilcrotónico e convertendo-se o átomo de halogênio no assim produzido ácido 3-(3-halogeno-4-metoxifenil)-3-metilbutírico em um grupo hidroxila, é convertido em um grupo formila. Por uma reação de alquilação redutiva com aspartame, este derivado de aldeído pode ser fácil e eficientemente convertido em uma escala industrial no N-[N[3-(3-hidróxi-4-metoxifenil)-3-metilbutil]-L-<244>-aspartil]-L-fenilal anina 1-metil éster, que é útil como um adoçante que tem um alto grau de doçura. Assim, o derivado de aldeído é altamente excelente como um intermediário para a produção do adoçante.
BR0014565-3A 1999-10-08 2000-10-04 Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce BR0014565A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP28820899 1999-10-08
JP28820799 1999-10-08
JP29440999 1999-10-15
JP32809999 1999-11-18
PCT/JP2000/006933 WO2001027142A1 (en) 1999-10-08 2000-10-04 Process for producing aspartame derivative, crystals thereof, novel production intermediates therefor and process for producing the intermediate

Publications (1)

Publication Number Publication Date
BR0014565A true BR0014565A (pt) 2002-11-19

Family

ID=27479481

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014565-3A BR0014565A (pt) 1999-10-08 2000-10-04 Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce

Country Status (8)

Country Link
US (2) US20020132032A1 (pt)
EP (1) EP1219633A4 (pt)
KR (1) KR20020038797A (pt)
CN (2) CN1566141A (pt)
AU (1) AU7556700A (pt)
BR (1) BR0014565A (pt)
CA (1) CA2386859A1 (pt)
WO (1) WO2001027142A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0014565A (pt) * 1999-10-08 2002-11-19 Ajinomoto Kk Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce
JP2001199930A (ja) * 2000-01-20 2001-07-24 Ajinomoto Co Inc 新規アリ−ルプロピルアルデヒド誘導体、その製造法及びその使用等
EP2433922A1 (en) 2010-08-25 2012-03-28 Syngenta Participations AG Process for the preparation of dichlorofulvene
CN108474047B (zh) * 2016-01-29 2021-03-23 西铁城时计株式会社 用于检测是否为用6价铬还原化合物处理过的皮革的检测液
CN116284174A (zh) * 2023-03-07 2023-06-23 昆山亚香香料股份有限公司 一种电子烟甜味剂及生产工艺及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60193940A (ja) * 1984-03-16 1985-10-02 Mitsui Toatsu Chem Inc 新規芳香族アルケン化合物
FR2697844B1 (fr) * 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
RU2179979C1 (ru) * 1998-04-09 2002-02-27 Адзиномото Ко., Инк. Сложноэфирные производные аспартилдипептидов и подслащивающие вещества
OA11695A (en) * 1998-06-26 2005-01-13 Ajinomoto Kk Novel aspartyl dipeptide ester derivatives and sweeteners.
OA11654A (en) * 1998-09-18 2004-12-08 Ajinomoto Kk N-alkylaspartyldipeptide ester derivatives and sweeteners.
WO2001018034A1 (en) * 1999-09-07 2001-03-15 Ajinomoto Co., Inc. Process for producing aspartame derivative, method of purifying the same, crystals thereof and use of the same
US20040176472A1 (en) * 1999-10-07 2004-09-09 Ajinomoto Co., Inc. Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof
BR0014565A (pt) * 1999-10-08 2002-11-19 Ajinomoto Kk Processos para produzir derivado de aspartil dipeptìdeo éster, para produzir 3-(3-hidróxi -4-metoxifenil) -3 -metilbutilaldeìdo e para produzir n-[n-[3-(3-hiidróxi -4- metoxifenil) 3- metilbutil] -l- alfa-aspartil] -l- fenilalanina 1-metil éster, derivado de benzeno, cristal de n-[n-[3-(3-hidróxi-4-metóxifenil) -3-metilbutil]-l- alfa-aspartil] -l-fenilalanina 1-metil éster, adoçante ou um alimento e bebida ou outro produto com um sabor doce conferido, e, processo para conferir um sabor doce
WO2001038297A1 (en) * 1999-11-18 2001-05-31 Ajinomoto Co., Inc. Novel intermediate for sweetener with high sweetness and process for producing the same
CN1429234A (zh) * 2000-05-10 2003-07-09 味之素株式会社 天冬氨酰基二肽酯衍生物的制备方法

Also Published As

Publication number Publication date
EP1219633A4 (en) 2004-10-20
EP1219633A1 (en) 2002-07-03
CA2386859A1 (en) 2001-04-19
WO2001027142A1 (en) 2001-04-19
US20040230073A1 (en) 2004-11-18
CN1566141A (zh) 2005-01-19
AU7556700A (en) 2001-04-23
US20020132032A1 (en) 2002-09-19
CN1378556A (zh) 2002-11-06
KR20020038797A (ko) 2002-05-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.

B15K Others concerning applications: alteration of classification

Ipc: C07K 5/072 (2006.01), A23L 27/30 (2016.01), C07C 4