BR0015110A - Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos - Google Patents

Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos

Info

Publication number
BR0015110A
BR0015110A BR0015110-6A BR0015110A BR0015110A BR 0015110 A BR0015110 A BR 0015110A BR 0015110 A BR0015110 A BR 0015110A BR 0015110 A BR0015110 A BR 0015110A
Authority
BR
Brazil
Prior art keywords
kinesin
ksp
treating
compounds
ksp kinesin
Prior art date
Application number
BR0015110-6A
Other languages
English (en)
Inventor
Jeffrey T Finer
Gustave Bergnes
Bainian Feng
Whitney W Smith
John C Chabala
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of BR0015110A publication Critical patent/BR0015110A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paints Or Removers (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"MéTODOS DE TRATAMENTO DE DOENçAS DE PROLIFERAçãO CELULAR, DE TRATAMENTO DE UM DISTúRBIO ASSOCIADO COM A ATIVIDADE DA CINESINA KSP, DE INIBIçãO DA CINESINA KSP, DE TRIAGEM DE MODULADORES DA CINESINA KPS E DE TRIAGEM DE COMPOSTOS QUE SE LIGAM NA CINESINA KSP, E, COMPOSTO". Descrevem-se quinazolinonas de fórmulas 1a, 1b, 1c e 1d Elas são úteis no tratamento de doenças de proliferação celular e de distúrbios associados com a atividade da cinesina KSP.
BR0015110-6A 1999-10-27 2000-10-26 Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos BR0015110A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19825399P 1999-10-27 1999-10-27
US21310400P 2000-06-21 2000-06-21
PCT/US2000/029585 WO2001030768A1 (en) 1999-10-27 2000-10-26 Methods and compositions utilizing quinazolinones

Publications (1)

Publication Number Publication Date
BR0015110A true BR0015110A (pt) 2002-07-02

Family

ID=26893612

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015110-6A BR0015110A (pt) 1999-10-27 2000-10-26 Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos

Country Status (18)

Country Link
EP (2) EP1686120A3 (pt)
JP (2) JP2003512461A (pt)
KR (2) KR20020062930A (pt)
CN (1) CN100381428C (pt)
AT (1) ATE327224T1 (pt)
AU (2) AU774748B2 (pt)
BR (1) BR0015110A (pt)
CA (1) CA2388646C (pt)
CZ (1) CZ20021428A3 (pt)
DE (1) DE60028227T2 (pt)
ES (1) ES2263501T3 (pt)
HU (1) HUP0203430A3 (pt)
IL (2) IL149164A0 (pt)
MX (1) MXPA02004162A (pt)
NO (1) NO322825B1 (pt)
NZ (2) NZ518480A (pt)
PL (1) PL203998B1 (pt)
WO (1) WO2001030768A1 (pt)

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Also Published As

Publication number Publication date
HUP0203430A3 (en) 2003-07-28
KR20050049562A (ko) 2005-05-25
NO20021907D0 (no) 2002-04-23
IL149164A0 (en) 2002-11-10
EP1226129A1 (en) 2002-07-31
CN100381428C (zh) 2008-04-16
AU2004218601A1 (en) 2004-10-28
ATE327224T1 (de) 2006-06-15
MXPA02004162A (es) 2003-08-20
KR20020062930A (ko) 2002-07-31
JP4116332B2 (ja) 2008-07-09
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