BR0016064A - Compostos heterocìclicos e seus sais e uso medicinal dos mesmos - Google Patents

Compostos heterocìclicos e seus sais e uso medicinal dos mesmos

Info

Publication number
BR0016064A
BR0016064A BR0016064-4A BR0016064A BR0016064A BR 0016064 A BR0016064 A BR 0016064A BR 0016064 A BR0016064 A BR 0016064A BR 0016064 A BR0016064 A BR 0016064A
Authority
BR
Brazil
Prior art keywords
agent
hydrogen
action
lower alkyl
salts
Prior art date
Application number
BR0016064-4A
Other languages
English (en)
Inventor
Hiroshi Matsui
Hideo Kobayashi
Satoru Azukizawa
Masayasu Kasai
Akihisa Yoshimi
Hiroaki Shirahase
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of BR0016064A publication Critical patent/BR0016064A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTOS HETEROCìCLICOS E SEUS SAIS E USO MEDICINAL DOS MESMOS". Um composto heterocíclico da fórmula [I] em que R^ 1^ é átomo de hidrogênio ou alquila inferior, R^ 2^ é átomo de hidrogênio, alquila opcionalmente tendo um substituinte e semelhantes, R^ 3^ é átomo de hidrogênio, alquila inferior e semelhantes, A é uma ligação simples ou >N-R^ 5^ em que R^5^ é átomo de hidrogênio ou alquila inferior, B é alquileno inferior, e Y é arila opcionalmente tendo um substituinte e semelhantes, e um seu sal farmaceuticamente aceitável mostram uma ação hipoglicêmica, uma ação hipolipidêmica no sangue, uma ação de melhoramento de resistência à insuluna e uma ação ativadora de PPAR, e são úteis como um agente higoglicêmico, um agente hipolipidêmico, um melhorador de resistência à insulina, um agente terapêutico de diabetes, um agente terapêutico de complicação diabética, um melhorador de tolerância a glicose, um agente de antiaterosclerose, um agente antiobesidade, um agente antiinflamatório, um agente para a profilaxia ou tratamento de doença mediada por PPAR e um agente para a profilaxia ou tratamento de síndrome X.
BR0016064-4A 1999-12-03 2000-11-29 Compostos heterocìclicos e seus sais e uso medicinal dos mesmos BR0016064A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34554399 1999-12-03
JP2000295108 2000-09-27
PCT/JP2000/008464 WO2001040192A1 (en) 1999-12-03 2000-11-29 Novel heterocyclic compounds and salts thereof and medicinal use of the same

Publications (1)

Publication Number Publication Date
BR0016064A true BR0016064A (pt) 2004-07-27

Family

ID=26578048

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016064-4A BR0016064A (pt) 1999-12-03 2000-11-29 Compostos heterocìclicos e seus sais e uso medicinal dos mesmos

Country Status (20)

Country Link
US (1) US6589963B2 (pt)
EP (1) EP1236719A4 (pt)
KR (1) KR100716525B1 (pt)
CN (1) CN1215059C (pt)
AR (1) AR033349A1 (pt)
AU (1) AU782631C (pt)
BR (1) BR0016064A (pt)
CA (1) CA2393265A1 (pt)
CO (1) CO5440230A1 (pt)
CZ (1) CZ20021911A3 (pt)
HU (1) HUP0203431A3 (pt)
IL (2) IL149883A0 (pt)
MX (1) MXPA02005528A (pt)
NO (1) NO323922B1 (pt)
NZ (1) NZ519592A (pt)
PL (1) PL356769A1 (pt)
RU (1) RU2256661C2 (pt)
TW (1) TWI286549B (pt)
WO (1) WO2001040192A1 (pt)
YU (1) YU50302A (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt) 2001-01-26 2006-11-30 Schering Corp Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
RS20100015A (sr) 2001-01-26 2010-12-31 Schering Corporation Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
KR100874677B1 (ko) * 2001-05-29 2008-12-18 교토 야쿠힝 고교 가부시키가이샤 신규 복소환 유도체 및 그 의약 용도
WO2002096880A1 (en) 2001-05-29 2002-12-05 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic compound and medicinal use thereof
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1429756B1 (en) 2001-09-21 2006-11-22 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
WO2003059907A1 (en) * 2002-01-17 2003-07-24 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
DE10222034A1 (de) * 2002-05-17 2003-11-27 Bayer Ag Tetrahydroisochinolin-Derivate
JP2006508188A (ja) 2002-11-06 2006-03-09 シェーリング　コーポレイション 脱髄の処置のためのコレステロール吸収インヒビター
PA8594401A1 (es) * 2003-02-21 2004-09-16 Pfizer Acidos carboxilicos de heteroarilo condensado como agonista del ppar
DE602004016123D1 (de) 2003-03-07 2008-10-09 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1300115C (zh) * 2004-03-26 2007-02-14 厦门大学 一种合成1，2，3，4－四氢异喹啉衍生物的方法
CA2585172C (en) 2004-10-29 2014-08-12 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
AU2006277742B2 (en) * 2005-08-08 2010-08-26 Pfizer Inc. Salts and polymorphs of a VEGF-R inhibitor
AU2006287513A1 (en) * 2005-09-07 2007-03-15 Plexxikon, Inc. 1, 3-disubstituted indole derivatives for use as PPAR modulators
US7790745B2 (en) 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
US7863276B2 (en) 2005-10-25 2011-01-04 Kalypsys, Inc Salts of modulators of PPAR and methods of treating metabolic disorders
EP1790646A1 (fr) * 2005-11-24 2007-05-30 Sanofi-Aventis Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
WO2009019598A2 (en) * 2007-08-03 2009-02-12 Dr. Reddy's Laboratories Ltd. Inhalation therapy for respiratory disorders
KR101616737B1 (ko) * 2008-03-07 2016-05-02 브이티브이 테라퓨틱스 엘엘씨 당뇨병 치료를 위한 옥사디아조안트라센 화합물
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
WO2012033195A1 (ja) * 2010-09-10 2012-03-15 京都薬品工業株式会社 複素環化合物
CN102807526B (zh) * 2011-06-21 2015-12-02 寿光富康制药有限公司 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用
CN102702098A (zh) * 2012-05-24 2012-10-03 盛世泰科生物医药技术(苏州)有限公司 6-甲氧基-1,2,3,4四氢喹啉-5羧酸甲酯的合成
AR101196A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
EP4265258A4 (en) * 2020-12-18 2024-11-13 ASKA Pharmaceutical Co., Ltd. FIXED FORMULATION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
ATE186724T1 (de) 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
GB9604242D0 (en) * 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
DE69731003D1 (de) * 1996-07-01 2004-11-04 Lilly Co Eli Blutzuckersenkende und lipidsenkende verbindungen
IL121202A (en) * 1996-07-01 2001-08-26 Lilly Co Eli Hypoglycemic and hypolipidemic compounds, process for their preparation, pharmaceutial compositions comprising same, and uses thereof

Also Published As

Publication number Publication date
YU50302A (sh) 2006-01-16
WO2001040192A1 (en) 2001-06-07
CN1402712A (zh) 2003-03-12
TWI286549B (en) 2007-09-11
NO20022600D0 (no) 2002-05-31
PL356769A1 (en) 2004-07-12
NO323922B1 (no) 2007-07-23
US20030027836A1 (en) 2003-02-06
AR033349A1 (es) 2003-12-17
EP1236719A1 (en) 2002-09-04
RU2256661C2 (ru) 2005-07-20
CN1215059C (zh) 2005-08-17
HUP0203431A3 (en) 2003-11-28
HUP0203431A2 (hu) 2003-02-28
AU782631C (en) 2006-08-17
KR20020058079A (ko) 2002-07-12
CO5440230A1 (es) 2004-09-30
KR100716525B1 (ko) 2007-05-10
EP1236719A4 (en) 2003-06-25
IL149883A0 (en) 2002-11-10
US6589963B2 (en) 2003-07-08
NZ519592A (en) 2003-11-28
CA2393265A1 (en) 2001-06-07
HK1053657A1 (en) 2003-10-31
AU782631B2 (en) 2005-08-18
NO20022600L (no) 2002-08-05
AU1649501A (en) 2001-06-12
MXPA02005528A (es) 2002-09-02
IL149883A (en) 2007-03-08
CZ20021911A3 (cs) 2002-10-16

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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