BR0100689A - Fabricação de ácido cìclico - Google Patents
Fabricação de ácido cìclicoInfo
- Publication number
- BR0100689A BR0100689A BR0100689-4A BR0100689A BR0100689A BR 0100689 A BR0100689 A BR 0100689A BR 0100689 A BR0100689 A BR 0100689A BR 0100689 A BR0100689 A BR 0100689A
- Authority
- BR
- Brazil
- Prior art keywords
- dibenzyl
- oxo
- cis
- imidazolidinedicarboxylic
- metal salt
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 3
- QSMUFXXTSUEZJA-IYBDPMFKSA-N (4s,5r)-1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid Chemical compound N1([C@@H]([C@@H](N(C1=O)CC=1C=CC=CC=1)C(=O)O)C(O)=O)CC1=CC=CC=C1 QSMUFXXTSUEZJA-IYBDPMFKSA-N 0.000 abstract 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WIVKAHXCBJSNDF-IYBDPMFKSA-N (3as,6ar)-1,3-dibenzyl-3a,6a-dihydrofuro[3,4-d]imidazole-2,4,6-trione Chemical compound N1([C@@H]2[C@H](N(C1=O)CC=1C=CC=CC=1)C(=O)OC2=O)CC1=CC=CC=C1 WIVKAHXCBJSNDF-IYBDPMFKSA-N 0.000 abstract 2
- FZEXWQSUEVTZEC-UHFFFAOYSA-N 2,3-bis(benzylamino)butanedioic acid Chemical compound C=1C=CC=CC=1CNC(C(O)=O)C(C(=O)O)NCC1=CC=CC=C1 FZEXWQSUEVTZEC-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 229930003756 Vitamin B7 Natural products 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 229960002685 biotin Drugs 0.000 abstract 1
- 235000020958 biotin Nutrition 0.000 abstract 1
- 239000011616 biotin Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000011735 vitamin B7 Substances 0.000 abstract 1
- 235000011912 vitamin B7 Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Patente de Invenção: <B>"FABRICAçãO DE áCIDO CìCLICO"<D>. Processo para produção de ácido 2-oxo-1,3-dibenzil-4,5-imidazolidinadicarboxílico e, respectivamente de anidrido de ácido 2-oxo-1,3-dibenzil-4,5-imidazolidinadicarboxílico partindo de um sal de metal dial-calino de ácido meso-2,3-bis(benzilamino)succínico que compreende reação do sal de metal dialcalino de ácido meso-2,3-bis(benzilamino)succínico com clorofomiato de fenila em um sistema de solvente monofásico, consistindo em uma mistura de cerca de 2:1 a 1:1 de um éter miscível em água e solução de hidróxido de metal alcalino aquosa, a uma temperatura não excedendo cerca de 40°C e convertendo o sal de metal dialcalino de ácido 2-oxo-1,3-dibenzil-cis-4,5-imidazolidinadicarboxílico, por acidificação no ácido de 1-oxo-1,3-dibenzil-cis-4,5-imidazolidinadicarboxílico desejado e isolando este ou convertendo por aquecimento com anidrido acético, em um hidrocarboneto aromático como o solvente orgânico no anidrido de ácido 2-oxo-1,3-dibenzil-cis-4,5-imidazolidinadicarboxílico desejado e isolando o mesmo. Cada produto é um intermediário importante no processo de múltiplas etapas para a fabricação de biotina (vitamina H).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3742000 | 2000-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0100689A true BR0100689A (pt) | 2001-09-25 |
Family
ID=4513524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0100689-4A BR0100689A (pt) | 2000-02-25 | 2001-02-21 | Fabricação de ácido cìclico |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6291681B1 (pt) |
| EP (1) | EP1127879B1 (pt) |
| JP (1) | JP4833419B2 (pt) |
| KR (1) | KR100776104B1 (pt) |
| CN (1) | CN1155578C (pt) |
| AT (1) | ATE296291T1 (pt) |
| BR (1) | BR0100689A (pt) |
| CA (1) | CA2337620A1 (pt) |
| DE (1) | DE50106283D1 (pt) |
| ES (1) | ES2241699T3 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200300676A (en) * | 2001-12-04 | 2003-06-16 | Tanabe Seiyaku Co | Biotin intermediate and its production |
| EP1618110A2 (en) * | 2003-04-22 | 2006-01-25 | DSM IP Assets B.V. | A process for the stereoselective synthesis of lactones |
| US7032407B2 (en) | 2003-06-27 | 2006-04-25 | General Electric Company | Methods and apparatus for refrigerator compartment |
| US7463481B2 (en) * | 2005-03-09 | 2008-12-09 | Hewlett-Packard Development Company, L.P. | Computer with hinge post and hinge mount and related methods |
| CN113801125B (zh) * | 2021-09-16 | 2023-11-03 | 安徽泰格维生素实业有限公司 | 一种环酸酐的制备方法 |
| CN117362303B (zh) * | 2022-07-02 | 2026-02-03 | 黑龙江联顺生物科技有限公司 | 一种生物素中间体环酐的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS518270A (en) | 1974-07-11 | 1976-01-23 | Sumitomo Chemical Co | 22 okiso imidazorijin 4*55 jikarubonsanruino seiho |
| US5151525A (en) * | 1991-06-18 | 1992-09-29 | Ppg Industries, Inc. | Process for producing 2-oxo-1,3-dibenzyl-4,5-cis-imidazolidinedicarboxylic acid |
| EP1081139A3 (de) * | 1999-08-27 | 2001-09-05 | F. Hoffmann-La Roche Ag | Herstellung einer Imidazolidindicarbonsaüre |
-
2001
- 2001-02-09 US US09/780,253 patent/US6291681B1/en not_active Expired - Lifetime
- 2001-02-15 EP EP01103732A patent/EP1127879B1/de not_active Expired - Lifetime
- 2001-02-15 ES ES01103732T patent/ES2241699T3/es not_active Expired - Lifetime
- 2001-02-15 AT AT01103732T patent/ATE296291T1/de not_active IP Right Cessation
- 2001-02-15 DE DE50106283T patent/DE50106283D1/de not_active Expired - Lifetime
- 2001-02-21 JP JP2001044539A patent/JP4833419B2/ja not_active Expired - Fee Related
- 2001-02-21 BR BR0100689-4A patent/BR0100689A/pt not_active Application Discontinuation
- 2001-02-21 CA CA002337620A patent/CA2337620A1/en not_active Abandoned
- 2001-02-22 KR KR1020010008939A patent/KR100776104B1/ko not_active Expired - Fee Related
- 2001-02-23 CN CNB011049235A patent/CN1155578C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4833419B2 (ja) | 2011-12-07 |
| EP1127879B1 (de) | 2005-05-25 |
| CN1310176A (zh) | 2001-08-29 |
| US20010020101A1 (en) | 2001-09-06 |
| KR20010085473A (ko) | 2001-09-07 |
| CA2337620A1 (en) | 2001-08-25 |
| ES2241699T3 (es) | 2005-11-01 |
| US6291681B1 (en) | 2001-09-18 |
| EP1127879A1 (de) | 2001-08-29 |
| CN1155578C (zh) | 2004-06-30 |
| JP2001278867A (ja) | 2001-10-10 |
| ATE296291T1 (de) | 2005-06-15 |
| KR100776104B1 (ko) | 2007-11-15 |
| DE50106283D1 (de) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |