BR0104355A - Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor - Google Patents

Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor

Info

Publication number
BR0104355A
BR0104355A BR0104355-2A BR0104355A BR0104355A BR 0104355 A BR0104355 A BR 0104355A BR 0104355 A BR0104355 A BR 0104355A BR 0104355 A BR0104355 A BR 0104355A
Authority
BR
Brazil
Prior art keywords
taxanes
carbamoyloxy
substituted
antitumor agents
agents
Prior art date
Application number
BR0104355-2A
Other languages
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State Res Found filed Critical Univ Florida State Res Found
Publication of BR0104355A publication Critical patent/BR0104355A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Patente de Invenção: "TAXANOS SUBSTITUìDOS POR C7 CARBAMOILóXI COMO AGENTES ANTITUMOR". Os taxanos tendo um substituinte de carbamoilóxi em C(7), um substituinte de hidróxi em C(10), e uma faixa de C(2), C(9), C(14), e substituintes de cadeia lateral.
BR0104355-2A 2000-02-02 2001-02-02 Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor BR0104355A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17967000P 2000-02-02 2000-02-02
PCT/US2001/003592 WO2001057028A1 (en) 2000-02-02 2001-02-02 C7 carbamoyloxy substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
BR0104355A true BR0104355A (pt) 2002-01-02

Family

ID=22657498

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0104355-2A BR0104355A (pt) 2000-02-02 2001-02-02 Taxanos substituìdos por c7 carbamoilóxi como agentes antitumor

Country Status (23)

Country Link
US (3) US6359154B2 (pt)
EP (1) EP1165549B1 (pt)
JP (1) JP2003522168A (pt)
KR (1) KR20020002417A (pt)
CN (1) CN1362956A (pt)
AT (1) ATE392422T1 (pt)
AU (1) AU778991B2 (pt)
BR (1) BR0104355A (pt)
CA (1) CA2368510A1 (pt)
CZ (1) CZ20013521A3 (pt)
DE (1) DE60133600T2 (pt)
DK (1) DK1165549T3 (pt)
ES (1) ES2305056T3 (pt)
HK (1) HK1047937A1 (pt)
HU (1) HUP0200752A3 (pt)
IL (1) IL145643A0 (pt)
MX (1) MXPA01009923A (pt)
NO (1) NO20014757L (pt)
NZ (1) NZ514410A (pt)
PL (1) PL350024A1 (pt)
PT (1) PT1165549E (pt)
WO (1) WO2001057028A1 (pt)
ZA (1) ZA200108056B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638973B2 (en) * 2000-02-02 2003-10-28 Fsu Research Foundation, Inc. Taxane formulations
MXPA01009923A (es) * 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
KR20050032110A (ko) 2002-08-02 2005-04-06 이뮤노젠 아이엔씨 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도
CN110227164B (zh) * 2018-03-06 2021-11-23 江苏吉贝尔药业股份有限公司 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) * 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
PT552041E (pt) 1992-01-15 2000-12-29 Squibb & Sons Inc Processo enzimaticos para a resolucao de misturas enantiomericas de compostos uteis como intermediarios para a preparacao de taxanos
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
CA2109861C (en) 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
JP3031715B2 (ja) * 1993-02-05 2000-04-10 ブリン モーアー カレッジ 様々なａ環側鎖を有するタキソール、類似体及び中間体の合成
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
WO1996013495A1 (en) 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
AU724499B2 (en) 1996-05-06 2000-09-21 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
MXPA01009923A (es) * 2000-02-02 2003-08-01 Univ Florida State Res Found Taxanos sustituidos con carbamoiloxilo en c7 como agentes antitumorales.

Also Published As

Publication number Publication date
JP2003522168A (ja) 2003-07-22
US6359154B2 (en) 2002-03-19
KR20020002417A (ko) 2002-01-09
IL145643A0 (en) 2002-06-30
AU778991B2 (en) 2004-12-23
CA2368510A1 (en) 2001-08-09
ZA200108056B (en) 2003-12-01
ATE392422T1 (de) 2008-05-15
EP1165549B1 (en) 2008-04-16
PT1165549E (pt) 2008-06-20
CN1362956A (zh) 2002-08-07
DK1165549T3 (da) 2008-08-11
MXPA01009923A (es) 2003-08-01
NZ514410A (en) 2005-01-28
US6750245B2 (en) 2004-06-15
EP1165549A1 (en) 2002-01-02
NO20014757D0 (no) 2001-10-01
WO2001057028A1 (en) 2001-08-09
NO20014757L (no) 2001-11-29
AU3330201A (en) 2001-08-14
HUP0200752A2 (en) 2002-10-28
HUP0200752A3 (en) 2005-02-28
ES2305056T3 (es) 2008-11-01
DE60133600T2 (de) 2009-06-10
US20030060638A1 (en) 2003-03-27
US20050020635A1 (en) 2005-01-27
DE60133600D1 (de) 2008-05-29
HK1047937A1 (zh) 2003-03-14
CZ20013521A3 (cs) 2002-03-13
PL350024A1 (en) 2002-10-21
US20010051640A1 (en) 2001-12-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A., 9A., 10A. E 11A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.