BR0107357A - Método sintético para a fluormetilação de álcoois - Google Patents
Método sintético para a fluormetilação de álcooisInfo
- Publication number
- BR0107357A BR0107357A BR0107357-5A BR0107357A BR0107357A BR 0107357 A BR0107357 A BR 0107357A BR 0107357 A BR0107357 A BR 0107357A BR 0107357 A BR0107357 A BR 0107357A
- Authority
- BR
- Brazil
- Prior art keywords
- usando
- formula
- compound
- alcohols
- synthetic method
- Prior art date
Links
- 150000001298 alcohols Chemical class 0.000 title abstract 4
- 238000010189 synthetic method Methods 0.000 title abstract 2
- 238000005799 fluoromethylation reaction Methods 0.000 title 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 2
- 150000001805 chlorine compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000012320 chlorinating reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 fluoride compound Chemical class 0.000 abstract 1
- 239000012025 fluorinating agent Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/28—Preparation of ethers by reactions not forming ether-oxygen bonds from acetals, e.g. by dealcoholysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"MéTODO SINTéTICO PARA A FLUORMETILAçãO DE áLCOOIS". Um método para fluormetilar álcoois halogenados. O método inclui a etapa de proporcionar um álcool alfa-halogenado da fórmula R^ 1^ (CX~ 3~)~ 2~OH, em que R^ 1^ é selecionado a partir do grupo consistindo de hidrogênio e de grupos alquila. O álcool alfa-halogenado é reagido com um primeiro composto da fórmula CH~ 2~ (OR^ 2^)~ 2~ na presença de um catalisador ácido para formar um acetal. O acetal resultante é então clorado com um agente de cloração para formar um composto de cloreto da fórmula R^ 1^C (CX~ 3~)~ 2~OCH~ 2~C1. O composto de cloreto é então convertido a um composto de fluoreto da fórmula R^ 1^C (CX~ 3~)~ 2~OCH~ 2~F usando um agente de fluoração.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/587,414 US6245949B1 (en) | 2000-06-01 | 2000-06-01 | Synthetic method for the fluoromethylation of alcohols |
| PCT/US2001/017399 WO2001092192A1 (en) | 2000-06-01 | 2001-05-30 | Synthetic method for the fluoromethylation of alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0107357A true BR0107357A (pt) | 2004-01-06 |
Family
ID=24349705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0107357-5A BR0107357A (pt) | 2000-06-01 | 2001-05-30 | Método sintético para a fluormetilação de álcoois |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6245949B1 (pt) |
| EP (1) | EP1286940B1 (pt) |
| JP (1) | JP2003535070A (pt) |
| KR (1) | KR100849376B1 (pt) |
| CN (1) | CN1205159C (pt) |
| AR (1) | AR028936A1 (pt) |
| AT (1) | ATE321748T1 (pt) |
| AU (2) | AU2001265158B2 (pt) |
| BG (1) | BG107334A (pt) |
| BR (1) | BR0107357A (pt) |
| CA (1) | CA2407716A1 (pt) |
| CZ (1) | CZ20023787A3 (pt) |
| DE (1) | DE60118367T2 (pt) |
| DK (1) | DK1286940T3 (pt) |
| ES (1) | ES2261417T3 (pt) |
| HK (1) | HK1054369B (pt) |
| HU (1) | HUP0302227A3 (pt) |
| IL (2) | IL152856A0 (pt) |
| MX (1) | MXPA02011853A (pt) |
| NO (1) | NO20025790D0 (pt) |
| NZ (1) | NZ522503A (pt) |
| PE (1) | PE20011340A1 (pt) |
| PL (1) | PL365449A1 (pt) |
| PT (1) | PT1286940E (pt) |
| SK (1) | SK17522002A3 (pt) |
| TW (1) | TWI222436B (pt) |
| WO (1) | WO2001092192A1 (pt) |
| ZA (1) | ZA200208851B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6271422B1 (en) * | 2000-06-01 | 2001-08-07 | Abbott Laboratories | Method for fluoromethylation of alcohols via halogenative decarboxylation |
| BRPI0622035B1 (pt) * | 2006-09-29 | 2020-06-09 | Cristalia Produtos Quim Farmaceuticos Ltda | processo para preparação do éter clorometil 2,2,2-trifluoro-1-(trifluorometil) etílico |
| CN101337863B (zh) * | 2007-07-06 | 2012-04-25 | 江苏恒瑞医药股份有限公司 | 一种制备七氟烷的方法 |
| CN101314560B (zh) * | 2008-07-02 | 2011-06-15 | 鲁南制药集团股份有限公司 | 七氟烷的合成方法 |
| WO2010096959A1 (zh) * | 2009-02-25 | 2010-09-02 | 江苏恒瑞医药股份有限公司 | 制备氯甲基-1,1,1,3,3,3-六氟异丙基醚的方法 |
| CN106117022B (zh) * | 2016-08-03 | 2019-01-29 | 鲁南制药集团股份有限公司 | 一种回收利用七氟烷杂质f（1）的方法 |
| CN107698430B (zh) * | 2017-11-01 | 2021-01-08 | 华东医药（西安）博华制药有限公司 | 一种七氟烷反应液的后处理方法 |
| CN120025236B (zh) * | 2025-04-21 | 2025-06-27 | 江苏恒瑞医药股份有限公司 | 一种制备七氟烷及其中间体的方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683092A (en) * | 1970-07-31 | 1972-08-08 | Baxter Laboratories Inc | Method of anesthesia |
| US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| US4314087A (en) * | 1979-12-26 | 1982-02-02 | Baxter Travenol Laboratories, Inc. | Methods of synthesizing hexafluoroisopropanol from impure mixtures and synthesis of a fluoromethyl ether therefrom |
| US4847427A (en) | 1988-04-13 | 1989-07-11 | E. I. Du Pont De Nemours And Company | Process for preparing fluorocarbon polyethers |
| US4874901A (en) * | 1988-05-06 | 1989-10-17 | Boc, Inc. | Process for the production of polyfluorinated ethers |
| US4996371A (en) | 1990-01-16 | 1991-02-26 | Boc, Inc. | Method for fluorodecarboxylation |
| GB9600072D0 (en) * | 1996-01-04 | 1996-03-06 | Ici Plc | Process for the production of fluoromethylhexafluoroisopropylether |
| ES2169345T5 (es) * | 1996-02-21 | 2005-05-01 | Central Glass Company, Limited | Procedimiento de preparacion de eter de fluorometilo 1,1,1,3,3,3-hexafluoroisopropilico. |
| US5789630A (en) | 1996-02-27 | 1998-08-04 | University Of Iowa Research Foundation | Process for the synthesis of hexafluoropropanes |
| US5705710A (en) * | 1997-01-15 | 1998-01-06 | University Of Iowa Research Foundation | Process for the synthesis of hexafluoroisopropyl ethers |
| US5969193A (en) * | 1997-08-18 | 1999-10-19 | Medeva Pharmaceuticals Pa, Inc. | Method for the preparation of sevoflurane |
| US5886239A (en) * | 1997-11-21 | 1999-03-23 | Baxter International Inc. | Method of preparing monofluoromethyl ethers |
| US6100434A (en) * | 1999-03-26 | 2000-08-08 | Abbott Laboratories | Method for synthesizing sevoflurane and an intermediate thereof |
-
2000
- 2000-06-01 US US09/587,414 patent/US6245949B1/en not_active Expired - Lifetime
-
2001
- 2001-05-30 MX MXPA02011853A patent/MXPA02011853A/es active IP Right Grant
- 2001-05-30 PL PL01365449A patent/PL365449A1/xx unknown
- 2001-05-30 HK HK03105005.9A patent/HK1054369B/en not_active IP Right Cessation
- 2001-05-30 WO PCT/US2001/017399 patent/WO2001092192A1/en not_active Ceased
- 2001-05-30 JP JP2002500809A patent/JP2003535070A/ja not_active Ceased
- 2001-05-30 CZ CZ20023787A patent/CZ20023787A3/cs unknown
- 2001-05-30 AT AT01939665T patent/ATE321748T1/de not_active IP Right Cessation
- 2001-05-30 CN CNB018103073A patent/CN1205159C/zh not_active Expired - Fee Related
- 2001-05-30 KR KR1020027016189A patent/KR100849376B1/ko not_active Expired - Fee Related
- 2001-05-30 IL IL15285601A patent/IL152856A0/xx active IP Right Grant
- 2001-05-30 AU AU2001265158A patent/AU2001265158B2/en not_active Ceased
- 2001-05-30 ES ES01939665T patent/ES2261417T3/es not_active Expired - Lifetime
- 2001-05-30 EP EP01939665A patent/EP1286940B1/en not_active Expired - Lifetime
- 2001-05-30 AU AU6515801A patent/AU6515801A/xx active Pending
- 2001-05-30 NZ NZ522503A patent/NZ522503A/en unknown
- 2001-05-30 DK DK01939665T patent/DK1286940T3/da active
- 2001-05-30 CA CA002407716A patent/CA2407716A1/en not_active Abandoned
- 2001-05-30 PT PT01939665T patent/PT1286940E/pt unknown
- 2001-05-30 BR BR0107357-5A patent/BR0107357A/pt not_active Application Discontinuation
- 2001-05-30 SK SK1752-2002A patent/SK17522002A3/sk unknown
- 2001-05-30 HU HU0302227A patent/HUP0302227A3/hu unknown
- 2001-05-30 DE DE60118367T patent/DE60118367T2/de not_active Expired - Fee Related
- 2001-05-31 AR ARP010102631A patent/AR028936A1/es unknown
- 2001-06-01 PE PE2001000509A patent/PE20011340A1/es not_active Application Discontinuation
- 2001-06-01 TW TW090113352A patent/TWI222436B/zh not_active IP Right Cessation
-
2002
- 2002-10-31 ZA ZA200208851A patent/ZA200208851B/xx unknown
- 2002-11-14 IL IL152856A patent/IL152856A/en not_active IP Right Cessation
- 2002-11-28 BG BG107334A patent/BG107334A/bg unknown
- 2002-12-02 NO NO20025790A patent/NO20025790D0/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |