BR0110657A - Processo para a preparação de ácido l-ascórbico - Google Patents
Processo para a preparação de ácido l-ascórbicoInfo
- Publication number
- BR0110657A BR0110657A BR0110657-0A BR0110657A BR0110657A BR 0110657 A BR0110657 A BR 0110657A BR 0110657 A BR0110657 A BR 0110657A BR 0110657 A BR0110657 A BR 0110657A
- Authority
- BR
- Brazil
- Prior art keywords
- ascorbic acid
- preparation
- solvent
- keto
- gulonate
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 6
- 229960005070 ascorbic acid Drugs 0.000 title abstract 3
- 235000000069 L-ascorbic acid Nutrition 0.000 title abstract 2
- 239000002211 L-ascorbic acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 3
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 abstract 1
- VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE áCIDO L-ASCóRBICO". A invenção refere-se a um método para a produção de ácido L-ascórbico, por meio do qual o ácido 2-ceto-L-gulónico livre ou C~ 3~-C~ 10~ alquil éster do ácido 2-ceto-L-gulónico é lactonizado sob condições ácidas, na presença de um solvente miscível em água e dito solvente produz in situ um solvente em que o ácido ascórbico é fracamente solúvel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10022518A DE10022518A1 (de) | 2000-05-10 | 2000-05-10 | Verfahren zur Herstellung von L-Ascorbinsäure durch Lactonisierung von 2-Keto-L-gulonsäure oder 2-Keto-L-gulonsäureestern |
| PCT/EP2001/004961 WO2001085711A1 (de) | 2000-05-10 | 2001-05-03 | Verfahren zur herstellung von l-ascorbinsäure durch lactonisierung von 2-keto-l-gulonsäure oder 2-keto-l-gulonsäureestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0110657A true BR0110657A (pt) | 2003-03-18 |
Family
ID=7641279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0110657-0A BR0110657A (pt) | 2000-05-10 | 2001-05-03 | Processo para a preparação de ácido l-ascórbico |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6617463B2 (pt) |
| EP (1) | EP1280788B1 (pt) |
| JP (1) | JP2003533452A (pt) |
| CN (1) | CN1174972C (pt) |
| AT (1) | ATE277030T1 (pt) |
| AU (1) | AU5839101A (pt) |
| BR (1) | BR0110657A (pt) |
| DE (2) | DE10022518A1 (pt) |
| DK (1) | DK1280788T3 (pt) |
| ES (1) | ES2227187T3 (pt) |
| PT (1) | PT1280788E (pt) |
| WO (1) | WO2001085711A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003293666A1 (en) * | 2002-11-11 | 2004-06-03 | Basf Aktiengesellschaft | Method for the production of 2-keto-l-gulonic acid-c4-c10 alkyl esters |
| CN112724107B (zh) * | 2020-12-18 | 2024-01-30 | 南京工业大学 | 一种α-氧代-2-呋喃基乙酸及其酯的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2185383A (en) * | 1937-04-28 | 1940-01-02 | Charles Pflzer & Company | Preparation of levo-ascorbic acid |
| GB601789A (en) | 1943-08-04 | 1948-05-12 | Tno | Process for producing ascorbic acid from derivatives of l-keto-2 gulonic acid |
| US2462251A (en) * | 1945-05-16 | 1949-02-22 | Merck & Co Inc | Process for preparing ascorbic acids |
| CH490368A (fr) | 1968-02-01 | 1970-05-15 | Politechnika Slaska Im Wincent | Procédé de production de vitamine C |
| DD141832A1 (de) * | 1978-10-31 | 1980-05-21 | Joachim Schmidt | Verfahren und vorrichtung zur herstellung von l-ascorbinsaeure |
| JPS58177986A (ja) | 1982-04-09 | 1983-10-18 | Shionogi & Co Ltd | Ｌ−アスコルビン酸の製造方法 |
| CN86105960A (zh) | 1985-08-09 | 1987-05-13 | 鲁布里佐尔公司 | 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸 |
| JPH086662B2 (ja) | 1989-02-10 | 1996-01-29 | 日野自動車工業株式会社 | ディーゼルエンジンのカーボンフラワー除去装置 |
| FR2648136B1 (fr) | 1989-06-12 | 1994-06-17 | Rhone Poulenc Sante | Procede de preparation de l'acide ascorbique |
| EP0671405A1 (de) | 1994-01-18 | 1995-09-13 | F. Hoffmann-La Roche Ag | Herstellung von 2-Keto-L-gulonsäureestern |
| DE19547073C1 (de) | 1995-12-16 | 1996-11-14 | Merck Patent Gmbh | Verfahren zur Herstellung von Ascorbinsäure |
| WO1999003853A1 (de) * | 1997-07-16 | 1999-01-28 | Enco Engineering Chur Ag | Verfahren zur herstellung von ascorbat |
| DE19734086C1 (de) * | 1997-08-07 | 1998-08-13 | Merck Patent Gmbh | Verfahren zur Herstellung von L-Ascorbinsäure |
-
2000
- 2000-05-10 DE DE10022518A patent/DE10022518A1/de not_active Withdrawn
-
2001
- 2001-05-03 ES ES01931684T patent/ES2227187T3/es not_active Expired - Lifetime
- 2001-05-03 JP JP2001582312A patent/JP2003533452A/ja not_active Withdrawn
- 2001-05-03 US US10/275,565 patent/US6617463B2/en not_active Expired - Fee Related
- 2001-05-03 AU AU58391/01A patent/AU5839101A/en not_active Abandoned
- 2001-05-03 WO PCT/EP2001/004961 patent/WO2001085711A1/de not_active Ceased
- 2001-05-03 DE DE50103770T patent/DE50103770D1/de not_active Expired - Fee Related
- 2001-05-03 PT PT01931684T patent/PT1280788E/pt unknown
- 2001-05-03 DK DK01931684T patent/DK1280788T3/da active
- 2001-05-03 EP EP01931684A patent/EP1280788B1/de not_active Expired - Lifetime
- 2001-05-03 CN CNB018091423A patent/CN1174972C/zh not_active Expired - Fee Related
- 2001-05-03 AT AT01931684T patent/ATE277030T1/de not_active IP Right Cessation
- 2001-05-03 BR BR0110657-0A patent/BR0110657A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5839101A (en) | 2001-11-20 |
| US6617463B2 (en) | 2003-09-09 |
| DE10022518A1 (de) | 2001-11-15 |
| PT1280788E (pt) | 2005-02-28 |
| EP1280788B1 (de) | 2004-09-22 |
| EP1280788A1 (de) | 2003-02-05 |
| WO2001085711A1 (de) | 2001-11-15 |
| ATE277030T1 (de) | 2004-10-15 |
| US20030100771A1 (en) | 2003-05-29 |
| JP2003533452A (ja) | 2003-11-11 |
| DK1280788T3 (da) | 2004-10-18 |
| CN1427833A (zh) | 2003-07-02 |
| DE50103770D1 (de) | 2004-10-28 |
| ES2227187T3 (es) | 2005-04-01 |
| CN1174972C (zh) | 2004-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO DA RPI 2016 DE 25/08/2009. |