BR0112082A - Formas polimórficas/hidratos do dicloridrato de n-[4-(3cloro-4-fluorofenilamino)-7-(3-morfolin-4-ilpro póxi)-quinazolin-6-il)-acrilamida - Google Patents

Formas polimórficas/hidratos do dicloridrato de n-[4-(3cloro-4-fluorofenilamino)-7-(3-morfolin-4-ilpro póxi)-quinazolin-6-il)-acrilamida

Info

Publication number
BR0112082A
BR0112082A BR0112082-4A BR0112082A BR0112082A BR 0112082 A BR0112082 A BR 0112082A BR 0112082 A BR0112082 A BR 0112082A BR 0112082 A BR0112082 A BR 0112082A
Authority
BR
Brazil
Prior art keywords
fluorophenylamino
quinazolin
chloro
ylpropoxy
morpholin
Prior art date
Application number
BR0112082-4A
Other languages
English (en)
Inventor
Hubert Barth
Klaus Steiner
Simon Schneider
Dietmar Huels
Andreas Muehlenfeld
Manfred Westermayer
Original Assignee
Goedecke Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Gmbh filed Critical Goedecke Gmbh
Publication of BR0112082A publication Critical patent/BR0112082A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"FORMAS POLIMóRFICAS/HIDRATOS DO DICLORIDRATO DE N-[4-(3-CLORO-4-FLUOROFENILAMINO)-7-(3-MORFOLIN-4-ILPR OPóXI)-QUINAZOLIN-6-IL)-ACRILAMIDA". São descritas formas polimórficas/hidratos do dicloridrato a partir da base livre N-[4-(3-cloro-4-fluorofenilamino)-7-(3-morfolin-4-ilpropóxi)-quinazolin- 6-il)-acrilamida, processos para a preparação dos mesmos, bem como o uso dos mesmos para a preparação de um medicamento com ação irreversível de inibição da tirosina quinase.
BR0112082-4A 2000-06-30 2001-06-15 Formas polimórficas/hidratos do dicloridrato de n-[4-(3cloro-4-fluorofenilamino)-7-(3-morfolin-4-ilpro póxi)-quinazolin-6-il)-acrilamida BR0112082A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031971A DE10031971A1 (de) 2000-06-30 2000-06-30 Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung
PCT/EP2001/006733 WO2002000630A1 (en) 2000-06-30 2001-06-15 Polymorphic forms/hydrates of n-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride

Publications (1)

Publication Number Publication Date
BR0112082A true BR0112082A (pt) 2003-05-06

Family

ID=7647397

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112082-4A BR0112082A (pt) 2000-06-30 2001-06-15 Formas polimórficas/hidratos do dicloridrato de n-[4-(3cloro-4-fluorofenilamino)-7-(3-morfolin-4-ilpro póxi)-quinazolin-6-il)-acrilamida

Country Status (40)

Country Link
US (1) US20040034022A1 (pt)
EP (1) EP1299363A1 (pt)
JP (1) JP2004501902A (pt)
KR (1) KR20030014403A (pt)
CN (1) CN1438994A (pt)
AP (1) AP2002002694A0 (pt)
AR (1) AR031854A1 (pt)
AU (1) AU2001283861A1 (pt)
BG (1) BG107352A (pt)
BR (1) BR0112082A (pt)
CA (1) CA2412535A1 (pt)
CZ (1) CZ20024037A3 (pt)
DE (1) DE10031971A1 (pt)
DZ (1) DZ3342A1 (pt)
EA (1) EA005294B1 (pt)
EC (1) ECSP024413A (pt)
EE (1) EE200200714A (pt)
GT (1) GT200100124A (pt)
HN (1) HN2001000134A (pt)
HR (1) HRP20021019A2 (pt)
HU (1) HUP0300900A3 (pt)
IL (1) IL152419A0 (pt)
IS (1) IS6596A (pt)
MA (1) MA26924A1 (pt)
MX (1) MXPA03000101A (pt)
NO (1) NO20026193L (pt)
NZ (1) NZ522001A (pt)
OA (1) OA12301A (pt)
PA (1) PA8520801A1 (pt)
PE (1) PE20020116A1 (pt)
PL (1) PL365127A1 (pt)
PY (1) PY0112947A (pt)
SK (1) SK17642002A3 (pt)
SV (1) SV2002000517A (pt)
TN (1) TNSN01090A1 (pt)
UA (1) UA73588C2 (pt)
UY (1) UY26803A1 (pt)
WO (1) WO2002000630A1 (pt)
YU (1) YU99802A (pt)
ZA (1) ZA200209717B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2204A (en) * 2004-05-06 2011-02-07 Warner Lambert Co 4-phenylamino-quinazolin-6-yl-amides.
DE102006000122A1 (de) * 2006-03-17 2007-09-20 Aug. Winkhaus Gmbh & Co. Kg Schlüssel für einen Schließzylinder und Schließzylinder für einen solchen Schlüssel
EP3395811B1 (en) * 2015-12-25 2020-05-13 Xuanzhu Pharma Co., Ltd. Crystals of quinazoline derivative and preparation method therefor
JP6717947B2 (ja) * 2015-12-25 2020-07-08 シュアンチュー ファーマ カンパニー，リミティド キナゾリン誘導体の結晶及びその調製方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3370340B2 (ja) * 1996-04-12 2003-01-27 ワーナー―ランバート・コンパニー チロシンキナーゼの不可逆的阻害剤
ES2188254T3 (es) * 1998-11-19 2003-06-16 Warner Lambert Co N-(4-(3-chloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quin azolin-6-il)-acrilamada, un inhibidor irreversible de tirosina quinasas.

Also Published As

Publication number Publication date
ZA200209717B (en) 2003-12-01
DE10031971A1 (de) 2002-01-10
NO20026193D0 (no) 2002-12-23
IS6596A (is) 2002-10-28
DZ3342A1 (fr) 2002-01-03
HUP0300900A3 (en) 2004-01-28
HUP0300900A2 (hu) 2003-10-28
US20040034022A1 (en) 2004-02-19
AR031854A1 (es) 2003-10-08
TNSN01090A1 (fr) 2005-11-10
HN2001000134A (es) 2001-09-11
MA26924A1 (fr) 2004-12-20
HRP20021019A2 (en) 2004-02-29
GT200100124A (es) 2002-06-27
EE200200714A (et) 2004-08-16
SV2002000517A (es) 2002-07-03
YU99802A (sh) 2005-11-28
PY0112947A (es) 2003-11-03
PE20020116A1 (es) 2002-02-27
NZ522001A (en) 2004-07-30
PA8520801A1 (es) 2003-06-30
KR20030014403A (ko) 2003-02-17
UY26803A1 (es) 2002-01-31
PL365127A1 (pl) 2004-12-27
BG107352A (bg) 2003-07-31
CA2412535A1 (en) 2002-01-03
AU2001283861A1 (en) 2002-01-08
AP2002002694A0 (en) 2002-12-31
MXPA03000101A (es) 2004-09-13
WO2002000630A1 (en) 2002-01-03
CZ20024037A3 (cs) 2004-01-14
SK17642002A3 (sk) 2004-05-04
UA73588C2 (en) 2005-08-15
IL152419A0 (en) 2003-05-29
ECSP024413A (es) 2003-03-31
EA200300094A1 (ru) 2003-04-24
JP2004501902A (ja) 2004-01-22
OA12301A (en) 2003-11-10
NO20026193L (no) 2003-01-27
EA005294B1 (ru) 2004-12-30
CN1438994A (zh) 2003-08-27
EP1299363A1 (en) 2003-04-09

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009.