BR0113461A - Compostos ou sais farmaceuticamente aceitáveis, composições farmacêuticas, método de tratamento de doença ou condição mediada por erab, hadh2 ou (beta)-amilóide em mamìferos, métodos de inibição ou modulação da atividade enzimática de erab ou hadh2 e método de tratamento de mal de alzheimer ou demência em mamìferos - Google Patents

Compostos ou sais farmaceuticamente aceitáveis, composições farmacêuticas, método de tratamento de doença ou condição mediada por erab, hadh2 ou (beta)-amilóide em mamìferos, métodos de inibição ou modulação da atividade enzimática de erab ou hadh2 e método de tratamento de mal de alzheimer ou demência em mamìferos

Info

Publication number
BR0113461A
BR0113461A BR0113461-2A BR0113461A BR0113461A BR 0113461 A BR0113461 A BR 0113461A BR 0113461 A BR0113461 A BR 0113461A BR 0113461 A BR0113461 A BR 0113461A
Authority
BR
Brazil
Prior art keywords
hadh2
erab
mammals
treating
disease
Prior art date
Application number
BR0113461-2A
Other languages
English (en)
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of BR0113461A publication Critical patent/BR0113461A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS OU SAIS FARMACEUTICAMENTE ACEITáVEIS, COMPOSIçõES FARMACêUTICAS, MéTODO DE TRATAMENTO DE DOENçA OU CONDIçãO MEDIADA POR ERAB, HADH2 OU <225>-AMILóIDE EM MAMìFEROS, MéTODOS DE INIBIçãO OU MODULAçãO DA ATIVIDADE ENZIMáTICA DE ERAB OU HADH2 E MéTODO DE TRATAMENTO DE MAL DE ALZHEIMER OU DEMêNCIA EM MAMìFEROS". São descritos compostos de pirazol representados pela fórmula (I). Os compostos de pirazol e composições farmacêuticas que os contêm podem ser utilizados na inibição da atividade de ERAB ou HADH2 e no tratamento de condições e doenças mediadas por ERAB, HADH2 ou <225>-amilóide.
BR0113461-2A 2000-08-18 2001-08-17 Compostos ou sais farmaceuticamente aceitáveis, composições farmacêuticas, método de tratamento de doença ou condição mediada por erab, hadh2 ou (beta)-amilóide em mamìferos, métodos de inibição ou modulação da atividade enzimática de erab ou hadh2 e método de tratamento de mal de alzheimer ou demência em mamìferos BR0113461A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22612300P 2000-08-18 2000-08-18
PCT/US2001/041795 WO2002016365A1 (en) 2000-08-18 2001-08-17 Pyrazole compounds, pharmaceutical compositions, and methods for modulating or inhibiting erab or hadh2 activity

Publications (1)

Publication Number Publication Date
BR0113461A true BR0113461A (pt) 2003-07-01

Family

ID=22847647

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113461-2A BR0113461A (pt) 2000-08-18 2001-08-17 Compostos ou sais farmaceuticamente aceitáveis, composições farmacêuticas, método de tratamento de doença ou condição mediada por erab, hadh2 ou (beta)-amilóide em mamìferos, métodos de inibição ou modulação da atividade enzimática de erab ou hadh2 e método de tratamento de mal de alzheimer ou demência em mamìferos

Country Status (14)

Country Link
US (2) US20020132319A1 (pt)
EP (2) EP1311511A1 (pt)
JP (2) JP2004506737A (pt)
AR (1) AR035486A1 (pt)
AU (1) AU2001296854A1 (pt)
BR (1) BR0113461A (pt)
CA (2) CA2354653A1 (pt)
GT (1) GT200100169A (pt)
HK (1) HK1046288A1 (pt)
MX (1) MXPA03001455A (pt)
PA (1) PA8525801A1 (pt)
PE (1) PE20020394A1 (pt)
UY (1) UY26895A1 (pt)
WO (1) WO2002016365A1 (pt)

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DE10221052A1 (de) * 2002-05-10 2003-12-04 Transmit Technologietransfer Wirkstoffe zu Therapie, Diagnostik und Prophylaxe von Erkrankungen, bei denen abnorme Proteinstrukturen auftreten
WO2004102151A2 (en) * 2003-05-06 2004-11-25 New Century Pharmaceuticals Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on therir albumin binding properties
EP1684705A4 (en) * 2003-11-03 2008-02-20 New Century Pharmaceuticals ALBUMIN BINDING FACILITIES FOR THE EVALUATION OF MEDICAMENTAL INTERACTION EFFECTS AND METHOD FOR ASSESSING OR DESIGNING MEDICAMENT BASED ON THEIR ALBUMIN BONDING PROPERTIES
WO2005117538A2 (en) * 2004-04-12 2005-12-15 The Trustees Of Columbia University In The City Of New York METHODS AND COMPOSITIONS FOR INHIBITING ABAD/Aβ PROTEIN INTERACTION
US9132135B2 (en) * 2004-09-24 2015-09-15 University Of Maryland, Baltimore Method of treating organophosphorous poisoning
CN101044200A (zh) * 2004-09-24 2007-09-26 巴尔的摩马里兰大学 治疗有机磷中毒的方法
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
TWI698436B (zh) 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
HK1248221A1 (zh) 2015-02-05 2018-10-12 Forma Therapeutics, Inc. 异噻唑啉酮类，吡唑并嘧啶酮类和吡咯并嘧啶酮作为泛蛋白特异性蛋白酶7抑制剂
HK1248220A1 (zh) 2015-02-05 2018-10-12 Forma Therapeutics, Inc. 喹唑啉酮和偶氮喹唑啉作为泛特丁胺蛋白酶7抑制剂
HK1248222A1 (zh) 2015-02-05 2018-10-12 Forma Therapeutics, Inc. 噻吩并嘧啶酮作为泛素特异性蛋白酶7抑制剂
US20250101026A1 (en) * 2022-01-25 2025-03-27 Board Of Regents Of The University Of Nebraska Functionalized Allopurinol Derivatives for Treatment of Alzheimer’s Disease

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Also Published As

Publication number Publication date
GT200100169A (es) 2002-05-16
US20020065292A1 (en) 2002-05-30
US20020132319A1 (en) 2002-09-19
MXPA03001455A (es) 2004-05-04
US6964957B2 (en) 2005-11-15
PE20020394A1 (es) 2002-06-21
CA2415182A1 (en) 2002-02-28
HK1046288A1 (en) 2003-01-03
AU2001296854A1 (en) 2002-03-04
EP1311511A1 (en) 2003-05-21
EP1223176A3 (en) 2002-10-23
AR035486A1 (es) 2004-06-02
JP2004506737A (ja) 2004-03-04
CA2354653A1 (en) 2002-02-18
JP2002360269A (ja) 2002-12-17
WO2002016365A1 (en) 2002-02-28
UY26895A1 (es) 2002-04-26
PA8525801A1 (es) 2002-08-29
EP1223176A2 (en) 2002-07-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2021 DE 29/09/2009.