BR0114513A - Suspensão coloidal, sólida pulverulento, processo de preparação do sólido pulverulento, processo de preparação da suspensão, produtos intermediários do processo e especialidade farmacêutica, nutricional, fitossanitária ou cosmética - Google Patents

Suspensão coloidal, sólida pulverulento, processo de preparação do sólido pulverulento, processo de preparação da suspensão, produtos intermediários do processo e especialidade farmacêutica, nutricional, fitossanitária ou cosmética

Info

Publication number
BR0114513A
BR0114513A BR0114513-4A BR0114513A BR0114513A BR 0114513 A BR0114513 A BR 0114513A BR 0114513 A BR0114513 A BR 0114513A BR 0114513 A BR0114513 A BR 0114513A
Authority
BR
Brazil
Prior art keywords
suspension
preparation process
powdery solid
insulin
pharmaceutical
Prior art date
Application number
BR0114513-4A
Other languages
English (en)
Inventor
Nathan Bryson
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Publication of BR0114513A publication Critical patent/BR0114513A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SUSPENSãO COLOIDAL, SóLIDO PULVERULENTO, PROCESSO DE PREPARAçãO DO SóLIDO PULVERULENTO, PROCESSO DE PREPARAçãO DA SUSPENSãO, PRODUTOS INTERMEDIáRIOS DO PROCESSO E ESPECIALIDADE FARMACêUTICA, NUTRICIONAL, FITOSSANITáRIA OU COSMéTICA". A presente invenção trata de uma suspensão de partículas de vetorização (PV) de princípios ativos (PA) hidrofílicos (insulina). Essas PV são à base de um copolímero dibloco polietileno glicol/poliaminoácido neutros hidrofóbicos poliAANO. Essas partículas de PEG/poliAANO estão associadas a um PA hidrofílico (insulina). A presente invenção trata ainda de um sólido pulverulento a partir do qual são provenientes as PV, bem como da preparação desse sólido e dessa suspensão de PV à base de PEG/poliAANO-insulina. Essa preparação consiste em copolimerizar os N-carboxi/anidridos de AANO, em presença de N-metilpirrolidona, de metanol e de PEG funcionalizado amina. Obtém-se PEG/AANO que é associado com a insulina. Precipita-se com o auxílio de água de maneira a obter as PV. Eventualmente, neutraliza-se, dialisa-se, concentra-se e elimina-se a água. é produzido assim um sólido pulverulento ou PV em suspensão carregado de insulina e preparadas especialidades farmacêuticas.
BR0114513-4A 2000-10-06 2001-10-01 Suspensão coloidal, sólida pulverulento, processo de preparação do sólido pulverulento, processo de preparação da suspensão, produtos intermediários do processo e especialidade farmacêutica, nutricional, fitossanitária ou cosmética BR0114513A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0012836A FR2814951B1 (fr) 2000-10-06 2000-10-06 Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation
PCT/FR2001/003028 WO2002028374A1 (fr) 2000-10-06 2001-10-01 Suspension colloidale de particules submicroniques de vectorisation de principes actifs hydrophiles (insuline) et leur mode de preparation

Publications (1)

Publication Number Publication Date
BR0114513A true BR0114513A (pt) 2003-10-21

Family

ID=8855104

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114513-4A BR0114513A (pt) 2000-10-06 2001-10-01 Suspensão coloidal, sólida pulverulento, processo de preparação do sólido pulverulento, processo de preparação da suspensão, produtos intermediários do processo e especialidade farmacêutica, nutricional, fitossanitária ou cosmética

Country Status (11)

Country Link
US (1) US20040048782A1 (pt)
EP (1) EP1322296A1 (pt)
JP (1) JP2004510729A (pt)
KR (1) KR20030048419A (pt)
CN (1) CN1468095A (pt)
AU (1) AU2001293939A1 (pt)
BR (1) BR0114513A (pt)
CA (1) CA2424981A1 (pt)
FR (1) FR2814951B1 (pt)
MX (1) MXPA03002977A (pt)
WO (1) WO2002028374A1 (pt)

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Publication number Priority date Publication date Assignee Title
EA200501422A1 (ru) * 2003-03-04 2006-04-28 Дзе Текнолоджи Девелопмент Компани Лтд. Длительнодействующая инъецируемая композиция инсулина и способы её изготовления и применения
FR2862541B1 (fr) * 2003-11-21 2007-04-20 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interferons et leurs applications therapeutiques
FR2862535B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee d'interleukines et leurs applications therapeutiques
JP4929567B2 (ja) * 2004-08-05 2012-05-09 コニカミノルタエムジー株式会社 ポリマーミセル含有製剤の製造方法
EP2067801A1 (en) * 2005-01-04 2009-06-10 Intezyne Technologies Incorporated Synthesis of Hybrid Block Copolymers
US20110124840A1 (en) * 2005-02-11 2011-05-26 Kurt Breitenkamp Synthesis of Homopolymers and Block Copolymers
DE602006008625D1 (de) * 2005-04-01 2009-10-01 Intezyne Technologies Inc Polymermicellen für die arzneistoffzufuhr
JP2006321763A (ja) * 2005-05-20 2006-11-30 Hosokawa Funtai Gijutsu Kenkyusho:Kk 生体適合性ナノ粒子及びその製造方法
FR2904219B1 (fr) * 2006-07-28 2010-08-13 Flamel Tech Sa Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
WO2008026776A1 (en) * 2006-08-31 2008-03-06 Nanocarrier Co., Ltd. Transdermal composition, transdermal pharmaceutical composition and transdermal cosmetic composition comprising polymer micelle encapsulating active ingredient
KR20080095130A (ko) * 2007-04-23 2008-10-28 한국과학기술연구원 ｐＨ 민감성 블록공중합체를 이용한 약물전달체 제조 및응용
JP4653242B1 (ja) 2010-02-12 2011-03-16 ナノキャリア株式会社 粒子状医薬組成物
WO2013067022A1 (en) * 2011-10-31 2013-05-10 Xeris Pharmaceuticals, Inc. Formulations for the treatment of diabetes
US9957345B2 (en) 2014-08-18 2018-05-01 International Business Machines Corporation 3D printing with PHT based materials
US10023735B2 (en) 2014-08-18 2018-07-17 International Business Machines Corporation 3D printing with PHT/PHA based materials and polymerizable monomers
US9758620B2 (en) 2015-09-03 2017-09-12 International Business Machines Corporation Tailorable viscoelastic properties of PEG-hemiaminal organogel networks
US9873766B2 (en) 2015-11-24 2018-01-23 International Business Machines Corporation Systems chemistry approach to polyhexahydrotriazine polymeric structures
CN110483785B (zh) * 2019-07-01 2020-05-19 中山大学 一种三嵌段聚合物、载药纳米胶束、纳米药物及其制备方法和应用
FR3100248B1 (fr) * 2019-09-03 2022-01-07 Univ Bordeaux Procédé de préparation de polymères et copolymères contrôlés à base de peptides en solution aqueuse
CN113264997B (zh) * 2021-04-13 2023-07-04 康汉医药(广州)有限公司 一种蛋白药物在常温、高温条件下保存的方法
WO2025229946A1 (ja) * 2024-05-01 2025-11-06 国立大学法人筑波大学 （エチレングリコール）鎖とポリ（分岐鎖アミノ酸）鎖を含む親水－疎水性共重合体及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US5286495A (en) * 1992-05-11 1994-02-15 University Of Florida Process for microencapsulating cells
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
JP2690276B2 (ja) * 1995-01-10 1997-12-10 科学技術振興事業団 静電結合型高分子ミセル薬物担体とその薬剤
FR2732218B1 (fr) * 1995-03-28 1997-08-01 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation
FR2746035B1 (fr) * 1996-03-15 1998-06-12 Microparticules de gel composite susceptibles d'etre utilisees comme vecteur(s) de principe(s) actif(s), l'un de leurs procedes de preparation et leurs applications
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same

Also Published As

Publication number Publication date
WO2002028374A1 (fr) 2002-04-11
EP1322296A1 (fr) 2003-07-02
FR2814951A1 (fr) 2002-04-12
CN1468095A (zh) 2004-01-14
US20040048782A1 (en) 2004-03-11
CA2424981A1 (fr) 2002-04-11
MXPA03002977A (es) 2004-12-06
FR2814951B1 (fr) 2003-01-17
JP2004510729A (ja) 2004-04-08
KR20030048419A (ko) 2003-06-19
AU2001293939A1 (en) 2002-04-15

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]