BR0200341A - Bifenilsulfonamidas proveitosas como inibidores de metaloproteases da matriz - Google Patents
Bifenilsulfonamidas proveitosas como inibidores de metaloproteases da matrizInfo
- Publication number
- BR0200341A BR0200341A BR0200341-4A BR0200341A BR0200341A BR 0200341 A BR0200341 A BR 0200341A BR 0200341 A BR0200341 A BR 0200341A BR 0200341 A BR0200341 A BR 0200341A
- Authority
- BR
- Brazil
- Prior art keywords
- useful
- biphenylsulfonamides
- alkyl
- matrix metalloprotease
- inhibitors
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 2
- SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 cyclic sulfonamides Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"BIFENILSULFONAMIDAS PROVEITOSAS COMO INIBIDORES DE METALOPROTEASES DA MATRIZ". Os inibidores de enzimas MMP são sulfonamidas cíclicas de Fórmula I ou um seu sal farmaceuticamente aceitável, e sulfonamidas cíclicas de Fórmula III ou um seu sal farmaceuticamente aceitável, em que R^ 1^ e R^ 2^ incluem hidrogênio, alquila, e alquila substituído; R^ 3^ e R^ 4^ incluem hidrogênio, halogênio e alquila; X é OH ou NHOH. Os compostos de Fórmulas I e III são proveitosos para o tratamento de doenças mediadas por uma enzima MMP, incluindo o cancro, a osteoartrite, a artrite reumatóide, a insuficiência cardíaca e a inflamação.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26875501P | 2001-02-14 | 2001-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0200341A true BR0200341A (pt) | 2003-04-29 |
Family
ID=23024323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0200341-4A BR0200341A (pt) | 2001-02-14 | 2002-02-06 | Bifenilsulfonamidas proveitosas como inibidores de metaloproteases da matriz |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6686355B2 (pt) |
| EP (1) | EP1233016A1 (pt) |
| JP (1) | JP2002275168A (pt) |
| BR (1) | BR0200341A (pt) |
| CA (1) | CA2371480A1 (pt) |
| MX (1) | MXPA01013326A (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329680B2 (en) * | 2003-04-30 | 2008-02-12 | The Institute For Pharmaceutical Discovery, Llc | Heterocycle substituted carboxylic acids |
| US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
| US8492428B2 (en) | 2005-09-20 | 2013-07-23 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
| US7919519B2 (en) * | 2005-11-23 | 2011-04-05 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| EP1965807A4 (en) * | 2005-11-23 | 2010-10-27 | Epix Delaware Inc | S1P RECEPTOR MODULATING COMPOUNDS AND THEIR USE |
| TW200806633A (en) * | 2006-03-21 | 2008-02-01 | Epix Pharm Inc | S1P receptor modulating compounds and use thereof |
| US7652070B2 (en) * | 2007-04-02 | 2010-01-26 | Benjamin Rubin | Treatment method for MMP-implicated pathologies |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| MX2010002885A (es) | 2007-09-20 | 2010-04-01 | Amgen Inc | Derivados de acido 1-(4-(bencilbenzamido)-bencil)-azetidin-3-carbo xilico y compuestos relacionados como moduladores de receptores de s1p para el tratamiento de trastornos inmunitarios. |
| JPWO2009096198A1 (ja) * | 2008-02-01 | 2011-05-26 | 一般社団法人ファルマＩｐ | 新規ビアリール誘導体 |
| EP2149568A1 (en) | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| GB201018602D0 (en) | 2010-11-04 | 2010-12-22 | Vib Vzw | MMP8 inactivating antigen binding proteins |
| CA2828764A1 (en) * | 2011-03-03 | 2012-09-07 | Treventis Corporation | Anti-amyloid compounds and methods |
| CN103998435A (zh) | 2011-10-04 | 2014-08-20 | 法国国家健康医疗研究院 | 新型细胞凋亡诱导化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0821671T3 (da) | 1995-04-20 | 2001-04-23 | Pfizer | Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer |
| ES2233275T3 (es) | 1995-12-08 | 2005-06-16 | Agouron Pharmaceuticals, Inc. | Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas. |
| EE03965B1 (et) * | 1996-05-17 | 2003-02-17 | Warner-Lambert Company | Maatriksi metalloproteinaasi bifenüülsulfoonamiidinhibiitorid |
| DK0927168T3 (da) * | 1996-08-28 | 2003-03-10 | Procter & Gamble | 1,3-diheterocykliske metalloproteaseinhibitorer |
| US6008243A (en) | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| NZ334897A (en) | 1996-12-09 | 2001-02-23 | Warner Lambert Co | Medicaments for treating and preventing heart failure and ventricular dilatation |
| BR9807678A (pt) * | 1997-02-11 | 2000-02-15 | Pfizer | Derivados de ácidos arilsulfonil-hidroxâmicos |
| AU4925099A (en) | 1998-08-12 | 2000-03-06 | Pfizer Products Inc. | Tace inhibitors |
| EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
| US6934639B1 (en) | 2000-02-25 | 2005-08-23 | Wyeth | Methods for designing agents that interact with MMP-13 |
-
2001
- 2001-12-19 MX MXPA01013326A patent/MXPA01013326A/es active IP Right Grant
-
2002
- 2002-02-06 BR BR0200341-4A patent/BR0200341A/pt not_active IP Right Cessation
- 2002-02-08 EP EP02002814A patent/EP1233016A1/en not_active Withdrawn
- 2002-02-11 CA CA002371480A patent/CA2371480A1/en not_active Abandoned
- 2002-02-13 JP JP2002035616A patent/JP2002275168A/ja not_active Abandoned
- 2002-02-13 US US10/074,667 patent/US6686355B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020156074A1 (en) | 2002-10-24 |
| MXPA01013326A (es) | 2002-08-26 |
| EP1233016A1 (en) | 2002-08-21 |
| JP2002275168A (ja) | 2002-09-25 |
| US6686355B2 (en) | 2004-02-03 |
| CA2371480A1 (en) | 2002-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0200341A (pt) | Bifenilsulfonamidas proveitosas como inibidores de metaloproteases da matriz | |
| BR0015026A (pt) | Indóis substituìdos para a modulação da atividade de nfkb | |
| BR0307575A (pt) | Derivados de sulfonila como inibidores de histona desacetilase | |
| CY1111481T1 (el) | Υποκατεστημενα αρυλοκυκλοπροπυλακεταμιδια ως ενεργοποιητες γλυκοκινασης | |
| BR0208192A (pt) | Derivados espirotricìclicos e seu uso como inibidores da fosfodiesterase-7. | |
| BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
| NZ337298A (en) | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors | |
| BRPI0413152A (pt) | derivados de benzimidazol alquilado por n3 como inibidores de mek | |
| ATE361300T1 (de) | Derivate von heteroarylnitrilverbindungen | |
| BRPI0409227B8 (pt) | "composto, composição farmacêutica, uso de um composto e processo para a preparação de um composto de fórmula (i)" | |
| BR0210384A (pt) | Heteroarilas multicìclicas substituìdas por quinuclidinas para o tratamento de doença | |
| BRPI0407618A (pt) | derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização | |
| BR0010555A (pt) | Inibidores de neuraminidases | |
| DE50310516D1 (de) | Fredericamycin-derivate | |
| BR0002515A (pt) | Derivados de 4-arilpiperidina para o tratamento do prurido | |
| BR0313407A (pt) | Novo uso de derivados de benzotiazol | |
| AU2002215932A1 (en) | Nitroderivatives as drugs for diseases having an inflammatory basis | |
| BR0207278A (pt) | Derivados de ftalazinona-piperidina como inibidores de pde4 | |
| BRPI0518467A2 (pt) | derivado de Ácido antranÍlico, inibidor de produÇço de metaloprotease de matriz 13, e, agente terapÊutico para artrite reumatàide | |
| BRPI0410979A (pt) | composto, composição farmacêutica, e, métodos para tratar uma doença em um animal mediada pela catepsina s e para tratar um paciente submetido a uma terapia | |
| BRPI0512974A (pt) | novos derivados de hidantoìna para o tratamento de doenças obstrutivas das vias aéreas | |
| BR0315662A (pt) | Derivados de 1-(4-benzil-piperazin-1-il)-3-fenil-propenona | |
| AR012504A1 (es) | Utilizacion de derivados de tetrahidropiridina, para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan unadesmielinizacion. | |
| SE9903894D0 (sv) | Novel compounds | |
| NO20026014L (no) | Vitamin D-derivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1980 DE 16/12/2008. |