BR0207614A - Preparação medicinal aderente à mucosa uso de uma preparação aderente à mucosa e processo para ministração de uma subst ncia farmaceuticamente ativa - Google Patents
Preparação medicinal aderente à mucosa uso de uma preparação aderente à mucosa e processo para ministração de uma subst ncia farmaceuticamente ativaInfo
- Publication number
- BR0207614A BR0207614A BR0207614-4A BR0207614A BR0207614A BR 0207614 A BR0207614 A BR 0207614A BR 0207614 A BR0207614 A BR 0207614A BR 0207614 A BR0207614 A BR 0207614A
- Authority
- BR
- Brazil
- Prior art keywords
- adherent
- preparation
- mucosal
- active substance
- mucosa
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 230000001464 adherent effect Effects 0.000 abstract 4
- 210000004877 mucosa Anatomy 0.000 abstract 4
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 210000001124 body fluid Anatomy 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PREPARAçãO MEDICINAL ADERENTE à MUCOSA USO DE UMA PREPARAçãO ADERENTE à MUCOSA E PROCESSO PARA A MINISTRAçãO DE UMA SUBSTNCIA FARMACEUTICAMENTE ATIVA". A presente invenção refere-se a uma preparação medicinal aderente à mucosa para a ministração de uma substância ativa na medicina veterinária ou humana, contendo pelo menos uma substância ativa, a qual preparação está onde está uma matriz aderente à mucosa que se desintegra em um meio aquoso, a qual matriz contém pelo menos um polímero formador de matriz e onde pelo menos uma substância ativa é dissolvida ou dispersa, e em que a referida preparação se desintegra ou erode dentro de no máximo 15 minutos após a introdução em um meio aquoso ou fluidos corporais, ou em que a preparação inicialmente se torna um gel dentro de no máximo 15 minutos após a sua introdução em um meio aquoso ou em fluidos corporais, e se desintegra ou erode dentro de no máximo 30 minutos após a referida introdução.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10107659A DE10107659B4 (de) | 2001-02-19 | 2001-02-19 | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
| PCT/EP2002/001314 WO2002066016A2 (de) | 2001-02-19 | 2002-02-08 | Mucoadhäsive zerfallsfähige arzneizubereitung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207614A true BR0207614A (pt) | 2004-01-13 |
Family
ID=7674531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207614-4A BR0207614A (pt) | 2001-02-19 | 2002-02-08 | Preparação medicinal aderente à mucosa uso de uma preparação aderente à mucosa e processo para ministração de uma subst ncia farmaceuticamente ativa |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8906406B2 (pt) |
| EP (1) | EP1368004B1 (pt) |
| JP (2) | JP2004529101A (pt) |
| KR (1) | KR20030076687A (pt) |
| CN (1) | CN1599599A (pt) |
| AR (1) | AR033418A1 (pt) |
| AT (1) | ATE429213T1 (pt) |
| AU (1) | AU2002250904B2 (pt) |
| BR (1) | BR0207614A (pt) |
| CA (1) | CA2438651C (pt) |
| DE (2) | DE10107659B4 (pt) |
| DK (1) | DK1368004T3 (pt) |
| ES (1) | ES2328115T3 (pt) |
| MX (1) | MXPA03007434A (pt) |
| PT (1) | PT1368004E (pt) |
| WO (1) | WO2002066016A2 (pt) |
| ZA (1) | ZA200306563B (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US6887493B2 (en) * | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| DE10224612A1 (de) * | 2002-06-04 | 2003-12-24 | Lohmann Therapie Syst Lts | Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung |
| DE10251963A1 (de) * | 2002-11-08 | 2004-05-19 | Lts Lohmann Therapie-Systeme Ag | Transmucosale pharmazeutische Darreichungsform |
| DE10256774A1 (de) * | 2002-12-05 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Transmucosale und transdermale Arzneimittel mit verbesserter Wirkstoffresorption |
| US20040202698A1 (en) * | 2003-04-02 | 2004-10-14 | The Procter & Gamble Company | Drug delivery systems comprising an encapsulated active ingredient |
| DE102004017030A1 (de) * | 2004-04-02 | 2005-10-20 | Schering Ag | Flachkapseln |
| FI20041425A0 (fi) * | 2004-11-05 | 2004-11-05 | Orion Corp | Transmukosaalinen veterinäärinen koostumus |
| CA2591747A1 (en) * | 2004-12-23 | 2006-06-29 | Mcneil-Ppc, Inc. | Orally disintegrating pharmaceutical compositions with sensory cue agents |
| WO2007034287A2 (en) * | 2005-09-19 | 2007-03-29 | University Of The Witwatersrand, Johannesburg | Oramucosal pharmaceutical dosage form |
| WO2007079147A2 (en) * | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| KR101411100B1 (ko) * | 2006-01-23 | 2014-07-08 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. | 친지성 약물을 함유하는 나노캡슐을 포함하는 미소구체 |
| DE102006027795A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Raucherentwöhnungs-Kombinationswafer |
| DE102006027794A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antihypertonie-Kombinationswafer |
| EP2117354B1 (en) | 2006-12-18 | 2018-08-08 | Advanced BioNutrition Corp. | A dry food product containing live probiotic |
| FR2935084B1 (fr) * | 2008-08-19 | 2011-05-06 | Pancosma Sa Pour L Ind Des Produits Biochimiques | Additif pour l'alimentation animale et son procede de preparation |
| WO2010111565A2 (en) | 2009-03-27 | 2010-09-30 | Advanced Bionutrition Corporation | Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish |
| EP2435554B1 (en) | 2009-05-26 | 2017-07-26 | Advanced Bionutrition Corporation | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| PL2529004T3 (pl) | 2010-01-28 | 2017-12-29 | Advanced Bionutrition Corporation | Sucha szklista kompozycja zawierająca bioaktywny materiał |
| US9504750B2 (en) | 2010-01-28 | 2016-11-29 | Advanced Bionutrition Corporation | Stabilizing composition for biological materials |
| AR082682A1 (es) | 2010-08-13 | 2012-12-26 | Advanced Bionutrition Corp | Composicion estabilizadora de almacenamiento en seco para materiales biologicos |
| FR2972327B1 (fr) * | 2011-03-11 | 2017-08-11 | Laboratoires Le Stum | Composition nutraceutique mucoadhesive comprenant une association d'antioxydants |
| DE102014116903A1 (de) * | 2014-08-18 | 2016-02-18 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Cineolhaltige Zusammensetzung für die nasale Applikation |
| DE102014119576A1 (de) | 2014-12-23 | 2016-06-23 | Ernst-Moritz-Arndt-Universität Greifswald | Pharmazeutische Arzneimittelform zur Applikation auf Schleimhäuten |
| US12558395B2 (en) | 2015-07-29 | 2026-02-24 | Advanced Bionutrition Corp. | Stable dry probiotic compositions for special dietary uses |
| MY194231A (en) | 2015-07-29 | 2022-11-23 | Advanced Bionutrition Corp | Stable dry probiotic compositions for special dietary uses |
| DE102017112527B4 (de) * | 2017-06-07 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | Schnell zerfallende Schaumwafer mit hohem Flächengewicht |
| US20210161726A1 (en) | 2017-11-06 | 2021-06-03 | Besthealth4U Unipessoal Lda | Adhesion Materials and Methods of Manufacture |
| US12239893B2 (en) | 2018-01-31 | 2025-03-04 | Gary R. Krause | Speed-pong game |
| CA3155646A1 (en) * | 2019-09-24 | 2021-04-01 | Medisca Pharmaceutique Inc. | Gel base composition for compounding into a mucoadhesive delivery system |
| DE102021130950A1 (de) * | 2021-11-25 | 2023-05-25 | Lts Lohmann Therapie-Systeme Ag. | Applikationshilfe |
| CN116459268B (zh) * | 2023-03-29 | 2024-09-20 | 淄博维希尔生物技术有限公司 | 一种含替米考星的溶液组合物及其制备方法 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
| GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| US4175326A (en) * | 1977-10-26 | 1979-11-27 | Forsyth Dental Infirmary For Children | Hollow-fiber devices for and a method of the treament and diagnosis of oral diseases |
| GB2042888B (en) * | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
| US4329333A (en) | 1980-11-24 | 1982-05-11 | Arthur Barr | Method for the oral treatment of dogs and other animals |
| US4597959A (en) * | 1982-04-30 | 1986-07-01 | Arthur Barr | Sustained release breath freshener, mouth and palate coolant wafer composition and method of use |
| US5225196A (en) * | 1983-11-14 | 1993-07-06 | Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
| DE3681348D1 (de) * | 1985-06-11 | 1991-10-17 | Teijin Ltd | Oral-arzneizubereitung mit retardwirkung. |
| JP2702953B2 (ja) * | 1988-01-30 | 1998-01-26 | オリンパス光学工業株式会社 | 薬液含浸セラミックス |
| US4948580A (en) * | 1988-12-08 | 1990-08-14 | E. R. Squibb & Sons, Inc. | Muco-bioadhesive composition |
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| US5750136A (en) * | 1989-11-03 | 1998-05-12 | Riker Laboratories, Inc. | Bioadhesive composition and patch |
| US5558880A (en) * | 1989-12-22 | 1996-09-24 | Janssen Pharmaceutica Inc. | Pharmaceutical and other dosage forms |
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| BR9205864A (pt) * | 1991-04-08 | 1994-06-28 | Sumitomo Pharma | Formulações sólidas porosas contendo substâncias proteináceas fisiologicamente ativas. |
| IT1250421B (it) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive. |
| CA2133109A1 (en) * | 1992-03-30 | 1993-10-14 | Balgopal Gangadharan | Moisturizer |
| US6066337A (en) * | 1994-01-27 | 2000-05-23 | The Board Of Regents Of The University Of Oklahoma And Janssen Pharmaceutica, Inc. | Method for producing a rapidly dissolving dosage form |
| US5595761A (en) * | 1994-01-27 | 1997-01-21 | The Board Of Regents Of The University Of Oklahoma | Particulate support matrix for making a rapidly dissolving tablet |
| US5516522A (en) * | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| DE4419824A1 (de) | 1994-06-07 | 1995-12-14 | Lohmann Therapie Syst Lts | Volumen-expandierbares, als Wirkstoffträger insbesondere zur oralen Anwendung geeignete flächige Anwendungsform |
| US5639469A (en) * | 1994-06-15 | 1997-06-17 | Minnesota Mining And Manufacturing Company | Transmucosal delivery system |
| US5660848A (en) | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
| GB9517062D0 (en) * | 1995-08-18 | 1995-10-25 | Scherer Ltd R P | Pharmaceutical compositions |
| US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US5942243A (en) * | 1996-11-12 | 1999-08-24 | Polytherapeutics, Inc. | Mucoadhesive compositions for administration of biologically active agents to animal tissue |
| DE19652257A1 (de) * | 1996-12-16 | 1998-06-18 | Lohmann Therapie Syst Lts | Einzeln dosierte, bei Kontakt mit Flüssigkeit schnell zerfallende, wirkstoff- und insbesondere aromastoffhaltige, folienförmige Darreichnungsform |
| IT1289160B1 (it) * | 1997-01-08 | 1998-09-29 | Jagotec Ag | Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di |
| FR2766708B1 (fr) * | 1997-07-30 | 2000-05-05 | Galenix Dev | Composition contenant de l'hydroxypropylcellulose, de l'hydroxypropylmethylcellulose et/ou de l'ethylcellullose a titre d'agents desintegrants, et procede d'obtention |
| ATE204787T1 (de) | 1997-10-06 | 2001-09-15 | Adalbert Raps Stiftung | Verfahren zur herstellung eines pulverförmigen produktes aus einem flüssigen stoff oder stoffgemisch |
| US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| MXPA01003310A (es) * | 1998-10-02 | 2003-05-15 | 3M Innovative Properties Co | Sistema de suministro de farmaco originados en mucosa y aplicaciones animales. |
| WO2000035418A2 (en) * | 1998-12-18 | 2000-06-22 | Bayer Corporation | Chewable drug delivery system |
| US6635281B2 (en) * | 1998-12-23 | 2003-10-21 | Alza Corporation | Gastric retaining oral liquid dosage form |
| US6552024B1 (en) * | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| US6180682B1 (en) * | 1999-01-26 | 2001-01-30 | Virgil A. Place | Buccal drug delivery system for use in male contraception |
| US6231957B1 (en) * | 1999-05-06 | 2001-05-15 | Horst G. Zerbe | Rapidly disintegrating flavor wafer for flavor enrichment |
| US6284270B1 (en) * | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
| DE19954245A1 (de) | 1999-11-11 | 2001-07-19 | Lohmann Therapie Syst Lts | Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen |
| EP1246668B1 (en) | 1999-12-01 | 2005-11-30 | Natco Pharma Limited | An rapid acting freeze dired oral pharmaceutical composition for treating migraine |
| EP1120109A3 (en) * | 2000-01-24 | 2002-07-10 | Pfizer Products Inc. | Rapidly disintegrating and fast dissolving solid dosage form |
| KR100393478B1 (ko) * | 2000-03-29 | 2003-08-06 | 주식회사종근당 | 자가유화 매트릭스형 경점막·경피흡수제제 |
| DE10032456A1 (de) | 2000-07-04 | 2002-01-31 | Lohmann Therapie Syst Lts | Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen |
-
2001
- 2001-02-19 DE DE10107659A patent/DE10107659B4/de not_active Expired - Lifetime
-
2002
- 2002-02-08 KR KR10-2003-7010866A patent/KR20030076687A/ko not_active Ceased
- 2002-02-08 CA CA2438651A patent/CA2438651C/en not_active Expired - Lifetime
- 2002-02-08 DE DE50213479T patent/DE50213479D1/de not_active Expired - Lifetime
- 2002-02-08 BR BR0207614-4A patent/BR0207614A/pt not_active Application Discontinuation
- 2002-02-08 CN CNA028051734A patent/CN1599599A/zh active Pending
- 2002-02-08 ES ES02719783T patent/ES2328115T3/es not_active Expired - Lifetime
- 2002-02-08 AU AU2002250904A patent/AU2002250904B2/en not_active Ceased
- 2002-02-08 JP JP2002565576A patent/JP2004529101A/ja active Pending
- 2002-02-08 DK DK02719783T patent/DK1368004T3/da active
- 2002-02-08 AT AT02719783T patent/ATE429213T1/de active
- 2002-02-08 WO PCT/EP2002/001314 patent/WO2002066016A2/de not_active Ceased
- 2002-02-08 US US10/468,230 patent/US8906406B2/en not_active Expired - Fee Related
- 2002-02-08 PT PT02719783T patent/PT1368004E/pt unknown
- 2002-02-08 EP EP02719783A patent/EP1368004B1/de not_active Expired - Lifetime
- 2002-02-08 MX MXPA03007434A patent/MXPA03007434A/es active IP Right Grant
- 2002-02-15 AR ARP020100512A patent/AR033418A1/es unknown
-
2003
- 2003-08-22 ZA ZA200306563A patent/ZA200306563B/en unknown
-
2009
- 2009-05-27 JP JP2009127976A patent/JP2009185078A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1599599A (zh) | 2005-03-23 |
| HK1060055A1 (zh) | 2004-07-30 |
| PT1368004E (pt) | 2009-07-27 |
| AU2002250904B2 (en) | 2006-05-04 |
| MXPA03007434A (es) | 2003-11-18 |
| JP2009185078A (ja) | 2009-08-20 |
| DE10107659A1 (de) | 2002-09-05 |
| WO2002066016A2 (de) | 2002-08-29 |
| US20040081699A1 (en) | 2004-04-29 |
| KR20030076687A (ko) | 2003-09-26 |
| EP1368004B1 (de) | 2009-04-22 |
| EP1368004A2 (de) | 2003-12-10 |
| ES2328115T3 (es) | 2009-11-10 |
| WO2002066016A3 (de) | 2003-10-02 |
| DK1368004T3 (da) | 2009-08-17 |
| DE10107659B4 (de) | 2008-03-13 |
| CA2438651A1 (en) | 2002-08-29 |
| CA2438651C (en) | 2010-03-30 |
| ATE429213T1 (de) | 2009-05-15 |
| US8906406B2 (en) | 2014-12-09 |
| ZA200306563B (en) | 2004-02-10 |
| DE50213479D1 (de) | 2009-06-04 |
| AR033418A1 (es) | 2003-12-17 |
| JP2004529101A (ja) | 2004-09-24 |
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