BR0207698A - Adjuvante para uso em formulação de vacina, vacina, e, uso de um emulsificante polimérico - Google Patents

Adjuvante para uso em formulação de vacina, vacina, e, uso de um emulsificante polimérico

Info

Publication number
BR0207698A
BR0207698A BR0207698-5A BR0207698A BR0207698A BR 0207698 A BR0207698 A BR 0207698A BR 0207698 A BR0207698 A BR 0207698A BR 0207698 A BR0207698 A BR 0207698A
Authority
BR
Brazil
Prior art keywords
emulsifier
surfactants
low
vaccine
hlb
Prior art date
Application number
BR0207698-5A
Other languages
English (en)
Inventor
Theodorus T Jansen
Virgil Elisabeth Josep Schijns
Erick E Hermkens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of BR0207698A publication Critical patent/BR0207698A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

"ADJUVANTE PARA USO EM FORMULAçãO DE VACINA, VACINA, E, USO DE UM EMULSIFICANTE POLIMéRICO". A presente invenção proporciona adjuvantes, para uso em formulação de vacina, compreendendo uma emulsão de água-em-óleo, caracterizados pelo fato de que a citada emulsão compreende um emulsificante polimérico que é um copolímero em bloco possuindo a fórmula geral A-COO-B-OOC-A, na qual B é o resíduo divalente de um polialquileno-glicol solúvel em água e A é o resíduo de um ácido monocarboxílico complexo solúvel em óleo. Tal emulsificante polimérico, bem como sua preparação, têm sido descritos em GB 2.002.400 e WO9607689. Preferivelmente nos copolímeros em bloco de fórmula A-COO-B-OOC-A, o componente B é derivado de polietileno-glicol e os componentes A são derivados de poli(ácido hidróxi-esteárico), preferivelmente de poli(ácido 12-hidróxi-esteárico). Emulsificantes mais preferidos usados nos adjuvantes de acordo com a invenção são Arlacel P135, um Dipoli(hidróxi-estearato) de PEG 30. Outro emulsificante semelhante para utilização na invenção é ATLOX<32>4912. Ambos Arlacel P135 e ATLOX<32>4912 são copolímeros em bloco (A-B-A) de polietileno-glicol e ácido hidróxi-esteárico com um pelo molecular de aproximadamente 5.000 comercialmente disponível na ICI. Tem sido verificado que com o emprego destes emulsificantes adjuvantes baseados em emulsões de água-em-óleo que são estáveis e possuem viscosidade baixa podem ser obtidos os quais podem ser baseados em óleos metabolizáveis. Os citados adjuvantes possuem uma excelente atividade de adjuvante, e são bem tolerados.
BR0207698-5A 2001-02-28 2002-02-26 Adjuvante para uso em formulação de vacina, vacina, e, uso de um emulsificante polimérico BR0207698A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200745 2001-02-28
PCT/EP2002/002145 WO2002067899A1 (en) 2001-02-28 2002-02-26 Injectable water-in-oil emulsions

Publications (1)

Publication Number Publication Date
BR0207698A true BR0207698A (pt) 2004-04-20

Family

ID=8179948

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207698-5A BR0207698A (pt) 2001-02-28 2002-02-26 Adjuvante para uso em formulação de vacina, vacina, e, uso de um emulsificante polimérico

Country Status (13)

Country Link
US (1) US8496939B2 (pt)
EP (1) EP1367997B1 (pt)
JP (1) JP4057423B2 (pt)
AT (1) ATE438382T1 (pt)
AU (1) AU2002253085B2 (pt)
BR (1) BR0207698A (pt)
CA (1) CA2438692C (pt)
DE (1) DE60233206D1 (pt)
DK (1) DK1367997T3 (pt)
ES (1) ES2331058T3 (pt)
MX (1) MXPA03007766A (pt)
WO (1) WO2002067899A1 (pt)
ZA (1) ZA200306204B (pt)

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FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2860717B1 (fr) * 2003-10-13 2006-02-03 Ethypharm Sa Compositions de particules lipidiques solides monodisperses
FR2862536B1 (fr) * 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
US7485451B2 (en) * 2004-11-18 2009-02-03 Regents Of The University Of California Storage stable compositions of biological materials
FR2878746B1 (fr) * 2004-12-02 2007-02-23 Vetoquinol Sa Sa Nouvelle composition pharmaceutique utilisable dans le domaine des vaccins
FR2903602B1 (fr) * 2006-07-12 2012-10-26 Seppic Sa Formulation injectable a liberation prolongee de principes actifs, procede pour sa preparation
FR2910318B1 (fr) * 2006-12-20 2009-07-03 Flamel Technologies Sa Dispersion de polyaminoacides dans une phase lipidique continue.
SG193821A1 (en) 2008-08-29 2013-10-30 Boehringer Ingelheim Vetmed West nile virus vaccine
MX2011006788A (es) 2008-12-22 2012-09-28 Henkel Ag & Co Kgaa Limpiador a base de agua para la limpieza de pinturas a base de solventes.
AU2012229192B2 (en) 2011-03-14 2017-04-20 Boehringer Ingelheim Animal Health USA Inc. Equine Rhinitis vaccine
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WO2013174622A1 (en) 2012-05-21 2013-11-28 Basf Se Inverse dispersion comprising a cationic polymer and a stabilizing agent
EP2666789A1 (en) 2012-05-21 2013-11-27 Basf Se Inverse dispersion comprising an anionic or a nonionic polymer and a stabilizing agent
US9102900B2 (en) 2012-05-21 2015-08-11 Basf Se Inverse dispersion comprising a cationic polymer and a stabilizing agent
WO2016014743A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
WO2016014733A1 (en) 2014-07-23 2016-01-28 The Procter & Gamble Company Fabric and home care treatment compositions
CA2952985C (en) 2014-07-23 2020-04-28 The Procter & Gamble Company Fabric and home care treatment compositions
US10519402B2 (en) 2014-07-23 2019-12-31 The Procter & Gamble Company Treatment compositions
EP3172302B1 (en) 2014-07-23 2019-01-16 The Procter & Gamble Company Fabric and home care treatment compositions
EP3172300B1 (en) 2014-07-23 2018-12-26 The Procter and Gamble Company Fabric and home care treatment composition
EP3172307A1 (en) 2014-07-23 2017-05-31 The Procter and Gamble Company Treatment compositions
CN107072835B (zh) 2014-11-06 2021-03-02 宝洁公司 包括面向衣服的层合体的吸收制品
GB201506948D0 (en) 2015-04-23 2015-06-10 Croda Int Plc Emulsions for injectable formulations
US10689600B2 (en) 2016-01-25 2020-06-23 The Procter & Gamble Company Treatment compositions
MX2018009047A (es) 2016-01-25 2018-11-09 Procter & Gamble Composiciones de tratamiento.
EP3582733B1 (en) 2017-02-16 2022-08-17 The Procter & Gamble Company Absorbent articles with substrates having repeating patterns of apertures comprising a plurality of repeat units
US12127925B2 (en) 2018-04-17 2024-10-29 The Procter & Gamble Company Webs for absorbent articles and methods of making the same
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US12246090B2 (en) 2018-10-16 2025-03-11 Intervet Inc. Stable emulsions of bacterial antigens

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Also Published As

Publication number Publication date
MXPA03007766A (es) 2004-03-16
JP4057423B2 (ja) 2008-03-05
EP1367997A1 (en) 2003-12-10
ATE438382T1 (de) 2009-08-15
WO2002067899A1 (en) 2002-09-06
CA2438692A1 (en) 2002-09-06
CA2438692C (en) 2010-04-27
EP1367997B1 (en) 2009-08-05
DE60233206D1 (de) 2009-09-17
US20040071716A1 (en) 2004-04-15
DK1367997T3 (da) 2009-11-30
ES2331058T3 (es) 2009-12-21
ZA200306204B (en) 2004-09-09
AU2002253085B2 (en) 2006-03-09
US8496939B2 (en) 2013-07-30
JP2004523551A (ja) 2004-08-05

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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