BR0208513A - Processo de preparação de benazepril - Google Patents
Processo de preparação de benazeprilInfo
- Publication number
- BR0208513A BR0208513A BR0208513-5A BR0208513A BR0208513A BR 0208513 A BR0208513 A BR 0208513A BR 0208513 A BR0208513 A BR 0208513A BR 0208513 A BR0208513 A BR 0208513A
- Authority
- BR
- Brazil
- Prior art keywords
- benazepril
- preparation process
- preparation
- triflate
- ace
- Prior art date
Links
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 title abstract 3
- 229960004530 benazepril Drugs 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- ZJYKSSGYDPNKQS-LLVKDONJSA-N ethyl (2r)-2-hydroxy-4-phenylbutanoate Chemical compound CCOC(=O)[C@H](O)CCC1=CC=CC=C1 ZJYKSSGYDPNKQS-LLVKDONJSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
- XPDWGBQVDMORPB-UHFFFAOYSA-N trifluoromethane acid Natural products FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"PROCESSO DE PREPARAçãO DE BENAZEPRIL". A presente invenção se relaciona com um processo aperfeiçoado de preparação do éster trifluormetano sulfónico de etil(R)-2-hidroxi-4-fenil butirato, ora referido como triflate de Fórmula estrutural I e ao uso deste composto como intermediário na preparação do benazepril, que é inibidor de ACE (Enzima Conversora de Angiotensina - Angiotensin Converting Enzyme).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN374DE2001 | 2001-03-27 | ||
| PCT/IB2002/000764 WO2002076375A2 (en) | 2001-03-27 | 2002-03-14 | Process for the preparation of benazepril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0208513A true BR0208513A (pt) | 2004-10-26 |
Family
ID=32750417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0208513-5A BR0208513A (pt) | 2001-03-27 | 2002-03-14 | Processo de preparação de benazepril |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6919450B2 (pt) |
| EP (1) | EP1383741A4 (pt) |
| JP (1) | JP2004526735A (pt) |
| CN (1) | CN1585744A (pt) |
| BR (1) | BR0208513A (pt) |
| CA (1) | CA2442573A1 (pt) |
| RU (1) | RU2003131337A (pt) |
| WO (1) | WO2002076375A2 (pt) |
| ZA (1) | ZA200307494B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1829696A (zh) * | 2003-07-31 | 2006-09-06 | 兰贝克赛实验室有限公司 | 苯那普利的制备方法 |
| ATE425146T1 (de) * | 2005-05-12 | 2009-03-15 | Lupin Ltd | Verbessertes verfahren zur kristallisierung von benazeprilhydrochlorid |
| CN101511782B (zh) * | 2006-09-12 | 2013-08-07 | 和光纯药工业株式会社 | 磺酸酯的制造方法 |
| CN105061312B (zh) * | 2015-07-17 | 2017-12-12 | 惠州信立泰药业有限公司 | 一种改进的盐酸贝那普利的制备方法及含有该盐酸贝那普利的药物组合物 |
| CN113292495B (zh) * | 2021-06-18 | 2022-09-13 | 迪嘉药业集团有限公司 | 一种 (s)-氨基化合物的合成方法 |
| CN117538461B (zh) * | 2024-01-10 | 2024-03-26 | 地奥集团成都药业股份有限公司 | 一种盐酸贝那普利片有关物质的检测方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0072352B1 (de) | 1981-08-11 | 1986-03-05 | Ciba-Geigy Ag | Benzazepin-2-one, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese Verbindungen enthalten, sowie die Verbindungen zur therapeutischen Verwendung |
| US4410520A (en) | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| DE3303344A1 (de) | 1983-02-02 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern |
| DE3315464A1 (de) * | 1983-04-28 | 1984-10-31 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern |
| DE3328986A1 (de) * | 1983-08-11 | 1985-02-21 | Degussa Ag, 6000 Frankfurt | Verfahren zur praktisch stereospezifischen herstellung von optisch aktiven (alpha)-aminocarbonsaeureestern |
| US4785089A (en) * | 1985-06-13 | 1988-11-15 | Ciba-Geigy Corporation | Novel sulfonic acid esters and their preparation |
| JPH07113020B2 (ja) * | 1985-09-12 | 1995-12-06 | 三共株式会社 | ペルヒドロ―１，４―チアゼピン誘導体の製造法 |
-
2002
- 2002-03-14 CN CNA028091485A patent/CN1585744A/zh active Pending
- 2002-03-14 CA CA002442573A patent/CA2442573A1/en not_active Abandoned
- 2002-03-14 EP EP02703802A patent/EP1383741A4/en not_active Withdrawn
- 2002-03-14 WO PCT/IB2002/000764 patent/WO2002076375A2/en not_active Ceased
- 2002-03-14 JP JP2002574891A patent/JP2004526735A/ja active Pending
- 2002-03-14 US US10/472,811 patent/US6919450B2/en not_active Expired - Fee Related
- 2002-03-14 BR BR0208513-5A patent/BR0208513A/pt not_active Application Discontinuation
- 2002-03-14 RU RU2003131337/04A patent/RU2003131337A/ru not_active Application Discontinuation
-
2003
- 2003-09-26 ZA ZA200307494A patent/ZA200307494B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002076375A2 (en) | 2002-10-03 |
| CA2442573A1 (en) | 2002-10-03 |
| WO2002076375A3 (en) | 2003-11-06 |
| CN1585744A (zh) | 2005-02-23 |
| ZA200307494B (en) | 2004-09-03 |
| EP1383741A4 (en) | 2006-01-04 |
| RU2003131337A (ru) | 2005-05-10 |
| JP2004526735A (ja) | 2004-09-02 |
| US20040152889A1 (en) | 2004-08-05 |
| EP1383741A2 (en) | 2004-01-28 |
| US6919450B2 (en) | 2005-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |