BR0209028A - Método de transferência nuclear - Google Patents

Método de transferência nuclear

Info

Publication number
BR0209028A
BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
Authority
BR
Brazil
Prior art keywords
nuclear transfer
transfer method
relates
present
somatic cell
Prior art date
Application number
BR0209028-7A
Other languages
English (en)
Inventor
Ian Lewis
Gabor Vajta
Tayfur Tecirlioglu
Original Assignee
Univ Monash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Monash filed Critical Univ Monash
Publication of BR0209028A publication Critical patent/BR0209028A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
BR0209028-7A 2001-04-20 2002-04-19 Método de transferência nuclear BR0209028A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR4514A AUPR451401A0 (en) 2001-04-20 2001-04-20 A method of nuclear transfer
PCT/AU2002/000491 WO2002086103A1 (en) 2001-04-20 2002-04-19 A method of nuclear transfer

Publications (1)

Publication Number Publication Date
BR0209028A true BR0209028A (pt) 2005-05-31

Family

ID=3828509

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209028-7A BR0209028A (pt) 2001-04-20 2002-04-19 Método de transferência nuclear

Country Status (8)

Country Link
US (2) US20040177390A1 (pt)
JP (1) JP2004529648A (pt)
CN (1) CN1524121A (pt)
AU (1) AUPR451401A0 (pt)
BR (1) BR0209028A (pt)
CA (1) CA2444621A1 (pt)
NZ (1) NZ529007A (pt)
WO (1) WO2002086103A1 (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR047720A1 (es) * 2003-09-30 2006-02-15 Bio Sidus S A Un proceso para la obtencion de mamiferos transgenicos que produzcan proteinas exogenas en leche y los mamiferos producidos por dicho proceso
AU2006289468B2 (en) * 2005-09-08 2013-01-24 Aarhus Universitet Cell nuclear transfer
CN101580828B (zh) * 2009-05-06 2012-06-20 深圳华大基因科技有限公司 一种细胞核移植方法
CN101880689B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法
CN101880690B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法
CN102766655A (zh) * 2012-06-20 2012-11-07 中国农业科学院北京畜牧兽医研究所 一种生产体细胞克隆牛囊胚的方法
DK2986729T3 (en) 2013-04-16 2018-10-29 Regeneron Pharma TARGETED MODIFICATION OF ROOT THROUGH
WO2015088643A1 (en) 2013-12-11 2015-06-18 Regeneron Pharmaceuticals, Inc. Methods and compositions for the targeted modification of a genome
PT3080279T (pt) 2013-12-11 2018-12-17 Regeneron Pharma Métodos e composições para a modificação direcionada de um genoma
RU2704283C9 (ru) 2014-06-06 2020-02-07 Регенерон Фармасьютикалз, Инк. Способы и композиции для модификации целевого локуса
PT3161128T (pt) 2014-06-26 2018-11-21 Regeneron Pharma Métodos e composições para modificações genéticas alvejadas e métodos de utilização
CA2968440A1 (en) 2014-11-21 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification using paired guide rnas
BR112017013104A2 (pt) 2014-12-19 2018-05-15 Regeneron Pharmaceuticals, Inc. métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano.
AU2016233250C1 (en) 2015-03-16 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
EP3689139B1 (en) 2015-05-29 2025-01-01 Regeneron Pharmaceuticals, Inc. Rodent cells having a disruption in a c9orf72 locus
WO2017064715A1 (en) 2015-10-13 2017-04-20 Fertilesafe Ltd. Devices and methods for preparation of a biological sample for a cryoprocedure
US11617365B2 (en) * 2015-10-13 2023-04-04 Fertilesafe Ltd. Devices and methods for preparation of a biological sample for a cryoprocedure
SG11201806427WA (en) 2016-02-16 2018-08-30 Regeneron Pharma Non-human animals having a mutant kynureninase gene
US20170332610A1 (en) 2016-05-20 2017-11-23 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
KR20190041476A (ko) 2016-07-29 2019-04-22 리제너론 파마슈티칼스 인코포레이티드 C-절단된 피브릴린-1의 발현을 유도하는 돌연변이를 포함하는 마우스
EP3518667B1 (en) 2016-09-30 2024-10-30 Regeneron Pharmaceuticals, Inc. Rodents having a hexanucleotide repeat expansion in a c9orf72 locus
CN110461146A (zh) 2017-02-27 2019-11-15 再生元制药公司 视网膜劈裂的非人类动物模型
EP4484562A3 (en) 2017-06-27 2025-03-26 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized asgr1 locus
CN110891420B (zh) 2017-07-31 2022-06-03 瑞泽恩制药公司 Cas转基因小鼠胚胎干细胞和小鼠及其应用
CA3068072A1 (en) 2017-07-31 2019-02-07 Regeneron Pharmaceuticals, Inc. Methods and compositions for assessing crispr/cas-mediated disruption or excision and crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
JP2020530990A (ja) 2017-07-31 2020-11-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ｉｎ ｖｉｖｏでの外因性ドナー核酸とのＣＲＩＳＰＲ／Ｃａｓ誘導性組換えの評価
JP7139419B2 (ja) 2017-09-29 2022-09-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化ｔｔｒ遺伝子座を含む非ヒト動物および使用方法
ES2911249T3 (es) 2017-11-10 2022-05-18 Regeneron Pharma Animales no humanos que comprenden una mutación de slc30a8 y métodos de uso
IL274740B2 (en) 2017-11-30 2024-06-01 Regeneron Pharma Non-human animals comprising a humanized trkb locus
KR20240038811A (ko) 2018-03-19 2024-03-25 리제너론 파마슈티칼스 인코포레이티드 CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
WO2020056122A1 (en) 2018-09-13 2020-03-19 Regeneron Pharmaceuticals, Inc. Complement factor h gene knockout rat as a model of c3 glomerulopathy
US11690362B2 (en) 2018-12-20 2023-07-04 Regeneran Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
US11891618B2 (en) 2019-06-04 2024-02-06 Regeneron Pharmaceuticals, Inc. Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
JP7706380B2 (ja) 2019-06-27 2025-07-11 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔｄｐ－４３タンパク症のモデル化
CN110904034A (zh) * 2019-11-15 2020-03-24 芜湖职业技术学院 一种去除卵细胞细胞核的方法
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
CN111004775B (zh) * 2020-01-08 2023-05-02 中国医学科学院医学生物学研究所 一种物理性去除卵母细胞透明带的方法
CN115175559A (zh) 2020-01-28 2022-10-11 瑞泽恩制药公司 包含人源化pnpla3基因座的非人动物及其使用方法
WO2021158883A1 (en) 2020-02-07 2021-08-12 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized klkb1 locus and methods of use
EP4125348A1 (en) 2020-03-23 2023-02-08 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
US20230232796A1 (en) 2020-06-26 2023-07-27 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus
CN113061572A (zh) * 2021-04-21 2021-07-02 广西壮族自治区畜牧研究所 手工克隆程序中无透明带胚胎培养的微穴改进方法
US20250017183A1 (en) 2021-11-04 2025-01-16 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a modified cacng1 locus
US12582104B2 (en) 2021-12-08 2026-03-24 Regeneron Pharmaceuticals, Inc. Mutant myocilin disease model and uses thereof
EP4451863A1 (en) 2021-12-20 2024-10-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
CN114350600B (zh) * 2022-01-26 2023-08-18 中国农业大学 一种提高冷冻卵母细胞体外培育质量的培养液及其应用
EP4475671A1 (en) 2022-02-07 2024-12-18 Regeneron Pharmaceuticals, Inc. Compositions and methods for defining optimal treatment timeframes in lysosomal disease
CA3242729A1 (en) 2022-02-11 2023-08-17 Regeneron Pharmaceuticals, Inc. Compositions and methods for screening 4r tau targeting agents
US20250344681A1 (en) 2022-05-31 2025-11-13 Regeneron Pharmaceuticals, Inc. Animal model of tdp-43 proteinopathy
IL317261A (en) 2022-07-29 2025-01-01 Regeneron Pharma Non-human animals containing a modified transferrin receptor locus
KR20250044256A (ko) 2022-08-05 2025-03-31 리제너론 파마슈티칼스 인코포레이티드 Tdp-43의 응집 저항성 변이체
EP4593590A1 (en) 2022-09-29 2025-08-06 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
WO2024163650A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Animals comprising a modified klhdc7b locus
KR20260032927A (ko) 2023-06-30 2026-03-10 리제너론 파마슈티칼스 인코포레이티드 상동성 지향 복구를 증가시키는 방법 및 조성물
WO2025122754A1 (en) 2023-12-07 2025-06-12 Regeneron Pharmaceuticals, Inc. Gaa knockout non-human animals
WO2025250495A1 (en) 2024-05-28 2025-12-04 Regeneron Pharmaceuticals, Inc. Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ336493A (en) * 1997-01-02 2001-01-26 Univ Monash A method of oocyte enucleation and production of reconstituted embryos

Also Published As

Publication number Publication date
CA2444621A1 (en) 2002-10-31
WO2002086103A1 (en) 2002-10-31
US20080092249A1 (en) 2008-04-17
AUPR451401A0 (en) 2001-05-24
JP2004529648A (ja) 2004-09-30
NZ529007A (en) 2005-05-27
CN1524121A (zh) 2004-08-25
US20040177390A1 (en) 2004-09-09

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Legal Events

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

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B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2099 DE 29/03/2011.

B15K Others concerning applications: alteration of classification

Ipc: C12N 15/873 (2010.01)