BR0209028A - Método de transferência nuclear - Google Patents
Método de transferência nuclearInfo
- Publication number
- BR0209028A BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
- Authority
- BR
- Brazil
- Prior art keywords
- nuclear transfer
- transfer method
- relates
- present
- somatic cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000001082 somatic cell Anatomy 0.000 abstract 2
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 210000004940 nucleus Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR4514A AUPR451401A0 (en) | 2001-04-20 | 2001-04-20 | A method of nuclear transfer |
| PCT/AU2002/000491 WO2002086103A1 (en) | 2001-04-20 | 2002-04-19 | A method of nuclear transfer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209028A true BR0209028A (pt) | 2005-05-31 |
Family
ID=3828509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209028-7A BR0209028A (pt) | 2001-04-20 | 2002-04-19 | Método de transferência nuclear |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040177390A1 (pt) |
| JP (1) | JP2004529648A (pt) |
| CN (1) | CN1524121A (pt) |
| AU (1) | AUPR451401A0 (pt) |
| BR (1) | BR0209028A (pt) |
| CA (1) | CA2444621A1 (pt) |
| NZ (1) | NZ529007A (pt) |
| WO (1) | WO2002086103A1 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718845B2 (en) * | 2003-09-30 | 2010-05-18 | Sterrenbeld Biotechnologie North America, Inc. | Production of growth hormone in the milk of a transgenic bovine and methods of purification of the growth hormone from the milk |
| KR101383825B1 (ko) | 2005-09-08 | 2014-04-10 | 오르후스 우니베르시테트 | 세포 핵 이식 |
| CN101580828B (zh) * | 2009-05-06 | 2012-06-20 | 深圳华大基因科技有限公司 | 一种细胞核移植方法 |
| CN101880690B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法 |
| CN101880689B (zh) * | 2010-06-12 | 2012-12-19 | 中国科学院西北高原生物研究所 | 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法 |
| CN102766655A (zh) * | 2012-06-20 | 2012-11-07 | 中国农业科学院北京畜牧兽医研究所 | 一种生产体细胞克隆牛囊胚的方法 |
| SI2986729T1 (sl) | 2013-04-16 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Ciljana sprememba genoma podgane |
| KR102170502B1 (ko) | 2013-12-11 | 2020-10-28 | 리제너론 파마슈티칼스 인코포레이티드 | 게놈의 표적화된 변형을 위한 방법 및 조성물 |
| DK3080279T3 (en) | 2013-12-11 | 2018-11-05 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED MODIFICATION OF A GENOM |
| JP6688231B2 (ja) | 2014-06-06 | 2020-04-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 標的遺伝子座を修飾するための方法及び組成物 |
| SG10201911411YA (en) | 2014-06-26 | 2020-02-27 | Regeneron Pharma | Methods and compositions for targeted genetic modifications and methods of use |
| KR102531016B1 (ko) | 2014-11-21 | 2023-05-10 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
| NZ732895A (en) | 2014-12-19 | 2022-05-27 | Regeneron Pharma | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| BR112017019620A2 (pt) | 2015-03-16 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | ?roedor geneticamente modificado, célula ou tecido, métodos para produção de um roedor geneticamente modificado e de uma população de neurônios motores, métodos para seleção de um agente candidato para modular a disfunção neuronal motora e de um agente candidato para redução do estresse oxidativo em um neurônio motor, ácido nucleico, e, célula de roedor? |
| SG10201911257YA (en) | 2015-05-29 | 2020-01-30 | Regeneron Pharma | Non-human animals having a disruption in a c9orf72 locus |
| US11998003B2 (en) | 2015-10-13 | 2024-06-04 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
| US11617365B2 (en) * | 2015-10-13 | 2023-04-04 | Fertilesafe Ltd. | Devices and methods for preparation of a biological sample for a cryoprocedure |
| WO2017143062A1 (en) | 2016-02-16 | 2017-08-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a mutant kynureninase gene |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| EP3490373B1 (en) | 2016-07-29 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice comprising mutations resulting in expression of c-truncated fibrillin-1 |
| US10781453B2 (en) | 2016-09-30 | 2020-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus |
| US11064685B2 (en) | 2017-02-27 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of retinoschisis |
| IL319209A (en) | 2017-06-27 | 2025-04-01 | Regeneron Pharma | Non-human animals containing a humanized ASGR1 locus |
| SG11201912236YA (en) | 2017-07-31 | 2020-01-30 | Regeneron Pharma | Crispr reporter non-human animals and uses thereof |
| WO2019028029A1 (en) | 2017-07-31 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | EVALUATION OF CRISPR / CAS INDUCED RECOMBINATION WITH IN VIVO EXOGENIC DONOR NUCLEIC ACID |
| CA3067872A1 (en) | 2017-07-31 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | Cas-transgenic mouse embryonic stem cells and mice and uses thereof |
| SG11202000771UA (en) | 2017-09-29 | 2020-04-29 | Regeneron Pharma | Non-human animals comprising a humanized ttr locus and methods of use |
| ES2911249T3 (es) | 2017-11-10 | 2022-05-18 | Regeneron Pharma | Animales no humanos que comprenden una mutación de slc30a8 y métodos de uso |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化trkb遺伝子座を含む非ヒト動物 |
| CN111885915B (zh) | 2018-03-19 | 2023-04-28 | 瑞泽恩制药公司 | 使用crispr/cas系统对动物进行转录调制 |
| ES2974200T3 (es) | 2018-09-13 | 2024-06-26 | Regeneron Pharma | Rata nuligénica para el gen del factor H del complemento como modelo de glomerulopatía C3 |
| CN116064550A (zh) | 2018-12-20 | 2023-05-05 | 瑞泽恩制药公司 | 核酸酶介导的重复扩增 |
| ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
| AU2020286382B2 (en) | 2019-06-04 | 2026-03-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| JP7698587B2 (ja) | 2019-06-07 | 2025-06-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化アルブミン遺伝子座を含む非ヒト動物 |
| KR20220024134A (ko) | 2019-06-27 | 2022-03-03 | 리제너론 파마슈티칼스 인코포레이티드 | Tdp-43 단백질이상질환 모델링 |
| CN110904034A (zh) * | 2019-11-15 | 2020-03-24 | 芜湖职业技术学院 | 一种去除卵细胞细胞核的方法 |
| WO2021108363A1 (en) | 2019-11-25 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Crispr/cas-mediated upregulation of humanized ttr allele |
| CN111004775B (zh) * | 2020-01-08 | 2023-05-02 | 中国医学科学院医学生物学研究所 | 一种物理性去除卵母细胞透明带的方法 |
| KR20220133248A (ko) | 2020-01-28 | 2022-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 pnpla3 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| EP4099821A1 (en) | 2020-02-07 | 2022-12-14 | Regeneron Pharmaceuticals, Inc. | <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use |
| EP4125348A1 (en) | 2020-03-23 | 2023-02-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use |
| EP4171215A2 (en) | 2020-06-26 | 2023-05-03 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ace2 locus |
| CN113061572A (zh) * | 2021-04-21 | 2021-07-02 | 广西壮族自治区畜牧研究所 | 手工克隆程序中无透明带胚胎培养的微穴改进方法 |
| KR20240107104A (ko) | 2021-11-04 | 2024-07-08 | 리제너론 파마슈티칼스 인코포레이티드 | 변형된 cacng1 유전자좌를 포함하는 비인간 동물 |
| CA3238939A1 (en) | 2021-12-08 | 2023-06-15 | Gaurang Patel | Mutant myocilin disease model and uses thereof |
| US20250049006A1 (en) | 2021-12-20 | 2025-02-13 | C/O Regeneron Pharmaceuticals, Inc. | Non-human animals comprising humanized ace2 and tmprss loci |
| CN114350600B (zh) * | 2022-01-26 | 2023-08-18 | 中国农业大学 | 一种提高冷冻卵母细胞体外培育质量的培养液及其应用 |
| US20250194571A1 (en) | 2022-02-07 | 2025-06-19 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for defining optimal treatment timeframes in lysosomal disease |
| CA3242729A1 (en) | 2022-02-11 | 2023-08-17 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for screening 4r tau targeting agents |
| WO2023235677A1 (en) | 2022-05-31 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Animal model of tdp-43 proteinopathy |
| JP2025527122A (ja) | 2022-07-29 | 2025-08-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 改変型トランスフェリン受容体座位を含む非ヒト動物 |
| JP2025525745A (ja) | 2022-08-05 | 2025-08-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Tdp-43の凝集耐性バリアント |
| WO2024073679A1 (en) | 2022-09-29 | 2024-04-04 | Regeneron Pharmaceuticals, Inc. | Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes |
| KR20250144399A (ko) | 2023-02-01 | 2025-10-10 | 리제너론 파마슈티칼스 인코포레이티드 | 변형된 klhdc7b 유전자좌를 포함하는 동물 |
| AU2024309884A1 (en) | 2023-06-30 | 2025-12-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for increasing homology-directed repair |
| WO2025122754A1 (en) | 2023-12-07 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Gaa knockout non-human animals |
| WO2025250495A1 (en) | 2024-05-28 | 2025-12-04 | Regeneron Pharmaceuticals, Inc. | Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ336493A (en) * | 1997-01-02 | 2001-01-26 | Univ Monash | A method of oocyte enucleation and production of reconstituted embryos |
-
2001
- 2001-04-20 AU AUPR4514A patent/AUPR451401A0/en not_active Abandoned
-
2002
- 2002-04-19 CA CA002444621A patent/CA2444621A1/en not_active Abandoned
- 2002-04-19 NZ NZ529007A patent/NZ529007A/en unknown
- 2002-04-19 JP JP2002583618A patent/JP2004529648A/ja active Pending
- 2002-04-19 CN CNA028125819A patent/CN1524121A/zh active Pending
- 2002-04-19 US US10/475,168 patent/US20040177390A1/en not_active Abandoned
- 2002-04-19 WO PCT/AU2002/000491 patent/WO2002086103A1/en not_active Ceased
- 2002-04-19 BR BR0209028-7A patent/BR0209028A/pt not_active IP Right Cessation
-
2007
- 2007-06-08 US US11/808,383 patent/US20080092249A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040177390A1 (en) | 2004-09-09 |
| JP2004529648A (ja) | 2004-09-30 |
| CN1524121A (zh) | 2004-08-25 |
| CA2444621A1 (en) | 2002-10-31 |
| AUPR451401A0 (en) | 2001-05-24 |
| NZ529007A (en) | 2005-05-27 |
| WO2002086103A1 (en) | 2002-10-31 |
| US20080092249A1 (en) | 2008-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0209028A (pt) | Método de transferência nuclear | |
| BR0108713A (pt) | Expressão hìbrida de proteìnas de neisseria | |
| BR0010616A (pt) | Sequências de ácido nucléico a proteìnas envolvidas em sìntese de isoprenóide | |
| WO2005010670A3 (en) | Apparatus and method for direct memory access in a hub-based memory system | |
| HUP0105052A2 (hu) | Eljárások nukleinsav amplifikálására és szekvenálására | |
| BR0317265A (pt) | Métodos para produzir uma disposição de elementos micro-ópticos aberrados, uma disposição de cantos de cubo com divergência controlada, e para produzir um artigo que compreende uma disposição de cantos de cubo | |
| TW200700725A (en) | Detection of nucleic acid associated with disease | |
| BR9811657A (pt) | Clonagem usando-se núcleos doadores oriundos de células diferenciadas não-carentes de soro | |
| WO2003080816A3 (en) | Stem cell culture | |
| DK1161521T3 (da) | Transplantation af hæmatopoietiske celler | |
| WO2002014520A3 (en) | Process for inducing direct somatic embryogenesis and secondary embryogenesis in monocotyledonous plant cells, and rapidly regenerating fertile plants | |
| WO2006072046A3 (en) | Method for sex biasing of artificial insemination | |
| FR2812004B1 (fr) | Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons | |
| ATE365217T1 (de) | Nukelinsäuresequenzen für proteine, die an der tocopherolbiosynthese beteiligt sind | |
| BR0204359A (pt) | Trocador de calor com tanque plástico - conjunto de tanque coletor, lateral | |
| AU4985201A (en) | Human gene critical to fertility | |
| WO2001009282A3 (de) | Vorrichtung zum züchten und/oder behandeln von zellen | |
| BR0016531A (pt) | Método para produzir embriões clonados e adultos a partir de células cultivadas | |
| EP1295611A4 (en) | COMPOUNDS FOR THE TRANSFER OF OLIGONUCLEOTIDES (03.01.02) | |
| BR0209253A (pt) | Processo e dispositivo para a preparação de uma solução de acrilamida aquosa com um biocatalisador | |
| WO2003051927A3 (en) | Production of f(ab')2 fragments in mammalian cells | |
| BR0013959A (pt) | Clonagem de porcos usando células ou núcleos doadores a partir de células diferenciadas e produção de porcino pluripotente | |
| WO2001030980A3 (en) | Methods and compositions for enhancing developmental potential of oocytes and zygotes | |
| WO2003027290A1 (fr) | Procede pour conferer ou reguler la fertilite d'un cytoplasme a sterilite male de riz bt au moyen d'un gene de restauration de la fertilite, et procede d'estimation de la presence d'un gene de restauration de la fertilite | |
| IL169109A0 (en) | Method and system for utilizing somatic cell nuclear transfer embryos as cell donors for additional nuclear transfer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: APRESENTAR RELATORIO DESCRITIVO |
|
| B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] |
Free format text: COMPLEMENTAR 7A ANUIDADE DE ACORDO COM TABELA VIGENTE REFERENTE A GUIA 220805229806 E COMPROVAR RECOLHIMENTO DA 8A ANUIDADE. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI 2082 DE 30/11/2010. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2099 DE 29/03/2011. |
|
| B15K | Others concerning applications: alteration of classification |
Ipc: C12N 15/873 (2010.01) |