BR0211445A - Processo para a preparação de derivados de 3-espiro' cicloexan-1,3' - '3h! indolin - 2'- ona! - Google Patents

Processo para a preparação de derivados de 3-espiro' cicloexan-1,3' - '3h! indolin - 2'- ona!

Info

Publication number
BR0211445A
BR0211445A BR0211445-3A BR0211445A BR0211445A BR 0211445 A BR0211445 A BR 0211445A BR 0211445 A BR0211445 A BR 0211445A BR 0211445 A BR0211445 A BR 0211445A
Authority
BR
Brazil
Prior art keywords
formula
compound
indolin
derivatives
cyclohexan
Prior art date
Application number
BR0211445-3A
Other languages
English (en)
Inventor
Eva Csikos
Csaba Goenczi
Felix Hajdu
Istvan Hermecz
Gergely Heja
Gergelyne Heja
Csilla Majlath
Lajos Nagy
Andrea Santane Csutor
Tiborne Szomor
Gyoergyne Szvoboda
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0103122A external-priority patent/HU0103122D0/hu
Priority claimed from HU0202193A external-priority patent/HUP0202193A2/hu
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0211445A publication Critical patent/BR0211445A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE 3-ESPIRO<39>CICLOEXAN-1,3<39> - <39>H!INDOLIN - 2<39> - ONA!". A invenção está relacionada com um processo para a preparação de um composto de fórmula (I) pela reação de um composto de fórmula (II) com um composto de fórmula (III) caracterizada pela dissolução dos compostos de fórmula (II) e fórmula (III) em um solvente orgânico imiscível na água na presença de um catalisador de transferência de fase, reagindo com a.) uma solução aquosa de uma base, ou b.) uma base na forma sólida diretamente e se desejado transformando o composto de fórmula (I) dessa forma obtido no seu sal.
BR0211445-3A 2001-07-31 2002-07-25 Processo para a preparação de derivados de 3-espiro' cicloexan-1,3' - '3h! indolin - 2'- ona! BR0211445A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0103122A HU0103122D0 (en) 2001-07-31 2001-07-31 Chemical process chemical process chemical process
HU0202193A HUP0202193A2 (hu) 2002-07-04 2002-07-04 Eljárás egy spiro[ciklohexán-1,3'-[3'H]indolin]-2'-on-származék előállítására
PCT/HU2002/000075 WO2003011827A1 (en) 2001-07-31 2002-07-25 Process for the preparation of 3-spiro'cyclohexam-1,3'-'3h!indolin-2'-one! derivatives

Publications (1)

Publication Number Publication Date
BR0211445A true BR0211445A (pt) 2004-07-20

Family

ID=89980593

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211445-3A BR0211445A (pt) 2001-07-31 2002-07-25 Processo para a preparação de derivados de 3-espiro' cicloexan-1,3' - '3h! indolin - 2'- ona!

Country Status (15)

Country Link
US (1) US7619082B2 (pt)
EP (1) EP1421064B1 (pt)
JP (1) JP4520145B2 (pt)
CN (1) CN1243736C (pt)
AT (1) ATE295350T1 (pt)
BR (1) BR0211445A (pt)
CA (1) CA2453946C (pt)
DE (1) DE60204154T2 (pt)
DK (1) DK1421064T3 (pt)
ES (1) ES2240781T3 (pt)
HR (1) HRP20040200A2 (pt)
MX (1) MXPA04000949A (pt)
PL (1) PL205571B1 (pt)
PT (1) PT1421064E (pt)
WO (1) WO2003011827A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2740136B1 (fr) * 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
HU225150B1 (en) * 1999-07-15 2006-07-28 Sanofi Aventis Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride
HUP9902376A3 (en) * 1999-07-15 2002-11-28 Sanofi Aventis Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts

Also Published As

Publication number Publication date
HRP20040200A2 (en) 2005-06-30
CN1537099A (zh) 2004-10-13
US20040225124A1 (en) 2004-11-11
ATE295350T1 (de) 2005-05-15
PT1421064E (pt) 2005-08-31
CN1243736C (zh) 2006-03-01
PL367292A1 (en) 2005-02-21
JP2005501053A (ja) 2005-01-13
EP1421064A1 (en) 2004-05-26
DE60204154D1 (de) 2005-06-16
CA2453946C (en) 2008-12-09
WO2003011827A1 (en) 2003-02-13
DK1421064T3 (da) 2005-08-29
ES2240781T3 (es) 2005-10-16
EP1421064B1 (en) 2005-05-11
DE60204154T2 (de) 2006-01-19
PL205571B1 (pl) 2010-05-31
MXPA04000949A (es) 2004-06-25
JP4520145B2 (ja) 2010-08-04
US7619082B2 (en) 2009-11-17
CA2453946A1 (en) 2003-02-13

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS (FR)

Free format text: ALTERADO DE: SANOFI-SYNTHELABO

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012.