BR0212077A - Compostos de aminopirróis como agentes antiinflamatórios - Google Patents

Compostos de aminopirróis como agentes antiinflamatórios

Info

Publication number
BR0212077A
BR0212077A BR0212077-1A BR0212077A BR0212077A BR 0212077 A BR0212077 A BR 0212077A BR 0212077 A BR0212077 A BR 0212077A BR 0212077 A BR0212077 A BR 0212077A
Authority
BR
Brazil
Prior art keywords
compounds
inflammatory agents
aminopyrrole
diseases
aminopyrrole compounds
Prior art date
Application number
BR0212077-1A
Other languages
English (en)
Inventor
David Michael Goldstein
David Mark Rotstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0212077A publication Critical patent/BR0212077A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTOS DE AMINOPIRRóIS COMO AGENTES ANTIINFLAMATóRIOS". A presente invenção fornece um composto de aminopirrol da fórmula (I) uma sua pró-droga, um seu isómero individual, uma mistura de seus isómeros ou um seu sal farmaceuticamente aceitável, e métodos para preparar estes compostos e seu uso no tratamento de doenças, especialmente doenças inflamatórias.
BR0212077-1A 2001-08-30 2002-08-26 Compostos de aminopirróis como agentes antiinflamatórios BR0212077A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31616901P 2001-08-30 2001-08-30
PCT/EP2002/009505 WO2003020715A1 (en) 2001-08-30 2002-08-26 Aminopyrrole compounds as antiinflammatory agents

Publications (1)

Publication Number Publication Date
BR0212077A true BR0212077A (pt) 2004-09-28

Family

ID=23227809

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212077-1A BR0212077A (pt) 2001-08-30 2002-08-26 Compostos de aminopirróis como agentes antiinflamatórios

Country Status (16)

Country Link
US (1) US6696471B2 (pt)
EP (1) EP1423378B1 (pt)
JP (1) JP2005506324A (pt)
KR (1) KR20040029075A (pt)
CN (1) CN1281603C (pt)
AR (1) AR037140A1 (pt)
AT (1) ATE309239T1 (pt)
AU (1) AU2002331179B2 (pt)
BR (1) BR0212077A (pt)
CA (1) CA2458808A1 (pt)
DE (1) DE60207273T2 (pt)
ES (1) ES2252509T3 (pt)
MX (1) MXPA04001810A (pt)
PL (1) PL373115A1 (pt)
RU (1) RU2315045C2 (pt)
WO (1) WO2003020715A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US20080113016A1 (en) * 2004-07-26 2008-05-15 Gary Steven Firestein Method for Prevention or Treatment of Inflammatory Disease
CA2681420A1 (en) * 2007-03-20 2008-09-25 Cadila Pharmaceuticals Limited P38 inhibitors
EP3368052B1 (en) 2015-10-27 2021-12-08 Children's Hospital Medical Center Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and genetic manipulation
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071144A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
CA2260213C (en) 1996-07-11 2005-03-29 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
WO1998007425A1 (en) * 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
IL139169A0 (en) 1998-05-05 2001-11-25 Hoffmann La Roche Pyrazole derivatives as p-38 map kinase inhibitors
JP2002514640A (ja) * 1998-05-14 2002-05-21 ジー・ディー・サール・アンド・カンパニー ｐ３８キナーゼ阻害剤としての１，５−ジアリール置換ピラゾール類

Also Published As

Publication number Publication date
KR20040029075A (ko) 2004-04-03
DE60207273D1 (de) 2005-12-15
US20030130319A1 (en) 2003-07-10
EP1423378A1 (en) 2004-06-02
ATE309239T1 (de) 2005-11-15
RU2315045C2 (ru) 2008-01-20
CN1547578A (zh) 2004-11-17
JP2005506324A (ja) 2005-03-03
ES2252509T3 (es) 2006-05-16
CA2458808A1 (en) 2003-03-13
AR037140A1 (es) 2004-10-27
CN1281603C (zh) 2006-10-25
DE60207273T2 (de) 2006-07-20
PL373115A1 (en) 2005-08-08
MXPA04001810A (es) 2004-07-08
AU2002331179B2 (en) 2008-04-17
RU2004109817A (ru) 2005-10-20
WO2003020715A1 (en) 2003-03-13
US6696471B2 (en) 2004-02-24
EP1423378B1 (en) 2005-11-09

Similar Documents

Publication Publication Date Title
BR0210122A (pt) Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo
AR024060A1 (es) Nuevos compuestos farmaceuticamente activos
UY27740A1 (es) Nuevos compuestos
ECSP045483A (es) Derivados de heteroarilamida benzocondensada de tienopiridinas útiles como agentes terapéuticos, composiciones farmacéuticas que incluyen a los mismos, y métodos para su uso
BR9406979A (pt) Composto,composicão farmaceutica para tratar uma doenca inflamatória suscetivel de tratamento com um agente anti- inflamatório nao esteroidal processos para tratar uma doenca inflamatória e para preparar um composto sal famacéuticamente aceitável uso de um composto composicão farmaceutica anti-inflamatória nao esteroidal
PA8485601A1 (es) Azalidas de 13 miembros y su uso como agentes antibioticos.
BR0211119A (pt) Composto, método de tratar um paciente que tenha, ou de prevenir um paciente de pegar, uma doença ou condição, uso de um composto, e, método para fabricar um composto
MX340965B (es) Combinaciones para el tratamiento de enfermedades que involucran la proliferacion celular.
BR0210391A (pt) Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
WO2001019829A3 (en) Pyrazolopyrimidines as therapeutic agents
BRPI0412526A (pt) composto, uso de um composto, composição farmacêutica, formulação em aerossol farmacêutica, e, método para o tratamento de um paciente humano ou animal com uma condição anti-inflamatória e/ou alérgica
ECSP034732A (es) Derivado de fenetanolamina para el tratamiento de enfermedades respiratorias
BRPI0406883A (pt) Composto, composição farmacêutica, método de tratar um distúrbio, e, uso de um composto
PA8657201A1 (es) Compuestos de 3h-oxazolo y 3h-tiazolo [4, 5-d] pirimidin-2-ona 3, 5-disustituida y 3, 5, 7 - trisustituida y profarmacos de los mismos
BR0314052A (pt) Imidazolpiridinas e métodos para sua fabricação e uso
BRPI0517263A (pt) novos derivados de sulfonamida como moduladores do receptor de glicocorticóide para o tratamento de doenças inflamatórias
PT1404324E (pt) Formas de dosagem administradas oralmente de pró-fármacos análogas de gaba tendo toxicidade reduzida
ECSP055701A (es) Nuevos derivados de pirimidinamida y el uso de los mismos
UY27023A1 (es) Derivados de fenil cetonas sustituidas como antagonistas de ip
MA27129A1 (fr) Les pyrrolopyrimidines en tant qu'inhibiteurs du kinase de proteine.
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
BR0113590A (pt) 7-oxo-piridopirimidinas
BR0316458A (pt) Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto
PA8542901A1 (es) Uso de (z)-2-ciano-3-hidroxi-but-2-acido enoico-(4-trifluorometilfenil)-amida para tratar la esclerosis multiple
BR0210392A (pt) Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.