BR0212846A - Agentes antimicrobianos fotodinâmicos de porfirina - Google Patents

Agentes antimicrobianos fotodinâmicos de porfirina

Info

Publication number
BR0212846A
BR0212846A BR0212846-2A BR0212846A BR0212846A BR 0212846 A BR0212846 A BR 0212846A BR 0212846 A BR0212846 A BR 0212846A BR 0212846 A BR0212846 A BR 0212846A
Authority
BR
Brazil
Prior art keywords
porphyrins
porphyrin
antimicrobial agents
photodynamic
bacteria
Prior art date
Application number
BR0212846-2A
Other languages
English (en)
Inventor
Jerry Bommer
Giulio Jori
Original Assignee
Frontier Scient Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frontier Scient Inc filed Critical Frontier Scient Inc
Publication of BR0212846A publication Critical patent/BR0212846A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"AGENTES ANTIMICROBIANOS FOTODINâMICOS DE PORFIRINA". é descrita uma série de novas porfirinas positivamente carregadas que apresentam uma eficiência notavelmente maior na foto sensibilização de bactérias Gram positivas e Gram negativas à ação da luz visível, causando a morte de tais bactérias quando presentes em concentrações muito mais baixas e em tempos de irradiação muito mais curtos que as porfirinas descritas na técnica anterior. Tais porfirinas são caracterizadas pela presença de até quatro cargas positivas nos substituintes periféricos e pelo menos uma terminação hidrofóbica compreendendo entre 6 e 22 carbonos inclusive, com origem em um ou mais dos sítios carregados.
BR0212846-2A 2001-09-26 2002-06-26 Agentes antimicrobianos fotodinâmicos de porfirina BR0212846A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/964,286 US6573258B2 (en) 2000-09-27 2001-09-26 Photodynamic porphyrin antimicrobial agents
PCT/US2002/020148 WO2003026646A1 (en) 2001-09-26 2002-06-26 Photodynamic porphyrin antimicrobial agents

Publications (1)

Publication Number Publication Date
BR0212846A true BR0212846A (pt) 2004-10-13

Family

ID=25508357

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212846-2A BR0212846A (pt) 2001-09-26 2002-06-26 Agentes antimicrobianos fotodinâmicos de porfirina

Country Status (11)

Country Link
US (1) US6573258B2 (pt)
EP (1) EP1429758A4 (pt)
JP (1) JP4698948B2 (pt)
CN (1) CN1257712C (pt)
AU (1) AU2002322316B2 (pt)
BR (1) BR0212846A (pt)
CA (1) CA2459928C (pt)
IL (2) IL160743A0 (pt)
MX (1) MXPA04002783A (pt)
RU (1) RU2004109160A (pt)
WO (1) WO2003026646A1 (pt)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
JP2001521939A (ja) * 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
EP1155019B1 (en) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
JP2005508864A (ja) * 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
EP1513537A4 (en) * 2002-06-07 2006-09-06 Univ Duke Substituted porphyrins
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
EP1457113A1 (en) * 2003-03-12 2004-09-15 Salbert Co Ltd Alkylated porphyrins as pesticides acting both in the presence and absence of light
US20040259852A1 (en) * 2003-06-18 2004-12-23 White Hillary D. Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome
US8883769B2 (en) * 2003-06-18 2014-11-11 White Mountain Pharma, Inc. Methods for the treatment of fibromyalgia and chronic fatigue syndrome
US20080234182A1 (en) * 2007-03-22 2008-09-25 Innovative Biologics, Inc. Blockers of pore-forming virulence factors and their use as anti-infectives
JP2007538112A (ja) * 2004-01-29 2007-12-27 ピナクル ファーマシューティカルズ β−シクロデキストリン誘導体およびそれらの炭疽致死毒に対する使用
KR20060135922A (ko) * 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
CN1980661B (zh) * 2004-06-07 2011-09-28 耶达研究及发展有限公司 阳离子细菌叶绿素衍生物及其用途
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
JP2009510083A (ja) * 2005-09-28 2009-03-12 イノテック ファーマシューティカルズ コーポレイション Ｎ−ベンジル置換ピリジルポルフィリン化合物およびその使用方法
US20090030257A1 (en) * 2007-07-25 2009-01-29 Ceramoptec Industries Inc. Anti-microbial photodynamic therapy
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
JP2012504553A (ja) 2008-07-29 2012-02-23 フロンティア サイエンティフィック インコーポレイテッド 微生物の殺滅または増殖抑制のためのテトラキス（ｎ−アルキルピリジニウム）−ポルフィリン誘導体の使用
US8859760B2 (en) 2008-07-29 2014-10-14 Frontier Scientific, Inc. Compositions for killing or preventing the growth of microbes
EP2442641A4 (en) * 2009-06-16 2016-03-09 Univ Columbia METHOD FOR REDUCING SIDE EFFECTS OF THE TRANSFUSION OF AGED RED BLOOD CELLS
IT1402153B1 (it) 2010-10-08 2013-08-28 Uni Degli Studi Camerino Composizione comprendente un larvicida fotoattivabile
CN102167704B (zh) * 2011-03-20 2014-05-14 扬州大学 水溶性卟啉金（ⅲ）抗癌化合物及其制备方法
US8626106B2 (en) 2011-12-06 2014-01-07 Tensorcom, Inc. Method and apparatus of an input resistance of a passive mixer to broaden the input matching bandwidth of a common source/gate LNA
FR2987259B1 (fr) 2012-02-29 2014-02-21 Oreal Utilisation comme agent antipelliculaire de composes catalytiques d'oxydation choisi parmi les porphyrines, les phthalocyanines et les porphyrazines
JP2015522554A (ja) 2012-06-04 2015-08-06 サンコー・エナジー・インコーポレーテッド パラフィン油及び沈降防止剤を含む製剤
US20160286801A1 (en) 2013-03-15 2016-10-06 Suncor Energy Inc. Herbicidal Compositions
EP2835054A1 (en) 2013-08-05 2015-02-11 Nimartech Limited Porphyrinoid compounds, method and apparatus for water photodisinfection.
RU2549953C2 (ru) * 2013-12-25 2015-05-10 Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор для фотодинамической терапии
CN107072190B (zh) 2014-09-29 2020-10-09 弗莱德哈钦森癌症研究中心 使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法
US10111842B2 (en) * 2014-12-31 2018-10-30 University Of Oslo Eutectic solvents and uses thereof
CN104862373B (zh) * 2015-06-11 2018-01-02 河北工业大学 一种高通量筛选光动力抗菌光敏剂的方法
CN111194166A (zh) * 2017-08-16 2020-05-22 桑科能源股份有限公司 植物中微生物病原体的光动力学抑制
MX2021008944A (es) 2019-01-25 2021-08-24 Suncor Energy Inc Compuestos fotosensibilizadores, metodos de fabricacion y aplicacion a las plantas.
AU2020222515B2 (en) 2019-02-15 2025-10-09 Nutrien Ag Solutions (Canada) Inc. The use of protoporphyrin IX derivatives to improve the health of plants
MX2021009795A (es) * 2019-02-15 2021-09-08 Suncor Energy Inc Combinaciones de fotosensibilizador y agente quelante para usar como insecticidas.
BR102019014681A2 (pt) * 2019-07-16 2021-01-26 Universidade De São Paulo - Usp processo de obtenção de superfícies poliméricas funcionalizadas com fotossensibilizadores, material polimérico funcionalizado e seu uso
CN115006582B (zh) * 2022-07-18 2023-06-02 南通大学 一种抗炎抗氧化纳米敷料及其制备方法
CN116003820B (zh) * 2023-02-15 2023-12-19 山东大学 一种基于钯卟啉和三蝶烯的多孔有机聚合物及其制备方法与应用
CN117462673A (zh) * 2023-10-17 2024-01-30 河南大学 一种具有光热和光动力学性能的蠕虫状纳米卟啉共价有机框架在抗菌方面的应用
CN117327210B (zh) * 2023-12-01 2024-02-02 潍坊医学院 一种基于β-环糊精对苯二甲醛包合物的卟啉微孔复合材料及其制备方法和应用
CN119912460A (zh) * 2025-03-31 2025-05-02 上海光声制药有限公司 卟啉衍生物、其制备方法及其用于抑菌的用途

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JP3425111B2 (ja) * 2000-01-26 2003-07-07 科学技術振興事業団 イオン性ポルフィリン化合物

Also Published As

Publication number Publication date
US20030050296A1 (en) 2003-03-13
RU2004109160A (ru) 2005-03-10
IL160743A0 (en) 2004-08-31
WO2003026646A1 (en) 2003-04-03
IL160743A (en) 2010-02-17
US6573258B2 (en) 2003-06-03
JP2005505574A (ja) 2005-02-24
EP1429758A1 (en) 2004-06-23
AU2002322316B2 (en) 2006-07-13
CN1257712C (zh) 2006-05-31
CN1558760A (zh) 2004-12-29
CA2459928A1 (en) 2003-04-03
MXPA04002783A (es) 2005-04-08
JP4698948B2 (ja) 2011-06-08
EP1429758A4 (en) 2006-08-30
CA2459928C (en) 2010-03-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. A61K 31/409, 31/4439; C07D 487/22; A61P 31/04, 31/00

Ipc: A61K 31/409 (2011.01), A61K 31/4439 (2011.01), C07

B15V Prolongation of time limit allowed

Free format text: RECONHECIDO O OBSTACULO ADMINISTRATIVO E DEVOLVIDO O PRAZO DE 31 DIAS PARA CUMPRIMENTO DE EXIGENCIA, NOS TERMOS DO ARTIGO 221 PARAGRAFO 2O DA LPI E DA RESOLUCAO 116/04.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS ANUIDADES EM DEBITO.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2316 DE 26-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.