BR0215954A - Métodos de redução da possibilidade de mortalidade em um animal, de expressão virulenta em um patógeno intestinal, e da expressão de adesina / lectina pa-i em uma célula bacteriana, de inibição de expressão de adesina / lectina pa-i em um patógeno intestinal, de ativação induzida por intestino de adesina / lectina pa-i, de mudança morfológica induzida por c4-hsl de um patógeno intestinal, e de aderência de célula bacteriana em um intestino de mamìfero, de melhoria de patogênese intestinal, de prevenção de uma doença ou condição anormal, de infecção de pele e respiratória, de uma doença sexualmente transmitida, de um distúrbio de trato digestivo, de perda de capacidade lactante em um animal, e de desenvolvimento de um distúrbio epitelial mediado por micróbio em uma animal de idade de amamentação, de irrigação de pelo menos uma porção do trato urinário, e para monitoração da administração de poli (etileno-glicol) (peg) a um animal, composição farmacêutica, kits para a prevenção ou tratamento terapêutico de sepsia derivada de intestino, e para a monitoração da administração de poli (etileno-glicol), e, preservativo - Google Patents
Métodos de redução da possibilidade de mortalidade em um animal, de expressão virulenta em um patógeno intestinal, e da expressão de adesina / lectina pa-i em uma célula bacteriana, de inibição de expressão de adesina / lectina pa-i em um patógeno intestinal, de ativação induzida por intestino de adesina / lectina pa-i, de mudança morfológica induzida por c4-hsl de um patógeno intestinal, e de aderência de célula bacteriana em um intestino de mamìfero, de melhoria de patogênese intestinal, de prevenção de uma doença ou condição anormal, de infecção de pele e respiratória, de uma doença sexualmente transmitida, de um distúrbio de trato digestivo, de perda de capacidade lactante em um animal, e de desenvolvimento de um distúrbio epitelial mediado por micróbio em uma animal de idade de amamentação, de irrigação de pelo menos uma porção do trato urinário, e para monitoração da administração de poli (etileno-glicol) (peg) a um animal, composição farmacêutica, kits para a prevenção ou tratamento terapêutico de sepsia derivada de intestino, e para a monitoração da administração de poli (etileno-glicol), e, preservativoInfo
- Publication number
- BR0215954A BR0215954A BR0215954-6A BR0215954A BR0215954A BR 0215954 A BR0215954 A BR 0215954A BR 0215954 A BR0215954 A BR 0215954A BR 0215954 A BR0215954 A BR 0215954A
- Authority
- BR
- Brazil
- Prior art keywords
- animal
- adhesin
- lectin
- expression
- intestinal
- Prior art date
Links
- 229920001223 polyethylene glycol Polymers 0.000 title abstract 6
- 241001465754 Metazoa Species 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 206010040047 Sepsis Diseases 0.000 title abstract 4
- 208000035475 disorder Diseases 0.000 title abstract 4
- 244000000074 intestinal pathogen Species 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000012544 monitoring process Methods 0.000 title abstract 3
- 108090001090 Lectins Proteins 0.000 title 3
- 102000004856 Lectins Human genes 0.000 title 3
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 title 3
- 239000002523 lectin Substances 0.000 title 3
- 230000001580 bacterial effect Effects 0.000 title 2
- 210000000936 intestine Anatomy 0.000 title 2
- 206010057190 Respiratory tract infections Diseases 0.000 title 1
- 208000019802 Sexually transmitted disease Diseases 0.000 title 1
- 230000002159 abnormal effect Effects 0.000 title 1
- 230000004913 activation Effects 0.000 title 1
- 230000021164 cell adhesion Effects 0.000 title 1
- 230000006806 disease prevention Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 210000001035 gastrointestinal tract Anatomy 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000000968 intestinal effect Effects 0.000 title 1
- 230000002262 irrigation Effects 0.000 title 1
- 238000003973 irrigation Methods 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 230000004660 morphological change Effects 0.000 title 1
- 230000008506 pathogenesis Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 206010040872 skin infection Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000001635 urinary tract Anatomy 0.000 title 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
- 229930182816 L-glutamine Natural products 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 235000013350 formula milk Nutrition 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000011477 surgical intervention Methods 0.000 abstract 1
Classifications
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- Pharmacology & Pharmacy (AREA)
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- Virology (AREA)
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- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
"MéTODOS DE REDUçãO DA POSSIBILIDADE DE MORTALIDADE EM UM ANIMAL, DE EXPRESSãO VIRULENTA EM UM PATóGENO INTESTINAL, E DA EXPRESSãO DE ADESINA / LECTINA PA-I EM UMA CéLULA BACTERIANA, DE INIBIçãO DE EXPRESSãO DE ADESINA / LECTINA PA-I EM UM PATóGENO INTESTINAL, DE ATIVAçãO INDUZIDA POR INTESTINO DE ADESINA / LECTINA PA-I, DE MUDANçA MORFOLóGICA INDUZIDA POR C4-HSL DE UM PATóGENO INTESTINAL, E DE ADERêNCIA DE CéLULA BACTERIANA EM UM INTESTINO DE MAMìFERO, DE MELHORIA DE PATOGêNESE INTESTINAL, DE PREVENçãO DE UMA DOENçA OU CONDIçãO ANORMAL, DE INFECçãO DE PELE E RESPIRATóRIA, DE UMA DOENçA SEXUALMENTE TRANSMITIDA, DE UM DISTúRBIO DE TRATO DIGESTIVO, DE PERDA DE CAPACIDADE LACTANTE EM UM ANIMAL, E DE DESENVOLVIMENTO DE UM DISTúRBIO EPITELIAL MEDIADO POR MICRóBIO EM UMA ANIMAL DE IDADE DE AMAMENTAçãO, DE IRRIGAçãO DE PELO MENOS UMA PORçãO DO TRATO URINáRIO, E PARA MONITORAçãO DA ADMINISTRAçãO DE POLI(ETILENOGLICOL) (PEG) A UM ANIMAL, COMPOSIçãO FARMACêUTICA, KITS PARA A PREVENçãO OU TRATAMENTO TERAPêUTICO DE SEPSIA DERIVADA DE INTESTINO, E PARA A MONITORAçãO DA ADMINISTRAçãO DE POLI(ETILENO-GLICOL), E, PRESERVATIVO". A presente invenção proporciona composições farmacêuticas na forma de polímeros biocompatíveis de peso molecular relativamente alto tais como poli(etileno-glicol), opcionalmente suplementados com um polímero protetor tal como dextrano e/ou nutrientes patogênicos essenciais tal como L-glutamina. Também são proporcionados métodos para prevenir ou tratar sepsia derivada de intestino atribuível a patógenos intestinais tal como Pseudomonas aeruginosa pela administração de poli(etileno-glicol) de peso molecular alto bem como métodos para monitorar a administração de poli(etileno-glicol) de peso molecular alto, tal como em métodos de prevenção, melhoria ou tratamento de distúrbios epiteliais induzidos por micróbio, conforme exemplificados por sepsia derivada de intestino. Freq³entemente, a sepsia derivada de intestino decorre de uma complicação em mamíferos se recuperando de intervenção cirúrgica ou sofrendo de um distúrbio ou doença, proporcionando indicações de animais adequados para receberem tratamento preventivo. Finalmente, a invenção proporciona uma composição compreendendo fórmula infantil e poli(etileno-glicol) e métodos para usar esta composição.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/037948 WO2004047778A1 (en) | 2002-11-26 | 2002-11-26 | Materials and methods for preventing and treating microbe-mediated epithelial disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0215954A true BR0215954A (pt) | 2005-09-13 |
Family
ID=32391449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0215954-6A BR0215954A (pt) | 2002-11-26 | 2002-11-26 | Métodos de redução da possibilidade de mortalidade em um animal, de expressão virulenta em um patógeno intestinal, e da expressão de adesina / lectina pa-i em uma célula bacteriana, de inibição de expressão de adesina / lectina pa-i em um patógeno intestinal, de ativação induzida por intestino de adesina / lectina pa-i, de mudança morfológica induzida por c4-hsl de um patógeno intestinal, e de aderência de célula bacteriana em um intestino de mamìfero, de melhoria de patogênese intestinal, de prevenção de uma doença ou condição anormal, de infecção de pele e respiratória, de uma doença sexualmente transmitida, de um distúrbio de trato digestivo, de perda de capacidade lactante em um animal, e de desenvolvimento de um distúrbio epitelial mediado por micróbio em uma animal de idade de amamentação, de irrigação de pelo menos uma porção do trato urinário, e para monitoração da administração de poli (etileno-glicol) (peg) a um animal, composição farmacêutica, kits para a prevenção ou tratamento terapêutico de sepsia derivada de intestino, e para a monitoração da administração de poli (etileno-glicol), e, preservativo |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20060198817A1 (pt) |
| EP (1) | EP1567117B1 (pt) |
| JP (1) | JP5271475B2 (pt) |
| KR (1) | KR101087412B1 (pt) |
| CN (1) | CN100536836C (pt) |
| AT (1) | ATE544354T1 (pt) |
| AU (1) | AU2002352938B8 (pt) |
| BR (1) | BR0215954A (pt) |
| CA (1) | CA2507018C (pt) |
| DK (1) | DK1567117T3 (pt) |
| ES (1) | ES2381998T3 (pt) |
| PT (1) | PT1567117E (pt) |
| WO (1) | WO2004047778A1 (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006140784A (ru) * | 2004-04-20 | 2008-05-27 | Дзе Юниверсити Оф Чикаго (Us) | Терапевтическая система доставки, содержащая высокомолекулярное пэг-подобное соединение |
| GB2421908A (en) * | 2004-12-23 | 2006-07-12 | Univ College London Hospitals | Medicament for treatment of inflammatory diseases |
| RU2365376C2 (ru) * | 2005-05-23 | 2009-08-27 | Владимир Александрович Малыгин | Набор для лечения дисбактериоза и способ лечения |
| AU2006255274A1 (en) * | 2005-06-03 | 2006-12-14 | The University Of Chicago | Modulation of microbial pathogen-host cell interactions |
| WO2007101264A2 (en) * | 2006-02-28 | 2007-09-07 | The University Of Chicago | Method for treating endothelial and epithelial cell disorders by administering high molecular weight peg-like compounds |
| GB0612748D0 (en) * | 2006-06-27 | 2006-08-09 | Univ College London Hospitals | Treatment and/or prevention of inflammatory lung disease |
| WO2009036081A1 (en) * | 2007-09-10 | 2009-03-19 | University Of Kentucky Research Foundation | Systems and methods for diagnosis and monitoring of bacteria-related conditions |
| MX2011009988A (es) * | 2009-03-23 | 2011-11-18 | Univ Chicago | Metodos para la prevencion y el tratamiento de trastornos epiteliales inducidos por radiaciones. |
| ES2951828T3 (es) | 2010-09-23 | 2023-10-25 | Leading Biosciences Inc | Administración de inhibidores de serina proteasa al estómago |
| ES2804258T3 (es) | 2010-12-31 | 2021-02-05 | Abbott Lab | Procedimientos para reducir la incidencia de estrés oxidativo usando oligosacáridos de leche humana, vitamina C y agentes antiinflamatorios |
| CN107019701B (zh) | 2010-12-31 | 2020-07-28 | 雅培制药有限公司 | 使用人乳低聚糖来降低婴儿、幼儿或儿童的坏死性小肠结肠炎的发病率的方法 |
| WO2012149349A2 (en) * | 2011-04-27 | 2012-11-01 | Northshore University Healthsystem | Prophylaxis and treatment of enteropathogenic bacterial infection |
| EP2734210B1 (en) | 2011-07-22 | 2017-11-22 | Abbott Laboratories | Galactooligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract |
| CA2846603A1 (en) | 2011-08-29 | 2013-03-07 | Abbott Laboratories | Human milk oligosaccharides for preventing injury and/or promoting healing of the gastrointestinal tract |
| BR112014006175B1 (pt) * | 2011-09-16 | 2020-02-11 | Ucb Pharma S.A. | Anticorpos capazes de neutralisar as exotoxinas principais tcda e tcdb de clostridium difficile |
| CN103520202B (zh) * | 2012-07-02 | 2015-09-02 | 舒泰神（北京）生物制药股份有限公司 | 用于通便和清肠的药物组合物 |
| JP6275239B2 (ja) * | 2013-03-15 | 2018-02-07 | ミッドウェイ ファーマシューティカルズ， インコーポレイテッド | Ｈｍｗｐｅｇによる骨粗鬆症の管理 |
| ITPD20130133A1 (it) * | 2013-05-14 | 2014-11-15 | Sanypet S P A | Prodotto per l'alimentazione di cani affetti da disturbi infiammatori dell'intestino |
| EP3122349B1 (en) | 2014-03-25 | 2021-12-22 | Leading Biosciences, Inc. | Compositions for the treatment of autodigestion |
| EP4403222B1 (en) * | 2016-09-30 | 2025-11-19 | The University of Chicago | Phosphorylated tri-block copolymers with pathogen virulence-suppressing properties |
| CN109637293B (zh) * | 2019-02-16 | 2020-11-24 | 哈尔滨学院 | 一种用于蒲丰投针实验的数学概率演示装置 |
| EP3791885A1 (en) * | 2019-09-13 | 2021-03-17 | Consejo Superior de Investigaciones Cientificas (CSIC) | Polyethylene glycol for use in the prevention of abdominal inflammatory diseases and/or associated diseases |
| CN115531364B (zh) * | 2021-06-30 | 2024-02-23 | 中国科学技术大学 | 预防或治疗轮状病毒感染的微生物代谢物制剂及其用途 |
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| US3487150A (en) * | 1965-10-23 | 1969-12-30 | Cornell Res Foundation Inc | Dextran sulphate treatment of peptic ulcers |
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| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
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| US4659572A (en) * | 1985-04-15 | 1987-04-21 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Burn wound dressing material |
| USH1198H (en) * | 1985-04-26 | 1993-06-01 | Cetus Corporation | Pseudomonas aeruginosa type-specific human monoclonal antibodies, their preparation and use |
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| US4977137B1 (en) * | 1987-06-03 | 1994-06-28 | Baylor College Medicine | Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract |
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-
2002
- 2002-11-26 BR BR0215954-6A patent/BR0215954A/pt not_active Application Discontinuation
- 2002-11-26 EP EP02789898A patent/EP1567117B1/en not_active Expired - Lifetime
- 2002-11-26 AT AT02789898T patent/ATE544354T1/de active
- 2002-11-26 JP JP2004555237A patent/JP5271475B2/ja not_active Expired - Fee Related
- 2002-11-26 AU AU2002352938A patent/AU2002352938B8/en not_active Ceased
- 2002-11-26 DK DK02789898.0T patent/DK1567117T3/da active
- 2002-11-26 CN CNB028299604A patent/CN100536836C/zh not_active Expired - Fee Related
- 2002-11-26 WO PCT/US2002/037948 patent/WO2004047778A1/en not_active Ceased
- 2002-11-26 US US10/535,918 patent/US20060198817A1/en not_active Abandoned
- 2002-11-26 CA CA2507018A patent/CA2507018C/en not_active Expired - Fee Related
- 2002-11-26 PT PT02789898T patent/PT1567117E/pt unknown
- 2002-11-26 ES ES02789898T patent/ES2381998T3/es not_active Expired - Lifetime
- 2002-11-26 KR KR1020057009411A patent/KR101087412B1/ko not_active Expired - Fee Related
-
2015
- 2015-11-09 US US14/936,088 patent/US9549946B2/en not_active Expired - Fee Related
-
2016
- 2016-12-13 US US15/377,568 patent/US20170281668A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2507018A1 (en) | 2004-06-10 |
| WO2004047778A1 (en) | 2004-06-10 |
| EP1567117B1 (en) | 2012-02-08 |
| US20160129038A1 (en) | 2016-05-12 |
| JP5271475B2 (ja) | 2013-08-21 |
| CA2507018C (en) | 2014-03-25 |
| CN100536836C (zh) | 2009-09-09 |
| DK1567117T3 (da) | 2012-05-21 |
| PT1567117E (pt) | 2012-05-09 |
| AU2002352938A1 (en) | 2004-06-18 |
| AU2002352938B8 (en) | 2009-10-08 |
| AU2002352938B2 (en) | 2009-09-10 |
| EP1567117A4 (en) | 2009-07-08 |
| KR20050115855A (ko) | 2005-12-08 |
| ES2381998T3 (es) | 2012-06-04 |
| HK1081445A1 (zh) | 2006-05-19 |
| KR101087412B1 (ko) | 2011-11-25 |
| US9549946B2 (en) | 2017-01-24 |
| CN1697644A (zh) | 2005-11-16 |
| ATE544354T1 (de) | 2012-02-15 |
| US20170281668A1 (en) | 2017-10-05 |
| JP2006515837A (ja) | 2006-06-08 |
| EP1567117A1 (en) | 2005-08-31 |
| US20060198817A1 (en) | 2006-09-07 |
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