BR0309743A - Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados - Google Patents

Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados

Info

Publication number
BR0309743A
BR0309743A BR0309743-9A BR0309743A BR0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A
Authority
BR
Brazil
Prior art keywords
gamma
butyrolactams
preparation
amino acids
highly functionalized
Prior art date
Application number
BR0309743-9A
Other languages
English (en)
Inventor
Peter Garth Blazecka
James Guy Davidson Iii
Ji Zhang
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0309743A publication Critical patent/BR0309743A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE GAMA-BUTIROLACTAMAS E GAMA-AMINOáCIDOS ALTAMENTE FUNCIONALIZADOS". A presente invenção refere-se a um processo para a preparação de <sym>-butirolactamas e <sym>-aminoácidos altamente funcionalizados por aminação redutiva de ácido muco-hálico ou dos seus derivados, e descreve um processo para a preparação de pregabalina ou ácido 3-aminometil-5-metil-octanóico, análogos de GABA com atividade medicinal desejável (Fórmula I).
BR0309743-9A 2002-04-30 2003-04-17 Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados BR0309743A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37699102P 2002-04-30 2002-04-30
PCT/IB2003/001646 WO2003093220A1 (en) 2002-04-30 2003-04-17 Process for preparing highly functionalized y-butyrolactams and y-amino acids

Publications (1)

Publication Number Publication Date
BR0309743A true BR0309743A (pt) 2005-02-09

Family

ID=29401429

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309743-9A BR0309743A (pt) 2002-04-30 2003-04-17 Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados

Country Status (15)

Country Link
US (2) US20030225149A1 (pt)
EP (1) EP1499583A1 (pt)
JP (1) JP2005523932A (pt)
KR (1) KR20040106415A (pt)
CN (1) CN1649827A (pt)
AR (1) AR039467A1 (pt)
AU (1) AU2003219425A1 (pt)
BR (1) BR0309743A (pt)
CA (1) CA2483830A1 (pt)
IL (1) IL164781A0 (pt)
MX (1) MXPA04010771A (pt)
PL (1) PL373296A1 (pt)
RU (1) RU2004131840A (pt)
TW (1) TW200400929A (pt)
WO (1) WO2003093220A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
AP2466A (en) * 2004-06-21 2012-09-17 Warner Lambert Co Preparation of pregabalin and related compounds
KR20140066210A (ko) * 2004-08-04 2014-05-30 포움 서플라이즈 인코포레이션 폴리우레탄 폼에서의 반응도 변동 및 촉매 분해
US7417165B2 (en) * 2005-04-06 2008-08-26 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2006110783A2 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
KR20070067077A (ko) 2005-05-10 2007-06-27 테바 파마슈티컬 인더스트리즈 리미티드 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
WO2006122259A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
KR100893312B1 (ko) * 2005-05-10 2009-04-15 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린 및 이의 염의 제조 방법
CZ297970B6 (cs) * 2005-08-10 2007-05-09 Zentiva, A. S Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu)
WO2007035890A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP2071032A3 (en) * 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
WO2008118427A2 (en) * 2007-03-22 2008-10-02 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2008127646A2 (en) * 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
AU2008261076B2 (en) * 2007-06-05 2013-10-24 Akzo Nobel Coatings Inc. Radiation curable coating composition derived from epoxidized vegetable oils
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010100122A1 (en) 2009-03-05 2010-09-10 Akzo Nobel Coatings International B.V. Hydroxyl functional oil polyols and coating compositions prepared from hydroxyl functional oil polyols
WO2011086565A1 (en) * 2010-01-15 2011-07-21 Lupin Limited Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids
US20130280544A1 (en) 2010-12-28 2013-10-24 Akzo Nobel Coatings International B.V. Radiation curable coating compositions for metal
GB201121317D0 (en) 2011-12-09 2012-01-25 Syngenta Ltd Herbicidal compounds
US9273226B2 (en) 2011-12-21 2016-03-01 Akzo Nobel Coatings International B.V. Solvent-based coating compositions
ES2629692T3 (es) 2011-12-21 2017-08-14 Akzo Nobel Coatings International B.V. Composiciones de revestimiento basadas en agua
BR112015024859A2 (pt) * 2013-03-27 2017-10-10 Pfizer Ireland Pharmaceuticals processo e intermediários para a preparação de pregabalina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935210A (en) 1971-07-29 1976-01-27 Sandoz, Inc. Preparation of 1-aryl-4,5-dihalo-pyridazone-6
RU94046105A (ru) * 1992-05-20 1997-06-20 Нортвестерн Юниверсити (Us) АНАЛОГИ γ -АМИНОМАСЛЯНОЙ КИСЛОТЫ И L-ГЛУТАМИНОВОЙ КИСЛОТЫ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
DZ2770A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
US6306910B1 (en) 1998-07-09 2001-10-23 Warner-Lambert Company Use of Gaba-analogues for treating insomnia
CA2374755C (en) * 1999-06-10 2010-03-30 Warner-Lambert Company Mono- and disubstituted 3-propyl gamma-aminobutyric acids

Also Published As

Publication number Publication date
JP2005523932A (ja) 2005-08-11
TW200400929A (en) 2004-01-16
RU2004131840A (ru) 2005-05-27
MXPA04010771A (es) 2005-03-07
AU2003219425A1 (en) 2003-11-17
KR20040106415A (ko) 2004-12-17
US6924377B2 (en) 2005-08-02
AR039467A1 (es) 2005-02-23
IL164781A0 (en) 2005-12-18
US20030236415A1 (en) 2003-12-25
US20030225149A1 (en) 2003-12-04
CA2483830A1 (en) 2003-11-13
WO2003093220A1 (en) 2003-11-13
PL373296A1 (en) 2005-08-22
CN1649827A (zh) 2005-08-03
EP1499583A1 (en) 2005-01-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.

B08J Incorrect entry in the gazette republished [chapter 8.10 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2105 DE 10/05/2011. TEXTO CORRETO: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010.