BR0311308A - Briodina 1 modificada com imunogenicidade reduzida - Google Patents

Briodina 1 modificada com imunogenicidade reduzida

Info

Publication number
BR0311308A
BR0311308A BR0311308-6A BR0311308A BR0311308A BR 0311308 A BR0311308 A BR 0311308A BR 0311308 A BR0311308 A BR 0311308A BR 0311308 A BR0311308 A BR 0311308A
Authority
BR
Brazil
Prior art keywords
modified
reduced immunogenicity
briodine
brodine
immunogenic
Prior art date
Application number
BR0311308-6A
Other languages
English (en)
Inventor
Matthew Baker
Francis J Carr
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BR0311308A publication Critical patent/BR0311308A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"BRIODINA 1 MODIFICADA COM IMUNOGENICIDADE REDUZIDA". A presente invenção refere-se à modificação da briodina 1 para resultar em proteínas briodina 1 que são substancialmente não-imunogênicas ou menos imunogênicas que qualquer correspondente não modificado quando utilizadas in vivo. A invenção refere-se, além disso, a peptídeos de epitopos de células derivados da dita proteína não-modificada através dos quais é possível criar variações da briodina 1 modificada com imunogenicidade reduzida.
BR0311308-6A 2002-06-11 2003-06-10 Briodina 1 modificada com imunogenicidade reduzida BR0311308A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02012911 2002-06-11
PCT/EP2003/006055 WO2003103715A1 (en) 2002-06-11 2003-06-10 Modified byrodin 1 with reduced immunogenicity

Publications (1)

Publication Number Publication Date
BR0311308A true BR0311308A (pt) 2005-02-15

Family

ID=29724385

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311308-6A BR0311308A (pt) 2002-06-11 2003-06-10 Briodina 1 modificada com imunogenicidade reduzida

Country Status (13)

Country Link
US (1) US20060019885A1 (pt)
EP (1) EP1511519A1 (pt)
JP (1) JP2005535304A (pt)
KR (1) KR20050010898A (pt)
CN (1) CN1658905A (pt)
AU (1) AU2003274705A1 (pt)
BR (1) BR0311308A (pt)
CA (1) CA2489153A1 (pt)
MX (1) MXPA04012210A (pt)
PL (1) PL372202A1 (pt)
RU (1) RU2004139047A (pt)
WO (1) WO2003103715A1 (pt)
ZA (1) ZA200500219B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240145028A1 (en) * 2022-10-26 2024-05-02 Deargen Inc. Method For Data Augmentation Related To Target Protein

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1737961T3 (pl) * 2004-03-19 2013-12-31 Merck Patent Gmbh Zmodyfikowane białka bouganiny, cytotoksyny i sposoby oraz ich zastosowania
US11258531B2 (en) 2005-04-07 2022-02-22 Opanga Networks, Inc. System and method for peak flow detection in a communication network
US9065595B2 (en) 2005-04-07 2015-06-23 Opanga Networks, Inc. System and method for peak flow detection in a communication network
EP1915131A4 (en) * 2005-08-12 2012-07-25 Astrazeneca Ab PROCESS
TW200848039A (en) * 2007-02-09 2008-12-16 Astrazeneca Ab Pharmaceutical compositions
WO2014127211A1 (en) * 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541110A (en) * 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
WO1998052976A1 (en) * 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
EP1051432B1 (en) * 1998-12-08 2007-01-24 Biovation Limited Method for reducing immunogenicity of proteins
AU2002256624B2 (en) * 2001-02-19 2007-12-06 Merck Patent Gmbh Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240145028A1 (en) * 2022-10-26 2024-05-02 Deargen Inc. Method For Data Augmentation Related To Target Protein

Also Published As

Publication number Publication date
RU2004139047A (ru) 2006-01-20
MXPA04012210A (es) 2005-02-25
CA2489153A1 (en) 2003-12-18
ZA200500219B (en) 2005-10-27
CN1658905A (zh) 2005-08-24
EP1511519A1 (en) 2005-03-09
US20060019885A1 (en) 2006-01-26
AU2003274705A1 (en) 2003-12-22
JP2005535304A (ja) 2005-11-24
PL372202A1 (en) 2005-07-11
WO2003103715A1 (en) 2003-12-18
KR20050010898A (ko) 2005-01-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07K 14/415 (2006.01), A61K 38/00 (2006.01)