BR0311332A - Método para produção de material cristalino - Google Patents
Método para produção de material cristalinoInfo
- Publication number
- BR0311332A BR0311332A BR0311332-9A BR0311332A BR0311332A BR 0311332 A BR0311332 A BR 0311332A BR 0311332 A BR0311332 A BR 0311332A BR 0311332 A BR0311332 A BR 0311332A
- Authority
- BR
- Brazil
- Prior art keywords
- ultrasound
- solution
- sup
- vessel
- crystalline material
- Prior art date
Links
- 239000002178 crystalline material Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002604 ultrasonography Methods 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 3
- 108010011485 Aspartame Proteins 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
- B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0063—Control or regulation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T117/00—Single-crystal, oriented-crystal, and epitaxy growth processes; non-coating apparatus therefor
- Y10T117/10—Apparatus
- Y10T117/1024—Apparatus for crystallization from liquid or supercritical state
- Y10T117/1028—Crucibleless apparatus having means providing movement of discrete droplets or solid particles to thin-film precursor [e.g., Verneuil method]
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Disintegrating Or Milling (AREA)
- Transducers For Ultrasonic Waves (AREA)
Abstract
"MéTODO PARA PRODUçãO DE MATERIAL CRISTALINO". Um material cristalino suficientemente puro para uso em produtos farmacêuticos pode ser feito pela formação de uma solução saturada do material, alteração da temperatura da solução de modo que ela se torne supersaturada, e sujeição da solução a irradiação por ultra-som de alta intensidade, a freq³ência do ultra-som sendo explorada sobre uma faixa de freq³ências. Por exemplo, o ultra-som pode ser variado entre 19,5 e instalação de fio metálico de guia 20,5 kHz, e esta variação pode ser senoidal. Preferentemente, o ultra-som é provido apenas brevemente, a saber, por menos que 5 s, antes de permitir que a solução se resfrie gradualmente sem ulterior irradiação. O ultra-som pode ser aplicado usando um recipiente com uma disposição de transdutores ultra-sónicos fixados em uma parede, de modo que cada transdutor irradia não mais que 3 W/cm^ 2^, ainda a dissipação de energia dentro do recipiente é entre 25 e 150 W/Iitro. Este método pode reduzir a largura de zona metaestável para menos do que 10 K. O método é aplicável, em particular, para aspartame.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0212626.6A GB0212626D0 (en) | 2002-05-31 | 2002-05-31 | Production of crystalline ingredients |
| GB0302555A GB0302555D0 (en) | 2003-02-05 | 2003-02-05 | Production of Crystalline materials |
| PCT/GB2003/002017 WO2003101578A1 (en) | 2002-05-31 | 2003-05-13 | Production of crystalline materials by using high intensity ultrasound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0311332A true BR0311332A (pt) | 2005-03-15 |
Family
ID=29713390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0311332-9A BR0311332A (pt) | 2002-05-31 | 2003-05-13 | Método para produção de material cristalino |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7357835B2 (pt) |
| EP (1) | EP1509301B1 (pt) |
| JP (1) | JP4329936B2 (pt) |
| CN (1) | CN100342939C (pt) |
| AT (1) | ATE350121T1 (pt) |
| AU (1) | AU2003230006B2 (pt) |
| BR (1) | BR0311332A (pt) |
| CA (1) | CA2485941C (pt) |
| DE (1) | DE60310923T2 (pt) |
| DK (1) | DK1509301T3 (pt) |
| ES (1) | ES2279109T3 (pt) |
| IL (1) | IL165135A (pt) |
| MX (1) | MXPA04011508A (pt) |
| NO (1) | NO20045574L (pt) |
| NZ (1) | NZ536716A (pt) |
| OA (1) | OA12826A (pt) |
| PT (1) | PT1509301E (pt) |
| WO (1) | WO2003101578A1 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7244307B2 (en) * | 2002-05-31 | 2007-07-17 | Accentus Plc | Production of crystalline materials by using high intensity ultrasound |
| GB0405108D0 (en) * | 2004-03-06 | 2004-04-07 | Accentus Plc | Removal of sodium oxalate from a bayer liquor |
| GB0413511D0 (en) * | 2004-06-17 | 2004-07-21 | Accentus Plc | Precipitation of gibbsite from a bayer liquor |
| GB0415237D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Formation of sugar coatings |
| GB0415227D0 (en) * | 2004-07-07 | 2004-08-11 | Accentus Plc | Precipitation of silica in a Bayer process |
| GB0503193D0 (en) * | 2005-02-16 | 2005-03-23 | Accentus Plc | Ultrasonic treatment plant |
| US7597148B2 (en) * | 2005-05-13 | 2009-10-06 | Baker Hughes Incorporated | Formation and control of gas hydrates |
| EP1782797A1 (en) * | 2005-11-02 | 2007-05-09 | Pharmatex Italia Srl | Process for the preparation of sterile powdered pharmaceutical compounds. |
| GB0524823D0 (en) * | 2005-12-06 | 2006-01-11 | Accentus Plc | Removal of contaminants from a bayer liquor |
| GB0821419D0 (en) * | 2008-11-24 | 2008-12-31 | Bio Sep Ltd | Processing of biomass |
| NZ597065A (en) * | 2009-05-14 | 2014-08-29 | Cavitus Pty Ltd | Density modification |
| US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
| EP2399658A1 (en) | 2010-06-24 | 2011-12-28 | Biosyn Arzneimittel GmbH | Method for producing pharmacologically pure crystals |
| EP2500072A1 (en) | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
| WO2012142927A1 (zh) * | 2011-04-18 | 2012-10-26 | 合肥贝霓医药科技有限公司 | 一种纯化二氢吡啶类钙通道阻滞剂并制备其纳米的方法 |
| US20160136598A1 (en) | 2013-07-03 | 2016-05-19 | Pusonics S.L. | Ultrasonic system for mixing multiphase media and liquids, and associated method |
| US10604730B2 (en) * | 2015-10-16 | 2020-03-31 | Terressentia Corporation | Alcoholic beverage maturing device |
| CN107008028B (zh) * | 2017-05-22 | 2023-09-08 | 天津晶润锐拓科技发展有限公司 | 一种通过超声波控制结晶成核过程的结晶器 |
| MY195987A (en) * | 2017-11-22 | 2023-02-27 | Aak Ab Publ | Process for Dry Fractionation of a Palm Oil Olein |
| CN107963929A (zh) * | 2017-12-05 | 2018-04-27 | 上海永通化工有限公司 | 一种植物营养元素结晶体及其制备方法 |
| CN110354528B (zh) * | 2019-08-21 | 2021-11-19 | 贺剑 | 溶液结晶系统及促进溶液结晶的方法 |
| EP3925932A1 (en) | 2020-06-17 | 2021-12-22 | Biosyn Arzneimittel GmbH | Contained production of pharmaceutically pure crystals |
| CN113521791A (zh) * | 2021-06-23 | 2021-10-22 | 福建江夏学院 | 一种光电半导体薄膜的超声波振荡制备装置 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1347350A (en) * | 1918-02-26 | 1920-07-20 | Gen Electric | Crystal production |
| US2876083A (en) * | 1953-06-29 | 1959-03-03 | Prietl Franz | Process of producing crystals from particles of crystallizable substance distributedin a liquid |
| US3892539A (en) * | 1969-09-26 | 1975-07-01 | Merck & Co Inc | Process for production of crystals in fluidized bed crystallizers |
| EP0314469B1 (en) * | 1987-10-27 | 1993-06-23 | Fujitsu Limited | Process and apparatus for preparation of single crystal of biopolymer |
| US5362455A (en) * | 1990-05-03 | 1994-11-08 | Praxair Technology, Inc. | Draft tube, direct contact cryogenic crystallizer |
| GB2276567B (en) | 1993-04-03 | 1996-11-27 | Atomic Energy Authority Uk | Processing vessel |
| DE4431872C1 (de) | 1994-09-07 | 1996-01-11 | Santrade Ltd | Anwendung von Ultraschall bei der Verfestigung von Schmelzen oder übersättigten Lösungen auf Förderbändern oder Aufnahmetrommeln |
| WO2000033366A1 (de) * | 1998-11-30 | 2000-06-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur herstellung von multikristallinem halbleitermaterial |
| GB9827360D0 (en) | 1998-12-12 | 1999-02-03 | Aea Technology Plc | Process and apparatus for irradiating fluids |
| FI122018B (fi) * | 2000-01-31 | 2011-07-29 | Danisco | Menetelmä betaiinin kiteyttämiseksi |
| US6630185B2 (en) * | 2000-07-18 | 2003-10-07 | Lipton, Division Of Conopco, Inc. | Crystallization process using ultrasound |
| JP5008215B2 (ja) * | 2000-09-29 | 2012-08-22 | 三菱瓦斯化学株式会社 | 晶析方法および装置 |
| KR100655834B1 (ko) * | 2000-11-22 | 2006-12-08 | 오츠카 세이야쿠 가부시키가이샤 | Ｏ／ｗ형 유화 조성물 및 그의 조제 방법 |
| ES2420104T3 (es) * | 2001-04-13 | 2013-08-22 | Otsuka Pharmaceutical Co., Ltd. | Promotores de la captación de azúcar |
| CN1250312C (zh) * | 2001-05-05 | 2006-04-12 | 阿山特斯有限公司 | 小晶体形成 |
| DE10123073A1 (de) | 2001-05-11 | 2003-03-27 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Kristallen aus in einem Lösungsmittel gelösten Feststoffen |
| US6958040B2 (en) * | 2001-12-28 | 2005-10-25 | Ekos Corporation | Multi-resonant ultrasonic catheter |
| AU2003207467A1 (en) * | 2002-01-07 | 2003-07-24 | Abbott Gmbh And Co. Kg | Crystallization of amino acids using ultrasonic agitation |
| US7063741B2 (en) * | 2002-03-27 | 2006-06-20 | General Electric Company | High pressure high temperature growth of crystalline group III metal nitrides |
-
2003
- 2003-05-13 JP JP2004508925A patent/JP4329936B2/ja not_active Expired - Fee Related
- 2003-05-13 CN CNB038121603A patent/CN100342939C/zh not_active Expired - Fee Related
- 2003-05-13 US US10/514,883 patent/US7357835B2/en not_active Expired - Fee Related
- 2003-05-13 MX MXPA04011508A patent/MXPA04011508A/es active IP Right Grant
- 2003-05-13 CA CA2485941A patent/CA2485941C/en not_active Expired - Fee Related
- 2003-05-13 DK DK03722846T patent/DK1509301T3/da active
- 2003-05-13 PT PT03722846T patent/PT1509301E/pt unknown
- 2003-05-13 EP EP03722846A patent/EP1509301B1/en not_active Expired - Lifetime
- 2003-05-13 BR BR0311332-9A patent/BR0311332A/pt not_active Application Discontinuation
- 2003-05-13 AU AU2003230006A patent/AU2003230006B2/en not_active Ceased
- 2003-05-13 NZ NZ536716A patent/NZ536716A/en unknown
- 2003-05-13 WO PCT/GB2003/002017 patent/WO2003101578A1/en not_active Ceased
- 2003-05-13 AT AT03722846T patent/ATE350121T1/de not_active IP Right Cessation
- 2003-05-13 DE DE60310923T patent/DE60310923T2/de not_active Expired - Lifetime
- 2003-05-13 ES ES03722846T patent/ES2279109T3/es not_active Expired - Lifetime
- 2003-05-13 OA OA1200400316A patent/OA12826A/en unknown
-
2004
- 2004-11-10 IL IL165135A patent/IL165135A/en not_active IP Right Cessation
- 2004-12-21 NO NO20045574A patent/NO20045574L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4329936B2 (ja) | 2009-09-09 |
| MXPA04011508A (es) | 2005-08-15 |
| ES2279109T3 (es) | 2007-08-16 |
| ATE350121T1 (de) | 2007-01-15 |
| EP1509301B1 (en) | 2007-01-03 |
| US20050188913A1 (en) | 2005-09-01 |
| CN1655857A (zh) | 2005-08-17 |
| EP1509301A1 (en) | 2005-03-02 |
| DE60310923D1 (de) | 2007-02-15 |
| CA2485941C (en) | 2011-02-01 |
| DK1509301T3 (da) | 2007-03-19 |
| AU2003230006A1 (en) | 2003-12-19 |
| IL165135A0 (en) | 2005-12-18 |
| AU2003230006B2 (en) | 2008-06-19 |
| NZ536716A (en) | 2006-08-31 |
| OA12826A (en) | 2006-07-11 |
| WO2003101578A1 (en) | 2003-12-11 |
| DE60310923T2 (de) | 2007-07-05 |
| CN100342939C (zh) | 2007-10-17 |
| US7357835B2 (en) | 2008-04-15 |
| IL165135A (en) | 2008-11-03 |
| PT1509301E (pt) | 2007-01-31 |
| JP2005527368A (ja) | 2005-09-15 |
| CA2485941A1 (en) | 2003-12-11 |
| NO20045574L (no) | 2004-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL165135A0 (en) | Production of crystalline materials by using high intensity ultrasound | |
| BR0309908A (pt) | Método para produção de material cristalino | |
| CN204601410U (zh) | 多频环阵探头及包含其的超声理疗仪 | |
| WO2002070063A3 (en) | Method and apparatus for the generation of ultrasonic energy fields within circular structures containing a liquid | |
| CN103341241B (zh) | 一种高强度聚焦超声换能器阵列 | |
| Lucas et al. | Research applications and opportunities in power ultrasonics | |
| JP2007522904A5 (pt) | ||
| JP2005527367A5 (pt) | ||
| PT1148943E (pt) | Processo e aparelho para irradiar fluidos | |
| Dezhkunov | Multibubble sonoluminescence intensity dependence on liquid temperature at different ultrasound intensities | |
| RU2121812C1 (ru) | Формирователь акустических волн литотриптора | |
| CN223734138U (zh) | 晶片加工装置 | |
| CN202223769U (zh) | 超声换能器的声场监控装置 | |
| Lebedev et al. | Ultrasonic oscillating system for radiators of gas media | |
| ES2008968A6 (es) | Radiador sonico o ultrasonico focalizado para aplicaciones de alta intensidad en fluidos. | |
| CN1265851C (zh) | 一种特超声治疗仪 | |
| CN210207522U (zh) | 一种用于医美的双频换能器 | |
| Bains et al. | Application of ultrasound in periodontics: Part I | |
| Umemura et al. | Enhancement of sonochemical reactions by second harmonic superimposition | |
| JP3795601B2 (ja) | 微弱超音波を用いた湖沼の汚染物質分解装置 | |
| Tsujimura et al. | Development of a Calcium Imaging System for Mouse-derived Myoblast Cell Line C2C12 under Ultrasound Stimulation | |
| Carnell et al. | The generation of negative pressure waves for cavitation studies | |
| Jarosz | Ultrasonic interstitial heating in phantoms | |
| JPH0832110B2 (ja) | 超音波探触子 | |
| JPH0614977A (ja) | 超音波殺菌方法及び装置 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: ACCENTUS PLC (GB) Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS ATRAVES DA PETICAO NO 020070184946/RJ DE 28/12/2007. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 8O COMBINADO COM O ART. 13 DA LPI (LEI 9279/96). |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |