BR0316552A - Microorganismos metabolicamente engenheirado e geneticamente transformado, e, método para produzir um produto metabólico desejado - Google Patents
Microorganismos metabolicamente engenheirado e geneticamente transformado, e, método para produzir um produto metabólico desejadoInfo
- Publication number
- BR0316552A BR0316552A BR0316552-3A BR0316552A BR0316552A BR 0316552 A BR0316552 A BR 0316552A BR 0316552 A BR0316552 A BR 0316552A BR 0316552 A BR0316552 A BR 0316552A
- Authority
- BR
- Brazil
- Prior art keywords
- metabolite
- enzyme
- metabolically engineered
- transformed
- suitably
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- 230000002503 metabolic effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002207 metabolite Substances 0.000 abstract 6
- 108090000790 Enzymes Proteins 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 101710088194 Dehydrogenase Proteins 0.000 abstract 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 abstract 2
- 230000037353 metabolic pathway Effects 0.000 abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- 230000026731 phosphorylation Effects 0.000 abstract 2
- 238000006366 phosphorylation reaction Methods 0.000 abstract 2
- 101710130324 NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
"MICROORGANISMOS METABOLICAMENTE ENGENHEIRADO E GENETICAMENTE TRANSFORMADO, E, MéTODO PARA PRODUZIR UM PRODUTO METABóLICO DESEJADO". Um microorganismo metabolicamente engenheirado tem um primeiro caminho metabólico operativo em que um primeiro metabólito é transformado em um segundo metabólito em uma reação em que NAD é um cofator para uma primeira enzima, adequadamente uma desidrogenase de fosforilação, a dita etapa de reação produzindo NADH. O dito segundo metabólito é transformado em pelo menos um outro metabólito em uma reação catalisada por uma segunda enzima, adequadamente uma cinase. O organismo tem um segundo caminho metabólico operativo caracterizado por uma atividade enzimática em excesso de um nível nativo em relação a uma terceira enzima, adequadamente uma desidrogenase que não de fosforilação, por exemplo GAPN, que catalisa uma reação não reversível em que NADP é um cofator e NADPH é um produto. O dito primeiro metabólito é transformado em um dito outro metabólito sem o envolvimento da dita segunda enzima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0227435.5A GB0227435D0 (en) | 2002-11-25 | 2002-11-25 | Metabolically engineered micro-organisms having reduced production of undesired metobolic products |
| PCT/EP2003/013231 WO2004048559A1 (en) | 2002-11-25 | 2003-11-25 | Metabolically engineered micro-organisms having reduced production of undesired metabolic products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0316552A true BR0316552A (pt) | 2005-10-04 |
Family
ID=9948449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0316552-3A BR0316552A (pt) | 2002-11-25 | 2003-11-25 | Microorganismos metabolicamente engenheirado e geneticamente transformado, e, método para produzir um produto metabólico desejado |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060257983A1 (pt) |
| EP (1) | EP1565554A1 (pt) |
| CN (1) | CN100363490C (pt) |
| AU (1) | AU2003292106B2 (pt) |
| BR (1) | BR0316552A (pt) |
| CA (1) | CA2506195A1 (pt) |
| GB (1) | GB0227435D0 (pt) |
| WO (1) | WO2004048559A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2314560T3 (da) | 2004-03-26 | 2012-06-11 | Purdue Research Foundation | Fremgangsmåder til produktionen af xylitol |
| ES2620770T3 (es) * | 2006-03-13 | 2017-06-29 | Cargill, Incorporated | Proceso de fermentación que emplea células de levadura que tienen una ruta alterada desde dihidroxiacetona fosfato hasta glicerol |
| BRPI0921734A2 (pt) | 2008-10-31 | 2019-01-08 | California Inst Of Techn | micro-organismos criados geneticamente capazes de produzir compostos-alvo sob condições anaeróbicas |
| US20120045803A1 (en) * | 2009-02-23 | 2012-02-23 | Kirin Holdings Kabushiki Kaisha | Method for production of substance in candida utilis using xylose as carbon source |
| EP2277989A1 (en) * | 2009-07-24 | 2011-01-26 | Technische Universiteit Delft | Fermentative glycerol-free ethanol production |
| BR112012031362A2 (pt) | 2010-06-03 | 2015-10-13 | Mascoma Corp | levedura expressando enzimas sacarolíticas para bioprocessamento consolidado usando amido e celulose |
| EP3483279A1 (en) | 2011-04-05 | 2019-05-15 | Lallemand Hungary Liquidity Management LLC | Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors |
| US9745560B2 (en) | 2012-08-29 | 2017-08-29 | Lallemand Hungary Liquidity Management Llc | Expression of enzymes in yeast for lignocellulose derived oligomer CBP |
| EP2925873B1 (en) | 2012-11-30 | 2017-07-12 | Novozymes, Inc. | 3-hydroxypropionic acid production by recombinant yeasts |
| WO2015023989A1 (en) | 2013-08-15 | 2015-02-19 | Lallemand Hungary Liquidity Management Llc | Methods for the improvement of product yield and production in a microorganism through glycerol recycling |
| CN104195059B (zh) * | 2014-08-15 | 2016-08-24 | 陕西科技大学 | 多形汉逊酵母突变菌株及多形汉逊酵母生产d-阿拉伯糖醇的方法 |
| CN104357344A (zh) * | 2014-11-19 | 2015-02-18 | 江南大学 | 一种强化解脂亚洛酵母合成α-酮戊二酸的方法 |
| US12247208B2 (en) * | 2017-05-23 | 2025-03-11 | Danstar Ferment Ag | Optimization of biomass-based fermentations |
| BR112021010778A2 (pt) | 2018-12-07 | 2021-08-31 | Lallemand Hungary Liquidity Management Llc. | Modulação da geração de nadph por célula hospedeira de levedura recombinante durante fermentação |
| KR102207867B1 (ko) * | 2020-01-21 | 2021-01-26 | 씨제이제일제당 주식회사 | Nadp 의존적 글리세르알데하이드-3-포스페이트 디하이드로지나제를 포함하는 미생물을 이용하여 ｌ-아미노산을 생산하는 방법 |
| CN116096870A (zh) * | 2020-05-13 | 2023-05-09 | 诺维信公司 | 用于改善的戊糖发酵的工程化微生物 |
| US20240229046A1 (en) * | 2021-05-18 | 2024-07-11 | Zymergen Inc. | Engineered biosynthetic pathways for production of deoxyhydrochorismic acid by fermentation |
| WO2025230690A1 (en) * | 2024-05-01 | 2025-11-06 | Cargill, Incorporated | Genetically modified yeast and fermentation processes for the production of xylitol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL84007A0 (en) * | 1986-10-08 | 1988-02-29 | Gen Hospital Corp | Recombinant dna molecules which contain a plant-derived genetic sequence for glyceraldehyde phosphate dehydrogenase and a method of producing plant glyceraldehyde phosphate dehydrogenase |
| WO1995011985A1 (en) * | 1993-10-28 | 1995-05-04 | Ajinomoto Co., Inc. | Process for producing substance |
-
2002
- 2002-11-25 GB GBGB0227435.5A patent/GB0227435D0/en not_active Ceased
-
2003
- 2003-11-25 CA CA002506195A patent/CA2506195A1/en not_active Abandoned
- 2003-11-25 AU AU2003292106A patent/AU2003292106B2/en not_active Ceased
- 2003-11-25 WO PCT/EP2003/013231 patent/WO2004048559A1/en not_active Ceased
- 2003-11-25 US US10/536,495 patent/US20060257983A1/en not_active Abandoned
- 2003-11-25 EP EP03767646A patent/EP1565554A1/en not_active Withdrawn
- 2003-11-25 BR BR0316552-3A patent/BR0316552A/pt not_active IP Right Cessation
- 2003-11-25 CN CNB2003801041333A patent/CN100363490C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2506195A1 (en) | 2004-06-10 |
| GB0227435D0 (en) | 2002-12-31 |
| AU2003292106B2 (en) | 2009-07-16 |
| US20060257983A1 (en) | 2006-11-16 |
| EP1565554A1 (en) | 2005-08-24 |
| WO2004048559A1 (en) | 2004-06-10 |
| CN1717481A (zh) | 2006-01-04 |
| CN100363490C (zh) | 2008-01-23 |
| WO2004048559A8 (en) | 2005-08-25 |
| AU2003292106A1 (en) | 2004-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |