BR0318395A - método para preparar uma solução aquosa de meloxicam e a solução aquosa resultante - Google Patents
método para preparar uma solução aquosa de meloxicam e a solução aquosa resultanteInfo
- Publication number
- BR0318395A BR0318395A BRPI0318395-5A BR0318395A BR0318395A BR 0318395 A BR0318395 A BR 0318395A BR 0318395 A BR0318395 A BR 0318395A BR 0318395 A BR0318395 A BR 0318395A
- Authority
- BR
- Brazil
- Prior art keywords
- solution
- meloxicam
- preparing
- aqueous
- ophthalmic solution
- Prior art date
Links
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 title abstract 5
- 229960001929 meloxicam Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 239000000243 solution Substances 0.000 title abstract 3
- 239000007864 aqueous solution Substances 0.000 title 1
- 229940054534 ophthalmic solution Drugs 0.000 abstract 3
- 239000002997 ophthalmic solution Substances 0.000 abstract 3
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- 208000030533 eye disease Diseases 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"MéTODO PARA PREPARAR UMA SOLUçãO AQUOSA DE MELOXICAM E A SOLUçãO AQUOSA RESULTANTE". A presente invenção refere-se a um método para solubilizar um agente ativo inibidor seletivo de ciclooxigenase-2 (COX-2), como meloxicam, e um método para preparar uma solução oftálmica a partir do meloxicam solubilizado para o tratamento de diversas afecções oculares. A presente invenção refere-se também a uma solução oftálmica aquosa, que resulta do referido método, a qual é caracterizada por sua segurança, inocuidade e eficácia no tratamento do paciente. A nova solução oftálmica aquosa distingue-se pelo fato de que seu valor farmacêutico reside no manejo de um veículo de fácil acesso, que não apenas permite a solubilidade do meloxicam, mas também favorece uma maior tolerância do paciente ao tratamento de seu mal no olho ou de sua recuperação pós-cirúrgica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2003/000054 WO2005004876A1 (es) | 2003-07-10 | 2003-07-10 | Metodo para preparar una solucion acuosa de meloxicam y solucion acuosa resultante |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0318395A true BR0318395A (pt) | 2006-08-01 |
Family
ID=34056954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318395-5A BR0318395A (pt) | 2003-07-10 | 2003-07-10 | método para preparar uma solução aquosa de meloxicam e a solução aquosa resultante |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070092539A1 (pt) |
| EP (2) | EP1972340A3 (pt) |
| AU (1) | AU2003243055A1 (pt) |
| BR (1) | BR0318395A (pt) |
| MX (1) | MXJL06000001A (pt) |
| WO (1) | WO2005004876A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| TR200809200A1 (tr) * | 2008-12-01 | 2009-12-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Meloksikam içeren farmasötik formülasyonlar |
| EP2440185B1 (en) * | 2009-06-09 | 2015-04-08 | Aurinia Pharmaceuticals Inc. | Topical drug delivery systems for ophthalmic use |
| CN103110575B (zh) * | 2013-03-07 | 2014-11-05 | 宁夏康亚药业有限公司 | 一种美洛昔康滴眼液及其制备方法和应用 |
| US20180168932A1 (en) * | 2016-12-20 | 2018-06-21 | Apotex Technologies Inc. | Meloxicam Dosage Forms |
| US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
| US12059423B2 (en) * | 2018-05-11 | 2024-08-13 | Nanjing Delova Biotech Co., Ltd. | Meloxicam composition, pharmaceutical preparation and preparation method and use thereof |
| US20240207283A1 (en) * | 2021-05-28 | 2024-06-27 | Veterinary Pharmacy Corporation | Water soluble complex compositions and methods thereof |
| CN115494174B (zh) * | 2022-09-23 | 2024-03-29 | 南京瑞孚医药科技有限公司 | 一种高效液相色谱法检测美洛昔康中硫脲的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679135B1 (fr) * | 1991-07-18 | 1995-05-19 | Europhta Sa Laboratoire | Nouvelles compositions ophtalmiques a adhesivite amelioree et leurs procedes de preparation. |
| ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| MX9701946A (es) | 1997-03-14 | 1998-04-30 | Arturo Jimenez Bayardo | Solucion oftalmica transportadora. |
| KR20010023256A (ko) * | 1997-08-27 | 2001-03-26 | 헥살 아게 | 용해도와 생체 이용성이 개선된 신규의 멜록시캄 의약조성물 |
| CN1175904C (zh) * | 1998-05-15 | 2004-11-17 | 若素制药株式会社 | 抗炎滴眼剂 |
| WO2001037838A1 (en) * | 1999-11-24 | 2001-05-31 | Wakamoto Pharmaceutical Co., Ltd. | Ophthalmic aqueous preparation |
| DE10161077A1 (de) * | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
-
2003
- 2003-07-10 BR BRPI0318395-5A patent/BR0318395A/pt not_active IP Right Cessation
- 2003-07-10 EP EP08159211A patent/EP1972340A3/en not_active Withdrawn
- 2003-07-10 US US10/564,271 patent/US20070092539A1/en not_active Abandoned
- 2003-07-10 AU AU2003243055A patent/AU2003243055A1/en not_active Abandoned
- 2003-07-10 EP EP03817445A patent/EP1649858A1/en not_active Withdrawn
- 2003-07-10 WO PCT/MX2003/000054 patent/WO2005004876A1/es not_active Ceased
-
2006
- 2006-01-10 MX MXJL06000001A patent/MXJL06000001A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXJL06000001A (es) | 2006-04-11 |
| US20070092539A1 (en) | 2007-04-26 |
| WO2005004876A1 (es) | 2005-01-20 |
| EP1972340A2 (en) | 2008-09-24 |
| EP1649858A1 (en) | 2006-04-26 |
| AU2003243055A1 (en) | 2005-01-28 |
| EP1972340A3 (en) | 2008-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |