BR0318449A - processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i - Google Patents

processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i

Info

Publication number
BR0318449A
BR0318449A BRPI0318449-8A BR0318449A BR0318449A BR 0318449 A BR0318449 A BR 0318449A BR 0318449 A BR0318449 A BR 0318449A BR 0318449 A BR0318449 A BR 0318449A
Authority
BR
Brazil
Prior art keywords
forma
manufacturing
clopidogrel bisulfate
manufacture
present
Prior art date
Application number
BRPI0318449-8A
Other languages
English (en)
Inventor
Jaweed Mukarram Siddi Mohammed
Aravind Yekanathsa Merwade
Anjum Reyaz Khan
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of BR0318449A publication Critical patent/BR0318449A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA FABRICAçãO DE (+)-(S)-CLOPIDOGREL BISSULFATO FORMA-I". A presente invenção refere-se a um novo processo para fabricação de um agente de inibição de agregação de plaquetas sangüíneas. Em particular, a presente invenção refere-se a um processo para a fabricação de bissulfato de metil-(+)-(S)-<244>-(2-clorofenil)-6,7-dihidrotieno¢3,2-c!piridina-S(4H)- acetato Forma-I.
BRPI0318449-8A 2003-08-04 2003-08-04 processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i BR0318449A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2003/003104 WO2005012300A1 (en) 2003-08-04 2003-08-04 A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i

Publications (1)

Publication Number Publication Date
BR0318449A true BR0318449A (pt) 2006-08-01

Family

ID=34113359

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318449-8A BR0318449A (pt) 2003-08-04 2003-08-04 processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i

Country Status (9)

Country Link
US (2) US7291735B2 (pt)
EP (1) EP1651646B1 (pt)
JP (1) JP2007516934A (pt)
AT (1) ATE557028T1 (pt)
AU (1) AU2003253120A1 (pt)
BR (1) BR0318449A (pt)
CA (1) CA2534893A1 (pt)
ES (1) ES2387802T3 (pt)
WO (1) WO2005012300A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
BR0318449A (pt) * 2003-08-04 2006-08-01 Wockhardt Ltd processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
PT1680430E (pt) * 2003-11-03 2010-04-26 Cadila Healthcare Ltd Processos para a preparação da forma i de bissulfato de (s)-(+)-clopidogrel
HRP20160757T1 (hr) 2004-04-19 2016-08-12 Krka, Tovarna Zdravil, D.D., Novo Mesto Postupak za proizvodnju polimorfnog oblika i od klopidogrel-vodik-sulfata
CA2594763A1 (en) * 2005-02-24 2006-08-31 Teva Pharmaceutical Industries Ltd. Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
WO2007017886A1 (en) * 2005-08-11 2007-02-15 Arch Pharmalabs Limited Novel process for preparation of clopidogrel bisulphate polymorphic form i
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
US7985859B2 (en) 2007-05-30 2011-07-26 Wockhardt Ltd. Processes for the preparation of clopidogrel
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
CA2725997A1 (en) * 2008-06-24 2009-12-30 Zach System S.P.A. Process for the preparation of clopidogrel hydrogen sulfate crystalline form i
WO2011042804A2 (en) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
CN102796114A (zh) * 2011-05-25 2012-11-28 浙江京新药业股份有限公司 一种制备(+)-(s-)-氯吡格雷硫酸氢盐1晶型的方法
WO2014118802A1 (en) 2013-01-31 2014-08-07 Pharmazell Gmbh An improved process for the preparation of clopidogrel bisulfate form-i
CN103193792A (zh) * 2013-03-13 2013-07-10 广东中科药物研究有限公司 一种治疗缺血性心脑血管疾病的新化合物
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107337683B (zh) * 2017-08-16 2019-08-16 中荣凯特（北京）生物科技有限公司 一种噻吩并吡啶类衍生物硫酸氢盐的晶型ⅱ及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
BR0318449A (pt) * 2003-08-04 2006-08-01 Wockhardt Ltd processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i

Also Published As

Publication number Publication date
US20080051581A1 (en) 2008-02-28
AU2003253120A1 (en) 2005-02-15
JP2007516934A (ja) 2007-06-28
EP1651646B1 (en) 2012-05-09
US20060183907A1 (en) 2006-08-17
CA2534893A1 (en) 2005-02-10
ES2387802T3 (es) 2012-10-02
US7291735B2 (en) 2007-11-06
WO2005012300A1 (en) 2005-02-10
US7482453B2 (en) 2009-01-27
EP1651646A1 (en) 2006-05-03
ATE557028T1 (de) 2012-05-15
EP1651646A4 (en) 2007-03-21

Similar Documents

Publication Publication Date Title
BR0318449A (pt) processo para fabricação de (+)-(s)-clopidogrel bissulfato forma-i
BR9911219A (pt) Forma polimórfica de hidrogeno sulfato de clopidogrel
MX2008013724A (es) Proceso para la preparacion de formas polimorficas de hidrogeno sulfato clopidrogel.
BG108868A (en) Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
GB0321256D0 (en) Novel crystalline compounds
DK1620439T3 (da) Hidtil ukendte polymorfer af olanzapinhydrochlorid
PL354642A1 (en) Method of manufacture of alanzapine, new derivative of n-demethyl olanzapine and method of manufacture of new derivative of n-demethyl olanzapine
ATE403660T1 (de) Benzo 4,5 thieno 3,2-b pyran-2-on enthaltende duftstoffzusammensetzungen
DK1501838T3 (da) Fremgangsmåde til fremstilling af clopidogrel
ECSP066932A (es) Formas polimórficas de hidrobromuro acetato de metil(+)-(s)- alfa-(2-clorofenil)-6,7-dihidrotieno[3,2-c]piridina-5(4h), hidrobromuro de clopidogrel
TNSN06311A1 (en) Clopidogrel salt and polymorphic forms thereof
GEP20104957B (en) A PROCESS FOR THE PREPARATION OF POLYMORPH FORM I OF (S)-(+)-METHYL-ά-(2-CHLOROPHENYL)-6,7-DYHIDRO-THIENO-[3,2-c]PYRIDINE-5(4H)-ACETATE HYDROGEN SULFATE
EA200600137A1 (ru) Способ получения аморфной формы ингибитора агрегации тромбоцитов
NO20030605L (no) Fremgangsmåte for fremstilling av imidazo-(1,2-C)(2,3)- benzodiazepiner, samt mellomprodukter ved fremstillingen derav
WO2007032023A8 (en) A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
UA86772C2 (en) Process for the preparation of the polymorph form of methyl (s)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate
ATE291025T1 (de) Thienopyrimidine
HU0700809D0 (en) Racemisation process for producing methyl (r,s)-(+)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4h)-acetate hydrogene sulfate intermediate
PL357427A1 (en) Method of manufacture of crystalline form of methyl 1 hydrogen sulphate (+)-(s)-alpha- (2-chlorophenylo)-4,5,6,7-tetra hydrotieno[3,2-c]pirydynylo-5-acetate
ITMI20020132A0 (it) Processo per l&#39;ottenimento dell&#39;acido (6s)-5,6,7,8-tetraidrofolico
DE602006021792D1 (de) Verfahren zur herstellung von olanzapin
WO2008108742A3 (en) Polymorphic forms of clopidogrel hydrobromide
BRPI0408771A (pt) processo para a produção de imidazopiridin-8-onas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.