BR0318685A - compostos de cetona e composições para controle de colesterol e usos relacionados - Google Patents
compostos de cetona e composições para controle de colesterol e usos relacionadosInfo
- Publication number
- BR0318685A BR0318685A BRPI0318685-7A BR0318685A BR0318685A BR 0318685 A BR0318685 A BR 0318685A BR 0318685 A BR0318685 A BR 0318685A BR 0318685 A BR0318685 A BR 0318685A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- ketone compounds
- useful
- methods
- compounds
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- -1 ketone compounds Chemical class 0.000 title abstract 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000018914 glucose metabolism disease Diseases 0.000 abstract 1
- 229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940075461 other therapeutic product in atc Drugs 0.000 abstract 1
- 208000013223 septicemia Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
- C07C59/353—Saturated compounds containing more than one carboxyl group containing keto groups containing rings
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- C—CHEMISTRY; METALLURGY
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
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- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
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- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07F9/24—Esteramides
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- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
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- C07C2601/14—The ring being saturated
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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Abstract
"COMPOSTOS DE CETONA E COMPOSIçõES PARA CONTROLE DE COLESTEROL E USOS RELACIONADOS". A presente invenção refere-se a novos compostos de cetona, composições compreendendo compostos de cetona, e métodos úteis para tratar e prevenir doenças cardiovasculares, dislipidemias, e distúrbios do metabolismo da glicose compreendendo administrar uma composição que compreende um composto de cetona. Os compostos composições, e métodos da invenção são também úteis para tratar e prevenir doença de Alzheimer, Síndrome X, distúrbios relacionados a receptor ativado por proliferador de peroxissoma, septicemia, distúrbios trombóticos, obesidade, pancreatite, hipertensão, doença renal, inflamação, e impotência. Em certas modalidades, os compostos, composições, e métodos da invenção são úteis em terapia de combinação com outros produtos terapêuticos, tais como agentes hipocolesterolêmicos e agentes hipoglicêmicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/041448 WO2005068412A1 (en) | 2003-12-24 | 2003-12-24 | Ketone compounds and compositions for cholesterol management and related uses |
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| Publication Number | Publication Date |
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| BR0318685A true BR0318685A (pt) | 2006-12-19 |
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| BRPI0318685-7A BR0318685A (pt) | 2003-12-24 | 2003-12-24 | compostos de cetona e composições para controle de colesterol e usos relacionados |
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| EP (1) | EP1701931B1 (pt) |
| JP (1) | JP2007525408A (pt) |
| AU (1) | AU2003304703A1 (pt) |
| BR (1) | BR0318685A (pt) |
| CA (1) | CA2549995C (pt) |
| WO (1) | WO2005068412A1 (pt) |
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| ES2625429T3 (es) | 2003-01-23 | 2017-07-19 | Esperion Therapeutics Inc. | Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes |
| JP2007525408A (ja) | 2003-12-24 | 2007-09-06 | エスペリオン セラピューティクス,インコーポレイテッド | コレステロール管理および関連使用のためのケトン化合物および組成物 |
| JP2013537240A (ja) * | 2010-09-20 | 2013-09-30 | カリウス セラピューティクス エスエー | 糖尿病および脂質異常症の処置のための方法および組成物 |
| CA2947127A1 (en) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
| EP3267989A4 (en) | 2015-03-13 | 2018-11-07 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| US11286249B2 (en) * | 2019-06-07 | 2022-03-29 | Eli Lilly And Company | Pyrrolidine compounds |
| MX2021015936A (es) | 2019-06-21 | 2022-04-26 | Esperion Therapeutics Inc | Metodos para preparar acido bempedoico y composiciones del mismo. |
| CN111253246B (zh) * | 2020-03-16 | 2023-03-17 | 中国医学科学院基础医学研究所 | 酰基酸类衍生物及其制备方法和医药用途 |
| CN112479856B (zh) * | 2021-01-18 | 2022-05-13 | 南京工业大学 | 一种贝派地酸的合成方法 |
| CN113797190A (zh) * | 2021-09-24 | 2021-12-17 | 徐州医科大学 | 正丁基丙二酸二乙酯在制备防治肥胖药物中应用 |
| WO2023078333A1 (zh) * | 2021-11-03 | 2023-05-11 | 上海拓界生物医药科技有限公司 | 一种取代的苯丙酸衍生物及其用途一种取代的苯丙酸衍生物及其用途 |
| CN120787221A (zh) * | 2023-03-24 | 2025-10-14 | 上海京新生物医药有限公司 | 一种环状胺衍生物及其组合物与应用 |
| CN116589341A (zh) * | 2023-04-14 | 2023-08-15 | 苏州汉德创宏生化科技有限公司 | 一种抗高血酯药物中间体的制备方法 |
| CN119894882A (zh) * | 2023-04-21 | 2025-04-25 | 深圳信立泰药业股份有限公司 | 一种叔胺类化合物及其制备方法和医药用途 |
| WO2024230805A1 (zh) * | 2023-05-11 | 2024-11-14 | 江苏恒瑞医药股份有限公司 | 一种脂蛋白化合物晶型及其制备方法 |
| WO2025024218A1 (en) * | 2023-07-21 | 2025-01-30 | Eli Lilly And Company | PYRROLIDINE COMPOUNDS WITH Lp(a) LOWERING ACTIVITY |
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| DE3423166A1 (de) | 1984-06-22 | 1986-01-02 | Epis S.A., Zug | Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
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| US5504073A (en) | 1994-07-01 | 1996-04-02 | Warner-Lambert Company | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption |
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| AU773915B2 (en) | 1999-04-28 | 2004-06-10 | Georgetown University | Ligands for metabotropic glutamate receptors |
| WO2001046110A2 (en) | 1999-12-23 | 2001-06-28 | The University Of Georgia Research Foundation, Inc. | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
| US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| CA2425311C (en) * | 2000-10-11 | 2011-06-14 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| ES2625429T3 (es) | 2003-01-23 | 2017-07-19 | Esperion Therapeutics Inc. | Compuestos de hidroxilo y composiciones para el control del colesterol y utilizaciones correspondientes |
| JP2007525408A (ja) | 2003-12-24 | 2007-09-06 | エスペリオン セラピューティクス,インコーポレイテッド | コレステロール管理および関連使用のためのケトン化合物および組成物 |
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| WO2005068412A1 (en) | 2005-07-28 |
| US20140228439A1 (en) | 2014-08-14 |
| US7705177B2 (en) | 2010-04-27 |
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| US8975300B2 (en) | 2015-03-10 |
| US20070155704A1 (en) | 2007-07-05 |
| JP2007525408A (ja) | 2007-09-06 |
| US8642653B2 (en) | 2014-02-04 |
| US8084498B2 (en) | 2011-12-27 |
| AU2003304703A1 (en) | 2005-08-03 |
| US20100137444A1 (en) | 2010-06-03 |
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