BR112012000534A2 - métodos e composições para uso em terapias celulares - Google Patents

métodos e composições para uso em terapias celulares

Info

Publication number: BR112012000534A2
Authority: BR; Brazil
Prior art keywords: compositions; methods; cell therapies; therapies; cell
Prior art date: 2009-07-09

Application number

BR112012000534A

Other languages

English (en)

Inventor

Buscher Dirk

Lombardo Eleuterio

Original Assignee

Cellerix Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-09

Filing date

2010-07-09

Publication date

2017-06-13

2010-07-09 Application filed by Cellerix Sa filed Critical Cellerix Sa

2017-06-13 Publication of BR112012000534A2 publication Critical patent/BR112012000534A2/pt

Links

238000002659 cell therapy Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Developmental Biology & Embryology (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Virology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Neurology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Transplantation (AREA)

BR112012000534A 2009-07-09 2010-07-09 métodos e composições para uso em terapias celulares BR112012000534A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22427509P	2009-07-09	2009-07-09
PCT/IB2010/001968 WO2011004264A1 (en)	2009-07-09	2010-07-09	Methods and compositions for use in cellular therapies

Publications (1)

Publication Number	Publication Date
BR112012000534A2 true BR112012000534A2 (pt)	2017-06-13

Family

ID=42782196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012000534A BR112012000534A2 (pt)	2009-07-09	2010-07-09	métodos e composições para uso em terapias celulares

Country Status (19)

Country	Link
US (1)	US8679834B2 (pt)
EP (2)	EP3150703A1 (pt)
JP (1)	JP5892931B2 (pt)
KR (1)	KR101788885B1 (pt)
CN (2)	CN107007626A (pt)
AU (1)	AU2010269962B2 (pt)
BR (1)	BR112012000534A2 (pt)
CA (1)	CA2767300C (pt)
DK (1)	DK2451943T3 (pt)
ES (1)	ES2479542T3 (pt)
HU (1)	HUE031921T2 (pt)
IL (1)	IL217377A (pt)
MX (1)	MX359639B (pt)
NZ (1)	NZ597975A (pt)
PL (1)	PL2451943T3 (pt)
PT (1)	PT2451943T (pt)
RU (1)	RU2610427C2 (pt)
SG (2)	SG10201403758SA (pt)
WO (1)	WO2011004264A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060045872A1 (en)	2004-08-25	2006-03-02	Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco	Use of adipose tissue-derived stromal stem cells in treating fistula
CA2623353C (en)	2005-09-23	2017-02-21	Cellerix, S.L.	Cell populations having immunoregulatory activity, method for isolation and uses
US11090363B2 (en)	2009-07-10	2021-08-17	University of Pittsburgh—of the Commonwealth System of Higher Education	Vasoactive intestinal peptide release from microparticles
WO2011006029A1 (en)	2009-07-10	2011-01-13	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Artificial cell constructs for inducing immunological tolerance
WO2012095743A2 (en) *	2011-01-12	2012-07-19	Cellerix Sa	Methods and compositions for use in intralymphatic cellular therapies
RS57886B1 (sr)	2011-11-30	2019-01-31	Astellas Inst For Regenerative Medicine	Mezenhimalne stromalne ćelije i primene vezane za njih
US8961956B2 (en)	2011-11-30	2015-02-24	Ocata Therapeutics, Inc.	Mesenchymal stromal cells and uses related thereto
CN104822384A (zh) *	2012-03-30	2015-08-05	南加州大学	用于间充质干细胞诱导的免疫调节的组合物和治疗方法
CA2876499C (en)	2012-07-12	2021-10-26	Imstem Biotechnology, Inc.	Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US10258652B2 (en)	2014-12-18	2019-04-16	Pluristem Ltd.	Methods and compositions for treating and preventing muscle wasting disorders
WO2016107563A1 (zh) *	2014-12-29	2016-07-07	西比曼生物科技（上海）有限公司	一种用于治疗上呼吸道疾病的脂肪间充质祖细胞复合物
US20180015125A1 (en)	2015-03-23	2018-01-18	Pluristem Ltd.	Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof
US20210205370A1 (en)	2016-02-18	2021-07-08	Pluristem Ltd.	Methods and compositions for treating cancers and neoplasms
GB201604304D0 (en)	2016-03-14	2016-04-27	Tigenix S A U	Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
WO2018002930A1 (en)	2016-06-30	2018-01-04	Stem Cell Medicine Ltd.	Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells
CA3062123A1 (en)	2017-05-15	2018-11-22	Stem Cell Medicine Ltd.	Treatment of multiple sclerosis with adipose-derived stem cells
WO2018211486A1 (en)	2017-05-15	2018-11-22	Stem Cell Medicine Ltd.	Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells
CN107349419A (zh) *	2017-07-17	2017-11-17	广东颜值科技有限公司	一种细胞组合物及其制备方法和应用
CN107281469A (zh) *	2017-07-17	2017-10-24	广东颜值科技有限公司	一种细胞组合物及其制备方法和应用
US12268714B2 (en)	2018-09-14	2025-04-08	Luca Science Inc.	Transplantation of mitochondria into lymphoid organ and composition therefor
US11975030B2 (en) *	2019-03-19	2024-05-07	Figene, Llc	Treatment of chronic obstructive pulmonary disease and lung degeneration using activated fibroblasts and exosome derivatives thereof
US11878037B2 (en)	2019-05-31	2024-01-23	Figene, Llc	Concurrent activation of regenerative and tolerogenic processes by fibroblast-based compositions for the treatment of multiple sclerosis
WO2021207192A1 (en) *	2020-04-08	2021-10-14	Figene, Llc	Methods and compositions for allergy and asthma treatment using fibroblasts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2493081C (en) *	2002-07-12	2013-04-23	The Johns Hopkins University	Reagents and methods for engaging unique clonotypic lymphocyte receptors
EP2260861A1 (en) *	2002-12-06	2010-12-15	NorthWest Biotherapeutics, Inc.	Administration of dendritic cells partially matured in vitro for the treatment of tumors
CA2623353C (en)	2005-09-23	2017-02-21	Cellerix, S.L.	Cell populations having immunoregulatory activity, method for isolation and uses
US8241621B2 (en) *	2006-12-18	2012-08-14	Medistem Laboratories	Stem cell mediated treg activation/expansion for therapeutic immune modulation
EP2581441A1 (en) *	2007-08-09	2013-04-17	Genzyme Corporation	Method of treating autoimmune disease with mesenchymal stem cells
US20110262402A1 (en) *	2007-09-07	2011-10-27	Masahiko Kuroda	Therapeutic and prophylactic agents for arthritis
US20110150845A1 (en) *	2008-05-02	2011-06-23	Massachusetts Institute Of Technology	Methods and compositions for modulating immunological tolerance
GB0814249D0 (en)	2008-08-04	2008-09-10	Cellerix Sa	Uses of mesenchymal stem cells

2010
- 2010-07-09 WO PCT/IB2010/001968 patent/WO2011004264A1/en not_active Ceased
- 2010-07-09 SG SG10201403758SA patent/SG10201403758SA/en unknown
- 2010-07-09 US US13/382,426 patent/US8679834B2/en active Active
- 2010-07-09 EP EP16199980.0A patent/EP3150703A1/en not_active Withdrawn
- 2010-07-09 CA CA2767300A patent/CA2767300C/en active Active
- 2010-07-09 SG SG2012001574A patent/SG177582A1/en unknown
- 2010-07-09 MX MX2012000396A patent/MX359639B/es active IP Right Grant
- 2010-07-09 AU AU2010269962A patent/AU2010269962B2/en active Active
- 2010-07-09 BR BR112012000534A patent/BR112012000534A2/pt not_active Application Discontinuation
- 2010-07-09 ES ES10752171.8T patent/ES2479542T3/es active Active
- 2010-07-09 CN CN201710067652.0A patent/CN107007626A/zh active Pending
- 2010-07-09 NZ NZ597975A patent/NZ597975A/en unknown
- 2010-07-09 RU RU2012104529A patent/RU2610427C2/ru active
- 2010-07-09 DK DK10752171.8T patent/DK2451943T3/en active
- 2010-07-09 JP JP2012519080A patent/JP5892931B2/ja active Active
- 2010-07-09 HU HUE10752171A patent/HUE031921T2/en unknown
- 2010-07-09 PL PL10752171T patent/PL2451943T3/pl unknown
- 2010-07-09 CN CN2010800308900A patent/CN102549147A/zh active Pending
- 2010-07-09 KR KR1020127003364A patent/KR101788885B1/ko active Active
- 2010-07-09 EP EP10752171.8A patent/EP2451943B1/en active Active
- 2010-07-09 PT PT107521718T patent/PT2451943T/pt unknown
2012
- 2012-01-05 IL IL217377A patent/IL217377A/en active IP Right Grant

Also Published As

Publication number	Publication date
IL217377A (en)	2017-10-31
RU2610427C2 (ru)	2017-02-10
MX359639B (es)	2018-10-04
ES2479542T1 (es)	2014-08-20
ES2479542T3 (es)	2017-05-26
CA2767300C (en)	2020-01-07
US20120308585A1 (en)	2012-12-06
PT2451943T (pt)	2017-01-20
DK2451943T3 (en)	2017-02-06
SG10201403758SA (en)	2014-10-30
KR101788885B1 (ko)	2017-10-20
CN107007626A (zh)	2017-08-04
KR20120051006A (ko)	2012-05-21
EP3150703A1 (en)	2017-04-05
CN102549147A (zh)	2012-07-04
PL2451943T3 (pl)	2017-04-28
MX2012000396A (es)	2012-07-17
SG177582A1 (en)	2012-03-29
JP5892931B2 (ja)	2016-03-23
IL217377A0 (en)	2012-02-29
HUE031921T2 (en)	2017-08-28
NZ597975A (en)	2014-06-27
RU2012104529A (ru)	2013-08-20
AU2010269962B2 (en)	2016-04-14
EP2451943A1 (en)	2012-05-16
WO2011004264A1 (en)	2011-01-13
AU2010269962A1 (en)	2012-03-01
JP2012532859A (ja)	2012-12-20
CA2767300A1 (en)	2011-01-13
US8679834B2 (en)	2014-03-25
EP2451943B1 (en)	2016-11-23

Legal Events

Date	Code	Title	Description
2017-12-12	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2018-04-10	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-02	B07G	Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
2018-07-31	B07B	Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
2021-06-01	B350	Update of information on the portal [chapter 15.35 patent gazette]
2021-09-28	B07G	Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]	Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI (NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021).
2021-10-05	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2022-02-01	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2022-07-12	B09B	Patent application refused [chapter 9.2 patent gazette]
2022-11-01	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.
2024-05-21	B25B	Requested transfer of rights rejected	Owner name: CELLERIX SA (ES) Free format text: INDEFERIDO O PEDIDO DE TRANSFERENCIA CONTIDO NA PETICAO 870220071137 DE 09/08/2022DEVIDO AO DESPACHO PUBLICADO NA RPI 2704 DE 01/11/2022.

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